DE60331297D1 - Verfahren zur verstärkung der oligonucleotid-vermittelten nucleinsäuresequenzänderung unter verwendung von zusammensetzungen mit einem hydroxyharnstoff - Google Patents
Verfahren zur verstärkung der oligonucleotid-vermittelten nucleinsäuresequenzänderung unter verwendung von zusammensetzungen mit einem hydroxyharnstoffInfo
- Publication number
- DE60331297D1 DE60331297D1 DE60331297T DE60331297T DE60331297D1 DE 60331297 D1 DE60331297 D1 DE 60331297D1 DE 60331297 T DE60331297 T DE 60331297T DE 60331297 T DE60331297 T DE 60331297T DE 60331297 D1 DE60331297 D1 DE 60331297D1
- Authority
- DE
- Germany
- Prior art keywords
- oligonucleotide
- nucleic acid
- acid sequence
- hydroxyal
- reinforcing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36305302P | 2002-03-07 | 2002-03-07 | |
US36334102P | 2002-03-07 | 2002-03-07 | |
US36305402P | 2002-03-07 | 2002-03-07 | |
US41698302P | 2002-10-07 | 2002-10-07 | |
PCT/US2003/007217 WO2003075856A2 (en) | 2002-03-07 | 2003-03-07 | Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phage beta protein, or hydroxyurea |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60331297D1 true DE60331297D1 (de) | 2010-04-01 |
Family
ID=27808811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60331297T Expired - Fee Related DE60331297D1 (de) | 2002-03-07 | 2003-03-07 | Verfahren zur verstärkung der oligonucleotid-vermittelten nucleinsäuresequenzänderung unter verwendung von zusammensetzungen mit einem hydroxyharnstoff |
Country Status (9)
Country | Link |
---|---|
US (1) | US7566535B2 (de) |
EP (1) | EP1490013B1 (de) |
JP (1) | JP2005518817A (de) |
AT (1) | ATE458047T1 (de) |
AU (1) | AU2003220119A1 (de) |
CA (1) | CA2478479A1 (de) |
DE (1) | DE60331297D1 (de) |
IL (1) | IL163875A0 (de) |
WO (1) | WO2003075856A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
US20070072815A1 (en) * | 2004-05-04 | 2007-03-29 | Kmiec Eric B | Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration |
EP2342337B1 (de) | 2008-09-11 | 2015-05-27 | Keygene N.V. | Verfahren zur entwicklung diagnostischer marker |
US8993328B2 (en) * | 2008-09-22 | 2015-03-31 | Rutgers, The State University Of New Jersey | Media conditioning for improving gene delivery efficiency to differentiating embryonic stem cells |
EP3140269B1 (de) | 2014-05-09 | 2023-11-29 | Yale University | Hyperverzweigte polyglycerolbeschichtete partikel und verfahren zur herstellung und verwendung davon |
US11918695B2 (en) | 2014-05-09 | 2024-03-05 | Yale University | Topical formulation of hyperbranched polymer-coated particles |
WO2016094845A2 (en) | 2014-12-12 | 2016-06-16 | Woolf Tod M | Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides |
US20180003711A1 (en) * | 2014-12-22 | 2018-01-04 | Universität Zürich | Directed evolution of membrane proteins in eukaryotic cells with a cell wall |
AU2017221405A1 (en) | 2016-02-16 | 2018-09-20 | Carnegie Mellon University | Compositions for enhancing targeted gene editing and methods of use thereof |
CA3048501A1 (en) * | 2017-01-10 | 2018-07-19 | Christiana Care Health Services, Inc. | Methods for in vitro site-directed mutagenesis using gene editing technologies |
US20210024882A1 (en) * | 2019-07-08 | 2021-01-28 | Life Technologies Corporation | Compositions and methods for enhancing cell culture |
WO2021207673A1 (en) * | 2020-04-09 | 2021-10-14 | The Regents of the University of Colorodo, a body corporate | Compositions, methods and uses for production of hematopoietic stem cells (hscs) |
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US217377A (en) * | 1879-07-08 | hislop | ||
US51270A (en) * | 1865-11-28 | Improvement in children s bedclothes-retainers | ||
US143052A (en) * | 1873-09-23 | Improvement in flexible vertically-extensible attachments for boats | ||
US119570A (en) * | 1871-10-03 | Improvement in coopers crozes and howels | ||
US5139941A (en) * | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US5955363A (en) * | 1990-01-03 | 1999-09-21 | Promega Corporation | Vector for in vitro mutagenesis and use thereof |
US5432272A (en) * | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
US6136601A (en) * | 1991-08-21 | 2000-10-24 | Epoch Pharmaceuticals, Inc. | Targeted mutagenesis in living cells using modified oligonucleotides |
US5962426A (en) * | 1993-06-25 | 1999-10-05 | Yale University | Triple-helix forming oligonucleotides for targeted mutagenesis |
US5801154A (en) * | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
PT733059E (pt) * | 1993-12-09 | 2001-03-30 | Univ Jefferson | Compostos e metodos para mutacoes dirigidas ao local em celulas eucarioticas |
US5604090A (en) * | 1994-06-06 | 1997-02-18 | Fred Hutchinson Cancer Research Center | Method for increasing transduction of cells by adeno-associated virus vectors |
US5780296A (en) * | 1995-01-17 | 1998-07-14 | Thomas Jefferson University | Compositions and methods to promote homologous recombination in eukaryotic cells and organisms |
JP3770333B2 (ja) * | 1995-03-15 | 2006-04-26 | 大日本住友製薬株式会社 | 組換えdnaウイルスおよびその製造方法 |
US5776744A (en) * | 1995-06-07 | 1998-07-07 | Yale University | Methods and compositions for effecting homologous recombination |
US5912340A (en) * | 1995-10-04 | 1999-06-15 | Epoch Pharmaceuticals, Inc. | Selective binding complementary oligonucleotides |
US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
US6025155A (en) | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
US5888983A (en) * | 1996-05-01 | 1999-03-30 | Thomas Jefferson University | Method and oligonucleobase compounds for curing diseases caused by mutations |
US5760012A (en) * | 1996-05-01 | 1998-06-02 | Thomas Jefferson University | Methods and compounds for curing diseases caused by mutations |
US5731181A (en) * | 1996-06-17 | 1998-03-24 | Thomas Jefferson University | Chimeric mutational vectors having non-natural nucleotides |
WO1997047307A1 (en) | 1996-06-14 | 1997-12-18 | The Uab Research Foundation | Use of histone deacetylase inhibitors to activate transgene expression |
US5928638A (en) * | 1996-06-17 | 1999-07-27 | Systemix, Inc. | Methods for gene transfer |
US6057102A (en) * | 1996-08-08 | 2000-05-02 | The Aaron Diamond Aids Research Center | HIV coreceptor mutants |
ES2192672T3 (es) * | 1996-11-18 | 2003-10-16 | Takeshi Imanishi | Nuevos analogos de nucleotidos. |
WO1998026060A2 (en) * | 1996-12-12 | 1998-06-18 | Julianna Lisziewicz | Materials and methods for gene transfer |
JP3756313B2 (ja) * | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
US6043389A (en) * | 1997-03-11 | 2000-03-28 | Mor Research Applications, Ltd. | Hydroxy and ether-containing oxyalkylene esters and uses thereof |
US6387673B1 (en) | 1997-05-01 | 2002-05-14 | The Salk Institute For Biological Studies | Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds |
AUPO721997A0 (en) | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
US6821759B1 (en) * | 1997-06-23 | 2004-11-23 | The Rockefeller University | Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof |
AU9063398A (en) | 1997-09-12 | 1999-04-05 | Exiqon A/S | Oligonucleotide analogues |
US6262116B1 (en) | 1998-01-23 | 2001-07-17 | Sloan-Kettering Institute For Cancer Research | Transcription therapy for cancers |
US6010907A (en) | 1998-05-12 | 2000-01-04 | Kimeragen, Inc. | Eukaryotic use of non-chimeric mutational vectors |
US6004804A (en) * | 1998-05-12 | 1999-12-21 | Kimeragen, Inc. | Non-chimeric mutational vectors |
CA2346943A1 (en) | 1998-10-13 | 2000-04-20 | Fujisawa Pharmaceutical Co., Ltd. | Cyclic tetrapeptide compound and use thereof |
CA2346152A1 (en) | 1998-10-16 | 2000-04-27 | Novartis Ag | Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors |
DE19983694T1 (de) | 1998-10-28 | 2002-05-29 | Univ Washington Seattle | Zielgerichtete Genmodifikation durch parvovirale Vektoren |
JP2002538348A (ja) | 1999-02-24 | 2002-11-12 | ナムローゼ・フェンノートシャップ・ケマ | 液体燃料を燃焼させるための燃焼ユニット及び該燃焼ユニットを含む動力生成システム |
JP4269041B2 (ja) | 1999-03-02 | 2009-05-27 | 国立大学法人九州工業大学 | 新規な環状テトラペプチド誘導体とその医薬用途 |
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EP1159415B1 (de) | 1999-03-04 | 2009-12-23 | Revivicor, Inc. | Genetische veränderung von somatischen zellen und deren verwendungen |
DE60044241D1 (de) | 1999-03-18 | 2010-06-02 | Exiqon As | Xylo-lna analoge |
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KR100782896B1 (ko) | 1999-05-04 | 2007-12-06 | 엑시콘 에이/에스 | L-리보-lna 유사체 |
AU5886000A (en) * | 1999-06-25 | 2001-01-31 | Northwestern University | Compositions, kits, and methods for modulating survival and differentiation of multi-potential hematopoietic progenitor cells |
JP2001064177A (ja) | 1999-08-16 | 2001-03-13 | Schering Ag | ベンズアミド誘導体を有効成分とする製剤 |
US6271360B1 (en) * | 1999-08-27 | 2001-08-07 | Valigen (Us), Inc. | Single-stranded oligodeoxynucleotide mutational vectors |
JP2001081031A (ja) | 1999-08-30 | 2001-03-27 | Schering Ag | 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤 |
CA2383885A1 (en) | 1999-09-08 | 2001-03-15 | Sloan-Kettering Institute For Cancer Research | Crystal structure of a deacetylase and inhibitors thereof |
PL200861B1 (pl) | 1999-09-08 | 2009-02-27 | Sloan Kettering Inst Cancer | Pochodna kwasu suberynowego, jej zastosowanie i kompozycja farmaceutyczna |
AR025996A1 (es) | 1999-10-07 | 2002-12-26 | Valigen Us Inc | Plantas no transgenicas resistentes a los herbicidas. |
EP1230394A4 (de) | 1999-11-10 | 2002-12-18 | Uab Research Foundation | Vektortransduktion hematopoietischer stammzellen mittels lentivirus |
AU783504C (en) | 1999-11-23 | 2006-08-03 | Methylgene Inc. | Inhibitors of histone deacetylase |
EP1252196B1 (de) | 2000-01-05 | 2005-11-02 | Novartis AG | Hydrogele |
ATE489360T1 (de) | 2000-03-24 | 2010-12-15 | Methylgene Inc | Inhibitoren der histon-deacetylase |
IL151948A0 (en) | 2000-03-27 | 2003-04-10 | Univ Delaware | Oligonucleotides for targeted alteration of a genetic sequence and methods utilizing the same |
US6936467B2 (en) | 2000-03-27 | 2005-08-30 | University Of Delaware | Targeted chromosomal genomic alterations with modified single stranded oligonucleotides |
EP1170008A1 (de) | 2000-07-07 | 2002-01-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Valproinsäure und dessen Derivate als Inhibitoren der Histone deacetylase |
EP1302476B1 (de) | 2000-07-17 | 2009-03-11 | Astellas Pharma Inc. | Reduziertes fk228 und seine verwendung |
IL154099A0 (en) | 2000-07-27 | 2003-07-31 | Univ Delaware | A method and kit for enhancing oligonucleotide-mediated gene alteration |
EP1311661B1 (de) * | 2000-08-14 | 2012-10-03 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Erhöhte homologe rekombination vermittelt durch lambda rekombinationsproteine |
WO2002026967A2 (en) | 2000-09-25 | 2002-04-04 | Thomas Jefferson University | Targeted gene correction by single-stranded oligodeoxynucleotides |
US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
-
2003
- 2003-03-07 AT AT03716412T patent/ATE458047T1/de not_active IP Right Cessation
- 2003-03-07 EP EP03716412A patent/EP1490013B1/de not_active Expired - Lifetime
- 2003-03-07 CA CA002478479A patent/CA2478479A1/en not_active Abandoned
- 2003-03-07 US US10/384,918 patent/US7566535B2/en not_active Expired - Fee Related
- 2003-03-07 AU AU2003220119A patent/AU2003220119A1/en not_active Abandoned
- 2003-03-07 DE DE60331297T patent/DE60331297D1/de not_active Expired - Fee Related
- 2003-03-07 IL IL16387503A patent/IL163875A0/xx unknown
- 2003-03-07 JP JP2003574132A patent/JP2005518817A/ja active Pending
- 2003-03-07 WO PCT/US2003/007217 patent/WO2003075856A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
IL163875A0 (en) | 2005-12-18 |
CA2478479A1 (en) | 2003-09-18 |
EP1490013B1 (de) | 2010-02-17 |
WO2003075856A2 (en) | 2003-09-18 |
US7566535B2 (en) | 2009-07-28 |
US20030207451A1 (en) | 2003-11-06 |
ATE458047T1 (de) | 2010-03-15 |
WO2003075856A3 (en) | 2004-06-24 |
EP1490013A4 (de) | 2005-12-28 |
JP2005518817A (ja) | 2005-06-30 |
EP1490013A2 (de) | 2004-12-29 |
AU2003220119A1 (en) | 2003-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |