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DE69004596D1 - Benzodiazepin-Analoge. - Google Patents

Benzodiazepin-Analoge.

Info

Publication number
DE69004596D1
DE69004596D1 DE90302094T DE69004596T DE69004596D1 DE 69004596 D1 DE69004596 D1 DE 69004596D1 DE 90302094 T DE90302094 T DE 90302094T DE 69004596 T DE69004596 T DE 69004596T DE 69004596 D1 DE69004596 D1 DE 69004596D1
Authority
DE
Germany
Prior art keywords
independently
carbon atoms
och3
group
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE90302094T
Other languages
English (en)
Inventor
John E Taylor
Sun Hyuk Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Bioscience Inc
Original Assignee
Ipsen Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Bioscience Inc filed Critical Ipsen Bioscience Inc
Application granted granted Critical
Publication of DE69004596D1 publication Critical patent/DE69004596D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE90302094T 1989-02-27 1990-02-27 Benzodiazepin-Analoge. Expired - Lifetime DE69004596D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/316,463 US4957915A (en) 1989-02-27 1989-02-27 Benzodiazepine analogs

Publications (1)

Publication Number Publication Date
DE69004596D1 true DE69004596D1 (de) 1993-12-23

Family

ID=23229158

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90302094T Expired - Lifetime DE69004596D1 (de) 1989-02-27 1990-02-27 Benzodiazepin-Analoge.

Country Status (6)

Country Link
US (1) US4957915A (de)
EP (1) EP0385735B1 (de)
JP (1) JPH02268168A (de)
AT (1) ATE97409T1 (de)
CA (1) CA2010769A1 (de)
DE (1) DE69004596D1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206238A (en) * 1990-11-13 1993-04-27 Merck & Co., Inc. Cholecystokinin antagonists
US5580979A (en) * 1994-03-15 1996-12-03 Trustees Of Tufts University Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions
AU5588400A (en) 1999-05-26 2000-12-18 Du Pont Pharmaceuticals Company 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors
ES2168926B1 (es) * 1999-12-14 2003-10-16 Prous Science S A Derivados de ciclopenta- ciclohexa- y ciclohepta (b)quinoleina, procedimiento para su fabricacion, utilizacion y composicion farmaceutica correspondiente.
EA017249B8 (ru) * 2007-05-10 2013-01-30 Олбани Молекьюлар Рисерч, Инк. Арил- и гетероарилзамещенные тетрагидробензо-1,4-диазепины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1034872A (en) * 1962-04-16 1966-07-06 American Home Prod Benzodiazepine derivatives
CH477458A (fr) * 1965-01-09 1969-08-31 Clin Byla Ets Procédé pour la préparation de dérivés de benzodiazépines
DK240184D0 (da) * 1984-05-15 1984-05-15 Ferrosan As Beta-carboline-3-carboxylic acid derivatives and method of preparing the same
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
DE3431195A1 (de) * 1984-08-24 1986-03-06 Troponwerke GmbH & Co KG, 5000 Köln Neue benzodiazepine, verfahren zu ihrer herstellung sowie ihre verwendung
EP0452765B1 (de) * 1985-09-11 1999-10-20 Btg International Limited Pharmazeutische Zubereitungen und medizinische Verwendungen von Dioxopiperidinderivaten, insbesondere als Verstärker der Immunantwort sowie als antivirale und antibakterielle Wirkstoffe
EP0270494B1 (de) * 1986-11-25 1992-08-19 Ciba-Geigy Ag Einige Cycloalka[b]pyrazolo[3,4-d]pyridin-3-on-Derivate

Also Published As

Publication number Publication date
EP0385735A1 (de) 1990-09-05
US4957915A (en) 1990-09-18
EP0385735B1 (de) 1993-11-18
JPH02268168A (ja) 1990-11-01
CA2010769A1 (en) 1990-08-27
ATE97409T1 (de) 1993-12-15

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Legal Events

Date Code Title Description
8332 No legal effect for de