DK1355930T3 - Fremgangsmåde til identifikation, isolering og fremstilling af antigener mod et specifikt patogen - Google Patents
Fremgangsmåde til identifikation, isolering og fremstilling af antigener mod et specifikt patogenInfo
- Publication number
- DK1355930T3 DK1355930T3 DK02716669T DK02716669T DK1355930T3 DK 1355930 T3 DK1355930 T3 DK 1355930T3 DK 02716669 T DK02716669 T DK 02716669T DK 02716669 T DK02716669 T DK 02716669T DK 1355930 T3 DK1355930 T3 DK 1355930T3
- Authority
- DK
- Denmark
- Prior art keywords
- specific pathogen
- isolating
- identifying
- antigens against
- producing antigens
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 244000052769 pathogen Species 0.000 title abstract 2
- 230000001717 pathogenic effect Effects 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000013566 allergen Substances 0.000 abstract 1
- 230000005784 autoimmunity Effects 0.000 abstract 1
- 230000000521 hyperimmunizing effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Computational Biology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0013001A AT410798B (de) | 2001-01-26 | 2001-01-26 | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1355930T3 true DK1355930T3 (da) | 2006-03-06 |
Family
ID=3636418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02716669T DK1355930T3 (da) | 2001-01-26 | 2002-01-21 | Fremgangsmåde til identifikation, isolering og fremstilling af antigener mod et specifikt patogen |
Country Status (24)
Country | Link |
---|---|
US (4) | US7968297B2 (fr) |
EP (6) | EP2412722A1 (fr) |
JP (2) | JP2004531476A (fr) |
KR (4) | KR20090101973A (fr) |
CN (2) | CN101492496A (fr) |
AT (2) | AT410798B (fr) |
AU (3) | AU2002247641B8 (fr) |
BR (1) | BR0207067A (fr) |
CA (2) | CA2792244A1 (fr) |
CZ (1) | CZ20032201A3 (fr) |
DE (1) | DE60207194T2 (fr) |
DK (1) | DK1355930T3 (fr) |
ES (1) | ES2252438T3 (fr) |
HU (1) | HUP0402048A3 (fr) |
IL (4) | IL157082A0 (fr) |
IS (1) | IS6895A (fr) |
MX (1) | MXPA03006702A (fr) |
NO (1) | NO20033364L (fr) |
NZ (4) | NZ551802A (fr) |
PL (2) | PL214482B1 (fr) |
RU (1) | RU2289817C2 (fr) |
SK (1) | SK10492003A3 (fr) |
WO (1) | WO2002059148A2 (fr) |
ZA (1) | ZA200305764B (fr) |
Families Citing this family (126)
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WO2002053180A2 (fr) | 2001-01-03 | 2002-07-11 | Willmar Poultry Company, Inc. | Compositions immunisantes et leurs procedes d'utilisation |
AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
AU2002322127B2 (en) | 2001-06-15 | 2008-08-21 | Inhibitex, Inc. | Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus |
GB0200865D0 (en) * | 2002-01-16 | 2002-03-06 | Univ Bristol | Method |
GB2387600A (en) * | 2002-04-19 | 2003-10-22 | Pantherix Ltd | Pantothenate kinase |
CN1649626A (zh) * | 2002-10-03 | 2005-08-03 | 英特塞尔股份公司 | 可与触珠蛋白受体配体结合相互作用的分子的用途 |
CN1756843B (zh) | 2003-03-04 | 2012-03-21 | 英特塞尔股份公司 | 化脓链球菌抗原 |
AU2004226262A1 (en) | 2003-03-31 | 2004-10-14 | Intercell Ag | Staphylococcus epidermidis antigens |
EP2311987A1 (fr) | 2003-04-15 | 2011-04-20 | Intercell AG | S. pneumoniae antigènes |
WO2004094467A2 (fr) * | 2003-04-22 | 2004-11-04 | Intercell Ag | Antigenes h. pylori |
EP2287177A3 (fr) | 2003-05-07 | 2011-08-31 | Intercell AG | Antigènes I + II de Streptococcus agalactiae |
AU2004242842B2 (en) | 2003-05-30 | 2011-11-03 | Intercell Ag | Enterococcus antigens |
DE602004025579D1 (de) * | 2003-07-24 | 2010-04-01 | Merck & Co Inc | Polypeptide zur induktion einer schützenden immunantwort gegen staphylococcus aureus |
WO2005009378A2 (fr) * | 2003-07-24 | 2005-02-03 | Merck & Co., Inc. | Polypeptides utilises pour induire une reponse immunitaire vis-a-vis du staphylocoque dore |
US8119147B2 (en) | 2003-09-19 | 2012-02-21 | Epitopix, Llc | Compositions produced using enteric pathogens and methods of use |
EP1725575B1 (fr) * | 2004-02-18 | 2012-11-28 | Merck Sharp & Dohme Corp. | Polypeptides d'induction d'une reponse immune protectrice contre staphylococcus aureus |
US20070172498A1 (en) * | 2004-02-27 | 2007-07-26 | Anderson Annaliesa S | Polypeptides for inducing a protective immune response against staphyloococcus aureus |
JP2005278537A (ja) * | 2004-03-30 | 2005-10-13 | Dai Ichi Seiyaku Co Ltd | 新規ポリペプチド |
EP1740604A2 (fr) * | 2004-04-27 | 2007-01-10 | Intercell AG | Antigenes de lambliase (diarrhee des voyageurs) |
WO2006065272A2 (fr) | 2004-05-21 | 2006-06-22 | Idaho Research Foundation, Inc. | Procedes permettant de modifier la production d'acide acetique et de favoriser la mort cellulaire chez les bacteries |
EP1753441A2 (fr) * | 2004-05-25 | 2007-02-21 | Merck & Co., Inc. | Polypeptides permettant d'induire une reponse immunitaire de protection contre staphylococcus aureus |
US20090317412A1 (en) * | 2004-06-04 | 2009-12-24 | Alexander Jeffery L | Induction of an immune response against streptococcus pneumoniae polyaccharides |
FR2871237B1 (fr) * | 2004-06-08 | 2011-03-11 | Abag | Nouveaux polypeptides pour la mise en evidence in vitro et la prevention des infections staphylococciques sur protheses articulaires et autres materiels etrangers implantes |
FR2871159A1 (fr) * | 2004-06-08 | 2005-12-09 | Abag Sa | Nouvelles proteines permettant, notamment, la mise en evidence in vitro et la prevention des infections a staphylocoques a coagulase negative |
EP1784212A4 (fr) * | 2004-07-06 | 2008-09-17 | Merck & Co Inc | Polypeptides utilises pour induire une reponse immunitaire protectrice contre le staphylococcus aureus |
WO2007001361A2 (fr) * | 2004-09-17 | 2007-01-04 | Merck & Co., Inc. | Polypeptides pour induire une reponse immunitaire de protection dirigee contre staphylococcus aureus |
EP2305296A1 (fr) | 2004-09-22 | 2011-04-06 | GlaxoSmithKline Biologicals SA | Composition immunogène pour la vaccination contre des staphylocoques |
AU2005333603A1 (en) | 2004-10-21 | 2007-01-04 | Wyeth | Immunogenic compositions of Staphylococcus epidermidis polypeptide antigens |
EP1804822B1 (fr) * | 2004-10-29 | 2009-07-22 | Intercell AG | Vaccins anti-vhc pour patients atteints du vhc chronique |
EP1843785B1 (fr) | 2005-01-21 | 2016-07-27 | Merck Sharp & Dohme Corp. | Polypeptides pour induire une réponse immune protectrice contre staphylococcus aureus |
EP2361926A3 (fr) | 2005-01-21 | 2011-12-21 | Epitopix, LLC | Polypeptides de yersinia spp. et leurs procedes d'utilisation |
CN101119744B (zh) | 2005-02-14 | 2013-03-13 | 埃皮托皮克斯有限责任公司 | 来自金黄色葡萄球菌的多肽和使用方法 |
JP2008534970A (ja) * | 2005-04-04 | 2008-08-28 | ヴィヴェンティア バイオテック インコーポレーティッド | 抗原の同定のための方法および系 |
WO2006121664A2 (fr) * | 2005-05-05 | 2006-11-16 | Merck & Co., Inc. | Polypeptides induisant une reponse immunitaire de protection contre staphylococcus aureus |
US20070003954A1 (en) * | 2005-05-12 | 2007-01-04 | The Board Of Regents Of The University Of Texas System | Protein and antibody profiling using small molecule microarrays |
US20090220538A1 (en) * | 2005-07-14 | 2009-09-03 | Bharat Biotech International Limited | vaccine for staphylococcal infections |
WO2008019162A2 (fr) * | 2006-01-18 | 2008-02-14 | University Of Chicago | Compositions et procédés se rapportant à des protéines de bactéries staphylococciques |
MX337528B (es) | 2006-03-30 | 2016-03-09 | Glaxosmithkline Biolog Sa | Composición inmunogénica que comprende un sacárido capsular estafilocócico o-acetilado y una proteína estafilocócica. |
GB0610776D0 (en) * | 2006-05-31 | 2006-07-12 | Univ Bath | Novel applications for staphylococcus aureus Sbi protein |
EP2059526A2 (fr) * | 2006-09-15 | 2009-05-20 | Intercell AG | Antigènes de borrelia |
US20080102067A1 (en) * | 2006-10-25 | 2008-05-01 | Cook Mark E | Immunogenic composition |
EP1923069A1 (fr) | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protecteurs contre S. pneumoniae et compositions, méthodes et utilisations associés |
EP1935984A1 (fr) * | 2006-12-20 | 2008-06-25 | Unilever N.V. | Procédé d'assistance à la conduite et appareil d'assistance à la conduite |
US8124108B2 (en) | 2007-01-24 | 2012-02-28 | Merck Sharp & Dohme Corp. | Polypeptides for inducing a protective immune response against Staphylococcus epidermidis |
CN101636493A (zh) * | 2007-03-19 | 2010-01-27 | 默克公司 | 用于诱导针对表皮葡萄球菌的保护性免疫反应的多肽 |
AU2008265218A1 (en) * | 2007-06-18 | 2008-12-24 | Intercell Ag | Chlamydia antigens |
US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
CN101951948B (zh) | 2007-08-31 | 2015-12-09 | 芝加哥大学 | 与针对葡萄球菌性肺部疾病和病症进行免疫相关的方法和组合物 |
RU2481395C2 (ru) * | 2007-10-18 | 2013-05-10 | Унилевер Н.В. | Способ получения пенообразующего средства |
CN101458255B (zh) * | 2007-12-14 | 2013-03-06 | 武汉大学 | 丙型肝炎病毒包膜抗原夹心法试剂盒及检测方法 |
US20090196852A1 (en) * | 2008-02-04 | 2009-08-06 | Watkinson D Tobin | Compositions and methods for diagnosing and treating immune disorders |
HUE027249T2 (en) | 2008-03-03 | 2016-10-28 | Novartis Ag | TLR activity modulator compounds and preparations |
US8241643B2 (en) | 2008-03-17 | 2012-08-14 | Intercell Ag | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
WO2009158682A2 (fr) * | 2008-06-27 | 2009-12-30 | Watkinson D Tobin | Compositions et procédés pour diagnostiquer et traiter des troubles pathogènes |
US20100015171A1 (en) * | 2008-07-15 | 2010-01-21 | Statens Serum Institute | Vaccines comprising tb 10.4 |
US8758765B2 (en) | 2008-07-29 | 2014-06-24 | The University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
WO2010039563A2 (fr) * | 2008-09-30 | 2010-04-08 | University Of Maryland, Baltimore | Vaccin protecteur contre des biofilms de staphylococcus aureus renfermant des immunogènes associés à la paroi cellulaire |
CN102333540B (zh) * | 2008-10-06 | 2015-04-22 | 芝加哥大学 | 与细菌eap、emp和/或adsa蛋白相关的组合物和方法 |
CN102186967B (zh) * | 2008-10-16 | 2015-11-25 | 荷兰联合利华有限公司 | 包含消泡剂的疏水蛋白溶液 |
MX2011005579A (es) | 2008-11-26 | 2011-06-30 | Merck Sharp & Dohme | Polipeptidos para inducir una respuesta inmune protectora contra staphylococcus aureus. |
CN102292105A (zh) | 2008-11-26 | 2011-12-21 | 默沙东公司 | 用于诱导抗金黄色葡萄球菌的保护性免疫应答的多肽 |
SG195555A1 (en) * | 2008-12-24 | 2013-12-30 | Emd Millipore Corp | Caustic stable chromatography ligands |
US20130243779A1 (en) | 2009-02-05 | 2013-09-19 | Intercell Ag | Peptides protective against e. faecalis, methods and uses relating thereto |
BRPI1011856A2 (pt) * | 2009-03-23 | 2020-11-03 | Epitopix, Llc | polipeptídeos e composições de imunização contendo polipeptídeos gram-positivos e métodos de uso |
HUE026855T2 (en) | 2009-04-03 | 2016-07-28 | Univ Chicago | Preparations and method for Protein A (SPA) variants |
WO2011127032A1 (fr) | 2010-04-05 | 2011-10-13 | University Of Chicago | Compositions et procédés liés aux anticorps de la protéine a (spa) en tant que amplificateur de la réponse immunitaire |
SG175092A1 (en) * | 2009-04-14 | 2011-11-28 | Novartis Ag | Compositions for immunising against staphylococcus aerus |
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SG176837A1 (en) | 2009-06-22 | 2012-01-30 | Wyeth Llc | Immunogenic compositions of staphylococcus aureus antigens |
GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
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TWI445708B (zh) | 2009-09-02 | 2014-07-21 | Irm Llc | 作為tlr活性調節劑之化合物及組合物 |
MX2012002723A (es) | 2009-09-02 | 2012-04-11 | Novartis Ag | Composiciones inmunogenicas que incluyen moduladores de la actividad de receptores tipo toll. |
WO2011057148A1 (fr) | 2009-11-05 | 2011-05-12 | Irm Llc | Composés et compositions permettant de moduler l'activité des tlr-7 |
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CN102905703B (zh) | 2010-03-23 | 2016-09-28 | 诺华股份有限公司 | 作为tlr2激动剂用于治疗感染、炎症、呼吸疾病等的化合物(基于半胱氨酸的脂肽)和组合物 |
RU2644237C2 (ru) * | 2010-05-05 | 2018-02-08 | Нью-Йорк Юниверсити | Лейкоцидины staphylococcus aureus, терапевтические композиции и их применение |
AU2011274367B2 (en) | 2010-07-02 | 2015-04-23 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
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