DE60315984D1 - Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung - Google Patents

Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung

Info

Publication number: DE60315984D1
Authority: DE; Germany
Prior art keywords: hammender; benzoxoxolsulfonamides; protease; broad; substituted
Prior art date: 2002-05-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60315984T

Other languages

English (en)

Other versions

DE60315984T2 (de

Inventor

Dominique Louis Surleraux

Bernhard Joanna Vergouwen

Kock Herman Augustinus De

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen R&D Ireland ULC

Original Assignee

Tibotec Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-17

Filing date

2003-05-16

Publication date

2007-10-11

2003-05-16 Application filed by Tibotec Pharmaceuticals Ltd filed Critical Tibotec Pharmaceuticals Ltd

2007-10-11 Application granted granted Critical

2007-10-11 Publication of DE60315984D1 publication Critical patent/DE60315984D1/de

2008-05-29 Publication of DE60315984T2 publication Critical patent/DE60315984T2/de

2023-05-17 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60315984T 2002-05-17 2003-05-16 Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung Expired - Lifetime DE60315984T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP02076957		2002-05-17
EP02076957		2002-05-17
PCT/EP2003/050173 WO2003097616A1 (en)	2002-05-17	2003-05-16	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number	Publication Date
DE60315984D1 true DE60315984D1 (de)	2007-10-11
DE60315984T2 DE60315984T2 (de)	2008-05-29

Family

ID=29433159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60315984T Expired - Lifetime DE60315984T2 (de)	2002-05-17	2003-05-16	Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung

Country Status (29)

Country	Link
US (1)	US7462636B2 (de)
EP (1)	EP1517899B1 (de)
JP (2)	JP4674084B2 (de)
KR (2)	KR20100130234A (de)
CN (1)	CN100582097C (de)
AP (1)	AP2004003190A0 (de)
AR (1)	AR039887A1 (de)
AT (1)	ATE371652T1 (de)
AU (1)	AU2003238074B2 (de)
BR (1)	BR0310089A (de)
CA (1)	CA2485903C (de)
CY (1)	CY1107040T1 (de)
DE (1)	DE60315984T2 (de)
DK (1)	DK1517899T3 (de)
EA (1)	EA010908B1 (de)
ES (1)	ES2292976T3 (de)
HK (1)	HK1076099A1 (de)
HR (1)	HRP20050607B1 (de)
IL (1)	IL165043A0 (de)
MX (1)	MXPA04011466A (de)
MY (1)	MY135226A (de)
NO (1)	NO330184B1 (de)
NZ (1)	NZ536496A (de)
PL (1)	PL373425A1 (de)
PT (1)	PT1517899E (de)
SI (1)	SI1517899T1 (de)
TW (1)	TWI356700B (de)
WO (1)	WO2003097616A1 (de)
ZA (1)	ZA200410156B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003238074B2 (en) *	2002-05-17	2009-04-30	Tibotec Pharmaceuticals Ltd.	Broadspectrum substituted benzisoxazole sulfonamide HIV protease inhibitors
AU2005222435B2 (en) *	2004-03-11	2012-03-15	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
CN1997363B (zh) *	2004-05-07	2012-03-28	塞阔伊亚药品公司	抗耐药性反转录病毒蛋白酶抑制剂
DK1856125T3 (da)	2005-02-25	2009-12-07	Tibotec Pharm Ltd	Syntese af proteasehæmmerforstadie
WO2008118849A2 (en) *	2007-03-23	2008-10-02	University Of Massachusetts	Hiv-1 protease inhibitors
US8216495B2 (en) *	2008-03-25	2012-07-10	Formac Pharmaceuticals N.V.	Preparation method for solid dispersions
WO2011061590A1 (en)	2009-11-17	2011-05-26	Hetero Research Foundation	Novel carboxamide derivatives as hiv inhibitors
DE102010004957A1 (de)	2010-01-14	2011-07-21	Universitätsklinikum Jena, 07743	Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
BR112015009751A2 (pt)	2012-10-31	2017-07-11	Bayer Cropscience Ag	novos compostos heterocíclicos como pesticidas
CN105025887B (zh) *	2013-03-07	2017-07-28	陶氏环球技术有限责任公司	新颖极低粘度酯化纤维素醚

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5004751A (en) *	1987-08-28	1991-04-02	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
US5145684A (en)	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
DE69321845T2 (de) *	1992-08-25	1999-04-29	Monsanto Co	Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DE69415326T2 (de)	1993-08-24	1999-06-02	G.D. Searle & Co., Chicago, Ill.	Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
NZ274277A (en)	1993-10-01	1998-01-26	Astra Ab	Making spheroidal granules of an inhalable medicament powder by agglomerating, spheronising, then sizing
ES2303337T3 (es) *	1995-01-20	2008-08-01	G.D. Searle Llc	Inhibidores de la proteasa retroviral de bis-hidroxietilamino sulfonamida.
US5756533A (en)	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) *	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PT815124E (pt)	1995-03-10	2003-04-30	Searle & Co	Inibidores protease retroviral sulfonamida hidroxietilamino aminoacido heterociclocarbonilo
US5705500A (en) *	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
CA2236236A1 (en) *	1995-11-15	1997-05-22	G.D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
EP0904060B1 (de)	1996-05-20	2003-12-10	Janssen Pharmaceutica N.V.	Fungizide mittel mit verbesserter bioverfügbarkeit
CZ295502B6 (cs)	1997-03-26	2005-08-17	Janssen Pharmaceutica N. V.	Antifungální peleta, způsob její přípravy a farmaceutická dávková forma s obsahem těchto pelet
WO1999033792A2 (en)	1997-12-24	1999-07-08	Vertex Pharmaceuticals Incorporated	Prodrugs os aspartyl protease inhibitors
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
WO1999033795A1 (en)	1997-12-24	1999-07-08	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
EE200000386A (et)	1997-12-24	2001-12-17	Vertex Pharmaceuticals Incorporated	Aspartüülproteaasi inhibiitorite eelravimid
WO1999067254A2 (en)	1998-06-23	1999-12-29	The United States Of America Represented By The Secretary, Department Of Health And Human Services	Multi-drug resistant retroviral protease inhibitors and use thereof
EP2336134B1 (de) *	1998-06-23	2016-08-31	The United States of America, represented by the Secretary, Department of Health and Human Services	Fitnesstest und Verfahren zur Verminderung von HIV-Resistenz gegen Therapie
KR100792391B1 (ko)	1999-10-06	2008-01-08	티보텍 파마슈티칼즈 리미티드	레트로바이러스 프로테아제 저해제로서의헥사하이드로푸로[2,3-ｂ]푸란-3-일-Ｎ-[3-[(1,3-벤조디옥솔-5-일설포닐)(이소부틸)아미노]-1-벤질-2-하이드록시프로필]카바메이트
US7244752B2 (en) *	2001-04-09	2007-07-17	Tibotec Pharmaceuticals Ltd.	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors
AU2003238074B2 (en) *	2002-05-17	2009-04-30	Tibotec Pharmaceuticals Ltd.	Broadspectrum substituted benzisoxazole sulfonamide HIV protease inhibitors

2003
- 2003-05-16 AU AU2003238074A patent/AU2003238074B2/en not_active Ceased
- 2003-05-16 DK DK03735707T patent/DK1517899T3/da active
- 2003-05-16 PL PL03373425A patent/PL373425A1/xx unknown
- 2003-05-16 TW TW092113367A patent/TWI356700B/zh not_active IP Right Cessation
- 2003-05-16 CN CN03816458A patent/CN100582097C/zh not_active Expired - Fee Related
- 2003-05-16 AT AT03735707T patent/ATE371652T1/de active
- 2003-05-16 EA EA200401524A patent/EA010908B1/ru not_active IP Right Cessation
- 2003-05-16 US US10/514,539 patent/US7462636B2/en not_active Expired - Fee Related
- 2003-05-16 CA CA2485903A patent/CA2485903C/en not_active Expired - Fee Related
- 2003-05-16 AR ARP030101725A patent/AR039887A1/es active IP Right Grant
- 2003-05-16 SI SI200331012T patent/SI1517899T1/sl unknown
- 2003-05-16 KR KR1020107025714A patent/KR20100130234A/ko not_active Application Discontinuation
- 2003-05-16 DE DE60315984T patent/DE60315984T2/de not_active Expired - Lifetime
- 2003-05-16 AP AP2004003190A patent/AP2004003190A0/xx unknown
- 2003-05-16 MY MYPI20031819A patent/MY135226A/en unknown
- 2003-05-16 KR KR1020047018261A patent/KR101019648B1/ko not_active IP Right Cessation
- 2003-05-16 MX MXPA04011466A patent/MXPA04011466A/es active IP Right Grant
- 2003-05-16 EP EP03735707A patent/EP1517899B1/de not_active Expired - Lifetime
- 2003-05-16 WO PCT/EP2003/050173 patent/WO2003097616A1/en active IP Right Grant
- 2003-05-16 PT PT03735707T patent/PT1517899E/pt unknown
- 2003-05-16 ES ES03735707T patent/ES2292976T3/es not_active Expired - Lifetime
- 2003-05-16 IL IL16504303A patent/IL165043A0/xx not_active IP Right Cessation
- 2003-05-16 NZ NZ536496A patent/NZ536496A/en not_active IP Right Cessation
- 2003-05-16 BR BR0310089-8A patent/BR0310089A/pt not_active IP Right Cessation
- 2003-05-16 JP JP2004505349A patent/JP4674084B2/ja not_active Expired - Fee Related
2004
- 2004-12-14 NO NO20045444A patent/NO330184B1/no not_active IP Right Cessation
- 2004-12-15 ZA ZA2004/10156A patent/ZA200410156B/en unknown
2005
- 2005-06-29 HR HRP20050607AA patent/HRP20050607B1/hr not_active IP Right Cessation
- 2005-09-14 HK HK05108052A patent/HK1076099A1/xx not_active IP Right Cessation
2007
- 2007-11-29 CY CY20071101524T patent/CY1107040T1/el unknown
2010
- 2010-10-25 JP JP2010238833A patent/JP2011051999A/ja active Pending

Also Published As

Publication number	Publication date
NO20045444L (no)	2005-02-16
TW200404538A (en)	2004-04-01
JP2005527607A (ja)	2005-09-15
DK1517899T3 (da)	2007-12-03
EA200401524A1 (ru)	2005-06-30
PT1517899E (pt)	2007-11-16
CN1668605A (zh)	2005-09-14
HK1076099A1 (en)	2006-01-06
EP1517899A1 (de)	2005-03-30
AU2003238074A1 (en)	2003-12-02
ATE371652T1 (de)	2007-09-15
WO2003097616A1 (en)	2003-11-27
KR20050013549A (ko)	2005-02-04
KR20100130234A (ko)	2010-12-10
HRP20050607A2 (en)	2006-02-28
CA2485903C (en)	2011-08-16
AP2004003190A0 (en)	2004-12-31
NZ536496A (en)	2006-06-30
CY1107040T1 (el)	2012-09-26
DE60315984T2 (de)	2008-05-29
US7462636B2 (en)	2008-12-09
ZA200410156B (en)	2005-11-30
MY135226A (en)	2008-02-29
HRP20050607B1 (hr)	2014-07-04
AU2003238074B2 (en)	2009-04-30
JP4674084B2 (ja)	2011-04-20
KR101019648B1 (ko)	2011-03-07
TWI356700B (en)	2012-01-21
NO330184B1 (no)	2011-02-28
EA010908B1 (ru)	2008-12-30
BR0310089A (pt)	2005-02-15
EP1517899B1 (de)	2007-08-29
PL373425A1 (en)	2005-08-22
CN100582097C (zh)	2010-01-20
ES2292976T3 (es)	2008-03-16
AR039887A1 (es)	2005-03-09
IL165043A0 (en)	2005-12-18
SI1517899T1 (sl)	2008-02-29
US20050171173A1 (en)	2005-08-04
CA2485903A1 (en)	2003-11-27
JP2011051999A (ja)	2011-03-17
MXPA04011466A (es)	2005-02-14

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ATE390423T1 (de)	2008-04-15	Benzoazolylpiperazinderivate mit vr1- antagonistischer wirkung
NO20044046L (no)	2004-11-15	Substituerte hydroksyetylaminer
DE60326590D1 (de)	2009-04-23	Tend lamotrigin
ATE349458T1 (de)	2007-01-15	Etonogestrelester
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ATE496887T1 (de)	2011-02-15	Substituierte 5-aminomethyl-1h-pyrrol-2-carbons ureamide
ATE446750T1 (de)	2009-11-15	3-cyano-chinolin-derivate mit antiproliferativer wirkung
DE60315984D1 (de)	2007-10-11	Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung
DE602004027792D1 (de)	2010-08-05	Indazolamide mit analgetischer wirkung
DK1633719T3 (da)	2010-01-04	Substituerede spirobenzazepiner
ATA4142004A (de)	2005-12-15	Trägerverbau
DE502004009935D1 (de)	2009-10-01	Substituierte dihydrochinazoline ii
DE602004017199D1 (de)	2008-11-27	Silikonverbindungen mit mikrobizider wirkung
DE50311770D1 (de)	2009-09-17	Oberfräse
DE60330246D1 (de)	2010-01-07	Geschenkverpackung
ATA19152002A (de)	2004-11-15	Hubkupplung
SE0202927D0 (sv)	2002-10-03	Spridare
ATE396192T1 (de)	2008-06-15	N-sulfonylaminothiazole
IS2316B (is)	2007-11-15	Stöðugt rotvarnarefni
DE50306228D1 (de)	2007-02-15	Substituierte benzdioxepine
AT5889U3 (de)	2003-04-25	Brennholzspleisser
ATA16872002A (de)	2005-06-15	Zwischenstück

Legal Events

Date	Code	Title	Description
2008-09-18	8364	No opposition during term of opposition