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DE69737217D1 - Radiomarkierte Alkylamino-benzothiazole und -benzothiazole sowie ihre Verwendung als D4-Liganden - Google Patents

Radiomarkierte Alkylamino-benzothiazole und -benzothiazole sowie ihre Verwendung als D4-Liganden

Info

Publication number
DE69737217D1
DE69737217D1 DE69737217T DE69737217T DE69737217D1 DE 69737217 D1 DE69737217 D1 DE 69737217D1 DE 69737217 T DE69737217 T DE 69737217T DE 69737217 T DE69737217 T DE 69737217T DE 69737217 D1 DE69737217 D1 DE 69737217D1
Authority
DE
Germany
Prior art keywords
alkylaminobenzothiazoles
benzothiazoles
radiolabelled
ligands
radiolabelled alkylaminobenzothiazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69737217T
Other languages
English (en)
Other versions
DE69737217T2 (de
Inventor
Ludo E J Kennis
Josephus C Mertens
Serge M A Pieters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69737217D1 publication Critical patent/DE69737217D1/de
Application granted granted Critical
Publication of DE69737217T2 publication Critical patent/DE69737217T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69737217T 1996-05-10 1997-05-02 Radiomarkierte Alkylamino-benzothiazole und -benzothiazole sowie ihre Verwendung als D4-Liganden Expired - Lifetime DE69737217T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201282 1996-05-10
EP96201282 1996-05-10

Publications (2)

Publication Number Publication Date
DE69737217D1 true DE69737217D1 (de) 2007-02-15
DE69737217T2 DE69737217T2 (de) 2007-11-08

Family

ID=8223970

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69737217T Expired - Lifetime DE69737217T2 (de) 1996-05-10 1997-05-02 Radiomarkierte Alkylamino-benzothiazole und -benzothiazole sowie ihre Verwendung als D4-Liganden
DE69730962T Expired - Lifetime DE69730962T2 (de) 1996-05-10 1997-05-02 Alkylaminobenzothiazole und -benzoxazole derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69730962T Expired - Lifetime DE69730962T2 (de) 1996-05-10 1997-05-02 Alkylaminobenzothiazole und -benzoxazole derivate

Country Status (29)

Country Link
US (2) US6103725A (de)
EP (2) EP0912533B1 (de)
JP (1) JP3237759B2 (de)
KR (1) KR100330699B1 (de)
CN (1) CN1074766C (de)
AR (1) AR007079A1 (de)
AT (2) ATE350373T1 (de)
AU (1) AU710175B2 (de)
BG (1) BG64097B1 (de)
BR (1) BR9709065A (de)
CA (1) CA2253453C (de)
CZ (1) CZ295639B6 (de)
DE (2) DE69737217T2 (de)
EA (1) EA001360B1 (de)
EE (1) EE03563B1 (de)
ES (2) ES2230605T3 (de)
HK (2) HK1057044A1 (de)
HU (1) HUP9902993A3 (de)
ID (1) ID16889A (de)
IL (1) IL126968A0 (de)
MY (1) MY117852A (de)
NO (1) NO311027B1 (de)
NZ (1) NZ332309A (de)
PL (1) PL190721B1 (de)
SK (1) SK282919B6 (de)
TR (1) TR199802253T2 (de)
TW (1) TW593290B (de)
WO (1) WO1997043271A1 (de)
ZA (1) ZA974053B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (de) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituierte Octahydropyrrolo(1,2-a)pyrazinderivate als 5ht 1a Liganden
JP2002525373A (ja) * 1998-09-30 2002-08-13 ニューロゲン コーポレイション ２−ピペラジノアルキルアミノベンゾアゾール誘導体：ドーパミン受容体サブタイプ特殊リガンド
US6284759B1 (en) 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
WO2001000604A1 (en) * 1999-06-30 2001-01-04 Santen Pharmaceutical Co., Ltd. Brain sigma-1 receptor-binding ligand
US6908929B2 (en) 2000-03-31 2005-06-21 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
WO2001074810A2 (en) * 2000-03-31 2001-10-11 Ortho Mcneil Pharmaceutical, Inc. Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as h3 antagonists
GB0203299D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel compounds
PL377087A1 (pl) 2002-09-06 2006-01-23 Janssen Pharmaceutica, N.V. Związki heterocykliczne
CA2825161C (en) * 2004-02-24 2016-10-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
US7731940B2 (en) 2006-01-25 2010-06-08 The Regents Of The University Of California Compositions and methods related to serotonin 5-HT1A receptors
CA2718035C (en) 2008-03-21 2017-10-24 The General Hospital Corporation Inositol derivatives for the detection and treatment of alzheimer' s disease and related disorders
KR20190040502A (ko) * 2016-08-26 2019-04-18 브리스톨-마이어스 스큅 컴퍼니 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법
PT109740B (pt) * 2016-11-14 2020-07-30 Hovione Farmaciencia Sa Processo para a preparação de brometo de umeclidínio
KR20210091865A (ko) * 2020-01-14 2021-07-23 서울대학교산학협력단 혈관생성 저해 효과를 가지는 n-페닐벤조티아졸-2-아민 화합물 및 그를 포함하는 약제학적 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187162B1 (de) * 1984-05-22 1989-11-02 Sumitomo Chemical Company, Limited Radioaktives iodospiroperidol und herstellung
CA1302403C (en) * 1987-04-08 1992-06-02 Steven C. Quay Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor
US4929618A (en) * 1988-03-25 1990-05-29 Ube Industries, Ltd. Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles

Also Published As

Publication number Publication date
EA199801000A1 (ru) 1999-04-29
PL190721B1 (pl) 2005-12-30
CN1218461A (zh) 1999-06-02
KR100330699B1 (ko) 2002-08-27
EA001360B1 (ru) 2001-02-26
BG64097B1 (bg) 2003-12-31
EP0912533A1 (de) 1999-05-06
EP1325917A1 (de) 2003-07-09
SK153298A3 (en) 1999-03-12
US6224849B1 (en) 2001-05-01
TR199802253T2 (xx) 1999-02-22
AU710175B2 (en) 1999-09-16
CA2253453C (en) 2007-01-16
IL126968A0 (en) 1999-09-22
AU2956097A (en) 1997-12-05
BG102819A (en) 1999-08-31
JP2000503667A (ja) 2000-03-28
BR9709065A (pt) 1999-08-03
HK1018457A1 (en) 1999-12-24
HUP9902993A2 (hu) 2000-05-28
ATE277917T1 (de) 2004-10-15
PL329849A1 (en) 1999-04-12
HK1057044A1 (en) 2004-03-12
EE03563B1 (et) 2001-12-17
NO985227L (no) 1999-01-11
DE69730962T2 (de) 2006-03-30
EP1325917B1 (de) 2007-01-03
KR20000005227A (ko) 2000-01-25
CZ295639B6 (cs) 2005-09-14
NO985227D0 (no) 1998-11-09
TW593290B (en) 2004-06-21
ES2279923T3 (es) 2007-09-01
JP3237759B2 (ja) 2001-12-10
WO1997043271A1 (en) 1997-11-20
CZ355398A3 (cs) 1999-02-17
NZ332309A (en) 1999-08-30
DE69730962D1 (de) 2004-11-04
EP0912533B1 (de) 2004-09-29
CA2253453A1 (en) 1997-11-20
MY117852A (en) 2004-08-30
DE69737217T2 (de) 2007-11-08
SK282919B6 (sk) 2003-01-09
NO311027B1 (no) 2001-10-01
CN1074766C (zh) 2001-11-14
ES2230605T3 (es) 2005-05-01
ZA974053B (en) 1998-11-09
HUP9902993A3 (en) 2002-01-28
US6103725A (en) 2000-08-15
ATE350373T1 (de) 2007-01-15
EE9800378A (et) 1999-04-15
ID16889A (id) 1997-11-20
AR007079A1 (es) 1999-10-13

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: KENNIS, LUDO E. J., BEERSE, BE

Inventor name: MERTENS, JOSEPHUS C., BEERSE, BE

Inventor name: PIETERS, SERGE M. A., BEERSE, BE

8364 No opposition during term of opposition