DE69921994D1 - Heterozyklische verbindungen mit faktor xa hemmender wirkung - Google Patents

Heterozyklische verbindungen mit faktor xa hemmender wirkung

Info

Publication number: DE69921994D1
Authority: DE; Germany
Prior art keywords: factor; heterocyclic compounds; inhibiting effect; relates; antithrombotic
Prior art date: 1998-05-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69921994T

Other languages

English (en)

Other versions

DE69921994T2 (de

Inventor

William Caulkett

Roger James

Eric Pearson

Michael Slater

Peter Walker

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AstraZeneca AB

Original Assignee

AstraZeneca AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-02

Filing date

1999-04-27

Publication date

2004-12-23

1998-05-02 Priority claimed from GBGB9809351.1A external-priority patent/GB9809351D0/en

1999-02-16 Priority claimed from GBGB9903337.5A external-priority patent/GB9903337D0/en

1999-04-27 Application filed by AstraZeneca AB filed Critical AstraZeneca AB

2004-12-23 Publication of DE69921994D1 publication Critical patent/DE69921994D1/de

2005-12-01 Application granted granted Critical

2005-12-01 Publication of DE69921994T2 publication Critical patent/DE69921994T2/de

2019-04-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DE69921994T 1998-05-02 1999-04-27 Heterozyklische verbindungen mit faktor xa hemmender wirkung Expired - Lifetime DE69921994T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB9809351		1998-05-02
GBGB9809351.1A GB9809351D0 (en)	1998-05-02	1998-05-02	Heterocyclic derivatives
GB9903337		1999-02-16
GBGB9903337.5A GB9903337D0 (en)	1999-02-16	1999-02-16	Heterocyclic derivatives
PCT/GB1999/001308 WO1999057113A1 (en)	1998-05-02	1999-04-27	Heterocyclic derivatives which inhibit factor xa

Publications (2)

Publication Number	Publication Date
DE69921994D1 true DE69921994D1 (de)	2004-12-23
DE69921994T2 DE69921994T2 (de)	2005-12-01

Family

ID=26313572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69921994T Expired - Lifetime DE69921994T2 (de)	1998-05-02	1999-04-27	Heterozyklische verbindungen mit faktor xa hemmender wirkung

Country Status (23)

Country	Link
US (2)	US6753331B1 (de)
EP (2)	EP1082321B1 (de)
JP (1)	JP2002513790A (de)
KR (1)	KR20010043246A (de)
CN (1)	CN1133634C (de)
AT (1)	ATE282610T1 (de)
AU (1)	AU754453B2 (de)
BR (1)	BR9910179A (de)
CA (1)	CA2331042A1 (de)
DE (1)	DE69921994T2 (de)
EE (1)	EE200000527A (de)
ES (1)	ES2232131T3 (de)
HK (1)	HK1034711A1 (de)
HU (1)	HUP0101712A3 (de)
IL (1)	IL139406A (de)
NO (1)	NO320893B1 (de)
NZ (1)	NZ507835A (de)
PL (1)	PL343706A1 (de)
PT (1)	PT1082321E (de)
SI (1)	SI1082321T1 (de)
SK (1)	SK16512000A3 (de)
TR (1)	TR200003200T2 (de)
WO (1)	WO1999057113A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
GB9902989D0 (en)	1999-02-11	1999-03-31	Zeneca Ltd	Heterocyclic derivatives
GB9914342D0 (en) *	1999-06-19	1999-08-18	Zeneca Ltd	Compound
GB9917344D0 (en) *	1999-07-24	1999-09-22	Zeneca Ltd	Novel salt
TWI290136B (en)	2000-04-05	2007-11-21	Daiichi Seiyaku Co	Ethylenediamine derivatives
GB0012448D0 (en)	2000-05-24	2000-07-12	Astrazeneca Ab	New process
ATE369151T1 (de) *	2000-11-09	2007-08-15	Astrazeneca Ab	Orale pharmazeutische zusammensetzung mit einem blockcopolymer
GB0104752D0 (en) *	2001-02-27	2001-04-18	Astrazeneca Ab	Pharmaceutical compositions
US7365205B2 (en)	2001-06-20	2008-04-29	Daiichi Sankyo Company, Limited	Diamine derivatives
SI1569912T1 (sl)	2002-12-03	2015-09-30	Pharmacyclics Llc	Derivati 2-(2-hidroksibifenil-3-il)-1h-benzoimidazol-5-karboksamidina kot inhibitorji faktorja viia
WO2004108671A1 (en) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
JP4377881B2 (ja) *	2003-08-01	2009-12-02	日本曹達株式会社	フェニルアゾール化合物、製造法および抗酸化薬
SE0400014D0 (sv) *	2004-01-08	2004-01-08	Astrazeneca Ab	Heterocyclic derivatives
WO2007008143A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
CN101218227A (zh) *	2005-07-08	2008-07-09	阿斯利康(瑞典)有限公司	作为因子Xa的抑制剂的杂环磺酰胺衍生物
WO2007008144A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008145A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
UA128288C2 (uk)	2018-03-08	2024-05-29	Інсайт Корпорейшн	СПОЛУКИ АМІНОПІРАЗИНДІОЛУ ЯК ІНГІБІТОРИ PI3K-<font face="Symbol">g</font>
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors
MX2022000133A (es)	2019-07-01	2022-04-27	Tonix Pharma Ltd	Anticuerpos anti-cd154 y usos de los mismos.
WO2022150452A1 (en)	2021-01-06	2022-07-14	Seth Lederman	Methods of inducing immune tolerance with modified anti-cd154 antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115420A0 (en) *	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
WO1997023212A1 (en) *	1995-12-21	1997-07-03	The Du Pont Merck Pharmaceutical Company	ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR Xa INHIBITORS
GB9602166D0 (en) *	1996-02-02	1996-04-03	Zeneca Ltd	Aminoheterocyclic derivatives
GB9602294D0 (en) *	1996-02-05	1996-04-03	Zeneca Ltd	Heterocyclic compounds
UA56197C2 (uk) *	1996-11-08	2003-05-15	Зенека Лімітед	Гетероциклічні похідні
AU7453498A (en) *	1997-05-30	1998-12-30	Takeda Chemical Industries Ltd.	Sulfonamide derivatives, their production and use
GB9715894D0 (en) *	1997-07-29	1997-10-01	Zeneca Ltd	Heterocyclic derivatives
DE19743435A1 (de)	1997-10-01	1999-04-08	Merck Patent Gmbh	Benzamidinderivate

1999
- 1999-04-27 EP EP99918178A patent/EP1082321B1/de not_active Expired - Lifetime
- 1999-04-27 NZ NZ507835A patent/NZ507835A/xx unknown
- 1999-04-27 KR KR1020007012193A patent/KR20010043246A/ko not_active Application Discontinuation
- 1999-04-27 AT AT99918178T patent/ATE282610T1/de not_active IP Right Cessation
- 1999-04-27 EE EEP200000527A patent/EE200000527A/xx unknown
- 1999-04-27 EP EP04022155A patent/EP1528061A1/de not_active Withdrawn
- 1999-04-27 IL IL13940699A patent/IL139406A/en not_active IP Right Cessation
- 1999-04-27 PT PT99918178T patent/PT1082321E/pt unknown
- 1999-04-27 WO PCT/GB1999/001308 patent/WO1999057113A1/en not_active Application Discontinuation
- 1999-04-27 JP JP2000547083A patent/JP2002513790A/ja active Pending
- 1999-04-27 CN CNB99808218XA patent/CN1133634C/zh not_active Expired - Fee Related
- 1999-04-27 HU HU0101712A patent/HUP0101712A3/hu unknown
- 1999-04-27 CA CA002331042A patent/CA2331042A1/en not_active Abandoned
- 1999-04-27 SK SK1651-2000A patent/SK16512000A3/sk unknown
- 1999-04-27 DE DE69921994T patent/DE69921994T2/de not_active Expired - Lifetime
- 1999-04-27 US US09/674,559 patent/US6753331B1/en not_active Expired - Fee Related
- 1999-04-27 TR TR2000/03200T patent/TR200003200T2/xx unknown
- 1999-04-27 AU AU36206/99A patent/AU754453B2/en not_active Ceased
- 1999-04-27 SI SI9930725T patent/SI1082321T1/xx unknown
- 1999-04-27 PL PL99343706A patent/PL343706A1/xx not_active Application Discontinuation
- 1999-04-27 BR BR9910179-3A patent/BR9910179A/pt not_active Application Discontinuation
- 1999-04-27 ES ES99918178T patent/ES2232131T3/es not_active Expired - Lifetime
2000
- 2000-11-01 NO NO20005497A patent/NO320893B1/no unknown
2001
- 2001-07-26 HK HK01105226A patent/HK1034711A1/xx not_active IP Right Cessation
2004
- 2004-04-06 US US10/817,960 patent/US20040266759A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HK1034711A1 (en)	2001-11-02
IL139406A (en)	2004-07-25
CA2331042A1 (en)	1999-11-11
TR200003200T2 (tr)	2001-02-21
PL343706A1 (en)	2001-08-27
US20040266759A1 (en)	2004-12-30
HUP0101712A2 (hu)	2001-11-28
CN1133634C (zh)	2004-01-07
BR9910179A (pt)	2001-01-09
NO20005497L (no)	2000-12-21
EP1082321B1 (de)	2004-11-17
EE200000527A (et)	2002-02-15
CN1308631A (zh)	2001-08-15
NZ507835A (en)	2003-01-31
PT1082321E (pt)	2005-03-31
SK16512000A3 (sk)	2001-05-10
KR20010043246A (ko)	2001-05-25
AU3620699A (en)	1999-11-23
HUP0101712A3 (en)	2003-01-28
EP1528061A1 (de)	2005-05-04
NO20005497D0 (no)	2000-11-01
AU754453B2 (en)	2002-11-14
JP2002513790A (ja)	2002-05-14
ATE282610T1 (de)	2004-12-15
IL139406A0 (en)	2001-11-25
EP1082321A1 (de)	2001-03-14
SI1082321T1 (en)	2005-06-30
US6753331B1 (en)	2004-06-22
ES2232131T3 (es)	2005-05-16
NO320893B1 (no)	2006-02-06
WO1999057113A1 (en)	1999-11-11
DE69921994T2 (de)	2005-12-01

Publication	Publication Date	Title
DE69921994D1 (de)	2004-12-23	Heterozyklische verbindungen mit faktor xa hemmender wirkung
ATE266007T1 (de)	2004-05-15	Heterocyclische verbindungen als faktor xa inhibitoren
MY124122A (en)	2006-06-30	Heterocyclic derivatives
MY139302A (en)	2009-09-30	Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
ATE287874T1 (de)	2005-02-15	Heterozyklische verbindungen mit faktor xa hemmender wirkung
MY139102A (en)	2009-08-28	Substituted n-aryl heterocycles, process for their preparation and their use as medicaments
PT1015449E (pt)	2005-04-29	Derivados de (hetero)aril-sulfonamida, sua preparacao e sua utilizacao como inibidores do factor xa
NO20013921D0 (no)	2001-08-10	Heterosykliske derivater som inhibitorer av faktor XA

Legal Events

Date	Code	Title	Description
2006-01-05	8364	No opposition during term of opposition