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DE69529910D1 - Zellen, die einen cd4-scheinrezeptor tragen und entsprechende moleküle und verfahren - Google Patents

Zellen, die einen cd4-scheinrezeptor tragen und entsprechende moleküle und verfahren

Info

Publication number
DE69529910D1
DE69529910D1 DE69529910T DE69529910T DE69529910D1 DE 69529910 D1 DE69529910 D1 DE 69529910D1 DE 69529910 T DE69529910 T DE 69529910T DE 69529910 T DE69529910 T DE 69529910T DE 69529910 D1 DE69529910 D1 DE 69529910D1
Authority
DE
Germany
Prior art keywords
cells carrying
hiv
receptors
corresponding molecules
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69529910T
Other languages
English (en)
Other versions
DE69529910T2 (de
Inventor
Brian Seed
Babak Banapour
Charles Romeo
Waldemar Kolanus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/284,391 external-priority patent/US5851828A/en
Priority claimed from US08/394,388 external-priority patent/US6753162B1/en
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of DE69529910D1 publication Critical patent/DE69529910D1/de
Application granted granted Critical
Publication of DE69529910T2 publication Critical patent/DE69529910T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69529910T 1994-08-02 1995-07-26 Zellen, die einen cd4-scheinrezeptor tragen und entsprechende moleküle und verfahren Expired - Lifetime DE69529910T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/284,391 US5851828A (en) 1991-03-07 1994-08-02 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US08/394,388 US6753162B1 (en) 1991-03-07 1995-02-24 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
PCT/US1995/009468 WO1996003883A1 (en) 1994-08-02 1995-07-26 Cells bearing cd4 decoy receptors and related molecules and methods

Publications (2)

Publication Number Publication Date
DE69529910D1 true DE69529910D1 (de) 2003-04-17
DE69529910T2 DE69529910T2 (de) 2003-12-18

Family

ID=26962581

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69529910T Expired - Lifetime DE69529910T2 (de) 1994-08-02 1995-07-26 Zellen, die einen cd4-scheinrezeptor tragen und entsprechende moleküle und verfahren

Country Status (22)

Country Link
EP (1) EP0781095B1 (de)
JP (1) JP3832856B2 (de)
KR (1) KR100384249B1 (de)
CN (1) CN1142941C (de)
AT (1) ATE234011T1 (de)
AU (1) AU697489B2 (de)
CA (1) CA2195653C (de)
CZ (1) CZ293943B6 (de)
DE (1) DE69529910T2 (de)
DK (1) DK0781095T3 (de)
ES (1) ES2191058T3 (de)
FI (1) FI119868B (de)
HK (1) HK1002545A1 (de)
HU (1) HU221603B (de)
IL (1) IL114778A (de)
MX (1) MX9700800A (de)
NO (1) NO325081B1 (de)
NZ (1) NZ291017A (de)
PL (1) PL181085B1 (de)
PT (1) PT781095E (de)
UA (1) UA45349C2 (de)
WO (1) WO1996003883A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
BR9913942A (pt) * 1998-09-23 2001-10-16 Zymogenetics Inc Polinucleotìdeo e polipeptìdeo isolado, vetor de expressão, célula cultivada, constructo de dna codificador de uma proteìna de fusão, processos de produção de uma proteìna, de fusão de um polipeptìdeo e de um anticorpo para o polipeptìdeo e de detecção, em uma amostra de teste, da presença de um modulador da atividade da proteìna zalpha11 e de um ligante de receptor zalpha11 dentro de uma amostra de teste, e, anticorpo
RU2746486C2 (ru) * 2015-03-13 2021-04-14 Юниверсити Оф Мэрилэнд, Балтимор Универсальный антителоопосредованный биосенсор
SG10201912734PA (en) 2015-08-05 2020-02-27 Yoo Young Pharm Co Ltd Chimeric antigen receptor, and t cells in which chimeric antigen receptor is expressed
EP3353197A4 (de) * 2015-09-22 2018-11-14 The Trustees of The University of Pennsylvania Verfahren zur umleitung von t-zellen zur behandlung von hiv-infektion
WO2021061856A1 (en) * 2019-09-24 2021-04-01 The Regents Of The University Of California Receptors with heterologous transmembrane domain
IL307609B1 (en) * 2019-09-24 2024-11-01 The Regents Of The Univ Of California Notch receptors with hinge area
US20220348628A1 (en) * 2019-09-24 2022-11-03 The Regents Of The University Of California Novel receptors having a fibronectin repeat for ligand-dependent transcriptional regulation
WO2021061863A1 (en) * 2019-09-24 2021-04-01 The Regents Of The University Of California Notch receptors with minimal linker
CN112176037A (zh) * 2020-09-24 2021-01-05 深圳普瑞金生物药业有限公司 检测car-t细胞目的基因拷贝数的方法、引物对、探针及试剂盒
EP4112639A1 (de) * 2021-07-02 2023-01-04 Universitat de Barcelona Car-t/nk-zellen zur verwendung bei der behandlung von invasiven pilzinfektionen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6463394A (en) * 1987-09-04 1989-03-09 Kyowa Hakko Kogyo Kk Novel chimera polypeptide
PT89484B (pt) * 1988-01-22 1994-03-31 Gen Hospital Corp Genes clonados codificadores de proteinas de fusao ig-cd4 e sua utilizacao
IE920716A1 (en) * 1991-03-07 1992-09-09 Gen Hospital Corp Redirection of cellular immunity by receptor chimeras
US5851828A (en) * 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells

Also Published As

Publication number Publication date
KR970704357A (ko) 1997-09-06
EP0781095B1 (de) 2003-03-12
FI119868B (fi) 2009-04-30
JPH10503932A (ja) 1998-04-14
CN1158552A (zh) 1997-09-03
UA45349C2 (uk) 2002-04-15
CN1142941C (zh) 2004-03-24
PL318443A1 (en) 1997-06-09
EP0781095A4 (de) 1999-03-03
ES2191058T3 (es) 2003-09-01
HUT77253A (hu) 1998-03-02
HU221603B (hu) 2002-11-28
AU697489B2 (en) 1998-10-08
NZ291017A (en) 1998-05-27
NO970440L (no) 1997-03-26
HK1002545A1 (en) 1998-09-04
NO970440D0 (no) 1997-01-31
CA2195653C (en) 2010-04-27
IL114778A0 (en) 1995-11-27
DK0781095T3 (da) 2003-06-23
PT781095E (pt) 2003-06-30
IL114778A (en) 2008-08-07
DE69529910T2 (de) 2003-12-18
CA2195653A1 (en) 1996-02-15
CZ293943B6 (cs) 2004-08-18
WO1996003883A1 (en) 1996-02-15
MX9700800A (es) 1997-11-29
NO325081B1 (no) 2008-01-28
FI970428A0 (fi) 1997-01-31
ATE234011T1 (de) 2003-03-15
AU3201495A (en) 1996-03-04
KR100384249B1 (ko) 2003-08-30
JP3832856B2 (ja) 2006-10-11
EP0781095A1 (de) 1997-07-02
PL181085B1 (pl) 2001-05-31
FI970428A (fi) 1997-03-26
CZ26497A3 (en) 1997-10-15

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