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DK3175852T3 - Difluorlactamsammensætninger til EP4-medierede osteorelaterede sygdomme og tilstande - Google Patents

Difluorlactamsammensætninger til EP4-medierede osteorelaterede sygdomme og tilstande Download PDF

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Publication number
DK3175852T3
DK3175852T3 DK16192448.5T DK16192448T DK3175852T3 DK 3175852 T3 DK3175852 T3 DK 3175852T3 DK 16192448 T DK16192448 T DK 16192448T DK 3175852 T3 DK3175852 T3 DK 3175852T3
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DK
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Prior art keywords
difluorolactam
compositions
conditions
related diseases
osteo
Prior art date
Application number
DK16192448.5T
Other languages
English (en)
Inventor
Stephen Douglas Barrett
Fred Lawrence Ciske
Joseph Michael Colombo
Gregory William Endres
Bradlee David Germain
Andriy Kornilov
James Bernard Kramer
Adam Uzieblo
Thomas Allen Owen
James Paul O'malley
Original Assignee
Cayman Chemical Co Inc
Myometrics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cayman Chemical Co Inc, Myometrics Llc filed Critical Cayman Chemical Co Inc
Application granted granted Critical
Publication of DK3175852T3 publication Critical patent/DK3175852T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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DK16192448.5T 2012-07-19 2013-07-19 Difluorlactamsammensætninger til EP4-medierede osteorelaterede sygdomme og tilstande DK3175852T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261673514P 2012-07-19 2012-07-19
US201361793929P 2013-03-15 2013-03-15
EP13745254.6A EP2874620B1 (en) 2012-07-19 2013-07-19 Difluorolactam compositions for ep4-mediated osteo related diseases and conditions

Publications (1)

Publication Number Publication Date
DK3175852T3 true DK3175852T3 (da) 2019-05-27

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Application Number Title Priority Date Filing Date
DK16192448.5T DK3175852T3 (da) 2012-07-19 2013-07-19 Difluorlactamsammensætninger til EP4-medierede osteorelaterede sygdomme og tilstande
DK13745744.6T DK2875022T3 (da) 2012-07-19 2013-07-19 Difluorlactamforbindelser som ep4-receptorselektive agonister til anvendelse ved behandling af ep4-medierede sygdomme og tilstande

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DK13745744.6T DK2875022T3 (da) 2012-07-19 2013-07-19 Difluorlactamforbindelser som ep4-receptorselektive agonister til anvendelse ved behandling af ep4-medierede sygdomme og tilstande

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US (8) US9180116B2 (da)
EP (4) EP3175852B1 (da)
JP (3) JP6141430B2 (da)
KR (2) KR102131378B1 (da)
CN (4) CN106748951B (da)
AU (3) AU2013292356B2 (da)
CA (2) CA2879506C (da)
CY (1) CY1118929T1 (da)
DK (2) DK3175852T3 (da)
ES (3) ES2728159T3 (da)
HK (2) HK1206016A1 (da)
HR (1) HRP20170045T1 (da)
HU (2) HUE031885T2 (da)
IL (3) IL236637A (da)
LT (1) LT2875022T (da)
NZ (2) NZ704178A (da)
PH (1) PH12015500111A1 (da)
PL (1) PL2875022T3 (da)
PT (2) PT2875022T (da)
SI (1) SI2875022T1 (da)
WO (2) WO2014015247A1 (da)

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LT2875022T (lt) 2012-07-19 2017-03-10 Cayman Chemical Company, Incorporated Difluorlaktamo junginiai, tokie kaip ep4 receptoriaus selektyvūs agonistai, skirti naudoti ep4 sąlygotų ligų ir būsenų gydymui
AU2014229065B2 (en) * 2013-03-15 2017-03-09 Cayman Chemical Company, Inc. Methods of synthesizing a difluorolactam analog
SG11201507470WA (en) 2013-03-15 2015-10-29 Cayman Chemical Co Inc Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
US9676712B2 (en) 2013-03-15 2017-06-13 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
CN105392505A (zh) 2013-07-19 2016-03-09 开曼化学股份有限公司 用于促进骨生长的方法、系统和组合物
HU231033B1 (hu) 2016-03-22 2019-12-30 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás 3-as kötést tartalmazó optikailag aktív karbonsavak, karbonsav sók és karbonsav származékok előállítására
CN106699604B (zh) * 2017-01-09 2019-01-01 四川同晟生物医药有限公司 一种沙库比曲及其中间体的制备方法
EP3446661B1 (en) 2017-08-21 2021-12-29 Cook Medical Technologies LLC Braided stent crown geometry and flare

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