DE69924292D1 - Pyrazol verbindungen und ihre verwendung - Google Patents
Pyrazol verbindungen und ihre verwendungInfo
- Publication number
- DE69924292D1 DE69924292D1 DE69924292T DE69924292T DE69924292D1 DE 69924292 D1 DE69924292 D1 DE 69924292D1 DE 69924292 T DE69924292 T DE 69924292T DE 69924292 T DE69924292 T DE 69924292T DE 69924292 D1 DE69924292 D1 DE 69924292D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- same
- pyrazol compounds
- pyrazol
- organism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000013823 prenylation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11394898P | 1998-12-24 | 1998-12-24 | |
| US113948P | 1998-12-24 | ||
| US09/440,209 US6191147B1 (en) | 1998-12-24 | 1999-11-15 | Pyrazole compounds and uses thereof |
| US440209 | 1999-11-15 | ||
| PCT/US1999/030951 WO2000039083A2 (en) | 1998-12-24 | 1999-12-21 | Pyrazole compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69924292D1 true DE69924292D1 (de) | 2005-04-21 |
| DE69924292T2 DE69924292T2 (de) | 2006-04-13 |
Family
ID=26811662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69924292T Expired - Lifetime DE69924292T2 (de) | 1998-12-24 | 1999-12-21 | Pyrazol verbindungen und ihre verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6191147B1 (de) |
| EP (1) | EP1140900B1 (de) |
| JP (1) | JP2002533436A (de) |
| AT (1) | ATE291018T1 (de) |
| AU (2) | AU772943B2 (de) |
| CA (1) | CA2359462C (de) |
| DE (1) | DE69924292T2 (de) |
| WO (1) | WO2000039083A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001087287A2 (en) * | 2000-05-19 | 2001-11-22 | Applied Research Systems Ars Holding N.V. | Use of pyrazole derivatives for treating infertility |
| US7741346B2 (en) | 2001-11-30 | 2010-06-22 | Santen Pharmaceutical Co., Ltd. | Angiogenesis inhibitor |
| AU2003265394A1 (en) * | 2002-08-14 | 2004-03-03 | Ppd Discovery, Inc. | Prenylation inhibitors containing dimethyl-cyclobutane and methods of their synthesis and use |
| WO2004016592A1 (en) * | 2002-08-14 | 2004-02-26 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| US6649638B1 (en) * | 2002-08-14 | 2003-11-18 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| JP4691041B2 (ja) | 2003-11-20 | 2011-06-01 | チルドレンズ ホスピタル メディカル センター | Ｇｔｐアーゼ阻害剤および使用方法 |
| US6799739B1 (en) * | 2003-11-24 | 2004-10-05 | The Boeing Company | Aircraft control surface drive system and associated methods |
| WO2007016539A2 (en) | 2005-07-29 | 2007-02-08 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase |
| EP1939181A1 (de) * | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituierte Carboxamide und deren Verwendung für die Stimulierung der NO Synthase Expression |
| TWI448284B (zh) * | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| CA2695456A1 (en) * | 2007-08-15 | 2009-02-19 | Robert Dunn | 3' substituted compounds having 5-ht6 receptor affinity |
| WO2009051772A1 (en) * | 2007-10-17 | 2009-04-23 | Duke University | Geranylgeranyl transferase inhibitors and methods of making and using the same |
| US20110201649A1 (en) * | 2008-09-19 | 2011-08-18 | Sumitomo Chemical Company, Limited | agricultural composition |
| FR2949463B1 (fr) * | 2009-08-26 | 2011-09-16 | Commissariat Energie Atomique | Inhibiteurs de mmp |
| WO2011161645A1 (en) | 2010-06-25 | 2011-12-29 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| DK2588465T3 (en) | 2010-06-30 | 2017-05-01 | Ironwood Pharmaceuticals Inc | SGC stimulators |
| AU2011326241B2 (en) | 2010-11-09 | 2016-11-17 | Ironwood Pharmaceuticals, Inc. | sGC stimulators |
| CA2861804C (en) | 2011-12-27 | 2021-10-26 | Ironwood Pharmaceuticals, Inc. | 2-benzyl,3(pyrimidin-2-yl)substituted pyrazoles useful as sgc stimulators |
| WO2013166043A1 (en) | 2012-05-02 | 2013-11-07 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| EP4013402B1 (de) | 2019-08-16 | 2024-11-06 | Children's Hospital Medical Center | Cdc-42-inhibitoren zur verwendung bei der behandlung von altersverbundener depression, sarkopenie oder gebrechlichkeit |
| CN111961048B (zh) * | 2020-08-26 | 2022-05-13 | 南通大学 | 含取代β-咔啉结构的三氟甲基吡唑酰胺及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164381A (en) | 1986-05-29 | 1992-11-17 | Ortho Pharmaceutical Corporation | Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same |
| US4826868A (en) | 1986-05-29 | 1989-05-02 | Ortho Pharmaceutical Corporation | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use |
| PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| FR2665898B1 (fr) | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| DE4414974A1 (de) | 1994-04-29 | 1995-11-02 | Bayer Ag | Substituierte Pyrazolinderivate |
| DE69635114T2 (de) * | 1995-08-09 | 2006-03-02 | Banyu Pharmaceutical Co., Ltd. | Proteinfarnesyltransferase-inhibitoren in kombination mit hmgcoa-reduktase-inhibitoren zur behandlung von aids |
| US5633388A (en) | 1996-03-29 | 1997-05-27 | Viropharma Incorporated | Compounds, compositions and methods for treatment of hepatitis C |
| DE19623892A1 (de) | 1996-06-06 | 1997-12-11 | Hoechst Schering Agrevo Gmbh | Substituierte Pyrazolyl-pyrazolderivate |
| EE9900527A (et) | 1997-05-22 | 2000-06-15 | G.D. Searle & Co. | Substitueeritud pürasoolid kui p38 kinaasi inhibiitorid |
-
1999
- 1999-11-15 US US09/440,209 patent/US6191147B1/en not_active Expired - Lifetime
- 1999-12-21 AT AT99966665T patent/ATE291018T1/de not_active IP Right Cessation
- 1999-12-21 AU AU22166/00A patent/AU772943B2/en not_active Ceased
- 1999-12-21 CA CA2359462A patent/CA2359462C/en not_active Expired - Fee Related
- 1999-12-21 DE DE69924292T patent/DE69924292T2/de not_active Expired - Lifetime
- 1999-12-21 JP JP2000590996A patent/JP2002533436A/ja active Pending
- 1999-12-21 EP EP99966665A patent/EP1140900B1/de not_active Expired - Lifetime
- 1999-12-21 WO PCT/US1999/030951 patent/WO2000039083A2/en active IP Right Grant
-
2004
- 2004-06-29 AU AU2004202912A patent/AU2004202912A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6191147B1 (en) | 2001-02-20 |
| CA2359462A1 (en) | 2000-07-06 |
| WO2000039083A3 (en) | 2000-11-02 |
| DE69924292T2 (de) | 2006-04-13 |
| JP2002533436A (ja) | 2002-10-08 |
| CA2359462C (en) | 2010-07-06 |
| AU2216600A (en) | 2000-07-31 |
| AU772943B2 (en) | 2004-05-13 |
| ATE291018T1 (de) | 2005-04-15 |
| EP1140900A4 (de) | 2002-04-10 |
| AU2004202912A1 (en) | 2004-07-22 |
| EP1140900B1 (de) | 2005-03-16 |
| EP1140900A2 (de) | 2001-10-10 |
| WO2000039083A2 (en) | 2000-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69924292D1 (de) | Pyrazol verbindungen und ihre verwendung | |
| ATE228507T1 (de) | Substituierte 6-phenylphenanthridine | |
| ATE219765T1 (de) | Indolderivate als cgmp-pde inhibitoren | |
| SE9504661D0 (sv) | New compounds | |
| EA200300248A1 (ru) | Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции | |
| TR200201505T2 (tr) | Terapötik maddeler olarak pirazolopirimidinler | |
| TR200101499T1 (tr) | Azepinoindol türevleri, hazırlanmaları ve kullanımları. | |
| MY126862A (en) | Purine derivatives inhibitors of tyrosine protein kinase syk | |
| EA200000920A1 (ru) | Производные бициклических гидроксамовых кислот | |
| TR200200778T2 (tr) | Pirazol türevleri. | |
| DE60045508D1 (de) | Dalda-analoge und ihre verwendung | |
| ATE230392T1 (de) | Amidinophenyl-pyrrolidine, -pyrroline und - isoxazolidine und ihre derivate | |
| HUP0002272A2 (hu) | Piperazinszármazékok, eljárás előállításukra, e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk | |
| ATE316962T1 (de) | Pyrimidin-derivate als selective inhibitoren von cox-2 | |
| AP2000001761A0 (en) | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. | |
| ATE275143T1 (de) | Verbindungen | |
| TR200200125T2 (tr) | Yeni aminotiyazol türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar. | |
| AP2001002188A0 (en) | 5HT1 antagonists for antidepressant therapy. | |
| SE9504662D0 (sv) | New compounds | |
| ATE187956T1 (de) | Substituierte kondensierte und verbrückte bicyclische verbindungen als therapeutische mittel | |
| AP2000001760A0 (en) | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. | |
| AP2002002595A0 (en) | Heterocyclic amide derivatives. | |
| TR200001122T2 (tr) | Farmasötikler olarak bifenil türevleri. | |
| DE59803066D1 (de) | Substituierte benzyloxyimino-verbindungen | |
| TR200100475T2 (tr) | N-İkameli azabisikloheptan türevlerinin üretimleri ve kullanımları. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |