NO933964D0 - Nye perhydroisoindolderivater, deres fremstilling samt farmasoeytiske preparater inneholdende forbindelsene - Google Patents

Nye perhydroisoindolderivater, deres fremstilling samt farmasoeytiske preparater inneholdende forbindelsene

Info

Publication number: NO933964D0
Authority: NO; Norway
Prior art keywords: halogen; new; derivatives; preparation; perhydroiso
Prior art date: 1991-05-17

Application number

NO1993933964A

Other languages

English (en)

Norwegian (no)

Other versions

NO933964L (no

Inventor

Daniel Achard

Serge Grisoni

Stephen Hanessian

Claude Moutonnier

Jean-Francois Peyronel

Michel Tabart

Alain Truchon

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-17

Filing date

1993-11-02

Publication date

1993-11-02

1993-11-02 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1993-11-02 Publication of NO933964L publication Critical patent/NO933964L/no

1993-11-02 Publication of NO933964D0 publication Critical patent/NO933964D0/no

Links

238000002360 preparation method Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
229910052736 halogen Inorganic materials 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 2
150000003254 radicals Chemical class 0.000 abstract 2
QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
ODSNARDHJFFSRH-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-isoindole Chemical class C1CCCC2CNCC21 ODSNARDHJFFSRH-UHFFFAOYSA-N 0.000 abstract 1
102100024304 Protachykinin-1 Human genes 0.000 abstract 1
101800003906 Substance P Proteins 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 abstract 1
125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
-1 phenyl radicals Chemical class 0.000 abstract 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO1993933964A 1991-05-17 1993-11-02 Nye perhydroisoindolderivater, deres fremstilling samt farmasoeytiske preparater inneholdende forbindelsene NO933964D0 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9106035A FR2676442B1 (fr)	1991-05-17	1991-05-17	Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR1992/000429 WO1992020653A1 (fr)	1991-05-17	1992-05-15	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number	Publication Date
NO933964L NO933964L (no)	1993-11-02
NO933964D0 true NO933964D0 (no)	1993-11-02

Family

ID=9412907

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO1993933964A NO933964D0 (no)	1991-05-17	1993-11-02	Nye perhydroisoindolderivater, deres fremstilling samt farmasoeytiske preparater inneholdende forbindelsene

Country Status (23)

Country	Link
US (1)	US5451601A (de)
EP (2)	EP0514273A1 (de)
JP (1)	JPH06507627A (de)
AT (1)	ATE135687T1 (de)
AU (1)	AU1883692A (de)
CA (1)	CA2109298A1 (de)
CZ (1)	CZ244793A3 (de)
DE (1)	DE69209290T2 (de)
DK (1)	DK0586490T3 (de)
ES (1)	ES2085627T3 (de)
FI (1)	FI935071A0 (de)
FR (1)	FR2676442B1 (de)
GR (1)	GR3019386T3 (de)
HU (1)	HUT67649A (de)
IE (1)	IE921578A1 (de)
IL (1)	IL101866A0 (de)
MX (1)	MX9202287A (de)
NO (1)	NO933964D0 (de)
NZ (1)	NZ242772A (de)
SK (1)	SK126793A3 (de)
TW (1)	TW200459B (de)
WO (1)	WO1992020653A1 (de)
ZA (1)	ZA923540B (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
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FR2689888B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5508424A (en) *	1993-03-26	1996-04-16	Ortho Pharmaceutical Corporation	4-arylisoindole analgesics
FR2703679B1 (fr) *	1993-04-05	1995-06-23	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) *	1993-07-30	1999-08-01	Rhone Poulenc Rorer Sa	Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2709752B1 (fr) *	1993-07-30	1995-10-06	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710913B1 (fr) *	1993-10-07	1995-11-24	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710842B1 (fr) *	1993-10-07	1995-11-24	Rhone Poulenc Rorer Sa	Nouvelle application thérapeutique de dérivés de perhydroisoindole.
US6203803B1 (en)	1994-12-14	2001-03-20	Societe L'oreal S.A.	Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained
FR2719476B1 (fr) *	1994-05-05	1997-05-23	Oreal	Utilisation d'un antagoniste de substance P dans une composition cosmétique et composition obtenue.
FR2719474B1 (fr)	1994-05-05	1996-05-31	Oreal	Utilisation d'un antagoniste de substance P dans une composition cosmétique et composition obtenue.
FR2727411B1 (fr) *	1994-11-30	1997-01-03	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2728169A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
KR100885986B1 (ko)	1999-11-03	2009-03-03	에이엠알 테크놀로지, 인크.	노르에피네프린, 도파민 및 세로토닌의 재흡수를 방지하기위한 아릴 및 헤테로아릴 치환된테트라하이드로이소퀴놀린 및 이들의 용도
NZ523456A (en)	2000-07-11	2004-11-26	Albany Molecular Res Inc	Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
US7541357B2 (en)	2004-07-15	2009-06-02	Amr Technology, Inc.	Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2006123182A2 (en)	2005-05-17	2006-11-23	Merck Sharp & Dohme Limited	Cyclohexyl sulphones for treatment of cancer
WO2007011820A2 (en)	2005-07-15	2007-01-25	Amr Technology, Inc.	Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
WO2008084261A1 (en)	2007-01-10	2008-07-17	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa	Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
WO2008090117A1 (en)	2007-01-24	2008-07-31	Glaxo Group Limited	Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
US8389553B2 (en)	2007-06-27	2013-03-05	Merck Sharp & Dohme Corp.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
ES2446971T3 (es)	2009-05-12	2014-03-11	Albany Molecular Research, Inc.	Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
WO2010132442A1 (en)	2009-05-12	2010-11-18	Albany Molecular Reserch, Inc.	7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
EP2429293B1 (de)	2009-05-12	2014-10-29	Bristol-Myers Squibb Company	KRISTALLINE FORMEN VON (S)-7-([1,2,4]TRIAZOL[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLORPHENYL)-1,2,3,4-TETRAHYDROISOCHINOLIN UND IHRE VERWENDUNG
PE20121172A1 (es)	2009-10-14	2012-09-05	Merck Sharp & Dohme	Piperidinas sustituidas con actividad en la hdm2
EP2601293B1 (de)	2010-08-02	2017-12-06	Sirna Therapeutics, Inc.	Rna-interferenz-vermittelte hemmung der catenin (cadherin-assoziiertes protein)-beta-1 (ctnnb1)- genexpression mittels kurzer interferierender nukleinsäuren (sina)
DK2606134T3 (da)	2010-08-17	2019-07-22	Sirna Therapeutics Inc	RNA-Interferens-formidlet inhibering af hepatitis-B-virus (HBV)-genekspression ved hjælp af kort interfererende nukleinsyre (siNA)
EP2608669B1 (de)	2010-08-23	2016-06-22	Merck Sharp & Dohme Corp.	Neue pyrazolo-[1,5-a-]pyrimidinderivate als mtor-hemmer
EP2613782B1 (de)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazolderivate als erk-hemmer
EP2615916B1 (de)	2010-09-16	2017-01-04	Merck Sharp & Dohme Corp.	Kondensierte pyrazolderivate als neue erk-hemmer
ES2663009T3 (es)	2010-10-29	2018-04-10	Sirna Therapeutics, Inc.	Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
EP2654748B1 (de)	2010-12-21	2016-07-27	Merck Sharp & Dohme Corp.	Indazolderivate als erk-hemmer
WO2012145471A1 (en)	2011-04-21	2012-10-26	Merck Sharp & Dohme Corp.	Insulin-like growth factor-1 receptor inhibitors
US9023865B2 (en)	2011-10-27	2015-05-05	Merck Sharp & Dohme Corp.	Compounds that are ERK inhibitors
US20150299696A1 (en)	2012-05-02	2015-10-22	Sirna Therapeutics, Inc.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
AU2013323508B2 (en)	2012-09-28	2017-11-02	Merck Sharp & Dohme Corp.	Novel compounds that are ERK inhibitors
US9655899B2 (en)	2012-11-28	2017-05-23	Merck Sharp & Dohme Corp.	Compositions and methods for treating cancer
WO2014100065A1 (en)	2012-12-20	2014-06-26	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as hdm2 inhibitors
US9540377B2 (en)	2013-01-30	2017-01-10	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as HDM2 inhibitors
EP3041938A1 (de)	2013-09-03	2016-07-13	Moderna Therapeutics, Inc.	Kreisförmige polynukleotide
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
US11098059B2 (en)	2017-11-08	2021-08-24	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
US10947234B2 (en)	2017-11-08	2021-03-16	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
WO2020033282A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
EP3833667B1 (de)	2018-08-07	2024-03-13	Merck Sharp & Dohme LLC	Prmt5-inhibitoren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX18467A (es) *	1988-11-23	1993-07-01	Pfizer	Agentes terapeuticos de quinuclidinas
FR2654725B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2654726B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone et leur preparation.
FR2676443B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole et leur preparation.

1991
- 1991-05-17 FR FR9106035A patent/FR2676442B1/fr not_active Expired - Fee Related
1992
- 1992-05-14 IL IL101866A patent/IL101866A0/xx unknown
- 1992-05-15 DE DE69209290T patent/DE69209290T2/de not_active Expired - Fee Related
- 1992-05-15 DK DK92911474.2T patent/DK0586490T3/da active
- 1992-05-15 JP JP4510462A patent/JPH06507627A/ja active Pending
- 1992-05-15 WO PCT/FR1992/000429 patent/WO1992020653A1/fr active IP Right Grant
- 1992-05-15 TW TW081103795A patent/TW200459B/zh active
- 1992-05-15 CA CA002109298A patent/CA2109298A1/fr not_active Abandoned
- 1992-05-15 HU HU9303249A patent/HUT67649A/hu unknown
- 1992-05-15 MX MX9202287A patent/MX9202287A/es unknown
- 1992-05-15 CZ CS932447A patent/CZ244793A3/cs unknown
- 1992-05-15 ES ES92911474T patent/ES2085627T3/es not_active Expired - Lifetime
- 1992-05-15 SK SK1267-93A patent/SK126793A3/sk unknown
- 1992-05-15 AT AT92911474T patent/ATE135687T1/de active
- 1992-05-15 EP EP92401329A patent/EP0514273A1/de active Pending
- 1992-05-15 ZA ZA923540A patent/ZA923540B/xx unknown
- 1992-05-15 AU AU18836/92A patent/AU1883692A/en not_active Abandoned
- 1992-05-15 US US08/146,143 patent/US5451601A/en not_active Expired - Fee Related
- 1992-05-15 EP EP92911474A patent/EP0586490B1/de not_active Expired - Lifetime
- 1992-05-15 NZ NZ242772A patent/NZ242772A/en unknown
- 1992-07-01 IE IE157892A patent/IE921578A1/en not_active Application Discontinuation
1993
- 1993-11-02 NO NO1993933964A patent/NO933964D0/no unknown
- 1993-11-16 FI FI935071A patent/FI935071A0/fi unknown
1996
- 1996-03-21 GR GR950403441T patent/GR3019386T3/el unknown

Also Published As

Publication number	Publication date
EP0514273A1 (de)	1992-11-19
FI935071A (fi)	1993-11-16
WO1992020653A1 (fr)	1992-11-26
HUT67649A (en)	1995-04-28
DK0586490T3 (da)	1996-04-15
NO933964L (no)	1993-11-02
HU9303249D0 (en)	1994-03-28
IE921578A1 (en)	1992-11-18
CZ244793A3 (en)	1994-03-16
EP0586490A1 (de)	1994-03-16
NZ242772A (en)	1994-04-27
ATE135687T1 (de)	1996-04-15
IL101866A0 (en)	1992-12-30
SK126793A3 (en)	1994-11-09
JPH06507627A (ja)	1994-09-01
DE69209290D1 (de)	1996-04-25
TW200459B (de)	1993-02-21
CA2109298A1 (fr)	1992-11-18
ZA923540B (en)	1993-01-27
MX9202287A (es)	1993-02-01
EP0586490B1 (de)	1996-03-20
FR2676442A1 (fr)	1992-11-20
FR2676442B1 (fr)	1993-08-06
US5451601A (en)	1995-09-19
ES2085627T3 (es)	1996-06-01
AU1883692A (en)	1992-12-30
GR3019386T3 (en)	1996-06-30
DE69209290T2 (de)	1996-10-31
FI935071A0 (fi)	1993-11-16

Publication	Publication Date	Title
NO933964D0 (no)	1993-11-02	Nye perhydroisoindolderivater, deres fremstilling samt farmasoeytiske preparater inneholdende forbindelsene
IL96446A0 (en)	1991-08-16	Isoindolone derivatives,their preparation and the pharmaceutical compositions containing them
DK0635003T3 (da)	1999-02-15	Perhydroisoindolderivater, fremstilling af disse forbindelser og farmaceutiske præparater indeholdende disse forbindelser
NO953913D0 (no)	1995-10-02	Perhydroisoindolderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene
RU93058350A (ru)	1997-03-10	Производные пергидроизоиндола, способ их получения и содержащие их фармацевтические композиции