DK136904C - Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphaner eller syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphaner eller syreadditionssalte deraf

Info

Publication number: DK136904C
Authority: DK; Denmark
Prior art keywords: benzomorphanes; 9beta; racemic; dialkyl; heteroaryl
Prior art date: 1972-06-19

Application number

DK336173A

Other languages

English (en)

Other versions

DK136904B (da

Inventor

H Merz

A Langbein

K Stockhaus

H Wick

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-06-19

Filing date

1973-06-18

Publication date

1978-06-26

1973-06-18 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1977-12-12 Publication of DK136904B publication Critical patent/DK136904B/da

1978-06-26 Application granted granted Critical

1978-06-26 Publication of DK136904C publication Critical patent/DK136904C/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Hydrogenated Pyridines (AREA)

DK336173A 1972-06-19 1973-06-18 Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphaner eller syreadditionssalte deraf DK136904C (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2229695A DE2229695A1 (de)	1972-06-19	1972-06-19	2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Publications (2)

Publication Number	Publication Date
DK136904B DK136904B (da)	1977-12-12
DK136904C true DK136904C (da)	1978-06-26

Family

ID=5848060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK336173A DK136904C (da)	1972-06-19	1973-06-18	Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 2-(heteroaryl-methyl)-5,9beta-dialkyl-6,7-benzomorphaner eller syreadditionssalte deraf

Country Status (13)

Country	Link
US (1)	US3931194A (da)
JP (1)	JPS5711908B2 (da)
AT (6)	AT328629B (da)
BE (1)	BE801079A (da)
CH (9)	CH583228A5 (da)
DE (1)	DE2229695A1 (da)
DK (1)	DK136904C (da)
ES (8)	ES416037A1 (da)
FR (1)	FR2189056B1 (da)
GB (1)	GB1433817A (da)
NL (1)	NL7308483A (da)
NO (1)	NO137694C (da)
SE (1)	SE405121B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2437610A1 (de) *	1974-08-05	1976-02-26	Boehringer Sohn Ingelheim	Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1575009A (en) *	1976-06-21	1980-09-17	Acf Chemiefarma Nv	6,7-benzomorphan derivatives
JPS63177704A (ja) *	1987-01-16	1988-07-21	松山株式会社	農作業機連結装置
JP5451611B2 (ja)	2007-07-26	2014-03-26	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
CL2008003407A1 (es) *	2007-11-16	2010-01-11	Boehringer Ingelheim Int	Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
WO2009075835A1 (en)	2007-12-11	2009-06-18	Vitae Pharmaceutical, Inc	CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en)	2008-01-07	2009-08-16	Vitae Pharmaceuticals Inc	Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en)	2008-01-24	2013-11-26	Vitae Pharmaceuticals, Inc.	Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
US20110028445A1 (en) *	2008-02-12	2011-02-03	Boehringer Ingelheim International Gmbh	Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5730021B2 (ja)	2008-02-15	2015-06-03	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
JP5538365B2 (ja)	2008-05-01	2014-07-02	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
WO2009134392A1 (en)	2008-05-01	2009-11-05	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AU2009241727B2 (en)	2008-05-01	2013-05-02	Vitae Pharmaceuticals, Inc	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001151A1 (es)	2008-05-13	2010-08-13	Boehringer Ingelheim Int	Compuestos derivados de acidos carbociclicos aliciclicos de benzomorfanos, procedimiento de preparacion, composicion farmaceutica, utiles para tratar enfermedades influenciadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa, como trastornos metabolicos.
US8114868B2 (en)	2008-07-25	2012-02-14	Boehringer Ingelheim International Gmbh	Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8846668B2 (en)	2008-07-25	2014-09-30	Vitae Pharmaceuticals, Inc.	Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
UA109255C2 (ru)	2009-04-30	2015-08-10	Берінгер Інгельхайм Інтернешнл Гмбх	Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
US8927539B2 (en)	2009-06-11	2015-01-06	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
AR078887A1 (es)	2009-11-06	2011-12-07	Boehringer Ingelheim Int	Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
EP2582698B1 (en)	2010-06-16	2016-09-14	Vitae Pharmaceuticals, Inc.	Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
WO2013025664A1 (en)	2011-08-17	2013-02-21	Boehringer Ingelheim International Gmbh	Indenopyridine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE582575A (da) *	1958-09-22
FR1281227A (fr) *	1958-09-22	1962-01-12	Smith Kline French Lab	Perfectionnements apportés aux procédés pour la préparation de dérivés d'aralcoylbenzomorphane
CS166803B2 (da) *	1971-02-08	1976-03-29	Boehringer Sohn Ingelheim
SE392895B (sv) *	1971-08-24	1977-04-25	Sumitomo Chemical Co	Forfarande for framstellning av bensomorfanderivat och deras salter

1972
- 1972-06-19 DE DE2229695A patent/DE2229695A1/de not_active Withdrawn
1973
- 1973-06-05 US US05/367,114 patent/US3931194A/en not_active Expired - Lifetime
- 1973-06-06 AT AT490074*7A patent/AT328629B/de not_active IP Right Cessation
- 1973-06-06 AT AT489974*7A patent/AT329200B/de not_active IP Right Cessation
- 1973-06-06 AT AT489774*7A patent/AT328628B/de not_active IP Right Cessation
- 1973-06-06 AT AT494373A patent/AT325218B/de not_active IP Right Cessation
- 1973-06-06 AT AT489474*7A patent/AT328627B/de not_active IP Right Cessation
- 1973-06-06 AT AT489874*7A patent/AT329199B/de not_active IP Right Cessation
- 1973-06-14 CH CH1040876A patent/CH583228A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041076A patent/CH583230A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041176A patent/CH582697A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041576A patent/CH583231A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1040976A patent/CH583229A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH864373A patent/CH583227A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041476A patent/CH589649A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041376A patent/CH582698A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041276A patent/CH589648A5/xx not_active IP Right Cessation
- 1973-06-18 BE BE132406A patent/BE801079A/xx unknown
- 1973-06-18 NO NO2518/73A patent/NO137694C/no unknown
- 1973-06-18 GB GB2886973A patent/GB1433817A/en not_active Expired
- 1973-06-18 DK DK336173A patent/DK136904C/da active
- 1973-06-18 ES ES416037A patent/ES416037A1/es not_active Expired
- 1973-06-18 JP JP6863473A patent/JPS5711908B2/ja not_active Expired
- 1973-06-18 SE SE7308564A patent/SE405121B/xx unknown
- 1973-06-19 FR FR7322249A patent/FR2189056B1/fr not_active Expired
- 1973-06-19 NL NL7308483A patent/NL7308483A/xx not_active Application Discontinuation
1974
- 1974-10-30 ES ES431512A patent/ES431512A1/es not_active Expired
- 1974-10-30 ES ES431511A patent/ES431511A1/es not_active Expired
- 1974-10-30 ES ES0431516A patent/ES431516A1/es not_active Expired
- 1974-10-30 ES ES431514A patent/ES431514A1/es not_active Expired
- 1974-10-30 ES ES431510A patent/ES431510A1/es not_active Expired
- 1974-10-30 ES ES431515A patent/ES431515A1/es not_active Expired
- 1974-10-30 ES ES431513A patent/ES431513A1/es not_active Expired

Also Published As

Publication number	Publication date
ATA489474A (de)	1975-06-15
NL7308483A (da)	1973-12-21
CH583230A5 (da)	1976-12-31
AT328629B (de)	1976-03-25
DE2229695A1 (de)	1974-01-31
ATA489974A (de)	1975-07-15
CH589649A5 (da)	1977-07-15
CH583227A5 (da)	1976-12-31
JPS4961170A (da)	1974-06-13
AT329199B (de)	1976-04-26
DK136904B (da)	1977-12-12
ATA490074A (de)	1975-06-15
CH589648A5 (da)	1977-07-15
NO137694B (no)	1977-12-27
ES416037A1 (es)	1976-02-16
AT328628B (de)	1976-03-25
NO137694C (no)	1978-04-05
US3931194A (en)	1976-01-06
ES431515A1 (es)	1976-11-01
AT328627B (de)	1976-03-25
ES431511A1 (es)	1976-11-01
ES431512A1 (es)	1976-11-01
ES431516A1 (es)	1976-11-16
ATA489874A (de)	1975-07-15
GB1433817A (en)	1976-04-28
CH583228A5 (da)	1976-12-31
CH583231A5 (da)	1976-12-31
FR2189056A1 (da)	1974-01-25
JPS5711908B2 (da)	1982-03-08
AU5704673A (en)	1974-12-19
CH582698A5 (da)	1976-12-15
CH583229A5 (da)	1976-12-31
AT325218B (de)	1975-10-10
ES431510A1 (es)	1976-11-01
SE405121B (sv)	1978-11-20
ES431513A1 (es)	1976-11-01
FR2189056B1 (da)	1976-10-22
CH582697A5 (da)	1976-12-15
ATA489774A (de)	1975-06-15
AT329200B (de)	1976-04-26
BE801079A (fr)	1973-12-18
ES431514A1 (es)	1976-11-01

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