DK0699199T3 - Heteroatomsubstituerede alkylbenzylaminoquinuclidiner som substans P-antagonister - Google Patents

Heteroatomsubstituerede alkylbenzylaminoquinuclidiner som substans P-antagonister

Info

Publication number: DK0699199T3
Authority: DK; Denmark
Prior art keywords: alkyl; alkoxy; pct; hydrogen; independently
Prior art date: 1993-05-19

Application number

DK94914619T

Other languages

English (en)

Inventor

Kunio Satake

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-19

Filing date

1994-05-13

Publication date

2002-12-16

1994-05-13 Application filed by Pfizer filed Critical Pfizer

2002-12-16 Application granted granted Critical

2002-12-16 Publication of DK0699199T3 publication Critical patent/DK0699199T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK94914619T 1993-05-19 1994-05-13 Heteroatomsubstituerede alkylbenzylaminoquinuclidiner som substans P-antagonister DK0699199T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP11710293		1993-05-19
PCT/JP1994/000781 WO1994026740A1 (en)	1993-05-19	1994-05-13	Heteroatom substituted alkyl benzylaminoquinuclidines as substance p antagonists

Publications (1)

Publication Number	Publication Date
DK0699199T3 true DK0699199T3 (da)	2002-12-16

Family

ID=14703456

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94914619T DK0699199T3 (da)	1993-05-19	1994-05-13	Heteroatomsubstituerede alkylbenzylaminoquinuclidiner som substans P-antagonister

Country Status (12)

Country	Link
US (1)	US5741797A (da)
EP (1)	EP0699199B1 (da)
AT (1)	ATE228129T1 (da)
AU (1)	AU6691094A (da)
CA (1)	CA2161886C (da)
DE (1)	DE69431751T2 (da)
DK (1)	DK0699199T3 (da)
ES (1)	ES2184762T3 (da)
FI (1)	FI942314A (da)
IL (1)	IL109646A0 (da)
PT (1)	PT699199E (da)
WO (1)	WO1994026740A1 (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2205016A1 (en) *	1994-11-10	1996-05-23	Hans-Jurgen Ernst Hess	Nk-1 receptor antagonists for the treatment of eye disorders
ES2180693T3 (es)	1995-12-21	2003-02-16	Pfizer	3-((bencil 5-sustituido)amino)-2-fenilpiperidinas como antagonistas de la sustancia p.
MX9706944A (es) *	1996-09-12	1998-08-30	Pfizer	Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.
KR20040029375A (ko) *	2001-07-20	2004-04-06	화이자 프로덕츠 인코포레이티드	개, 고양이 및 말에서 결함있는 행태를 변화시키기 위한ｎｋ-1 수용체 길항제의 용도
US20060205724A1 (en) *	2002-05-29	2006-09-14	The Regents Of The University Of California	Antagonizing nk-1 receptors inhibits consumption of substances of abuse
US6861526B2 (en)	2002-10-16	2005-03-01	Pfizer Inc.	Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
NZ552397A (en)	2004-07-15	2011-04-29	Amr Technology Inc	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
ATE550019T1 (de)	2005-05-17	2012-04-15	Merck Sharp & Dohme	Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
EA019115B1 (ru)	2005-07-15	2014-01-30	Олбани Молекьюлар Рисерч, Инк.	Арил- и гетероарилзамещенные тетрагидробензазепины и их применение для блокировки обратного захвата норэпинефрина, допамина и серотонина
CN101277960A (zh)	2005-09-29	2008-10-01	默克公司	作为黑皮质素-4受体调节剂的酰化螺哌啶衍生物
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20070238630A1 (en) *	2006-03-29	2007-10-11	Phillips Douglas H	Subcutaneous skin cleanser
CA2664113C (en)	2006-09-22	2013-05-28	Merck & Co., Inc.	Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
CA2674436C (en)	2007-01-10	2012-07-17	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A.	Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
EP2145884B1 (en)	2007-04-02	2014-08-06	Msd K.K.	Indoledione derivative
JP5501227B2 (ja)	2007-06-27	2014-05-21	メルク・シャープ・アンド・ドーム・コーポレーション	ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体
US8598184B2 (en)	2008-03-03	2013-12-03	Tiger Pharmatech	Protein kinase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
CA2760837C (en)	2009-05-12	2018-04-03	Albany Molecular Research, Inc.	7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
JP5739415B2 (ja)	2009-05-12	2015-06-24	ブリストル−マイヤーズスクウィブカンパニー	（Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
WO2010132437A1 (en)	2009-05-12	2010-11-18	Albany Molecular Research, Inc.	Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
UA109417C2 (uk)	2009-10-14	2015-08-25	Мерк Шарп Енд Доме Корп.	ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ
WO2011163330A1 (en)	2010-06-24	2011-12-29	Merck Sharp & Dohme Corp.	Novel heterocyclic compounds as erk inhibitors
CN107090456B (zh)	2010-08-02	2022-01-18	瑟纳治疗公司	使用短干扰核酸的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1基因表达的抑制
US9029341B2 (en)	2010-08-17	2015-05-12	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
EP2608669B1 (en)	2010-08-23	2016-06-22	Merck Sharp & Dohme Corp.	NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2613782B1 (en)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
EP3327125B1 (en)	2010-10-29	2020-08-05	Sirna Therapeutics, Inc.	Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
US9351965B2 (en)	2010-12-21	2016-05-31	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
WO2012143874A1 (en)	2011-04-21	2012-10-26	Piramal Healthcare Limited	A process for the preparation of morpholino sulfonyl indole derivatives
EP2770987B1 (en)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP2844261B1 (en)	2012-05-02	2018-10-17	Sirna Therapeutics, Inc.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
EP2900241B1 (en)	2012-09-28	2018-08-08	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP3610890A1 (en)	2012-11-14	2020-02-19	The Johns Hopkins University	Methods and compositions for treating schizophrenia
WO2014085216A1 (en)	2012-11-28	2014-06-05	Merck Sharp & Dohme Corp.	Compositions and methods for treating cancer
AR094116A1 (es)	2012-12-20	2015-07-08	Merck Sharp & Dohme	Imidazopiridinas sustituidas como inhibidores de hdm2
EP2951180B1 (en)	2013-01-30	2018-05-02	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
WO2018071283A1 (en)	2016-10-12	2018-04-19	Merck Sharp & Dohme Corp.	Kdm5 inhibitors
US10947234B2 (en)	2017-11-08	2021-03-16	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
EP3706747A4 (en)	2017-11-08	2021-08-04	Merck Sharp & Dohme Corp.	PRMT5 INHIBITORS
WO2020033284A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
EP3833668A4 (en)	2018-08-07	2022-05-11	Merck Sharp & Dohme Corp.	PRMT5 INHIBITORS

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX18467A (es) *	1988-11-23	1993-07-01	Pfizer	Agentes terapeuticos de quinuclidinas
PL170525B1 (en) *	1991-05-22	1996-12-31	Pfizer	Method of obtaining novel derivatives of 3-amino quinuclidine
EP0587723B1 (en) *	1991-05-31	1996-03-06	Pfizer Inc.	Quinuclidine derivatives
PL172054B1 (pl) *	1991-06-20	1997-07-31	Pfizer	Sposób wytwarzania nowych pochodnych fluoroalkoksybenzyloaminowych zwiazków heterocyklicznych zawierajacych azot PL PL PL PL PL PL
JP2656702B2 (ja) *	1992-03-23	1997-09-24	ファイザー製薬株式会社	ペプチド性キヌクリジン
JP2656700B2 (ja) *	1992-10-28	1997-09-24	ファイザー製薬株式会社	置換キヌクリジン誘導体
US5294744A (en) *	1993-04-20	1994-03-15	Pfizer Inc.	Formylation process for aromatic aldehydes
JP3326489B2 (ja) *	1996-02-10	2002-09-24	好高青山	部品供給ロッド装置とそれによる供給方法
JPH09221677A (ja) *	1996-02-14	1997-08-26	Kansai Coke & Chem Co Ltd	石炭の高温予熱方法
JPH09319064A (ja) *	1996-05-29	1997-12-12	Konica Corp	写真製品の生産方法及び生産装置

1994
- 1994-05-12 IL IL10964694A patent/IL109646A0/xx unknown
- 1994-05-13 US US08/556,916 patent/US5741797A/en not_active Expired - Fee Related
- 1994-05-13 ES ES94914619T patent/ES2184762T3/es not_active Expired - Lifetime
- 1994-05-13 EP EP94914619A patent/EP0699199B1/en not_active Expired - Lifetime
- 1994-05-13 DE DE69431751T patent/DE69431751T2/de not_active Expired - Fee Related
- 1994-05-13 AT AT94914619T patent/ATE228129T1/de not_active IP Right Cessation
- 1994-05-13 AU AU66910/94A patent/AU6691094A/en not_active Abandoned
- 1994-05-13 PT PT94914619T patent/PT699199E/pt unknown
- 1994-05-13 DK DK94914619T patent/DK0699199T3/da active
- 1994-05-13 WO PCT/JP1994/000781 patent/WO1994026740A1/en active IP Right Grant
- 1994-05-13 CA CA002161886A patent/CA2161886C/en not_active Expired - Fee Related
- 1994-05-18 FI FI942314A patent/FI942314A/fi unknown

Also Published As

Publication number	Publication date
ES2184762T3 (es)	2003-04-16
CA2161886C (en)	1999-12-07
DE69431751D1 (de)	2003-01-02
US5741797A (en)	1998-04-21
FI942314A0 (fi)	1994-05-18
IL109646A0 (en)	1994-08-26
WO1994026740A1 (en)	1994-11-24
EP0699199A1 (en)	1996-03-06
ATE228129T1 (de)	2002-12-15
FI942314A (fi)	1994-11-20
AU6691094A (en)	1994-12-12
EP0699199B1 (en)	2002-11-20
PT699199E (pt)	2003-01-31
CA2161886A1 (en)	1994-11-24
DE69431751T2 (de)	2003-04-03

Publication	Publication Date	Title
DK0699199T3 (da)	2002-12-16	Heteroatomsubstituerede alkylbenzylaminoquinuclidiner som substans P-antagonister
FI944394A (fi)	1994-09-22	Kinuklidiinijohdannaisia P-aineen antagonisteina
ES530902A0 (es)	1984-11-16	Procedimiento para preparar derivados de piperazina
YU128091A (sh)	1994-01-20	Derivati hinuklidina
DE60107435D1 (de)	2004-12-30	2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmission
ES2169760T3 (es)	2002-07-16	Pirazoles sustituidos en 3,4 para el tratamiento de la inflamacion.
MY102027A (en)	1992-02-29	Leukotriene antagonists
NO881940L (no)	1988-05-04	4-aminokinolin-derivater og deres anvendelse som legemidler.
EA200301094A1 (ru)	2004-06-24	Аминопроизводные как ингибиторы протеазы
AR055959A1 (es)	2007-09-12	Derivados espiro para la modulacion de actividad de crth2
TW430660B (en)	2001-04-21	Novel benzindole derivatives for neuron cell protection, processes for production, and the pharmaceutical compounds containing them
SE8301412L (sv)	1983-09-17	Substituerade 1h-pyrazolo(1,5)pyrimidiner och forfarande for deras framstellning
ES2053748T3 (es)	1994-08-01	Oxazoles y tiazoles para el tratamiento de la demencia senil.
ES493922A0 (es)	1981-06-01	Procedimiento para la preparacion de 4-fenoxipiperidinas
ES498157A0 (es)	1981-12-01	Procedimiento para la obtencion de derivados de cefalospori-nas
DK0406112T3 (da)	1995-04-03	1-Benzhydrylazetidiner, deres fremstilling og deres anvendelse som mellemprodukter til fremstilling af forbindelser med antimikrobiel aktivitet
PT83345A (pt)	1986-10-01	Processo para a preparacao de ypsilon-carbolinas antipsicoticas
MX9709465A (es)	1998-02-28	Derivados de bencimidazol 2-sustituidos como inhibidores de la proliferacion de celulas del musculo liso.
ES520314A0 (es)	1984-04-16	Procedimiento para la preparacion de nuevas 4-fenil-4,5,6,7-tetrahidro-tieno (2,3-c)piridinas sustituidas con radicales basicos.
BG97173A (bg)	1993-12-24	Циклични производни на аминофенилоцетната киселина,метод за получаването им и приложението им
AU6039080A (en)	1981-02-05	Processes
ES392364A1 (es)	1973-10-01	Procedimiento para la produccion de una 3-alquil-7-fenilpi-rimido (1,2-a) (1,4) benzodiazepin-1 (5h)-ona.
YU46941B (sh)	1994-06-24	Aruloksi-ariltio-, heteroariloksi-, heteroariltio- alkenilenski derivati amina i postupak za njihovo dobijanje
ES519627A0 (es)	1983-11-16	Procedimiento para la preparacion de derivados de carbaciclina.
DK356287D0 (da)	1987-07-09	2,6-piperazindionderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse