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DE69124921D1 - Verfahren und Verbindungen zum Markieren von DNS mit Xanthin und Niederalkyl substituierten Xathinderivaten und Reagentrien für die "in situ" Detektion von Chromosomen - Google Patents

Verfahren und Verbindungen zum Markieren von DNS mit Xanthin und Niederalkyl substituierten Xathinderivaten und Reagentrien für die "in situ" Detektion von Chromosomen

Info

Publication number
DE69124921D1
DE69124921D1 DE69124921T DE69124921T DE69124921D1 DE 69124921 D1 DE69124921 D1 DE 69124921D1 DE 69124921 T DE69124921 T DE 69124921T DE 69124921 T DE69124921 T DE 69124921T DE 69124921 D1 DE69124921 D1 DE 69124921D1
Authority
DE
Germany
Prior art keywords
xanthine
chromosome
lower alkyl
alkyl substituted
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69124921T
Other languages
English (en)
Other versions
DE69124921T2 (de
Inventor
Kenneth Alexander Cruickshank
Douglas James Taron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Molecular Inc
Original Assignee
BP Corp North America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BP Corp North America Inc filed Critical BP Corp North America Inc
Application granted granted Critical
Publication of DE69124921D1 publication Critical patent/DE69124921D1/de
Publication of DE69124921T2 publication Critical patent/DE69124921T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69124921T 1990-11-08 1991-11-05 Verfahren und Verbindungen zum Markieren von DNS mit Xanthin und Niederalkyl substituierten Xathinderivaten und Reagentrien für die "in situ" Detektion von Chromosomen Expired - Fee Related DE69124921T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/611,305 US5512433A (en) 1990-11-08 1990-11-08 Methods and compounds for labeling DNA with xanthine and lower alkyl substituted xanthine derivatives and reagents for the in situ detection of chromosomes

Publications (2)

Publication Number Publication Date
DE69124921D1 true DE69124921D1 (de) 1997-04-10
DE69124921T2 DE69124921T2 (de) 1997-10-16

Family

ID=24448502

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69124921T Expired - Fee Related DE69124921T2 (de) 1990-11-08 1991-11-05 Verfahren und Verbindungen zum Markieren von DNS mit Xanthin und Niederalkyl substituierten Xathinderivaten und Reagentrien für die "in situ" Detektion von Chromosomen

Country Status (5)

Country Link
US (1) US5512433A (de)
EP (1) EP0485156B1 (de)
JP (1) JPH04287699A (de)
AT (1) ATE149512T1 (de)
DE (1) DE69124921T2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009022A1 (en) * 1992-10-09 1994-04-28 Oncor, Inc. Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue
EP0878552A1 (de) * 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molekularer Nachweis von chromosomalen Veränderungen
WO1999057309A1 (en) 1998-05-04 1999-11-11 Dako A/S Method and probes for the detection of chromosome aberrations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4213893A (en) * 1978-10-12 1980-07-22 Miles Laboratories, Inc. Flavin adenine dinucleotide-labeled conjugates for use in specific binding assays
US4533493A (en) * 1981-08-27 1985-08-06 Miles Laboratories, Inc. Theophylline immunogens, antibodies, labeled conjugates, and related derivatives
US4687737A (en) * 1982-11-12 1987-08-18 Massachusetts Institute Of Technology Mammalian suppressor genes
US4769377A (en) * 1983-02-18 1988-09-06 The Johns Hopkins University Adenosine receptor antagonists
US4626501A (en) * 1983-09-02 1986-12-02 Integrated Genetics, Inc. Labeled DNA
US4699876A (en) * 1984-01-27 1987-10-13 E. I. Du Pont De Nemours And Company Nonradiometric polynucleotide probes
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4833251A (en) * 1985-06-25 1989-05-23 Siska Diagnostics, Inc. Compounds for tagging nucleic acid probes
EP0310361A3 (de) * 1987-09-30 1989-05-24 Beckman Instruments, Inc. Aus drei Verzahnungen bestehendes Konjugat und Verfahren zu seiner Verwendung
EP0444115B2 (de) * 1988-11-15 2000-12-13 Yale University In-situ-unterdrückungs-hybridisierung und verwendungen
IL94906A (en) * 1989-07-19 1995-10-31 Univ California Methods and preparations for specific chromosome specification
US5258507A (en) * 1990-11-08 1993-11-02 Amoco Corporation Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes

Also Published As

Publication number Publication date
EP0485156B1 (de) 1997-03-05
DE69124921T2 (de) 1997-10-16
JPH04287699A (ja) 1992-10-13
ATE149512T1 (de) 1997-03-15
US5512433A (en) 1996-04-30
EP0485156A1 (de) 1992-05-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: VYSIS, INC. (N.D.GES.D. STAATES DELAWARE), DOWNERS

8339 Ceased/non-payment of the annual fee