DE602004009036D1 - Verbessertes verfahren zum nachweis von proteolytischen enzymen - Google Patents
Verbessertes verfahren zum nachweis von proteolytischen enzymenInfo
- Publication number
- DE602004009036D1 DE602004009036D1 DE602004009036T DE602004009036T DE602004009036D1 DE 602004009036 D1 DE602004009036 D1 DE 602004009036D1 DE 602004009036 T DE602004009036 T DE 602004009036T DE 602004009036 T DE602004009036 T DE 602004009036T DE 602004009036 D1 DE602004009036 D1 DE 602004009036D1
- Authority
- DE
- Germany
- Prior art keywords
- detection
- improved method
- proteolytic enzymes
- modified pro
- caspases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 3
- 102000035195 Peptidases Human genes 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 title 1
- 102000011727 Caspases Human genes 0.000 abstract 4
- 108010076667 Caspases Proteins 0.000 abstract 4
- 239000004365 Protease Substances 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03075319 | 2003-01-31 | ||
| EP03075319A EP1443116A1 (de) | 2003-01-31 | 2003-01-31 | Verbessertes Verfahren zum Nachweis von proteolytischen Enzymen |
| PCT/NL2004/000067 WO2004067768A2 (en) | 2003-01-31 | 2004-01-29 | Improved method for the detection of proteolytic enzymes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004009036D1 true DE602004009036D1 (de) | 2007-10-31 |
| DE602004009036T2 DE602004009036T2 (de) | 2008-06-19 |
Family
ID=32605369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004009036T Expired - Lifetime DE602004009036T2 (de) | 2003-01-31 | 2004-01-29 | Verbessertes verfahren zum nachweis von proteolytischen enzymen |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7361485B2 (de) |
| EP (2) | EP1443116A1 (de) |
| JP (1) | JP4708326B2 (de) |
| AT (1) | ATE373723T1 (de) |
| DE (1) | DE602004009036T2 (de) |
| WO (1) | WO2004067768A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1828775T3 (da) * | 2004-12-23 | 2009-11-30 | Tno | Fremgangsmåder til funktionel eftervisning af mannan-bindende lectinassocierede serinproteaser (MASP) og komplekser heraf |
| WO2007091881A2 (en) * | 2005-04-29 | 2007-08-16 | Leiden University Medical Center | Methods and means for detection of mycobacterium leprae infections |
| AU2012228407B2 (en) * | 2011-03-11 | 2016-10-13 | Merz Pharma Gmbh & Co. Kgaa | Method for the determination of botulinum neurotoxin biological activity |
| US9402876B2 (en) | 2013-11-27 | 2016-08-02 | Industrial Technology Research Institute | Method and pharmaceutical composition for hair growth |
| US20240355418A1 (en) * | 2021-09-02 | 2024-10-24 | University Of Washington | Multiplex, temporally resolved molecular signal recorder and related methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0856665A (ja) * | 1994-07-07 | 1996-03-05 | Nederland Centr Org Toegepast Natuur Onder | タンパク質分解酵素用の基質としての修飾された酵素前駆体 |
| EP0691409B1 (de) * | 1994-07-07 | 2002-10-23 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Modifizierte Proenzyme als Substrate für proteolische Enzyme |
| US6270980B1 (en) * | 1997-06-05 | 2001-08-07 | Idun Pharmaceuticals, Inc. | Rapid methods for identifying modifiers of cellular apoptosis activity |
| US6379950B1 (en) * | 1998-01-09 | 2002-04-30 | Thomas Jefferson University | Recombinant, active caspases and uses thereof |
-
2003
- 2003-01-31 EP EP03075319A patent/EP1443116A1/de not_active Withdrawn
-
2004
- 2004-01-29 US US10/543,735 patent/US7361485B2/en not_active Expired - Lifetime
- 2004-01-29 EP EP04706386A patent/EP1587952B1/de not_active Expired - Lifetime
- 2004-01-29 DE DE602004009036T patent/DE602004009036T2/de not_active Expired - Lifetime
- 2004-01-29 JP JP2006502732A patent/JP4708326B2/ja not_active Expired - Fee Related
- 2004-01-29 WO PCT/NL2004/000067 patent/WO2004067768A2/en active IP Right Grant
- 2004-01-29 AT AT04706386T patent/ATE373723T1/de active
-
2008
- 2008-02-29 US US12/074,132 patent/US20080187945A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1587952B1 (de) | 2007-09-19 |
| WO2004067768A2 (en) | 2004-08-12 |
| US20060240406A1 (en) | 2006-10-26 |
| US20080187945A1 (en) | 2008-08-07 |
| ATE373723T1 (de) | 2007-10-15 |
| JP2006516900A (ja) | 2006-07-13 |
| JP4708326B2 (ja) | 2011-06-22 |
| US7361485B2 (en) | 2008-04-22 |
| EP1587952A2 (de) | 2005-10-26 |
| WO2004067768A3 (en) | 2004-12-02 |
| DE602004009036T2 (de) | 2008-06-19 |
| EP1443116A1 (de) | 2004-08-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE226642T1 (de) | Modifizierte proenzyme als substrate für proteolische enzyme | |
| ATE193330T1 (de) | Reporterenzym-freisetzungstechnologie: verfahren zum nachweis der gegenwart von aspartat-proteasen und anderen aktivitaeten von hydrolytischen enzymen | |
| DE60142691D1 (de) | Verfahren und zusammensetzungen zur isolierung von metastatischen krebszellen und anwendung zur messung des metastatischen potentials eines krebses | |
| ATE510214T1 (de) | Krankheitsdiagnose | |
| ATE431427T1 (de) | Verbessertes verfahren zum nachweis von atp | |
| DE60233142D1 (de) | Verfahren und reagentien zum nachweis von endotoxin | |
| ATE478559T1 (de) | Nachweis von protease und protease-aktivität mithilfe einer einzel-nanosteigerungs-sers-sonde | |
| DE69937835D1 (de) | Antikörper für apoptosemarker und anwendungsverfahren | |
| DE602004026888D1 (de) | Kinase- und phosphatasetests | |
| ATE309264T1 (de) | Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren | |
| DE602005023517D1 (de) | Verfahren zur bestimmung von genotoxizität | |
| ATE491806T1 (de) | Signal-amplifikation mittels synthetischem zymogen | |
| DE602004009036D1 (de) | Verbessertes verfahren zum nachweis von proteolytischen enzymen | |
| ATE352038T1 (de) | Kit und verfahren zum nachweis von fäkalen parasiten | |
| DE60315992D1 (de) | Überwachung von zellen | |
| DE60310012D1 (de) | Verfahren, Assay und Kit zur Quantifizierung von HIV-Proteasehemmer | |
| ATE307142T1 (de) | Zweifarbiges fluorimetrisches proteaseassay | |
| DE60236996D1 (de) | Kulturmedium zum nachweis von bakterien der gattung listeria | |
| ATE288081T1 (de) | Verfahren zum selektieren von inhibitoren für enzyme | |
| DE60331414D1 (de) | Aggrecanase-1- und -2-peptidsubstrate und verfahren | |
| DE60118350D1 (de) | Fluoreszenz-verfahren zum nachweis von proteasen oder peptidasen | |
| WO2005110459A3 (en) | Method of inducing immunity against stratum corneum chymotrytic enzyme | |
| ATE210733T1 (de) | Verfahren zum diagnostischen nachweis von apoptose in zellen | |
| WO2003099846A3 (en) | System and method for screening for protease inhibitors and proteases | |
| EP1282694A4 (de) | AMINOSäUREDERIVATE SULFAMID UND BIS-SULFAMID ALS HEMMSTOFFE PROTEOLYTISCHER ENZYME |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |