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DE60004504D1 - Tetrahydropyranderivate und deren verwendung als therapeutische mittel - Google Patents

Tetrahydropyranderivate und deren verwendung als therapeutische mittel

Info

Publication number
DE60004504D1
DE60004504D1 DE60004504T DE60004504T DE60004504D1 DE 60004504 D1 DE60004504 D1 DE 60004504D1 DE 60004504 T DE60004504 T DE 60004504T DE 60004504 T DE60004504 T DE 60004504T DE 60004504 D1 DE60004504 D1 DE 60004504D1
Authority
DE
Germany
Prior art keywords
tetrahydropyranderivate
therapeutic agents
compounds
emesis
migraine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60004504T
Other languages
English (en)
Other versions
DE60004504T2 (de
Inventor
Neil Owen
Mary Seward
John Swain
John Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9906480.0A external-priority patent/GB9906480D0/en
Priority claimed from GBGB9924616.7A external-priority patent/GB9924616D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of DE60004504D1 publication Critical patent/DE60004504D1/de
Publication of DE60004504T2 publication Critical patent/DE60004504T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE60004504T 1999-03-19 2000-03-16 Tetrahydropyranderivate und deren verwendung als therapeutische mittel Expired - Fee Related DE60004504T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9906480 1999-03-19
GBGB9906480.0A GB9906480D0 (en) 1999-03-19 1999-03-19 Therapeutic agents
GB9924616 1999-10-18
GBGB9924616.7A GB9924616D0 (en) 1999-10-18 1999-10-18 Therapeutic agents
PCT/GB2000/000974 WO2000056727A1 (en) 1999-03-19 2000-03-16 Tetrahydropyran derivatives and their use as therapeutic agents

Publications (2)

Publication Number Publication Date
DE60004504D1 true DE60004504D1 (de) 2003-09-18
DE60004504T2 DE60004504T2 (de) 2004-06-24

Family

ID=26315315

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60004504T Expired - Fee Related DE60004504T2 (de) 1999-03-19 2000-03-16 Tetrahydropyranderivate und deren verwendung als therapeutische mittel

Country Status (23)

Country Link
US (1) US6458830B1 (de)
EP (1) EP1165540B1 (de)
JP (1) JP2002540107A (de)
KR (1) KR20010113773A (de)
CN (1) CN1344264A (de)
AT (1) ATE247096T1 (de)
AU (2) AU746251B2 (de)
BG (1) BG105859A (de)
BR (1) BR0009127A (de)
CA (1) CA2367985A1 (de)
CO (1) CO5150225A1 (de)
CZ (1) CZ20013377A3 (de)
DE (1) DE60004504T2 (de)
EA (1) EA200100902A1 (de)
EE (1) EE200100491A (de)
ES (1) ES2203434T3 (de)
HU (1) HUP0200441A3 (de)
IL (1) IL144236A0 (de)
NO (1) NO20014529L (de)
PE (1) PE20001556A1 (de)
PL (1) PL350123A1 (de)
SK (1) SK13322001A3 (de)
WO (2) WO2000056727A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10001785A1 (de) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms
GB0017256D0 (en) 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0020721D0 (en) 2000-08-22 2000-10-11 Merck Sharp & Dohme Therapeutic agents
PE20020444A1 (es) 2000-09-22 2002-06-14 Merck & Co Inc Antagonistas de receptores de taquiquinina zwitterionica
US6906085B2 (en) 2001-01-17 2005-06-14 Merck Sharp & Dohme Ltd. Tetrahydropyran derivatives as neurokinin receptor antagonists
GB0121874D0 (en) 2001-09-10 2001-10-31 Merck Sharp & Dohme Therapeutic agents
GB0217068D0 (en) * 2002-07-23 2002-08-28 Merck Sharp & Dohme Therapeutic agents
WO2004037843A2 (en) * 2002-10-25 2004-05-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
US20060166894A1 (en) * 2002-11-29 2006-07-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ace-inhibitors having antioxidant and no-donor activity
AU2004218228A1 (en) * 2003-03-07 2004-09-16 Merck Sharp & Dohme Limited Tetrahydropyran compounds as tachykinin antagonists
WO2006027345A2 (en) 2004-09-08 2006-03-16 Altana Pharma Ag Novel 3-thia-10-aza-phenanthrene derivatives
AU2005310229A1 (en) * 2004-11-30 2006-06-08 Mallinckrodt Inc. Crystallization method for benzphetamine
RU2382781C2 (ru) * 2005-04-22 2010-02-27 Дайити Санкио Компани, Лимитед Гетероциклическое соединение
CN100395242C (zh) * 2006-06-08 2008-06-18 华东理工大学 烷氧基萘和萘醌类吡喃碳糖苷化合物及其制备方法
DE102007010077B4 (de) * 2007-02-28 2010-04-08 RUHR-UNIVERSITäT BOCHUM [1,3]-Dioxane zur Modulation von GABAa-Rezeptoren
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
WO2014039504A1 (en) * 2012-09-04 2014-03-13 Lauren Sciences Llc Bolaamphiphilic compounds, compositions and uses thereof
JP2017525753A (ja) 2014-06-06 2017-09-07 フレクサス・バイオサイエンシーズ・インコーポレイテッドＦｌｅｘｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 免疫調節剤
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
US11242319B2 (en) 2014-11-05 2022-02-08 Flexus Biosciences, Inc. Immunoregulatory agents
AR102537A1 (es) 2014-11-05 2017-03-08 Flexus Biosciences Inc Agentes inmunomoduladores
HU231150B1 (hu) 2017-03-13 2021-03-29 Richter Gedeon Nyrt Eljárás racém 3-alkilpiperidin-3-karbonsav-etil-észterek optikai izomerjeinek elválasztására
US11440896B2 (en) * 2018-02-06 2022-09-13 Daiichi Sankyo Company, Limited Aminoalkyl compound
EP4371613A3 (de) 2018-02-26 2024-07-24 Ospedale San Raffaele S.r.l. Verbindungen zur verwendung bei der behandlung von augenschmerzen
EP4117673A1 (de) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Behandlung von stammzellenmangel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301920D0 (en) * 1993-02-01 1993-03-17 Foundation For Ethnobiology Th Polycetylenes

Also Published As

Publication number Publication date
PE20001556A1 (es) 2001-01-13
AU3304200A (en) 2000-10-09
NO20014529D0 (no) 2001-09-18
CZ20013377A3 (cs) 2002-02-13
EE200100491A (et) 2002-12-16
DE60004504T2 (de) 2004-06-24
IL144236A0 (en) 2002-05-23
ES2203434T3 (es) 2004-04-16
AU746251B2 (en) 2002-04-18
SK13322001A3 (sk) 2002-02-05
CO5150225A1 (es) 2002-04-29
WO2000056728A1 (en) 2000-09-28
CA2367985A1 (en) 2000-09-28
WO2000056727A1 (en) 2000-09-28
HUP0200441A2 (hu) 2002-07-29
AU3304400A (en) 2000-10-09
NO20014529L (no) 2001-11-13
EA200100902A1 (ru) 2002-02-28
US6458830B1 (en) 2002-10-01
HUP0200441A3 (en) 2002-09-30
BR0009127A (pt) 2001-12-26
KR20010113773A (ko) 2001-12-28
CN1344264A (zh) 2002-04-10
PL350123A1 (en) 2002-11-04
EP1165540B1 (de) 2003-08-13
JP2002540107A (ja) 2002-11-26
ATE247096T1 (de) 2003-08-15
BG105859A (bg) 2002-04-30
EP1165540A1 (de) 2002-01-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee