DK1342794T3 - Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker - Google Patents
Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæskerInfo
- Publication number
- DK1342794T3 DK1342794T3 DK02004954T DK02004954T DK1342794T3 DK 1342794 T3 DK1342794 T3 DK 1342794T3 DK 02004954 T DK02004954 T DK 02004954T DK 02004954 T DK02004954 T DK 02004954T DK 1342794 T3 DK1342794 T3 DK 1342794T3
- Authority
- DK
- Denmark
- Prior art keywords
- dna
- amount
- free floating
- free
- body fluids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02004954A EP1342794B1 (en) | 2002-03-05 | 2002-03-05 | Method and device for determination of tissue specificity of free floating DNA in bodily fluids |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1342794T3 true DK1342794T3 (da) | 2006-04-24 |
Family
ID=27741132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02004954T DK1342794T3 (da) | 2002-03-05 | 2002-03-05 | Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker |
Country Status (10)
Country | Link |
---|---|
US (1) | US20050221314A1 (es) |
EP (2) | EP1342794B1 (es) |
JP (1) | JP4727149B2 (es) |
AT (1) | ATE312946T1 (es) |
AU (1) | AU2003218691B2 (es) |
CA (1) | CA2478493A1 (es) |
DE (1) | DE60207979T2 (es) |
DK (1) | DK1342794T3 (es) |
ES (1) | ES2253461T3 (es) |
WO (1) | WO2003074730A1 (es) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060183128A1 (en) * | 2003-08-12 | 2006-08-17 | Epigenomics Ag | Methods and compositions for differentiating tissues for cell types using epigenetic markers |
DE10348407A1 (de) * | 2003-10-17 | 2005-05-19 | Widschwendter, Martin, Prof. | Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben |
US8912129B2 (en) * | 2005-11-17 | 2014-12-16 | Epigenomics Ag | Method for the determination of the DNA methylation level of a CPG position in identical cells within a tissue sample |
US20100124743A1 (en) * | 2007-01-23 | 2010-05-20 | Olympus Corporation | Method for diagnosis of cancer |
JP5378687B2 (ja) * | 2007-03-02 | 2013-12-25 | エフ.ホフマン−ラ ロシュ アーゲー | Basp1遺伝子および/またはsrd5a2遺伝子中のメチル化シトシンを利用する、肝臓癌、肝臓癌発症リスク、肝臓癌再発リスク、肝臓癌悪性度および肝臓癌の経時的進展の検出方法 |
US20100285463A1 (en) * | 2007-06-29 | 2010-11-11 | Medizinische Univversitat Innsbruck | Selecting nucleic acid samples suitable for genotyping |
US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
US9260753B2 (en) | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
EP3842551B1 (en) | 2012-09-04 | 2023-11-01 | Guardant Health, Inc. | Methods of analysing cell free polynucleotides |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
LT3354747T (lt) | 2012-09-20 | 2021-04-12 | The Chinese University Of Hong Kong | Neinvazinis naviko metilomos nustatymas iš plazmos |
US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
EP4414990A3 (en) | 2013-01-17 | 2024-11-06 | Personalis, Inc. | Methods and systems for genetic analysis |
WO2015031689A1 (en) | 2013-08-30 | 2015-03-05 | Personalis, Inc. | Methods and systems for genomic analysis |
JP6295578B2 (ja) * | 2013-09-30 | 2018-03-20 | 凸版印刷株式会社 | 反応容器、核酸解析装置、および核酸解析方法 |
GB2535066A (en) | 2013-10-03 | 2016-08-10 | Personalis Inc | Methods for analyzing genotypes |
ES2660989T3 (es) | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
EP3132055A2 (en) * | 2014-04-14 | 2017-02-22 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
HUE056267T2 (hu) | 2014-07-18 | 2022-02-28 | Univ Hong Kong Chinese | DNS-keverékek szöveteinek metilációs mintázatelemzése |
US10125399B2 (en) | 2014-10-30 | 2018-11-13 | Personalis, Inc. | Methods for using mosaicism in nucleic acids sampled distal to their origin |
US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
CA3008623C (en) * | 2015-12-17 | 2022-10-04 | Illumina, Inc. | Distinguishing methylation levels in complex biological samples |
WO2017106768A1 (en) | 2015-12-17 | 2017-06-22 | Guardant Health, Inc. | Methods to determine tumor gene copy number by analysis of cell-free dna |
US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
CA3025708A1 (en) | 2016-05-30 | 2017-12-07 | The Chinese University Of Hong Kong | Detecting hematological disorders using cell-free dna in blood |
US11566284B2 (en) | 2016-08-10 | 2023-01-31 | Grail, Llc | Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing |
US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
KR102344635B1 (ko) | 2016-09-30 | 2021-12-31 | 가던트 헬쓰, 인크. | 무세포 핵산의 다중-해상도 분석 방법 |
AU2017347790B2 (en) | 2016-10-24 | 2024-06-13 | Grail, Inc. | Methods and systems for tumor detection |
EP3548632A4 (en) | 2016-11-30 | 2020-06-24 | The Chinese University Of Hong Kong | ANALYSIS OF CELLULAR DNA IN URINE AND OTHER SAMPLES |
US10633713B2 (en) | 2017-01-25 | 2020-04-28 | The Chinese University Of Hong Kong | Diagnostic applications using nucleic acid fragments |
EP3366780B1 (en) * | 2017-02-23 | 2020-05-06 | Siemens Healthcare GmbH | Single-molecule sequence and high sensitivity methylation analysis for tissue-specific analysis |
US11179516B2 (en) | 2017-06-22 | 2021-11-23 | Baxter International Inc. | Systems and methods for incorporating patient pressure into medical fluid delivery |
TWI834642B (zh) | 2018-03-13 | 2024-03-11 | 美商格瑞爾有限責任公司 | 異常片段偵測及分類 |
CN112236520B (zh) | 2018-04-02 | 2025-01-24 | 格里尔公司 | 甲基化标记和标靶甲基化探针板 |
US11814750B2 (en) | 2018-05-31 | 2023-11-14 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
US10801064B2 (en) | 2018-05-31 | 2020-10-13 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
CN113286881A (zh) | 2018-09-27 | 2021-08-20 | 格里尔公司 | 甲基化标记和标靶甲基化探针板 |
AU2020216438A1 (en) | 2019-01-31 | 2021-07-29 | Guardant Health, Inc. | Compositions and methods for isolating cell-free DNA |
US11427874B1 (en) | 2019-08-26 | 2022-08-30 | Epi One Inc. | Methods and systems for detection of prostate cancer by DNA methylation analysis |
EP4055610A4 (en) | 2019-11-05 | 2023-11-29 | Personalis, Inc. | ESTIMATION OF TUMOR PURITY FROM SINGLE SAMPLES |
JP2023513470A (ja) | 2020-01-30 | 2023-03-31 | プログノミック インコーポレイテッド | 肺バイオマーカーおよびそれらの使用方法 |
EP4347886A1 (en) | 2021-06-03 | 2024-04-10 | Inherent Biosciences, Inc. | Dna methylation analysis to identify cell type |
US12007397B2 (en) | 2021-09-13 | 2024-06-11 | PrognomIQ, Inc. | Enhanced detection and quantitation of biomolecules |
CN116042848B (zh) * | 2021-10-28 | 2024-08-09 | 北京干细胞与再生医学研究院 | 一种通过血样检测判断动物体内存在移植物的方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4897355A (en) * | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4800159A (en) * | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
US6020124A (en) * | 1992-04-27 | 2000-02-01 | Trustees Of Dartmouth College | Detection of soluble gene sequences in biological fluids |
WO1993022456A1 (en) * | 1992-04-27 | 1993-11-11 | Trustees Of Dartmouth College | Detection of gene sequences in biological fluids |
US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
CH686982A5 (fr) * | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
US5552277A (en) * | 1994-07-19 | 1996-09-03 | The Johns Hopkins University School Of Medicine | Genetic diagnosis of prostate cancer |
DE4441057C2 (de) * | 1994-11-17 | 1999-02-25 | Wacker Chemie Gmbh | Verfahren zur kontinuierlichen Herstellung von Organopolysiloxanen |
EP0826066B1 (en) * | 1995-05-05 | 2000-09-13 | The Perkin-Elmer Corporation | Methods and reagents for combined pcr amplification and hybridization probing assay |
US6156504A (en) * | 1996-03-15 | 2000-12-05 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays |
US6017704A (en) * | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
US6291163B1 (en) * | 1996-08-28 | 2001-09-18 | The Johns Hopkins University School Of Medicine | Method for detecting cell proliferative disorders |
US6251594B1 (en) * | 1997-06-09 | 2001-06-26 | Usc/Norris Comprehensive Cancer Ctr. | Cancer diagnostic method based upon DNA methylation differences |
DE19754482A1 (de) * | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
DE69913654T2 (de) * | 1999-05-12 | 2004-06-09 | Hamamatsu Photonics K.K., Hamamatsu | Nachweis von Nukleinsäuren im Zytoplasma |
US6331393B1 (en) * | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
AU2001274866B2 (en) * | 2000-05-22 | 2006-11-09 | The Johns Hopkins University | Methods for assaying gene imprinting and methylated CpG islands |
US6927028B2 (en) * | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
US7045319B2 (en) * | 2001-10-30 | 2006-05-16 | Ribomed Biotechnologies, Inc. | Molecular detection systems utilizing reiterative oligonucleotide synthesis |
-
2002
- 2002-03-05 AT AT02004954T patent/ATE312946T1/de active
- 2002-03-05 DK DK02004954T patent/DK1342794T3/da active
- 2002-03-05 ES ES02004954T patent/ES2253461T3/es not_active Expired - Lifetime
- 2002-03-05 DE DE60207979T patent/DE60207979T2/de not_active Expired - Lifetime
- 2002-03-05 EP EP02004954A patent/EP1342794B1/en not_active Expired - Lifetime
-
2003
- 2003-03-05 US US10/506,693 patent/US20050221314A1/en not_active Abandoned
- 2003-03-05 WO PCT/EP2003/002245 patent/WO2003074730A1/en not_active Application Discontinuation
- 2003-03-05 CA CA002478493A patent/CA2478493A1/en not_active Abandoned
- 2003-03-05 EP EP03711926A patent/EP1483410A1/en not_active Withdrawn
- 2003-03-05 AU AU2003218691A patent/AU2003218691B2/en not_active Expired
- 2003-03-05 JP JP2003573175A patent/JP4727149B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60207979D1 (de) | 2006-01-19 |
CA2478493A1 (en) | 2003-09-12 |
JP4727149B2 (ja) | 2011-07-20 |
JP2005518809A (ja) | 2005-06-30 |
ES2253461T3 (es) | 2006-06-01 |
WO2003074730A1 (en) | 2003-09-12 |
EP1483410A1 (en) | 2004-12-08 |
DE60207979T2 (de) | 2006-09-28 |
AU2003218691A1 (en) | 2003-09-16 |
EP1342794A1 (en) | 2003-09-10 |
AU2003218691B2 (en) | 2008-06-12 |
ATE312946T1 (de) | 2005-12-15 |
EP1342794B1 (en) | 2005-12-14 |
US20050221314A1 (en) | 2005-10-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1342794T3 (da) | Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker | |
NO20076656L (no) | Forbedrede immunoassay metoder | |
NO20030251L (no) | Fremgangsmåte for differensiering mellom biologiske tilstander basert på skjulte mönstre fra biologiske data | |
DK1439897T3 (da) | Fremgangsmåder til adskillelse af sjældne celler fra væskeprøver | |
BRPI0809885B8 (pt) | artigo absorvente, e, método para detectar presença de um analito na urina | |
Wong et al. | Evaluation of an automated immunochemical fecal occult blood test for colorectal neoplasia detection in a Chinese population | |
WO2006119292A3 (en) | Methods for detection of biological substances | |
ATE447715T1 (de) | Automatische glykofingerabdruck-strategie | |
CA2623653A1 (en) | Use of n-myristoyltransferase on non-tumor tissue for cancer diagnosis | |
EP3027115B1 (en) | Non-invasive system for calculating a human or animal, reliable, standardized and complete score | |
JP4516124B2 (ja) | 肝線維症の診断方法 | |
WO2007015113A3 (en) | New protein isoforms of the pif-family and uses thereof | |
DE60239622D1 (de) | Verfahren zur diagnose oder überwachung eines fehlers im zuckerstoffwechsel | |
WO2003100006A3 (en) | Method of improved prostate cancer detection | |
WO2006089219A3 (en) | Neoepitope detection of disease using protein arrays | |
BR9910009A (pt) | Processos para coletar uma amostra derivada de um material fecal e para a detencção de sangue oculto em material fecal, e, kit de ensaio para teste de material fecal | |
ATE476527T1 (de) | Quantifizierungsverfahren für die vegf isoformen einer biologischen probe | |
Di Girolamo et al. | Evaluation of point‐of‐care analysers for blood gas and clinical chemistry in Hermann’s tortoises (Testudo hermanni) | |
KR20200049647A (ko) | 반려동물에서 종양질병의 보조적 진단을 위한 바이오마커 검사방법 | |
EP1376133A4 (en) | SCREENING PROCEDURE FOR THE PRÄDIABETIS CONDITION AND SCREENING REAGENT | |
JP2013522618A (ja) | 尿管感染症のための分子マーカー | |
CY1109461T1 (el) | Βελτιωμενες μεθοδοι ανοσολογικου προσδιορισμου | |
WO2002080775A1 (en) | Method of collecting a gastrointestinal tract sample | |
WO2003099107A3 (en) | Methods and kits for the detection of renal cell carcinoma in a biological fluid of a patient | |
WO2005005957A3 (en) | Method of detecting cancer using delta-catenin |