Nothing Special   »   [go: up one dir, main page]

DK1342794T3 - Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker - Google Patents

Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker

Info

Publication number
DK1342794T3
DK1342794T3 DK02004954T DK02004954T DK1342794T3 DK 1342794 T3 DK1342794 T3 DK 1342794T3 DK 02004954 T DK02004954 T DK 02004954T DK 02004954 T DK02004954 T DK 02004954T DK 1342794 T3 DK1342794 T3 DK 1342794T3
Authority
DK
Denmark
Prior art keywords
dna
amount
free floating
free
body fluids
Prior art date
Application number
DK02004954T
Other languages
Danish (da)
English (en)
Inventor
Kurt Berlin
Andrzej Sledziewski
Original Assignee
Epigenomics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag filed Critical Epigenomics Ag
Application granted granted Critical
Publication of DK1342794T3 publication Critical patent/DK1342794T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DK02004954T 2002-03-05 2002-03-05 Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker DK1342794T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02004954A EP1342794B1 (en) 2002-03-05 2002-03-05 Method and device for determination of tissue specificity of free floating DNA in bodily fluids

Publications (1)

Publication Number Publication Date
DK1342794T3 true DK1342794T3 (da) 2006-04-24

Family

ID=27741132

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02004954T DK1342794T3 (da) 2002-03-05 2002-03-05 Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker

Country Status (10)

Country Link
US (1) US20050221314A1 (es)
EP (2) EP1342794B1 (es)
JP (1) JP4727149B2 (es)
AT (1) ATE312946T1 (es)
AU (1) AU2003218691B2 (es)
CA (1) CA2478493A1 (es)
DE (1) DE60207979T2 (es)
DK (1) DK1342794T3 (es)
ES (1) ES2253461T3 (es)
WO (1) WO2003074730A1 (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060183128A1 (en) * 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
DE10348407A1 (de) * 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
US8912129B2 (en) * 2005-11-17 2014-12-16 Epigenomics Ag Method for the determination of the DNA methylation level of a CPG position in identical cells within a tissue sample
US20100124743A1 (en) * 2007-01-23 2010-05-20 Olympus Corporation Method for diagnosis of cancer
JP5378687B2 (ja) * 2007-03-02 2013-12-25 エフ.ホフマン−ラ ロシュ アーゲー Basp1遺伝子および/またはsrd5a2遺伝子中のメチル化シトシンを利用する、肝臓癌、肝臓癌発症リスク、肝臓癌再発リスク、肝臓癌悪性度および肝臓癌の経時的進展の検出方法
US20100285463A1 (en) * 2007-06-29 2010-11-11 Medizinische Univversitat Innsbruck Selecting nucleic acid samples suitable for genotyping
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
EP3842551B1 (en) 2012-09-04 2023-11-01 Guardant Health, Inc. Methods of analysing cell free polynucleotides
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
LT3354747T (lt) 2012-09-20 2021-04-12 The Chinese University Of Hong Kong Neinvazinis naviko metilomos nustatymas iš plazmos
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
EP4414990A3 (en) 2013-01-17 2024-11-06 Personalis, Inc. Methods and systems for genetic analysis
WO2015031689A1 (en) 2013-08-30 2015-03-05 Personalis, Inc. Methods and systems for genomic analysis
JP6295578B2 (ja) * 2013-09-30 2018-03-20 凸版印刷株式会社 反応容器、核酸解析装置、および核酸解析方法
GB2535066A (en) 2013-10-03 2016-08-10 Personalis Inc Methods for analyzing genotypes
ES2660989T3 (es) 2013-12-28 2018-03-27 Guardant Health, Inc. Métodos y sistemas para detectar variantes genéticas
EP3132055A2 (en) * 2014-04-14 2017-02-22 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna
HUE056267T2 (hu) 2014-07-18 2022-02-28 Univ Hong Kong Chinese DNS-keverékek szöveteinek metilációs mintázatelemzése
US10125399B2 (en) 2014-10-30 2018-11-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
CA3008623C (en) * 2015-12-17 2022-10-04 Illumina, Inc. Distinguishing methylation levels in complex biological samples
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
CA3025708A1 (en) 2016-05-30 2017-12-07 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free dna in blood
US11566284B2 (en) 2016-08-10 2023-01-31 Grail, Llc Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
KR102344635B1 (ko) 2016-09-30 2021-12-31 가던트 헬쓰, 인크. 무세포 핵산의 다중-해상도 분석 방법
AU2017347790B2 (en) 2016-10-24 2024-06-13 Grail, Inc. Methods and systems for tumor detection
EP3548632A4 (en) 2016-11-30 2020-06-24 The Chinese University Of Hong Kong ANALYSIS OF CELLULAR DNA IN URINE AND OTHER SAMPLES
US10633713B2 (en) 2017-01-25 2020-04-28 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
EP3366780B1 (en) * 2017-02-23 2020-05-06 Siemens Healthcare GmbH Single-molecule sequence and high sensitivity methylation analysis for tissue-specific analysis
US11179516B2 (en) 2017-06-22 2021-11-23 Baxter International Inc. Systems and methods for incorporating patient pressure into medical fluid delivery
TWI834642B (zh) 2018-03-13 2024-03-11 美商格瑞爾有限責任公司 異常片段偵測及分類
CN112236520B (zh) 2018-04-02 2025-01-24 格里尔公司 甲基化标记和标靶甲基化探针板
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
CN113286881A (zh) 2018-09-27 2021-08-20 格里尔公司 甲基化标记和标靶甲基化探针板
AU2020216438A1 (en) 2019-01-31 2021-07-29 Guardant Health, Inc. Compositions and methods for isolating cell-free DNA
US11427874B1 (en) 2019-08-26 2022-08-30 Epi One Inc. Methods and systems for detection of prostate cancer by DNA methylation analysis
EP4055610A4 (en) 2019-11-05 2023-11-29 Personalis, Inc. ESTIMATION OF TUMOR PURITY FROM SINGLE SAMPLES
JP2023513470A (ja) 2020-01-30 2023-03-31 プログノミック インコーポレイテッド 肺バイオマーカーおよびそれらの使用方法
EP4347886A1 (en) 2021-06-03 2024-04-10 Inherent Biosciences, Inc. Dna methylation analysis to identify cell type
US12007397B2 (en) 2021-09-13 2024-06-11 PrognomIQ, Inc. Enhanced detection and quantitation of biomolecules
CN116042848B (zh) * 2021-10-28 2024-08-09 北京干细胞与再生医学研究院 一种通过血样检测判断动物体内存在移植物的方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897355A (en) * 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4800159A (en) * 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US6020124A (en) * 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
WO1993022456A1 (en) * 1992-04-27 1993-11-11 Trustees Of Dartmouth College Detection of gene sequences in biological fluids
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
CH686982A5 (fr) * 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US5552277A (en) * 1994-07-19 1996-09-03 The Johns Hopkins University School Of Medicine Genetic diagnosis of prostate cancer
DE4441057C2 (de) * 1994-11-17 1999-02-25 Wacker Chemie Gmbh Verfahren zur kontinuierlichen Herstellung von Organopolysiloxanen
EP0826066B1 (en) * 1995-05-05 2000-09-13 The Perkin-Elmer Corporation Methods and reagents for combined pcr amplification and hybridization probing assay
US6156504A (en) * 1996-03-15 2000-12-05 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6291163B1 (en) * 1996-08-28 2001-09-18 The Johns Hopkins University School Of Medicine Method for detecting cell proliferative disorders
US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
DE69913654T2 (de) * 1999-05-12 2004-06-09 Hamamatsu Photonics K.K., Hamamatsu Nachweis von Nukleinsäuren im Zytoplasma
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
AU2001274866B2 (en) * 2000-05-22 2006-11-09 The Johns Hopkins University Methods for assaying gene imprinting and methylated CpG islands
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
US7045319B2 (en) * 2001-10-30 2006-05-16 Ribomed Biotechnologies, Inc. Molecular detection systems utilizing reiterative oligonucleotide synthesis

Also Published As

Publication number Publication date
DE60207979D1 (de) 2006-01-19
CA2478493A1 (en) 2003-09-12
JP4727149B2 (ja) 2011-07-20
JP2005518809A (ja) 2005-06-30
ES2253461T3 (es) 2006-06-01
WO2003074730A1 (en) 2003-09-12
EP1483410A1 (en) 2004-12-08
DE60207979T2 (de) 2006-09-28
AU2003218691A1 (en) 2003-09-16
EP1342794A1 (en) 2003-09-10
AU2003218691B2 (en) 2008-06-12
ATE312946T1 (de) 2005-12-15
EP1342794B1 (en) 2005-12-14
US20050221314A1 (en) 2005-10-06

Similar Documents

Publication Publication Date Title
DK1342794T3 (da) Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker
NO20076656L (no) Forbedrede immunoassay metoder
NO20030251L (no) Fremgangsmåte for differensiering mellom biologiske tilstander basert på skjulte mönstre fra biologiske data
DK1439897T3 (da) Fremgangsmåder til adskillelse af sjældne celler fra væskeprøver
BRPI0809885B8 (pt) artigo absorvente, e, método para detectar presença de um analito na urina
Wong et al. Evaluation of an automated immunochemical fecal occult blood test for colorectal neoplasia detection in a Chinese population
WO2006119292A3 (en) Methods for detection of biological substances
ATE447715T1 (de) Automatische glykofingerabdruck-strategie
CA2623653A1 (en) Use of n-myristoyltransferase on non-tumor tissue for cancer diagnosis
EP3027115B1 (en) Non-invasive system for calculating a human or animal, reliable, standardized and complete score
JP4516124B2 (ja) 肝線維症の診断方法
WO2007015113A3 (en) New protein isoforms of the pif-family and uses thereof
DE60239622D1 (de) Verfahren zur diagnose oder überwachung eines fehlers im zuckerstoffwechsel
WO2003100006A3 (en) Method of improved prostate cancer detection
WO2006089219A3 (en) Neoepitope detection of disease using protein arrays
BR9910009A (pt) Processos para coletar uma amostra derivada de um material fecal e para a detencção de sangue oculto em material fecal, e, kit de ensaio para teste de material fecal
ATE476527T1 (de) Quantifizierungsverfahren für die vegf isoformen einer biologischen probe
Di Girolamo et al. Evaluation of point‐of‐care analysers for blood gas and clinical chemistry in Hermann’s tortoises (Testudo hermanni)
KR20200049647A (ko) 반려동물에서 종양질병의 보조적 진단을 위한 바이오마커 검사방법
EP1376133A4 (en) SCREENING PROCEDURE FOR THE PRÄDIABETIS CONDITION AND SCREENING REAGENT
JP2013522618A (ja) 尿管感染症のための分子マーカー
CY1109461T1 (el) Βελτιωμενες μεθοδοι ανοσολογικου προσδιορισμου
WO2002080775A1 (en) Method of collecting a gastrointestinal tract sample
WO2003099107A3 (en) Methods and kits for the detection of renal cell carcinoma in a biological fluid of a patient
WO2005005957A3 (en) Method of detecting cancer using delta-catenin