DK1355668T3 - Anvendelse af IL-18 inhibitorer til behandling og/eller forebyggelsen af hjertesygdom - Google Patents

Anvendelse af IL-18 inhibitorer til behandling og/eller forebyggelsen af hjertesygdom

Info

Publication number: DK1355668T3
Authority: DK; Denmark
Prior art keywords: inhibitors; prevention; treatment; heart disease; heart
Prior art date: 2001-01-29

Application number

DK02718052T

Other languages

English (en)

Inventor

Benjamin Pomerantz

Charles Dinarello

Leonid Reznikov

Alden Harken

Yolande Chvatchko

Original Assignee

Serono Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-29

Filing date

2002-01-28

Publication date

2008-05-05

2002-01-28 Application filed by Serono Lab filed Critical Serono Lab

2008-05-05 Application granted granted Critical

2008-05-05 Publication of DK1355668T3 publication Critical patent/DK1355668T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Cell Biology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK02718052T 2001-01-29 2002-01-28 Anvendelse af IL-18 inhibitorer til behandling og/eller forebyggelsen af hjertesygdom DK1355668T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01101959		2001-01-29
PCT/EP2002/000844 WO2002060479A1 (en)	2001-01-29	2002-01-28	Use of il-18 inhibitors for the treatment and/or prevention of heart disease

Publications (1)

Publication Number	Publication Date
DK1355668T3 true DK1355668T3 (da)	2008-05-05

Family

ID=8176323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02718052T DK1355668T3 (da)	2001-01-29	2002-01-28	Anvendelse af IL-18 inhibitorer til behandling og/eller forebyggelsen af hjertesygdom

Country Status (32)

Country	Link
US (1)	US20040234523A1 (da)
EP (1)	EP1355668B1 (da)
JP (2)	JP4860897B2 (da)
KR (1)	KR100857376B1 (da)
CN (1)	CN1326562C (da)
AR (1)	AR032422A1 (da)
AT (1)	ATE380558T1 (da)
BG (1)	BG66483B1 (da)
BR (1)	BR0206819A (da)
CA (1)	CA2435466C (da)
CY (1)	CY1107203T1 (da)
CZ (1)	CZ305653B6 (da)
DE (1)	DE60224004T2 (da)
DK (1)	DK1355668T3 (da)
EA (2)	EA006767B1 (da)
EE (1)	EE05534B1 (da)
ES (1)	ES2295332T3 (da)
HK (1)	HK1062810A1 (da)
HR (1)	HRP20030609A2 (da)
HU (1)	HU229164B1 (da)
IL (2)	IL157024A0 (da)
ME (1)	ME00549B (da)
MX (1)	MXPA03006776A (da)
NO (1)	NO331083B1 (da)
PL (1)	PL213568B1 (da)
PT (1)	PT1355668E (da)
RS (1)	RS51125B (da)
SI (1)	SI1355668T1 (da)
SK (1)	SK287620B6 (da)
UA (1)	UA80676C2 (da)
WO (1)	WO2002060479A1 (da)
ZA (1)	ZA200305439B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102504024A (zh)	2000-02-10	2012-06-20	雅培制药有限公司	结合人白介素-18的抗体及制备和使用方法
AU1174402A (en)	2000-10-11	2002-04-22	Viron Therapeutics Inc	Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en)	2000-12-04	2010-05-18	Viron Therapeutics Inc.	Immunomodulatory protein and useful embodiments thereof
SI1622939T1 (sl)	2003-05-13	2012-06-29	Merck Serono Sa	Akrivne variante il-18 vezavnega proteina in medicinske uporabe le-tega
US7968684B2 (en) *	2003-11-12	2011-06-28	Abbott Laboratories	IL-18 binding proteins
JP4961559B2 (ja) *	2004-03-11	2012-06-27	友昭星野	インターロイキン１８阻害剤を有効成分とする疾患の予防又は治療剤
ES2385639T3 (es)	2005-06-03	2012-07-27	Ares Trading S.A.	Producción de una proteína de unión a IL-18 recombinante
DK1891088T3 (da)	2005-06-10	2012-01-30	Ares Trading Sa	Fremgangsmåde til rensning af et IL-18-bindende protein
AU2008324814B2 (en)	2007-11-05	2013-05-16	Solventum Intellectual Properties Company	Identification of tissue for debridement
JOP20200308A1 (ar)	2012-09-07	2017-06-16	Novartis Ag	جزيئات إرتباط il-18
KR102321172B1 (ko)	2013-09-05	2021-11-05	에이비2 바이오 에스에이	염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ)
US10882905B2 (en) *	2015-03-05	2021-01-05	Ab2 Bio Sa	IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases
US11091795B2 (en)	2016-07-11	2021-08-17	Arizona Board Of Regents On Behalf Of The University Of Arizona	Compositions and methods for diagnosing and treating arrhythmias

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204261B1 (en) *	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) *	1989-09-05	1997-02-25	Immunex Corporation	Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) *	1995-11-21	1999-02-25	Yamanouchi Pharma Co Ltd	Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
ATE310528T1 (de) *	1996-09-12	2005-12-15	Idun Pharmaceuticals Inc	Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie
AU7624798A (en) *	1996-12-06	1998-06-29	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1 beta converting enzyme
CN1269722A (zh) *	1997-03-18	2000-10-11	Basf公司	调节对皮质类固醇反应的方法及组合物
IL121860A0 (en) *	1997-08-14	1998-02-22	Yeda Res & Dev	Interleukin-18 binding proteins their preparation and use
DE19743687C1 (de) *	1997-10-06	1998-11-26	Henkel Kgaa	Detergensgemische und deren Verwendung
WO2000000490A2 (en) *	1998-06-26	2000-01-06	Eli Lilly And Company	5-ht1f agonists
EP1110969A4 (en) *	1998-09-01	2002-01-09	Hayashibara Biochem Lab	INTERLEUKIN 18-BINDING PROTEINS
EP1022027A1 (en) *	1999-01-22	2000-07-26	Applied Research Systems ARS Holding N.V.	Tumor necrosis factor antagonists and their use in endometriosis
DE60030097T2 (de) *	1999-03-16	2007-03-08	Cytovia, Inc., San Diego	Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung
US6355618B1 (en) *	1999-04-09	2002-03-12	Cytovia, Inc.	Caspase inhibitors and the use thereof
AU6078500A (en) *	1999-07-09	2001-01-30	Amgen, Inc.	Combination therapy for conditions leading to bone loss
CN102504024A (zh) *	2000-02-10	2012-06-20	雅培制药有限公司	结合人白介素-18的抗体及制备和使用方法
CA2407895C (en) *	2000-05-05	2012-12-18	Applied Research Systems Ars Holding N.V.	Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis
WO2002032374A2 (en) *	2000-10-18	2002-04-25	Immunex Corporation	Methods for treating il-18 mediated disorders

2002
- 2002-01-28 AT AT02718052T patent/ATE380558T1/de active
- 2002-01-28 ES ES02718052T patent/ES2295332T3/es not_active Expired - Lifetime
- 2002-01-28 ZA ZA200305439A patent/ZA200305439B/en unknown
- 2002-01-28 RS YUP-578/03A patent/RS51125B/sr unknown
- 2002-01-28 KR KR1020037009941A patent/KR100857376B1/ko active IP Right Grant
- 2002-01-28 US US10/470,303 patent/US20040234523A1/en not_active Abandoned
- 2002-01-28 JP JP2002560670A patent/JP4860897B2/ja not_active Expired - Lifetime
- 2002-01-28 SK SK1089-2003A patent/SK287620B6/sk not_active IP Right Cessation
- 2002-01-28 UA UA2003088056A patent/UA80676C2/uk unknown
- 2002-01-28 PL PL366802A patent/PL213568B1/pl unknown
- 2002-01-28 BR BR0206819-2A patent/BR0206819A/pt not_active Application Discontinuation
- 2002-01-28 CN CNB02807503XA patent/CN1326562C/zh not_active Expired - Lifetime
- 2002-01-28 ME MEP-2008-681A patent/ME00549B/me unknown
- 2002-01-28 WO PCT/EP2002/000844 patent/WO2002060479A1/en active IP Right Grant
- 2002-01-28 CA CA2435466A patent/CA2435466C/en not_active Expired - Lifetime
- 2002-01-28 EA EA200300844A patent/EA006767B1/ru not_active IP Right Cessation
- 2002-01-28 CZ CZ2003-2335A patent/CZ305653B6/cs not_active IP Right Cessation
- 2002-01-28 EP EP02718052A patent/EP1355668B1/en not_active Expired - Lifetime
- 2002-01-28 DK DK02718052T patent/DK1355668T3/da active
- 2002-01-28 IL IL15702402A patent/IL157024A0/xx unknown
- 2002-01-28 EE EEP200300328A patent/EE05534B1/xx unknown
- 2002-01-28 EA EA200501549A patent/EA010180B1/ru not_active IP Right Cessation
- 2002-01-28 SI SI200230667T patent/SI1355668T1/sl unknown
- 2002-01-28 PT PT02718052T patent/PT1355668E/pt unknown
- 2002-01-28 HU HU0303306A patent/HU229164B1/hu unknown
- 2002-01-28 MX MXPA03006776A patent/MXPA03006776A/es active IP Right Grant
- 2002-01-28 DE DE60224004T patent/DE60224004T2/de not_active Expired - Lifetime
- 2002-01-29 AR ARP020100315A patent/AR032422A1/es unknown
2003
- 2003-07-16 NO NO20033228A patent/NO331083B1/no not_active IP Right Cessation
- 2003-07-20 IL IL157024A patent/IL157024A/en active IP Right Grant
- 2003-07-28 HR HR20030609A patent/HRP20030609A2/xx not_active Application Discontinuation
- 2003-08-25 BG BG108128A patent/BG66483B1/bg unknown
2004
- 2004-08-02 HK HK04105655A patent/HK1062810A1/xx not_active IP Right Cessation
2008
- 2008-02-18 CY CY20081100195T patent/CY1107203T1/el unknown
- 2008-12-16 JP JP2008319532A patent/JP2009102354A/ja active Pending

Also Published As

Publication number	Publication date
ES2295332T3 (es)	2008-04-16
EA006767B1 (ru)	2006-04-28
IL157024A (en)	2014-02-27
CA2435466A1 (en)	2002-08-08
US20040234523A1 (en)	2004-11-25
CY1107203T1 (el)	2012-11-21
EE05534B1 (et)	2012-04-16
UA80676C2 (en)	2007-10-25
EA200300844A1 (ru)	2003-12-25
HUP0303306A2 (hu)	2004-01-28
IL157024A0 (en)	2004-02-08
KR20030070143A (ko)	2003-08-27
NO331083B1 (no)	2011-10-03
EP1355668B1 (en)	2007-12-12
ATE380558T1 (de)	2007-12-15
ME00549B (me)	2011-10-10
EP1355668A1 (en)	2003-10-29
EE200300328A (et)	2003-10-15
CZ305653B6 (cs)	2016-01-27
JP4860897B2 (ja)	2012-01-25
HK1062810A1 (en)	2004-11-26
PL366802A1 (en)	2005-02-07
HU229164B1 (en)	2013-09-30
HRP20030609A2 (en)	2005-06-30
MXPA03006776A (es)	2003-10-24
PL213568B1 (pl)	2013-03-29
AR032422A1 (es)	2003-11-05
BG66483B1 (bg)	2015-03-31
EA200501549A1 (ru)	2006-04-28
ZA200305439B (en)	2004-07-15
DE60224004T2 (de)	2009-07-23
BR0206819A (pt)	2004-02-03
RS51125B (sr)	2010-10-31
PT1355668E (pt)	2008-01-04
CZ20032335A3 (en)	2004-07-14
YU57803A (sh)	2006-05-25
JP2009102354A (ja)	2009-05-14
WO2002060479A1 (en)	2002-08-08
KR100857376B1 (ko)	2008-09-05
SK10892003A3 (sk)	2004-02-03
JP2004522748A (ja)	2004-07-29
BG108128A (bg)	2004-11-30
NO20033228L (no)	2003-09-26
NO20033228D0 (no)	2003-07-16
SI1355668T1 (sl)	2008-06-30
DE60224004D1 (de)	2008-01-24
CN1326562C (zh)	2007-07-18
HUP0303306A3 (en)	2005-12-28
EA010180B1 (ru)	2008-06-30
CA2435466C (en)	2012-04-03
CN1499982A (zh)	2004-05-26
SK287620B6 (sk)	2011-04-05

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NO20041872L (no)	2004-05-06	Esterforbindelser og medisinsk anvendelse derav
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NO20033854D0 (no)	2003-09-01	N-but-3-enyl-norbuprenorfin og fremgangsmåter for anvendelse
NO20050569D0 (no)	2005-02-02	Fremgangsmate for behandling av alvorlig hjertesvikt og medikament for dette
IS6966A (is)	2003-09-24	Cýanó-tengd díhýdrópýrimídín efnasambönd og notkun þeirra við meðhöndlun sjúkdóma
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NO20041214L (no)	2004-06-24	Substituerte benzimidazolforbindelser og deres anvendelse for behandling av cancer
NO20031806D0 (no)	2003-04-23	Anvendelse av pericytt apoptosehemmere for behandling og/eller forhindringav diabetisk retinopati
IS6967A (is)	2003-09-24	Ný cýanó-tengd díhýdrópýrimídín efnasambönd og notkun þeirra við meðhöndlun sjúkdóma
NO20033506L (no)	2003-10-08	Parasitticidale preparater og metoder for anvendelse
ITTO20010848A0 (it)	2001-09-05	Disposizione e metodo di purificazione o trattamento elettrochimico.
NO20054913D0 (no)	2005-10-24	Anvendelse av clustein for behandling og/eller forebyggelse av perifere nevrologiske lidelser
DE60222664D1 (de)	2007-11-08	Hautbehandlungsmittel