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DE602005009166D1 - Herstellung von 6-substituierten pyridoindolon-derivaten und ihre therapeutische verwendung - Google Patents

Herstellung von 6-substituierten pyridoindolon-derivaten und ihre therapeutische verwendung

Info

Publication number
DE602005009166D1
DE602005009166D1 DE602005009166T DE602005009166T DE602005009166D1 DE 602005009166 D1 DE602005009166 D1 DE 602005009166D1 DE 602005009166 T DE602005009166 T DE 602005009166T DE 602005009166 T DE602005009166 T DE 602005009166T DE 602005009166 D1 DE602005009166 D1 DE 602005009166D1
Authority
DE
Germany
Prior art keywords
pyridoxindoline
derivatives
substituted
preparation
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005009166T
Other languages
English (en)
Inventor
Bernard Bourrie
Pierre Casellas
Paola Ciapetti
Jean Marie Derocq
Samir Jegham
Yvette Muneaux
Camille-George Wermuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of DE602005009166D1 publication Critical patent/DE602005009166D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
DE602005009166T 2004-04-21 2005-04-20 Herstellung von 6-substituierten pyridoindolon-derivaten und ihre therapeutische verwendung Active DE602005009166D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0404251A FR2869316B1 (fr) 2004-04-21 2004-04-21 Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique.
PCT/FR2005/000971 WO2005108398A1 (fr) 2004-04-21 2005-04-20 Derives de pyridoindolone substitues en -6, leur preparation, leur application en therapeutique.

Publications (1)

Publication Number Publication Date
DE602005009166D1 true DE602005009166D1 (de) 2008-10-02

Family

ID=34945552

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005009166T Active DE602005009166D1 (de) 2004-04-21 2005-04-20 Herstellung von 6-substituierten pyridoindolon-derivaten und ihre therapeutische verwendung

Country Status (31)

Country Link
US (1) US7812165B2 (de)
EP (1) EP1742947B1 (de)
JP (1) JP4809830B2 (de)
KR (1) KR20070002094A (de)
CN (1) CN100537568C (de)
AR (1) AR048932A1 (de)
AT (1) ATE405565T1 (de)
AU (1) AU2005240816A1 (de)
BR (1) BRPI0510060A (de)
CA (1) CA2562561A1 (de)
CR (1) CR8677A (de)
DE (1) DE602005009166D1 (de)
DK (1) DK1742947T3 (de)
EC (1) ECSP066918A (de)
ES (1) ES2313371T3 (de)
FR (1) FR2869316B1 (de)
HK (1) HK1106223A1 (de)
IL (1) IL178444A0 (de)
MA (1) MA28546B1 (de)
MX (1) MXPA06012127A (de)
MY (1) MY137599A (de)
NO (1) NO20065323L (de)
PL (1) PL1742947T3 (de)
PT (1) PT1742947E (de)
RU (1) RU2364595C2 (de)
TN (1) TNSN06337A1 (de)
TW (1) TW200538114A (de)
UA (1) UA85709C2 (de)
UY (1) UY28864A1 (de)
WO (1) WO2005108398A1 (de)
ZA (1) ZA200608646B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823975B1 (fr) 2001-04-27 2003-05-30 Sanofi Synthelabo Nouvelle utilisation de pyridoindolone
US7456193B2 (en) 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2846329B1 (fr) 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique
FR2892416B1 (fr) * 2005-10-20 2008-06-27 Sanofi Aventis Sa Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268772A (en) 1968-03-15 1972-03-29 Glaxo Lab Ltd NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
US4263304A (en) * 1978-06-05 1981-04-21 Sumitomo Chemical Company, Limited 7 H-indolo[2,3-c]isoquinolines
SU833971A1 (ru) 1979-07-10 1981-05-30 Ленинградский Химико-Фармацевтическийинститут Способ получени 3-фенил-2-оксо- - КАРбОлиНОВ
FR2595701B1 (fr) * 1986-03-17 1988-07-01 Sanofi Sa Derives du pyrido-indole, leur application a titre de medicaments et les compositions les renfermant
JPH10501686A (ja) 1994-04-13 1998-02-17 ザ ロックフェラー ユニヴァーシティ 神経系の細胞へのｄｎａのａａｖ仲介送達
DE19502753A1 (de) * 1995-01-23 1996-07-25 Schering Ag Neue 9H-Pyrido[3,4-b]indol-Derivate
FR2765582B1 (fr) 1997-07-03 1999-08-06 Synthelabo Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique
FR2765581B1 (fr) * 1997-07-03 1999-08-06 Synthelabo Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique
CA2326319A1 (en) 1998-04-02 1999-10-14 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole derivatives: crf1 specific ligands
IT1313592B1 (it) 1999-08-03 2002-09-09 Novuspharma Spa Derivati di 1h-pirido 3,4-b indol-1-one.
US20020156016A1 (en) 2001-03-30 2002-10-24 Gerald Minuk Control of cell growth by altering cell membrane potentials
FR2823975B1 (fr) * 2001-04-27 2003-05-30 Sanofi Synthelabo Nouvelle utilisation de pyridoindolone
FR2846329B1 (fr) * 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique
FR2846330B1 (fr) 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par groupe heterocyclique, leur preparation et leur application en therapeutique
US7456193B2 (en) * 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2892416B1 (fr) 2005-10-20 2008-06-27 Sanofi Aventis Sa Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
HK1106223A1 (en) 2008-03-07
CR8677A (es) 2007-08-28
CN100537568C (zh) 2009-09-09
TNSN06337A1 (en) 2008-02-22
PT1742947E (pt) 2008-11-25
ES2313371T3 (es) 2009-03-01
TW200538114A (en) 2005-12-01
RU2364595C2 (ru) 2009-08-20
JP4809830B2 (ja) 2011-11-09
WO2005108398A1 (fr) 2005-11-17
NO20065323L (no) 2006-12-08
EP1742947A1 (de) 2007-01-17
ATE405565T1 (de) 2008-09-15
KR20070002094A (ko) 2007-01-04
RU2006140998A (ru) 2008-05-27
UY28864A1 (es) 2005-11-30
FR2869316B1 (fr) 2006-06-02
CN1956986A (zh) 2007-05-02
EP1742947B1 (de) 2008-08-20
MA28546B1 (fr) 2007-04-03
US20070129365A1 (en) 2007-06-07
AR048932A1 (es) 2006-06-14
FR2869316A1 (fr) 2005-10-28
CA2562561A1 (fr) 2005-11-17
JP2007533710A (ja) 2007-11-22
US7812165B2 (en) 2010-10-12
UA85709C2 (ru) 2009-02-25
PL1742947T3 (pl) 2009-01-30
DK1742947T3 (da) 2009-01-05
AU2005240816A1 (en) 2005-11-17
BRPI0510060A (pt) 2007-10-16
MY137599A (en) 2009-02-27
IL178444A0 (en) 2007-02-11
ECSP066918A (es) 2007-01-26
ZA200608646B (en) 2008-02-27
MXPA06012127A (es) 2007-01-31

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