Nothing Special   »   [go: up one dir, main page]

DK1412503T3 - Et fusionsprotein - Google Patents

Et fusionsprotein

Info

Publication number
DK1412503T3
DK1412503T3 DK02749112T DK02749112T DK1412503T3 DK 1412503 T3 DK1412503 T3 DK 1412503T3 DK 02749112 T DK02749112 T DK 02749112T DK 02749112 T DK02749112 T DK 02749112T DK 1412503 T3 DK1412503 T3 DK 1412503T3
Authority
DK
Denmark
Prior art keywords
fusion protein
molecule
functional
relates
present
Prior art date
Application number
DK02749112T
Other languages
English (en)
Inventor
Simon Arnett Jones
Nicholas Topley
Original Assignee
Univ Cardiff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cardiff filed Critical Univ Cardiff
Application granted granted Critical
Publication of DK1412503T3 publication Critical patent/DK1412503T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056Lectin superfamily, e.g. CD23, CD72
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5412IL-6
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869Interleukin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
DK02749112T 2001-08-03 2002-08-02 Et fusionsprotein DK1412503T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119015.6A GB0119015D0 (en) 2001-08-03 2001-08-03 A fusion protein
PCT/GB2002/003581 WO2003014359A2 (en) 2001-08-03 2002-08-02 A fusion protein

Publications (1)

Publication Number Publication Date
DK1412503T3 true DK1412503T3 (da) 2009-04-06

Family

ID=9919793

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02749112T DK1412503T3 (da) 2001-08-03 2002-08-02 Et fusionsprotein

Country Status (13)

Country Link
US (3) US20050064558A1 (da)
EP (1) EP1412503B1 (da)
JP (1) JP4360902B2 (da)
KR (1) KR100870296B1 (da)
AT (1) ATE419362T1 (da)
AU (1) AU2002319524B2 (da)
CA (1) CA2456183C (da)
DE (1) DE60230627D1 (da)
DK (1) DK1412503T3 (da)
ES (1) ES2320862T3 (da)
GB (1) GB0119015D0 (da)
NZ (1) NZ530943A (da)
WO (1) WO2003014359A2 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1962719A4 (en) 2005-08-29 2011-05-04 Technion Res And Dev Of Foundation Ltd MEDIA FOR BREEDING STEM CELLS
PT2733203T (pt) * 2006-08-02 2019-01-23 Technion Res & Dev Foundation Métodos de expansão de células estminais embrionárias numa cultura de suspensão
CA2729747A1 (en) * 2008-07-02 2010-01-07 Emergent Product Development Seattle, Llc Il6 immunotherapeutics
EA201170031A1 (ru) * 2008-07-02 2011-08-30 Эмерджент Продакт Дивелопмент Сиэтл, Ллс СВЯЗЫВАЮЩИЕ НЕСКОЛЬКО МИШЕНЕЙ БЕЛКИ, ОБЛАДАЮЩИЕ АНТАГОНИСТИЧЕСКИМ ДЕЙСТВИЕМ ПО ОТНОШЕНИЮ К TGF-β
JP2010271181A (ja) * 2009-05-21 2010-12-02 Kenji Yamamoto Ccr5を標的とする阻害剤の疾病治療効果、予防効果及び副作用を評価する方法
US20130052195A1 (en) 2009-12-23 2013-02-28 Emergent Product Development Seattle,LLC Compositions Comprising TNF-alpha and IL-6 Antagonists and Methods of Use Thereof
US9429463B2 (en) 2013-03-04 2016-08-30 International Road Dynamics, Inc. System and method for measuring moving vehicle information using electrical time domain reflectometry
EP2992898A1 (en) * 2014-09-04 2016-03-09 Klinikum rechts der Isar der Technischen Universität München T-cell adjuvant and its use for therapeutic or prophylactic vaccination

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
US5250836A (en) * 1989-12-20 1993-10-05 Fujitsu Limited Semiconductor device having silicon-on-insulator structure
IL122818A0 (en) * 1997-07-10 1998-08-16 Yeda Res & Dev Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
WO2000001731A1 (fr) * 1998-07-06 2000-01-13 Tosoh Corporation Proteine fusionnee avec liaison directe du recepteur il-6 a il-6
US20040170604A1 (en) * 1998-07-06 2004-09-02 Tosoh Corporation IL-6 receptor IL-6 direct fusion protein

Also Published As

Publication number Publication date
AU2002319524B2 (en) 2006-10-12
ATE419362T1 (de) 2009-01-15
EP1412503B1 (en) 2008-12-31
WO2003014359A2 (en) 2003-02-20
DE60230627D1 (de) 2009-02-12
US20090252705A1 (en) 2009-10-08
JP2005502337A (ja) 2005-01-27
WO2003014359A3 (en) 2003-10-16
US20050064558A1 (en) 2005-03-24
GB0119015D0 (en) 2001-09-26
ES2320862T3 (es) 2009-05-29
KR100870296B1 (ko) 2008-11-25
KR20040049838A (ko) 2004-06-12
JP4360902B2 (ja) 2009-11-11
CA2456183C (en) 2010-01-05
US20070172458A1 (en) 2007-07-26
EP1412503A2 (en) 2004-04-28
NZ530943A (en) 2005-09-30
CA2456183A1 (en) 2003-02-20

Similar Documents

Publication Publication Date Title
NO20054223L (no) Antistoffmolekyler som har spesifisitet for human IL-1beta
HUP0303246A2 (hu) Aktív fehérjék fokozott kinyerése
FI963101A (fi) Anti-TNF-vasta-aineiden käyttö lääkkeenä sellaisten sairauksien hoitoon, joissa seerumin interleukiini-6-taso on kohonnut
CY1118443T1 (el) Anti-tnf αντισωματα, συνθεσεις, μεθοδοι και χρησεις
HK1061566A1 (en) Proteins producing an altered immunogenic response and methods of making and using the same
NO20041917D0 (no) Spesifikke midler som binder humant angiopoietin-2
EA200801427A1 (ru) Молекулы антитела со специфической активностью в отношении интерлейкина-6 (ил-6) человека
WO2005063820A3 (en) Il-7 fusion proteins
DE60311272D1 (de) Neue purin- oder pyrrolol(2,3-d)pyrimidin-2-carbonsäurenitrile zur behandlung von mit cysteinproteaseaktivität assoziierten krankheiten
SI1641483T1 (sl) Fuzijski proteini
NO20023008L (no) Cykliske AMP-spesifikke fosfodiesterase-inhibitorer
BR0215383A (pt) proteases que produzem resposta imunogênica alterada e métodos de fabricação e uso das mesmas
WO2003057856A3 (en) Dominant negative proteins and methods thereof
DK1412503T3 (da) Et fusionsprotein
EA200400399A1 (ru) Способы лечения легочных заболеваний
WO2003016551A3 (en) Novel salicylic acid-binding protein encoding nucleic acid, sabp2, and methods of use thereof
WO2005035564A3 (en) Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders
SE0004892D0 (sv) Group 2 allergen specific IgE-Fabs and use thereof
CY1105017T1 (el) Αντισωματα που διεγειρουν τη παραγωγη toy il-1ra
EP1395674A4 (en) ISOLATED HUMAN PROTEASE PROTEINS, HUMAN PROTEASE PROTEIN CODING NUCLEIC ACID MOLECULES AND USES THEREOF
EP1379678A4 (en) HUMAN PROTEASE ISOLATED PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN PROTEASE PROTEINS AND USES THEREOF
WO2001075027A3 (fr) Nouveau polypeptide, helicase humaine 13, et polynucleotide codant pour ce polypeptide
WO2001087961A1 (fr) Nouveau polypeptide, proteine pax humaine 11.4, et polynucleotide codant pour ce polypeptide
WO2001079438A3 (fr) Nouveau polypeptide, proteine humaine de liaison 9 d'une proteine precurseur de l'amyloide, et polynucleotide codant pour ce polypeptide
WO2002063013A3 (en) Human acid phosphatase gene