DK0638075T3 - Thiazol- eller imidazolderivater som Maillard-reaktionsinhibitorer - Google Patents
Thiazol- eller imidazolderivater som Maillard-reaktionsinhibitorerInfo
- Publication number
- DK0638075T3 DK0638075T3 DK94907081T DK94907081T DK0638075T3 DK 0638075 T3 DK0638075 T3 DK 0638075T3 DK 94907081 T DK94907081 T DK 94907081T DK 94907081 T DK94907081 T DK 94907081T DK 0638075 T3 DK0638075 T3 DK 0638075T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- maillard reaction
- thiazole
- imidazole derivatives
- reaction inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3772093 | 1993-02-26 | ||
| JP23024393 | 1993-09-16 | ||
| PCT/JP1994/000260 WO1994019335A1 (en) | 1993-02-26 | 1994-02-21 | Thiazole or imidazole derivatives as maillard reaction inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0638075T3 true DK0638075T3 (da) | 2002-02-18 |
Family
ID=26376862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94907081T DK0638075T3 (da) | 1993-02-26 | 1994-02-21 | Thiazol- eller imidazolderivater som Maillard-reaktionsinhibitorer |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5677322A (da) |
| EP (1) | EP0638075B1 (da) |
| JP (2) | JP2821661B2 (da) |
| KR (2) | KR100250701B1 (da) |
| CN (2) | CN1037842C (da) |
| AT (1) | ATE212018T1 (da) |
| AU (1) | AU669427B2 (da) |
| CA (1) | CA2134347C (da) |
| DE (1) | DE69429641T2 (da) |
| DK (1) | DK0638075T3 (da) |
| ES (1) | ES2168294T3 (da) |
| PT (1) | PT638075E (da) |
| TW (1) | TW338041B (da) |
| WO (1) | WO1994019335A1 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197806B1 (en) | 1995-12-20 | 2001-03-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Eliminating agent for activated oxygen and free radicals |
| WO1997044324A1 (en) | 1996-05-21 | 1997-11-27 | Pharmacia & Upjohn Company | Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus |
| AU6518598A (en) * | 1997-03-28 | 1998-10-22 | Otsuka Pharmaceutical Co., Ltd. | Age production inhibitory composition comprising a maillard reaction inhibitor and vitamin b6 |
| EP2070535B1 (en) | 1998-08-24 | 2015-07-08 | Kurokawa, Kiyoshi | Drugs for relieving carbonyl stress and peritoneal dialysates |
| AU754989B2 (en) | 1998-11-16 | 2002-11-28 | Nippon Zoki Pharmaceutical Co., Ltd. | A therapeutic agent for intractable vasculitis |
| US6265571B1 (en) | 1999-07-12 | 2001-07-24 | Magellan Laboratories, Inc. | Purification process for anti-parasitic fermentation product |
| DE10052590A1 (de) * | 2000-10-24 | 2002-05-02 | Haarmann & Reimer Gmbh | Verwendung von 2-Hydrazino-1,3-thiazolen als Antioxidantien |
| JP4711523B2 (ja) | 2001-02-13 | 2011-06-29 | 日本臓器製薬株式会社 | 低アルブミン血症改善剤 |
| CN1243735C (zh) * | 2001-04-19 | 2006-03-01 | 卫材株式会社 | 2－亚氨基吡咯烷衍生物 |
| WO2003004989A2 (en) | 2001-06-21 | 2003-01-16 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
| JP4549970B2 (ja) * | 2003-02-19 | 2010-09-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 環状ベンズアミジン誘導体の製造方法 |
| US20050059790A1 (en) * | 2003-09-16 | 2005-03-17 | Roesler Richard R. | Process for preparing aspartates |
| JP4061332B2 (ja) | 2003-11-21 | 2008-03-19 | アクテリオン ファーマシューティカルズ リミテッド | 新規チアゾリジン−４−オン誘導体 |
| USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| WO2005073180A1 (ja) * | 2003-12-25 | 2005-08-11 | Kureha Corporation | ヒドロキサム酸誘導体、及び該誘導体を含むａｇｅ生成阻害剤 |
| KR101255879B1 (ko) * | 2006-11-23 | 2013-04-17 | 액테리온 파마슈티칼 리미티드 | 2-이미노-티아졸리딘-4-원 유도체의 신규한 제조 방법 |
| US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
| MX350891B (es) | 2012-08-17 | 2017-09-22 | Actelion Pharmaceuticals Ltd | Proceso para la preparacion de (2z,5z)-5-(3-cloro-4-((r)-2,3-dihid roxipropoxi) bencilideno)-2-(propilimino)-3-(o-tolil) tiazolidin-4-ona y el intermediario usado en dicho proceso. |
| GB201405991D0 (en) * | 2014-04-03 | 2014-05-21 | Cambridge Entpr Ltd | Novel compounds |
| CN107459496B (zh) * | 2016-06-03 | 2022-07-19 | 华东理工大学 | 噻唑类衍生物在治疗病毒感染中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2528844A1 (fr) * | 1982-06-18 | 1983-12-23 | Chauvin Blache Lab | Nouvelles thiazolyl-2 hydrazones, leur procede de preparation et leur application en therapeutique |
| US5258381A (en) * | 1984-03-19 | 1993-11-02 | The Rockefeller University | 2-substituted-2-imidazolines |
| EP0325936A3 (en) * | 1988-01-16 | 1990-01-17 | Ono Pharmaceutical Co., Ltd. | Aminoguanidine derivatives and inhibitory agents on maillard reaction containing them as active ingredients |
| TW221689B (da) * | 1991-08-27 | 1994-03-11 | Otsuka Pharma Co Ltd |
-
1994
- 1994-02-21 AT AT94907081T patent/ATE212018T1/de not_active IP Right Cessation
- 1994-02-21 PT PT94907081T patent/PT638075E/pt unknown
- 1994-02-21 CA CA002134347A patent/CA2134347C/en not_active Expired - Fee Related
- 1994-02-21 KR KR1019940703805A patent/KR100250701B1/ko not_active IP Right Cessation
- 1994-02-21 US US08/325,233 patent/US5677322A/en not_active Expired - Fee Related
- 1994-02-21 AU AU60458/94A patent/AU669427B2/en not_active Ceased
- 1994-02-21 DK DK94907081T patent/DK0638075T3/da active
- 1994-02-21 CN CN94190159A patent/CN1037842C/zh not_active Expired - Fee Related
- 1994-02-21 EP EP94907081A patent/EP0638075B1/en not_active Expired - Lifetime
- 1994-02-21 ES ES94907081T patent/ES2168294T3/es not_active Expired - Lifetime
- 1994-02-21 DE DE69429641T patent/DE69429641T2/de not_active Expired - Fee Related
- 1994-02-21 WO PCT/JP1994/000260 patent/WO1994019335A1/en active IP Right Grant
- 1994-02-25 JP JP6027096A patent/JP2821661B2/ja not_active Expired - Fee Related
- 1994-02-26 TW TW083101658A patent/TW338041B/zh active
- 1994-10-26 KR KR1019997007806A patent/KR100257180B1/ko active
-
1997
- 1997-06-06 CN CN97105550A patent/CN1067992C/zh not_active Expired - Fee Related
- 1997-12-10 JP JP9340305A patent/JPH10167965A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1184105A (zh) | 1998-06-10 |
| US5677322A (en) | 1997-10-14 |
| CN1106982A (zh) | 1995-08-16 |
| JPH10167965A (ja) | 1998-06-23 |
| JPH07133264A (ja) | 1995-05-23 |
| AU6045894A (en) | 1994-09-14 |
| PT638075E (pt) | 2002-06-28 |
| ES2168294T3 (es) | 2002-06-16 |
| EP0638075B1 (en) | 2002-01-16 |
| ATE212018T1 (de) | 2002-02-15 |
| TW338041B (en) | 1998-08-11 |
| CN1037842C (zh) | 1998-03-25 |
| CA2134347A1 (en) | 1994-08-27 |
| AU669427B2 (en) | 1996-06-06 |
| DE69429641T2 (de) | 2002-08-29 |
| DE69429641D1 (en) | 2002-02-21 |
| EP0638075A1 (en) | 1995-02-15 |
| KR950701328A (ko) | 1995-03-23 |
| JP2821661B2 (ja) | 1998-11-05 |
| KR100250701B1 (ko) | 2000-07-01 |
| WO1994019335A1 (en) | 1994-09-01 |
| CN1067992C (zh) | 2001-07-04 |
| CA2134347C (en) | 2003-04-29 |
| KR100257180B1 (ko) | 2000-05-15 |
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