ES431515A1 - Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos. - Google Patents

Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.

Info

Publication number: ES431515A1
Authority: ES; Spain
Prior art keywords: methyl; salts; benzomorphans; dialkyl; heteroaryl
Prior art date: 1972-06-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES431515A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CH Boehringer Sohn AG and Co KG

Original Assignee

CH Boehringer Sohn AG and Co KG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-06-19

Filing date

1974-10-30

Publication date

1976-11-01

1974-10-30 Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG

1976-11-01 Publication of ES431515A1 publication Critical patent/ES431515A1/es

Status Expired legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Steroid Compounds (AREA)

ES431515A 1972-06-19 1974-10-30 Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos. Expired ES431515A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2229695A DE2229695A1 (de)	1972-06-19	1972-06-19	2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Publications (1)

Publication Number	Publication Date
ES431515A1 true ES431515A1 (es)	1976-11-01

Family

ID=5848060

Family Applications (8)

Application Number	Title	Priority Date	Filing Date
ES416037A Expired ES416037A1 (es)	1972-06-19	1973-06-18	Procedimiento para la preparacion de 2-(heteroaril-metil)- 5,9b-dialcohil-6,7-benzomorfanos.
ES431513A Expired ES431513A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431510A Expired ES431510A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431515A Expired ES431515A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431514A Expired ES431514A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431511A Expired ES431511A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES0431516A Expired ES431516A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2-(heterdanilmetilo 5,9-beta-dialcohil-6,7- benzonortanos.
ES431512A Expired ES431512A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
ES416037A Expired ES416037A1 (es)	1972-06-19	1973-06-18	Procedimiento para la preparacion de 2-(heteroaril-metil)- 5,9b-dialcohil-6,7-benzomorfanos.
ES431513A Expired ES431513A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431510A Expired ES431510A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.

Family Applications After (4)

Application Number	Title	Priority Date	Filing Date
ES431514A Expired ES431514A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES431511A Expired ES431511A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES0431516A Expired ES431516A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2-(heterdanilmetilo 5,9-beta-dialcohil-6,7- benzonortanos.
ES431512A Expired ES431512A1 (es)	1972-06-19	1974-10-30	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.

Country Status (13)

Country	Link
US (1)	US3931194A (es)
JP (1)	JPS5711908B2 (es)
AT (6)	AT329199B (es)
BE (1)	BE801079A (es)
CH (9)	CH583231A5 (es)
DE (1)	DE2229695A1 (es)
DK (1)	DK136904C (es)
ES (8)	ES416037A1 (es)
FR (1)	FR2189056B1 (es)
GB (1)	GB1433817A (es)
NL (1)	NL7308483A (es)
NO (1)	NO137694C (es)
SE (1)	SE405121B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2437610A1 (de) *	1974-08-05	1976-02-26	Boehringer Sohn Ingelheim	Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1575009A (en) *	1976-06-21	1980-09-17	Acf Chemiefarma Nv	6,7-benzomorphan derivatives
JPS63177704A (ja) *	1987-01-16	1988-07-21	松山株式会社	農作業機連結装置
WO2009017671A1 (en)	2007-07-26	2009-02-05	Vitae Pharmaceuticals, Inc.	Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
TW200927115A (en) *	2007-11-16	2009-07-01	Boehringer Ingelheim Int	Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
CA2708303A1 (en)	2007-12-11	2009-06-18	Vitae Pharmaceuticals, Inc.	Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en)	2008-01-07	2009-08-16	Vitae Pharmaceuticals Inc	Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en)	2008-01-24	2009-07-30	Vitae Pharmaceuticals, Inc.	Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
ATE531696T1 (de) *	2008-02-12	2011-11-15	Boehringer Ingelheim Int	Harnstoff-derivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung
EP2254872A2 (en)	2008-02-15	2010-12-01	Vitae Pharmaceuticals, Inc.	Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5538365B2 (ja)	2008-05-01	2014-07-02	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
EP2291371B1 (en)	2008-05-01	2015-06-10	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
KR20110002492A (ko)	2008-05-01	2011-01-07	비타이 파마슈티컬즈, 인코포레이티드	11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
WO2009138386A2 (en)	2008-05-13	2009-11-19	Boehringer Ingelheim International Gmbh	Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
WO2010010157A2 (en)	2008-07-25	2010-01-28	Boehringer Ingelheim International Gmbh	INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
CN102119160B (zh)	2008-07-25	2014-11-05	贝林格尔·英格海姆国际有限公司	11β-羟基类固醇脱氢酶1的环状抑制剂
US8680093B2 (en)	2009-04-30	2014-03-25	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2440537A1 (en)	2009-06-11	2012-04-18	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
TWI531571B (zh)	2009-11-06	2016-05-01	維它藥物公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
JP5860042B2 (ja)	2010-06-16	2016-02-16	ヴァイティーファーマシューティカルズ，インコーポレイテッド	置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja)	2011-08-17	2014-09-22	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	インデノピリジン誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1281227A (fr) *	1958-09-22	1962-01-12	Smith Kline French Lab	Perfectionnements apportés aux procédés pour la préparation de dérivés d'aralcoylbenzomorphane
BE582575A (es) *	1958-09-22
CS166801B2 (es) *	1971-02-08	1976-03-29	Boehringer Sohn Ingelheim
SE392895B (sv) *	1971-08-24	1977-04-25	Sumitomo Chemical Co	Forfarande for framstellning av bensomorfanderivat och deras salter

1972
- 1972-06-19 DE DE2229695A patent/DE2229695A1/de not_active Withdrawn
1973
- 1973-06-05 US US05/367,114 patent/US3931194A/en not_active Expired - Lifetime
- 1973-06-06 AT AT489874*7A patent/AT329199B/de not_active IP Right Cessation
- 1973-06-06 AT AT490074*7A patent/AT328629B/de not_active IP Right Cessation
- 1973-06-06 AT AT489774*7A patent/AT328628B/de not_active IP Right Cessation
- 1973-06-06 AT AT494373A patent/AT325218B/de not_active IP Right Cessation
- 1973-06-06 AT AT489974*7A patent/AT329200B/de not_active IP Right Cessation
- 1973-06-06 AT AT489474*7A patent/AT328627B/de not_active IP Right Cessation
- 1973-06-14 CH CH1041576A patent/CH583231A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH864373A patent/CH583227A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041376A patent/CH582698A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041076A patent/CH583230A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041276A patent/CH589648A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041476A patent/CH589649A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1040876A patent/CH583228A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041176A patent/CH582697A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1040976A patent/CH583229A5/xx not_active IP Right Cessation
- 1973-06-18 DK DK336173A patent/DK136904C/da active
- 1973-06-18 SE SE7308564A patent/SE405121B/xx unknown
- 1973-06-18 BE BE132406A patent/BE801079A/xx unknown
- 1973-06-18 JP JP6863473A patent/JPS5711908B2/ja not_active Expired
- 1973-06-18 NO NO2518/73A patent/NO137694C/no unknown
- 1973-06-18 GB GB2886973A patent/GB1433817A/en not_active Expired
- 1973-06-18 ES ES416037A patent/ES416037A1/es not_active Expired
- 1973-06-19 NL NL7308483A patent/NL7308483A/xx not_active Application Discontinuation
- 1973-06-19 FR FR7322249A patent/FR2189056B1/fr not_active Expired
1974
- 1974-10-30 ES ES431513A patent/ES431513A1/es not_active Expired
- 1974-10-30 ES ES431510A patent/ES431510A1/es not_active Expired
- 1974-10-30 ES ES431515A patent/ES431515A1/es not_active Expired
- 1974-10-30 ES ES431514A patent/ES431514A1/es not_active Expired
- 1974-10-30 ES ES431511A patent/ES431511A1/es not_active Expired
- 1974-10-30 ES ES0431516A patent/ES431516A1/es not_active Expired
- 1974-10-30 ES ES431512A patent/ES431512A1/es not_active Expired

Also Published As

Publication number	Publication date
ES431513A1 (es)	1976-11-01
NL7308483A (es)	1973-12-21
ES431510A1 (es)	1976-11-01
FR2189056B1 (es)	1976-10-22
GB1433817A (en)	1976-04-28
AT329199B (de)	1976-04-26
NO137694B (no)	1977-12-27
CH589648A5 (es)	1977-07-15
CH582697A5 (es)	1976-12-15
ES431514A1 (es)	1976-11-01
CH583229A5 (es)	1976-12-31
CH583231A5 (es)	1976-12-31
JPS4961170A (es)	1974-06-13
CH583227A5 (es)	1976-12-31
AT328628B (de)	1976-03-25
DE2229695A1 (de)	1974-01-31
AT325218B (de)	1975-10-10
DK136904C (da)	1978-06-26
CH583228A5 (es)	1976-12-31
ES431511A1 (es)	1976-11-01
ES431512A1 (es)	1976-11-01
AT328629B (de)	1976-03-25
BE801079A (fr)	1973-12-18
ES431516A1 (es)	1976-11-16
AU5704673A (en)	1974-12-19
CH582698A5 (es)	1976-12-15
ES416037A1 (es)	1976-02-16
DK136904B (da)	1977-12-12
AT329200B (de)	1976-04-26
CH583230A5 (es)	1976-12-31
ATA489974A (de)	1975-07-15
ATA489874A (de)	1975-07-15
ATA490074A (de)	1975-06-15
FR2189056A1 (es)	1974-01-25
JPS5711908B2 (es)	1982-03-08
AT328627B (de)	1976-03-25
US3931194A (en)	1976-01-06
SE405121B (sv)	1978-11-20
ATA489774A (de)	1975-06-15
ATA489474A (de)	1975-06-15
NO137694C (no)	1978-04-05
CH589649A5 (es)	1977-07-15

Publication	Publication Date	Title
ES431511A1 (es)	1976-11-01	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES452767A1 (es)	1977-10-01	Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta.
ES431057A1 (es)	1976-10-16	Procedimiento para la preparacion de nuevos n-(metoximetil - furilmetil)-6, 7-benzomorfanos y -morfinanos.
ES395481A1 (es)	1973-12-16	Procedimiento para la preparacion de compuestos de nafti- lalcohilaminas.
ES439927A1 (es)	1977-06-01	Procedimiento para la obtencion de 7-metoxi-6-tiatetracicli-nas.
ES417559A1 (es)	1976-03-16	Procedimiento de preparacion de compuestos ciclisados que llevan un grupo urea.
ES416106A1 (es)	1976-02-16	Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoeteno-7a-hidroxialcohil-tetrahidro-nororipavinas y tebainas.
ES427115A1 (es)	1976-07-16	Procedimiento de preparacion de nuevos derivados del acido acetico.
ES424309A1 (es)	1976-06-16	Procedimiento para la preparacion de n-(heteroarilmetil)-7 -acil-6,14-endoetenotetrahidronororipavinas y -tebainas.
ES430201A1 (es)	1976-10-16	Procedimiento para la preparacion de n-(heteroarilmetil - delta7-desoxi-normorfinas y -norcodeinas.
ES470892A1 (es)	1979-02-01	Procedimiento para la preparacion de nuevos n-bencil-aminoa-cidos que contienen azufre
IE35788L (en)	1972-05-02	1, 5-benzodiazepinones.