DE69209290D1 - Perhydroisoindolderivate, ihre herstellung und diese enthaltende arzneimittel - Google Patents

Perhydroisoindolderivate, ihre herstellung und diese enthaltende arzneimittel

Info

Publication number: DE69209290D1
Authority: DE; Germany
Prior art keywords: halogen; derivatives; perhydroisoindol; production; products containing
Prior art date: 1991-05-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69209290T

Other languages

English (en)

Other versions

DE69209290T2 (de

Inventor

Daniel Achard

Serge Grisoni

Stephen Hanessian

Claude Moutonnier

Jean-Francois Peyronel

Michel Tabart

Alain Truchon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Rhone Poulenc Rorer SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-17

Filing date

1992-05-15

Publication date

1996-04-25

1992-05-15 Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA

1996-04-25 Application granted granted Critical

1996-04-25 Publication of DE69209290D1 publication Critical patent/DE69209290D1/de

1996-10-31 Publication of DE69209290T2 publication Critical patent/DE69209290T2/de

2012-05-16 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

ODSNARDHJFFSRH-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-isoindole Chemical class C1CCCC2CNCC21 ODSNARDHJFFSRH-UHFFFAOYSA-N 0.000 title abstract 2
229940126601 medicinal product Drugs 0.000 title 1
229910052736 halogen Inorganic materials 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 2
150000003254 radicals Chemical class 0.000 abstract 2
QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
102100024304 Protachykinin-1 Human genes 0.000 abstract 1
101800003906 Substance P Proteins 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 abstract 1
125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
-1 phenyl radicals Chemical class 0.000 abstract 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE69209290T 1991-05-17 1992-05-15 Perhydroisoindolderivate, ihre herstellung und diese enthaltende arzneimittel Expired - Fee Related DE69209290T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9106035A FR2676442B1 (fr)	1991-05-17	1991-05-17	Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR1992/000429 WO1992020653A1 (fr)	1991-05-17	1992-05-15	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number	Publication Date
DE69209290D1 true DE69209290D1 (de)	1996-04-25
DE69209290T2 DE69209290T2 (de)	1996-10-31

Family

ID=9412907

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69209290T Expired - Fee Related DE69209290T2 (de)	1991-05-17	1992-05-15	Perhydroisoindolderivate, ihre herstellung und diese enthaltende arzneimittel

Country Status (23)

Country	Link
US (1)	US5451601A (de)
EP (2)	EP0586490B1 (de)
JP (1)	JPH06507627A (de)
AT (1)	ATE135687T1 (de)
AU (1)	AU1883692A (de)
CA (1)	CA2109298A1 (de)
CZ (1)	CZ244793A3 (de)
DE (1)	DE69209290T2 (de)
DK (1)	DK0586490T3 (de)
ES (1)	ES2085627T3 (de)
FI (1)	FI935071A (de)
FR (1)	FR2676442B1 (de)
GR (1)	GR3019386T3 (de)
HU (1)	HUT67649A (de)
IE (1)	IE921578A1 (de)
IL (1)	IL101866A0 (de)
MX (1)	MX9202287A (de)
NO (1)	NO933964D0 (de)
NZ (1)	NZ242772A (de)
SK (1)	SK126793A3 (de)
TW (1)	TW200459B (de)
WO (1)	WO1992020653A1 (de)
ZA (1)	ZA923540B (de)

Families Citing this family (54)

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FR2689888B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5508424A (en) *	1993-03-26	1996-04-16	Ortho Pharmaceutical Corporation	4-arylisoindole analgesics
FR2703679B1 (fr) *	1993-04-05	1995-06-23	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) *	1993-07-30	1999-08-01	Rhone Poulenc Rorer Sa	Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2709752B1 (fr) *	1993-07-30	1995-10-06	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710913B1 (fr) *	1993-10-07	1995-11-24	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710842B1 (fr) *	1993-10-07	1995-11-24	Rhone Poulenc Rorer Sa	Nouvelle application thérapeutique de dérivés de perhydroisoindole.
US6203803B1 (en)	1994-12-14	2001-03-20	Societe L'oreal S.A.	Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained
FR2719476B1 (fr) *	1994-05-05	1997-05-23	Oreal	Utilisation d'un antagoniste de substance P dans une composition cosmétique et composition obtenue.
FR2719474B1 (fr) *	1994-05-05	1996-05-31	Oreal	Utilisation d'un antagoniste de substance P dans une composition cosmétique et composition obtenue.
FR2727411B1 (fr) *	1994-11-30	1997-01-03	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2728165A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
FR2728169A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
BR0015320A (pt)	1999-11-03	2002-07-09	Albany Molecular Res Inc	Composto, composição, métodos de tratamento de um distúrbio que e criado pela, ou é dependente da, disponibilidade diminuìda de serotonina, norepinefrina ou dopamina, para inibir a captação da serotonina, da dopamina e de norepinefrina sinápticas em um paciente em necessidade destes, e, kit
NZ523456A (en)	2000-07-11	2004-11-26	Albany Molecular Res Inc	Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
CN101119969B (zh)	2004-07-15	2014-04-09	阿尔巴尼分子研究公司	芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
ATE550019T1 (de)	2005-05-17	2012-04-15	Merck Sharp & Dohme	Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
JP5258561B2 (ja)	2005-07-15	2013-08-07	アルバニーモレキュラーリサーチ，インコーポレイテッド	アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
AR064777A1 (es)	2007-01-10	2009-04-22	Inst Di Reserche D Biolog Mole	Indazoles sustituidos con amida como inhibidores de poli (adp- ribosa) polimerasa (parp)
AU2008208920A1 (en)	2007-01-24	2008-07-31	Glaxo Group Limited	Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or R(-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an NK1
EP2170076B1 (de)	2007-06-27	2016-05-18	Merck Sharp & Dohme Corp.	4-carboxybenzylamino-derivate als histondeacetylase-hemmer
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
ES2662072T3 (es)	2009-05-12	2018-04-05	Albany Molecular Research, Inc.	7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma
AU2010247849B2 (en)	2009-05-12	2015-11-19	Albany Molecular Research, Inc.	Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
CN102638982B (zh)	2009-05-12	2015-07-08	百时美施贵宝公司	(S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
EA023838B1 (ru)	2009-10-14	2016-07-29	Мерк Шарп Энд Домэ Корп.	ЗАМЕЩЕННЫЕ ПИПЕРИДИНЫ, КОТОРЫЕ ПОВЫШАЮТ АКТИВНОСТЬ p53, И ИХ ПРИМЕНЕНИЕ
CA2805265A1 (en)	2010-08-02	2012-02-09	Merck Sharp & Dohme Corp.	Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
CN108676800B (zh)	2010-08-17	2022-11-11	瑟纳治疗公司	使用短干扰核酸(siNA)的乙型肝炎病毒(HBV)基因表达的RNA干扰介导的抑制
WO2012027236A1 (en)	2010-08-23	2012-03-01	Schering Corporation	NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2613782B1 (de)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazolderivate als erk-hemmer
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
EP3766975A1 (de)	2010-10-29	2021-01-20	Sirna Therapeutics, Inc.	Rna-interferenz-vermittelte inhibition von genexpression unter verwendung kurzer interferierender nukleinsäure (sina)
EP2654748B1 (de)	2010-12-21	2016-07-27	Merck Sharp & Dohme Corp.	Indazolderivate als erk-hemmer
JP2014514321A (ja)	2011-04-21	2014-06-19	メルク・シャープ・アンド・ドーム・コーポレーション	インスリン様増殖因子１受容体阻害剤
WO2013063214A1 (en)	2011-10-27	2013-05-02	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP3919620A1 (de)	2012-05-02	2021-12-08	Sirna Therapeutics, Inc.	Zusammensetzungen mit kurzer interferierender nukleinsäure (sina)
JP6280554B2 (ja)	2012-09-28	2018-02-14	メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋＳｈａｒｐ＆ＤｏｈｍｅＣｏｒｐ．	Ｅｒｋ阻害剤である新規化合物
LT2925888T (lt)	2012-11-28	2018-01-10	Merck Sharp & Dohme Corp.	Vėžio gydymo kompozicijos ir būdai
CA2895504A1 (en)	2012-12-20	2014-06-26	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as hdm2 inhibitors
EP2951180B1 (de)	2013-01-30	2018-05-02	Merck Sharp & Dohme Corp.	2,6,7,8-substituierte purine als hdm2-inhibitoren
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
EP3525785A4 (de)	2016-10-12	2020-03-25	Merck Sharp & Dohme Corp.	Kdm5-inhibitoren
WO2019094312A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
US10947234B2 (en)	2017-11-08	2021-03-16	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
EP3833668A4 (de)	2018-08-07	2022-05-11	Merck Sharp & Dohme Corp.	Prmt5-inhibitoren
WO2020033284A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX18467A (es) *	1988-11-23	1993-07-01	Pfizer	Agentes terapeuticos de quinuclidinas
FR2654725B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2654726B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone et leur preparation.
FR2676443B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole et leur preparation.

1991
- 1991-05-17 FR FR9106035A patent/FR2676442B1/fr not_active Expired - Fee Related
1992
- 1992-05-14 IL IL101866A patent/IL101866A0/xx unknown
- 1992-05-15 MX MX9202287A patent/MX9202287A/es unknown
- 1992-05-15 CA CA002109298A patent/CA2109298A1/fr not_active Abandoned
- 1992-05-15 HU HU9303249A patent/HUT67649A/hu unknown
- 1992-05-15 DK DK92911474.2T patent/DK0586490T3/da active
- 1992-05-15 SK SK1267-93A patent/SK126793A3/sk unknown
- 1992-05-15 TW TW081103795A patent/TW200459B/zh active
- 1992-05-15 NZ NZ242772A patent/NZ242772A/en unknown
- 1992-05-15 EP EP92911474A patent/EP0586490B1/de not_active Expired - Lifetime
- 1992-05-15 AU AU18836/92A patent/AU1883692A/en not_active Abandoned
- 1992-05-15 AT AT92911474T patent/ATE135687T1/de active
- 1992-05-15 ES ES92911474T patent/ES2085627T3/es not_active Expired - Lifetime
- 1992-05-15 US US08/146,143 patent/US5451601A/en not_active Expired - Fee Related
- 1992-05-15 DE DE69209290T patent/DE69209290T2/de not_active Expired - Fee Related
- 1992-05-15 WO PCT/FR1992/000429 patent/WO1992020653A1/fr active IP Right Grant
- 1992-05-15 ZA ZA923540A patent/ZA923540B/xx unknown
- 1992-05-15 EP EP92401329A patent/EP0514273A1/de active Pending
- 1992-05-15 JP JP4510462A patent/JPH06507627A/ja active Pending
- 1992-05-15 CZ CS932447A patent/CZ244793A3/cs unknown
- 1992-07-01 IE IE157892A patent/IE921578A1/en not_active Application Discontinuation
1993
- 1993-11-02 NO NO1993933964A patent/NO933964D0/no unknown
- 1993-11-16 FI FI935071A patent/FI935071A/fi unknown
1996
- 1996-03-21 GR GR950403441T patent/GR3019386T3/el unknown

Also Published As

Publication number	Publication date
DE69209290T2 (de)	1996-10-31
US5451601A (en)	1995-09-19
NZ242772A (en)	1994-04-27
JPH06507627A (ja)	1994-09-01
EP0586490B1 (de)	1996-03-20
NO933964L (no)	1993-11-02
EP0586490A1 (de)	1994-03-16
SK126793A3 (en)	1994-11-09
FR2676442B1 (fr)	1993-08-06
CA2109298A1 (fr)	1992-11-18
IL101866A0 (en)	1992-12-30
HUT67649A (en)	1995-04-28
GR3019386T3 (en)	1996-06-30
MX9202287A (es)	1993-02-01
WO1992020653A1 (fr)	1992-11-26
AU1883692A (en)	1992-12-30
NO933964D0 (no)	1993-11-02
FI935071A0 (fi)	1993-11-16
ES2085627T3 (es)	1996-06-01
TW200459B (de)	1993-02-21
DK0586490T3 (da)	1996-04-15
IE921578A1 (en)	1992-11-18
ZA923540B (en)	1993-01-27
ATE135687T1 (de)	1996-04-15
CZ244793A3 (en)	1994-03-16
EP0514273A1 (de)	1992-11-19
FI935071A (fi)	1993-11-16
FR2676442A1 (fr)	1992-11-20
HU9303249D0 (en)	1994-03-28

Publication	Publication Date	Title
DE69209290D1 (de)	1996-04-25	Perhydroisoindolderivate, ihre herstellung und diese enthaltende arzneimittel
ATE102923T1 (de)	1994-04-15	Isoindolonderivate, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IL105255A0 (en)	1993-08-18	Perhydroisoindole derivatives,their preparation and pharmaceutical compositions containing them
DE69402058D1 (de)	1997-04-17	Perhydroisoindol-derivate, deren herstellung und die sie behaltende pharmazeutische zusammenfassungen
RU93058350A (ru)	1997-03-10	Производные пергидроизоиндола, способ их получения и содержащие их фармацевтические композиции

Legal Events

Date	Code	Title	Description
1997-04-17	8364	No opposition during term of opposition
1998-05-07	8339	Ceased/non-payment of the annual fee