DE69631981D1 - Lansoprazolhaltige Arzneizusammensetzung und Herstellungsverfahren - Google Patents

Lansoprazolhaltige Arzneizusammensetzung und Herstellungsverfahren

Info

Publication number: DE69631981D1
Authority: DE; Germany
Prior art keywords: enteric coating; layer; image; composition; lansoprazole
Prior art date: 1995-09-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69631981T

Other languages

English (en)

Other versions

DE69631981T2 (de

Inventor

Pawan Seth

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ratiopharm GmbH

Original Assignee

Pharma Pass II LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-21

Filing date

1996-09-23

Publication date

2004-04-29

1995-12-07 Priority claimed from FR9514492A external-priority patent/FR2742050A1/fr

1996-02-23 Priority claimed from FR9602265A external-priority patent/FR2745181A1/fr

1996-04-23 Priority claimed from FR9605082A external-priority patent/FR2747573A1/fr

1996-09-23 Application filed by Pharma Pass II LLC filed Critical Pharma Pass II LLC

2004-04-29 Publication of DE69631981D1 publication Critical patent/DE69631981D1/de

2005-04-14 Application granted granted Critical

2005-04-14 Publication of DE69631981T2 publication Critical patent/DE69631981T2/de

2016-09-24 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)

DE69631981T 1995-09-21 1996-09-23 Lansoprazolhaltige Arzneizusammensetzung und Herstellungsverfahren Expired - Lifetime DE69631981T2 (de)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
FR9511094		1995-09-21
FR9511094		1995-09-21
FR9514492		1995-12-07
FR9514492A FR2742050A1 (fr)	1995-12-07	1995-12-07	Nouvelle composition contenant un benzimidazole acido-labile et son procede de preparation
FR9602265A FR2745181A1 (fr)	1996-02-23	1996-02-23	Nouvelle composition contenant un benzimidazole acido-labile et son procede de preparation
FR9602265		1996-02-23
FR9605082		1996-04-23
FR9605082A FR2747573A1 (fr)	1996-04-23	1996-04-23	Nouvelle composition contenant un benzimidazole acido-labile et son procede de preparation

Publications (2)

Publication Number	Publication Date
DE69631981D1 true DE69631981D1 (de)	2004-04-29
DE69631981T2 DE69631981T2 (de)	2005-04-14

Family

ID=27446956

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DE69634160T Expired - Lifetime DE69634160T2 (de)	1995-09-21	1996-09-23	Ein säurelabile Omeprazol enthaltende Arzneizusammensetzung und Verfahren zu deren Herstellung
DE69631834T Expired - Lifetime DE69631834T2 (de)	1995-09-21	1996-09-23	Neues ein säureempfindliches benzimidazol enthaltendes mittel und verfahren zu dessen herstellung
DE69628444T Expired - Lifetime DE69628444T2 (de)	1995-09-21	1996-09-23	Säurelabile omeprazol enthaltende pharmazeutische zusammensetzung und verfahren zu dessen herstellung
DE69631981T Expired - Lifetime DE69631981T2 (de)	1995-09-21	1996-09-23	Lansoprazolhaltige Arzneizusammensetzung und Herstellungsverfahren

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
DE69634160T Expired - Lifetime DE69634160T2 (de)	1995-09-21	1996-09-23	Ein säurelabile Omeprazol enthaltende Arzneizusammensetzung und Verfahren zu deren Herstellung
DE69631834T Expired - Lifetime DE69631834T2 (de)	1995-09-21	1996-09-23	Neues ein säureempfindliches benzimidazol enthaltendes mittel und verfahren zu dessen herstellung
DE69628444T Expired - Lifetime DE69628444T2 (de)	1995-09-21	1996-09-23	Säurelabile omeprazol enthaltende pharmazeutische zusammensetzung und verfahren zu dessen herstellung

Country Status (19)

Country	Link
US (3)	US6207198B1 (de)
EP (4)	EP0854718B1 (de)
JP (2)	JP3463266B2 (de)
KR (1)	KR100350138B1 (de)
CN (1)	CN1093855C (de)
AT (4)	ATE262332T1 (de)
AU (2)	AU713242B2 (de)
CA (1)	CA2231223C (de)
CZ (1)	CZ293595B6 (de)
DE (4)	DE69634160T2 (de)
DK (4)	DK0859612T3 (de)
ES (4)	ES2220989T3 (de)
HU (1)	HU227566B1 (de)
NO (1)	NO320489B1 (de)
NZ (1)	NZ318501A (de)
PL (1)	PL186605B1 (de)
PT (4)	PT859612E (de)
SK (1)	SK284291B6 (de)
WO (2)	WO1997012581A2 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3542189B2 (ja) *	1995-03-08	2004-07-14	株式会社ルネサステクノロジ	半導体装置の製造方法及び半導体装置
FR2758459B1 (fr) *	1997-01-17	1999-05-07	Pharma Pass	Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
GB9710800D0 (en) *	1997-05-23	1997-07-23	Cipla Limited	Pharmaceutical composition and method of preparing it
SI9700186B (sl)	1997-07-14	2006-10-31	Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D.	Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
FR2774288B1 (fr)	1998-01-30	2001-09-07	Ethypharm Sa	Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques
DK173431B1 (da) *	1998-03-20	2000-10-23	Gea Farmaceutisk Fabrik As	Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs
ZA9810765B (en) *	1998-05-28	1999-08-06	Ranbaxy Lab Ltd	Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
ATE321538T1 (de)	1998-08-12	2006-04-15	Altana Pharma Ag	Orale darreichungsform für pyridin-2- ylmethylsulfinyl-1h-benzimidazole
US6174902B1 (en)	1999-04-28	2001-01-16	Sepracor Inc.	R-rabeprazole compositions and methods
FR2793688B1 (fr)	1999-05-21	2003-06-13	Ethypharm Lab Prod Ethiques	Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques
IL130602A0 (en)	1999-06-22	2000-06-01	Dexcel Ltd	Stable benzimidazole formulation
ES2168043B1 (es) *	1999-09-13	2003-04-01	Esteve Labor Dr	Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.
RU2259828C2 (ru) *	1999-10-20	2005-09-10	Эйсай Ко., Лтд.	Способы стабилизации соединений на основе бензимидазола
US6761901B1 (en)	2000-05-02	2004-07-13	Enzrel Inc.	Liposome drug delivery
AU2001296908A1 (en) *	2000-09-29	2002-04-08	Geneva Pharmaceuticals, Inc.	Proton pump inhibitor formulation
ES2191521B1 (es) *	2000-11-22	2005-02-16	Laboratorios Belmac, S.A.	Nueva formulacion galenica del omeprazol en forma de comprimidos, procedimiento para su preparacion y aplicaciones en medicina humana y en veterinaria.
EP1405621B1 (de) *	2001-06-20	2011-05-11	Takeda Pharmaceutical Company Limited	Verfahren zur herstellung von tabletten
US20030091634A1 (en) *	2001-09-14	2003-05-15	Pawan Seth	Delayed release tablet of venlafaxin
WO2003026613A1 (en) *	2001-09-28	2003-04-03	Mcneil-Ppc, Inc.	Fondant-based pharmaceutical composition
US20030118647A1 (en) *	2001-12-04	2003-06-26	Pawan Seth	Extended release tablet of metformin
ES2198195B1 (es) *	2001-12-18	2004-10-01	Laboratorios Del Dr. Esteve, S.A.	Forma de dosificacion farmaceutica oral comprimida, con recubrimiento enterico, que contiene un compuesto de bencimidazol labil en medio acido.
EP1474108A2 (de)	2002-01-09	2004-11-10	Enzrel, Inc.	Liposom-arzneimittelabgabe von polyzyklischen, aromatischen, antioxidativen oder antiphlogistischen verbindungen
AU2003218113A1 (en) *	2002-03-11	2003-09-29	Dow Global Technologies Inc.	Stretch fabric with improved chemical resistance and durability
AU2003213844B2 (en) *	2002-03-11	2008-10-02	Dow Global Technologies Inc.	Reversible, heat-set, elastic fibers, and method of making and articles made from same
US20030228363A1 (en) *	2002-06-07	2003-12-11	Patel Mahendra R.	Stabilized pharmaceutical compositons containing benzimidazole compounds
US20050191353A1 (en) *	2002-08-16	2005-09-01	Amit Krishna Antarkar	Process for manufacture of stable oral multiple unit pharmaceutical composition containing benzimidazoles
MY148805A (en) *	2002-10-16	2013-05-31	Takeda Pharmaceutical	Controlled release preparation
US20040086567A1 (en) *	2002-10-30	2004-05-06	Pawan Seth	Bioequivalent composition of itraconazole and a hydrophilic polymer
WO2004060357A1 (en) *	2002-12-23	2004-07-22	Celltech Americas, Inc.	Acid labile drug compositions
EP1594479A1 (de) *	2003-01-31	2005-11-16	Ranbaxy Laboratories Limited	Stabile orale benzimidazol-zusammensetzungen und verfahren zu ihrer herstellung
US20040162320A1 (en) *	2003-02-14	2004-08-19	Pawan Seth	Solid composition containing nisoldipine a mixture of polyethylene oxides and an antioxidant
ES2234393B2 (es) *	2003-04-29	2006-09-01	Laboratorios Belmac, S.A.	"formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido".
US20050147663A1 (en) *	2003-07-17	2005-07-07	Mohan Mailatur S.	Method of treatment for improved bioavailability
JP2007524646A (ja) *	2003-07-17	2007-08-30	ドクターレディズラボラトリーズ，インコーポレイテッド	膨潤可能なコーティングを有する薬学的組成物
US20050013863A1 (en)	2003-07-18	2005-01-20	Depomed, Inc., A Corporation Of The State Of California	Dual drug dosage forms with improved separation of drugs
US7390503B1 (en)	2003-08-22	2008-06-24	Barr Laboratories, Inc.	Ondansetron orally disintegrating tablets
MXPA06002443A (es) *	2003-09-03	2006-08-31	Agi Therapeutics Ltd	Formulaciones inhibidoras de la bomba de protones y metodos para preparar y utilizar tales formulaciones.
TWI372066B (en) *	2003-10-01	2012-09-11	Wyeth Corp	Pantoprazole multiparticulate formulations
EP1667681A4 (de) *	2003-10-03	2009-09-30	Astron Res Pvt Ltd	Neues transmukosales abgabesystem
US20050181052A1 (en) *	2004-02-17	2005-08-18	Patel Satishkumar A.	Lansoprazole microtablets
US20050226923A1 (en) *	2004-04-07	2005-10-13	Gassert Chad M	Venlafaxine compositions in the form of microtablets
CA2469427A1 (en) *	2004-06-01	2005-12-01	Pharmascience Inc.	Dry mixed dosage form containing benzimidazole derivatives
US20050281876A1 (en)	2004-06-18	2005-12-22	Shun-Por Li	Solid dosage form for acid-labile active ingredient
US20060024362A1 (en)	2004-07-29	2006-02-02	Pawan Seth	Composition comprising a benzimidazole and process for its manufacture
TW200626185A (en) *	2004-12-17	2006-08-01	Bpsi Holdings Inc	Enteric film coating composition containing entericpolymer micronized with detackifier
EP1827429A4 (de) *	2004-12-20	2009-08-05	Reddys Lab Ltd Dr	Pharmatzeutische zusammensetzungen mit amorphen benzimidazolverbindungen
CN101111233A (zh)	2004-12-23	2008-01-23	兰贝克赛实验室有限公司	稳定的口服苯并咪唑组合物及其制备方法
EP1833469A2 (de) *	2005-01-03	2007-09-19	Lupin Ltd.	Pharmazeutische zusammensetzung aus säurelabilen substanzen
US20080279951A1 (en) *	2005-02-02	2008-11-13	Rajesh Gandhi	Stable Oral Benzimidazole Compositions Prepared by Non-Aqueous Layering Process
CN100393304C (zh) *	2005-02-28	2008-06-11	上海艾力斯医药科技有限公司	一种包含酸不稳定药物的微细颗粒及其制剂
US8673352B2 (en) *	2005-04-15	2014-03-18	Mcneil-Ppc, Inc.	Modified release dosage form
US20070009591A1 (en) *	2005-07-07	2007-01-11	Trivedi Jay S	ACE inhibitor formulation
ES2278511B1 (es) *	2005-07-28	2008-06-16	Laboratorios Almirall S.A.	Comprimidos con perfil de disolucion mejorado.
US20070141151A1 (en) *	2005-12-20	2007-06-21	Silver David I	Lansoprazole orally disintegrating tablets
EP1813275A1 (de) *	2005-12-20	2007-08-01	Teva Pharmaceutical Industries Ltd	In der Mundhöle zerfallende Lansoprazol-Tabletten
WO2007075980A2 (en) *	2005-12-20	2007-07-05	Teva Pharmaceutical Industries Ltd.	Lansoprazole orally disintegrating tablets
US7579476B2 (en) *	2006-02-24	2009-08-25	Praktikatalyst Pharma, Llc	Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals
RU2309732C1 (ru) *	2006-03-13	2007-11-10	Олег Ильич Эпштейн	Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата
US20100297226A1 (en) *	2006-06-01	2010-11-25	Dexcel Pharma Technologies Ltd.	Multiple unit pharmaceutical formulation
US8911787B2 (en)	2008-02-26	2014-12-16	Ranbaxy Laboratories Limited	Stable oral benzimidazole compositions and process of preparation thereof
EP2535045A1 (de) *	2011-06-15	2012-12-19	Laboratorios Del. Dr. Esteve, S.A.	Pharmazeutische Zusammensetzung von Lansoprazol
CN102846571A (zh) *	2012-09-29	2013-01-02	南京正科制药有限公司	一种埃索美拉唑镁微型片剂
CN103127026B (zh) *	2013-02-05	2017-02-15	悦康药业集团有限公司	一种奥美拉唑肠溶胶囊及其制备方法
WO2016174664A1 (en)	2015-04-29	2016-11-03	Dexcel Pharma Technologies Ltd.	Orally disintegrating compositions
US10736855B2 (en)	2016-02-25	2020-08-11	Dexcel Pharma Technologies Ltd.	Compositions comprising proton pump inhibitors
US10076494B2 (en)	2016-06-16	2018-09-18	Dexcel Pharma Technologies Ltd.	Stable orally disintegrating pharmaceutical compositions
CN113116894A (zh) *	2019-12-30	2021-07-16	北京康辰药业股份有限公司	一种抗肿瘤药物组合物以及提高化合物的溶解度的方法
GB202116644D0 (en)	2021-11-18	2022-01-05	Innovate Pharmaceuticals Ltd	Liquid composition

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE416649B (sv) *	1974-05-16	1981-01-26	Haessle Ab	Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (de) *	1977-09-19	1981-07-25	Hoffmann La Roche
SE7804231L (sv) *	1978-04-14	1979-10-15	Haessle Ab	Magsyrasekretionsmedel
FR2471186A1 (fr) *	1979-12-10	1981-06-19	Roussel Uclaf	Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation
CH644116A5 (de) *	1980-08-21	1984-07-13	Hoffmann La Roche	Imidazolderivate.
US4472409A (en) *	1981-11-05	1984-09-18	Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung	2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
SE8300736D0 (sv) *	1983-02-11	1983-02-11	Haessle Ab	Novel pharmacologically active compounds
IL71665A (en) *	1983-05-03	1988-05-31	Byk Gulden Lomberg Chem Fab	Fluoro-(2-pyridyl-methylthio)-dioxolo-(and dioxino-)benzimidazoles,processes for their preparation and pharmaceutical compositions containing the same
HU195220B (en) *	1983-05-03	1988-04-28	Byk Gulden Lomberg Chem Fqb	Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
DE3415971A1 (de) *	1983-05-03	1984-11-08	Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz	Acylierte benzimidazole, verfahren zu ihrer herstellung, ihre anwendung und sie enthaltende arzneimittel
GR81595B (de) *	1983-06-18	1984-12-11	Wyeth John & Brother Ltd
CA1259070A (en) *	1983-07-01	1989-09-05	Upjohn Company (The)	Substituted 2-¬monoannelated(3,4-,4,5-, and 5,6-)- pyridylalkylenesulfinyl\|-benzimidazoles
US4575554A (en) *	1983-12-05	1986-03-11	The Upjohn Company	Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
IE57646B1 (en) *	1983-12-16	1993-02-10	Wyeth John & Brother Ltd	Derivatives of imidazoquinolines and analogues thereof
IL75400A (en) *	1984-06-16	1988-10-31	Byk Gulden Lomberg Chem Fab	Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8404065D0 (sv) *	1984-08-10	1984-08-10	Haessle Ab	Novel biologically active compounds
JPS6150978A (ja) *	1984-08-16	1986-03-13	Takeda Chem Ind Ltd	ピリジン誘導体およびその製造法
AU4640985A (en) *	1984-08-31	1986-03-06	Nippon Chemiphar Co. Ltd.	Benzimidazole derivatives
US5250527A (en) *	1985-10-24	1993-10-05	Smithkline & French Laboratories Limited	Pyridyl containing benzimidazoles, compositions and use
GB2189699A (en) *	1986-04-30	1987-11-04	Haessle Ab	Coated acid-labile medicaments
GB2189698A (en) *	1986-04-30	1987-11-04	Haessle Ab	Coated omeprazole tablets
JPS6327424A (ja) *	1986-07-17	1988-02-05	Shionogi & Co Ltd	徐放性製剤およびその製造法
US4828848A (en) *	1987-01-29	1989-05-09	Owades Joseph L	Method of making salt-free pickles
GB8820353D0 (en) *	1988-08-26	1988-09-28	Staniforth J N	Controlled release tablet
US5126145A (en) *	1989-04-13	1992-06-30	Upsher Smith Laboratories Inc	Controlled release tablet containing water soluble medicament
US5133974A (en) *	1989-05-05	1992-07-28	Kv Pharmaceutical Company	Extended release pharmaceutical formulations
US5232706A (en) *	1990-12-31	1993-08-03	Esteve Quimica, S.A.	Oral pharmaceutical preparation containing omeprazol
YU48263B (sh) *	1991-06-17	1997-09-30	Byk Gulden Lomberg Chemische Fabrik Gmbh.	Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola
DK0519144T3 (da) *	1991-06-21	1998-03-23	Ilsan Ilac Ve Hammaddeleri San	Ny galenisk proces for omeprazol indeholdende pellets
US5178867A (en) *	1991-08-19	1993-01-12	Alza Corporation	Dosage form for delivering drug in short-time period
TW224049B (de) *	1991-12-31	1994-05-21	Sunkyong Ind Ltd
US5167964A (en) *	1992-02-14	1992-12-01	Warner-Lambert Company	Semi-enteric drug delivery systems and methods for preparing same
FR2692146B1 (fr) *	1992-06-16	1995-06-02	Ethypharm Sa	Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention.
US5374730A (en) *	1993-11-04	1994-12-20	Torcan Chemical Ltd.	Preparation of omeprazole and lansoprazole
SE9402431D0 (sv) *	1994-07-08	1994-07-08	Astra Ab	New tablet formulation
DK1078628T3 (da)	1994-07-08	2009-02-23	Astrazeneca Ab	Tabletteret flerenhedsdoseringsform
ES2094694B1 (es) *	1995-02-01	1997-12-16	Esteve Quimica Sa	Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
US5945124A (en) *	1995-07-05	1999-08-31	Byk Gulden Chemische Fabrik Gmbh	Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole
US5840332A (en) *	1996-01-18	1998-11-24	Perio Products Ltd.	Gastrointestinal drug delivery system
SE9704869D0 (sv) *	1997-12-22	1997-12-22	Astra Ab	New pharmaceutical formulaton II

1996
- 1996-09-23 NZ NZ318501A patent/NZ318501A/xx not_active IP Right Cessation
- 1996-09-23 DK DK96931211T patent/DK0859612T3/da active
- 1996-09-23 SK SK314-98A patent/SK284291B6/sk not_active IP Right Cessation
- 1996-09-23 EP EP96931210A patent/EP0854718B1/de not_active Expired - Lifetime
- 1996-09-23 DE DE69634160T patent/DE69634160T2/de not_active Expired - Lifetime
- 1996-09-23 ES ES96931210T patent/ES2220989T3/es not_active Expired - Lifetime
- 1996-09-23 ES ES03001111T patent/ES2236628T3/es not_active Expired - Lifetime
- 1996-09-23 PT PT96931211T patent/PT859612E/pt unknown
- 1996-09-23 PL PL96325838A patent/PL186605B1/pl not_active IP Right Cessation
- 1996-09-23 AT AT00127495T patent/ATE262332T1/de active
- 1996-09-23 CN CN96197132A patent/CN1093855C/zh not_active Expired - Fee Related
- 1996-09-23 PT PT00127495T patent/PT1092434E/pt unknown
- 1996-09-23 AT AT96931210T patent/ATE261303T1/de active
- 1996-09-23 DK DK96931210T patent/DK0854718T3/da active
- 1996-09-23 DE DE69631834T patent/DE69631834T2/de not_active Expired - Lifetime
- 1996-09-23 DE DE69628444T patent/DE69628444T2/de not_active Expired - Lifetime
- 1996-09-23 ES ES00127495T patent/ES2218054T3/es not_active Expired - Lifetime
- 1996-09-23 HU HU9900467A patent/HU227566B1/hu not_active IP Right Cessation
- 1996-09-23 DK DK03001111T patent/DK1308159T3/da active
- 1996-09-23 PT PT96931210T patent/PT854718E/pt unknown
- 1996-09-23 AU AU69988/96A patent/AU713242B2/en not_active Ceased
- 1996-09-23 AT AT03001111T patent/ATE286394T1/de active
- 1996-09-23 PT PT03001111T patent/PT1308159E/pt unknown
- 1996-09-23 US US09/043,145 patent/US6207198B1/en not_active Expired - Lifetime
- 1996-09-23 DE DE69631981T patent/DE69631981T2/de not_active Expired - Lifetime
- 1996-09-23 EP EP00127495A patent/EP1092434B1/de not_active Expired - Lifetime
- 1996-09-23 CA CA002231223A patent/CA2231223C/en not_active Expired - Fee Related
- 1996-09-23 AT AT96931211T patent/ATE241357T1/de active
- 1996-09-23 DK DK00127495T patent/DK1092434T3/da active
- 1996-09-23 EP EP96931211A patent/EP0859612B1/de not_active Expired - Lifetime
- 1996-09-23 ES ES96931211T patent/ES2201200T3/es not_active Expired - Lifetime
- 1996-09-23 EP EP03001111A patent/EP1308159B1/de not_active Expired - Lifetime
- 1996-09-23 JP JP51410897A patent/JP3463266B2/ja not_active Expired - Fee Related
- 1996-09-23 JP JP51410797A patent/JP3198337B2/ja not_active Expired - Fee Related
- 1996-09-23 US US09/043,663 patent/US6159499A/en not_active Expired - Lifetime
- 1996-09-23 WO PCT/IB1996/001055 patent/WO1997012581A2/en active IP Right Grant
- 1996-09-23 AU AU69987/96A patent/AU6998796A/en not_active Abandoned
- 1996-09-23 KR KR10-1998-0701884A patent/KR100350138B1/ko not_active IP Right Cessation
- 1996-09-23 CZ CZ1998879A patent/CZ293595B6/cs not_active IP Right Cessation
- 1996-09-23 WO PCT/IB1996/001054 patent/WO1997012580A2/en active IP Right Grant
1998
- 1998-03-20 NO NO19981284A patent/NO320489B1/no not_active IP Right Cessation
1999
- 1999-12-30 US US09/538,845 patent/US6248355B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1092434B1 (de)	2004-03-24
ATE261303T1 (de)	2004-03-15
CN1197456A (zh)	1998-10-28
EP0859612B1 (de)	2003-05-28
EP1092434A1 (de)	2001-04-18
EP1308159A1 (de)	2003-05-07
US6248355B1 (en)	2001-06-19
DK0859612T3 (da)	2003-09-22
JP3198337B2 (ja)	2001-08-13
AU6998796A (en)	1997-04-28
NZ318501A (en)	1999-06-29
EP0859612A2 (de)	1998-08-26
DK0854718T3 (da)	2004-07-12
AU6998896A (en)	1997-04-28
DE69634160T2 (de)	2005-12-22
EP1308159B1 (de)	2005-01-05
JPH11504343A (ja)	1999-04-20
PT854718E (pt)	2004-08-31
AU713242B2 (en)	1999-11-25
DE69631834T2 (de)	2005-02-10
EP0854718A2 (de)	1998-07-29
US6207198B1 (en)	2001-03-27
ES2218054T3 (es)	2004-11-16
WO1997012580A3 (en)	1997-06-12
CN1093855C (zh)	2002-11-06
ATE241357T1 (de)	2003-06-15
ES2220989T3 (es)	2004-12-16
KR100350138B1 (ko)	2003-03-10
US6159499A (en)	2000-12-12
WO1997012581A2 (en)	1997-04-10
DE69628444T2 (de)	2004-05-06
PT1092434E (pt)	2004-08-31
PL325838A1 (en)	1998-08-03
NO320489B1 (no)	2005-12-12
DK1092434T3 (da)	2004-07-26
JP3463266B2 (ja)	2003-11-05
PT859612E (pt)	2003-10-31
HU227566B1 (en)	2011-08-29
DE69631834D1 (de)	2004-04-15
JPH10511117A (ja)	1998-10-27
WO1997012581A3 (en)	1997-06-12
SK31498A3 (en)	1998-12-02
CA2231223A1 (en)	1997-04-10
DE69628444D1 (de)	2003-07-03
ATE262332T1 (de)	2004-04-15
ES2236628T3 (es)	2005-07-16
CA2231223C (en)	2003-03-18
HUP9900467A2 (hu)	1999-09-28
ATE286394T1 (de)	2005-01-15
ES2201200T3 (es)	2004-03-16
DE69634160D1 (de)	2005-02-10
PT1308159E (pt)	2005-02-28
EP0859612A4 (de)	1998-11-04
EP0854718B1 (de)	2004-03-10
WO1997012580A2 (en)	1997-04-10
HUP9900467A3 (en)	2001-09-28
CZ87998A3 (cs)	1998-08-12
DK1308159T3 (da)	2005-02-14
PL186605B1 (pl)	2004-01-30
NO981284D0 (no)	1998-03-20
DE69631981T2 (de)	2005-04-14
CZ293595B6 (cs)	2004-06-16
NO981284L (no)	1998-03-20
EP0854718A4 (de)	2000-04-26
SK284291B6 (sk)	2005-01-03

Publication	Publication Date	Title
DE69631981D1 (de)	2004-04-29	Lansoprazolhaltige Arzneizusammensetzung und Herstellungsverfahren
ATE414509T1 (de)	2008-12-15	Aus vielen einzeleinheiten zusammengesetzte tablettierte dosisform
LV11982A (lv)	1998-03-20	Pantoprazolu saturosa medikamenta perorali lietojamas formas
ATE244002T1 (de)	2003-07-15	Pharmazeutische formulierung mit omeprazol
IL136285A0 (en)	2001-05-20	Pharmaceutical compositions containing an acid-labile active component
ATE110379T1 (de)	1994-09-15	Therapeutisch aktive substituierte benzimidazole und verfahren zu ihrer herstellung.
IL162544A (en)	2010-04-29	Compressed oral pharmaceutical dosage form, with an enteric coating, which contains an acid-labile benzimidazole compound
TH19832EX (th)	1996-08-07	สูตรผสมทางเภสัชกรรมชนิดใหม่ที่ประกอบรวมด้วยเกลือแมกนีเซียมของออเมพราโซลที่มีรูปแบบทางกายภาพชนิดใหม่และวิธีสำหรับการผลิตเกลือนี้

Legal Events

Date	Code	Title	Description
2004-12-30	8332	No legal effect for de
2005-01-13	8370	Indication related to discontinuation of the patent is to be deleted
2005-05-19	8364	No opposition during term of opposition
2006-11-09	8327	Change in the person/name/address of the patent owner	Owner name: RATIOPHARM GMBH, 89079 ULM, DE