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DE3683541D1 - Selektionierte difluorverbindungen. - Google Patents

Selektionierte difluorverbindungen.

Info

Publication number
DE3683541D1
DE3683541D1 DE8686304296T DE3683541T DE3683541D1 DE 3683541 D1 DE3683541 D1 DE 3683541D1 DE 8686304296 T DE8686304296 T DE 8686304296T DE 3683541 T DE3683541 T DE 3683541T DE 3683541 D1 DE3683541 D1 DE 3683541D1
Authority
DE
Germany
Prior art keywords
difluor
compounds
derivatives
difluoroketone
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686304296T
Other languages
English (en)
Inventor
Diane Amy Trainor
Mark Morris Stein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeneca Inc
Original Assignee
ICI Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858514436A external-priority patent/GB8514436D0/en
Priority claimed from GB858514438A external-priority patent/GB8514438D0/en
Priority claimed from GB858514440A external-priority patent/GB8514440D0/en
Application filed by ICI Americas Inc filed Critical ICI Americas Inc
Application granted granted Critical
Publication of DE3683541D1 publication Critical patent/DE3683541D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
DE8686304296T 1985-06-07 1986-06-05 Selektionierte difluorverbindungen. Expired - Fee Related DE3683541D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB858514436A GB8514436D0 (en) 1985-06-07 1985-06-07 Selected difluoro derivatives
GB858514438A GB8514438D0 (en) 1985-06-07 1985-06-07 Selected difluoro ketone dipeptide derivatives
GB858514440A GB8514440D0 (en) 1985-06-07 1985-06-07 Difluoro ketone tripeptide derivatives

Publications (1)

Publication Number Publication Date
DE3683541D1 true DE3683541D1 (de) 1992-03-05

Family

ID=27262698

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686304296T Expired - Fee Related DE3683541D1 (de) 1985-06-07 1986-06-05 Selektionierte difluorverbindungen.

Country Status (16)

Country Link
US (1) US4880780A (de)
EP (1) EP0204571B1 (de)
JP (1) JPH07116159B2 (de)
AT (1) ATE71934T1 (de)
AU (1) AU594683B2 (de)
DE (1) DE3683541D1 (de)
DK (1) DK267686A (de)
ES (4) ES8801305A1 (de)
FI (1) FI86859C (de)
GR (1) GR861488B (de)
HU (1) HU208438B (de)
IE (1) IE59146B1 (de)
IL (1) IL79049A0 (de)
NO (1) NO170585C (de)
NZ (1) NZ216437A (de)
PT (1) PT82724B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
EP0249349B1 (de) * 1986-06-05 1992-10-14 Ici Americas Inc. Difluorketoverbindungen
GB8809316D0 (en) * 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
EP0371179A1 (de) * 1988-10-28 1990-06-06 Merrell Dow Pharmaceuticals Inc. Analoge von Peptidase-Substraten
EP0369391A3 (de) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituierte Amide
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
HU217612B (hu) * 1991-05-23 2000-03-28 Merrel Dow Pharmaceuticals Inc. Eljárás elasztáz és katepszin G inhibitor hatású peptidek előállítására
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5486529A (en) * 1992-04-16 1996-01-23 Zeneca Limited Certain pyridyl ketones for treating diseases involving leukocyte elastase
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
CA2189527C (en) * 1994-06-02 2000-12-19 William A. Metz, Jr. Novel elastase inhibitors
HU221311B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Perfluoroalkyl tripeptides inhibitors of elastase, pharmaceutical compositions comprising thereof and their use
PT762887E (pt) * 1994-06-02 2002-01-30 Merrell Pharma Inc Derivados do enol acetilado como pro-farmacos de inibidores de elastase
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US6673784B1 (en) 1996-03-19 2004-01-06 G. D. Searle & Co. Electrophilic ketones for the treatment of herpesvirus infections
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
UA79749C2 (en) 1996-10-18 2007-07-25 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
SV2003000617A (es) * 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
UY28500A1 (es) 2003-09-05 2005-04-29 Vertex Pharma Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc.
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
JP5436864B2 (ja) 2006-02-27 2014-03-05 バーテックス ファーマシューティカルズ インコーポレイテッド Ｖｘ−９５０を含む共結晶体およびそれを含む医薬組成物
MX2008011868A (es) * 2006-03-16 2008-12-15 Vertex Pharma Inhibidores deuterados de la proteasa de la hepatitis c.
CN101534824A (zh) * 2006-11-17 2009-09-16 艾博特公司 作为化学活素受体拮抗剂的氨基吡咯烷
AU2008219704A1 (en) 2007-02-27 2008-09-04 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
KR20090115970A (ko) 2007-02-27 2009-11-10 버텍스 파마슈티칼스 인코포레이티드 공-결정 및 그를 포함하는 제약 조성물
CL2008002549A1 (es) 2007-08-30 2010-09-03 Vertex Pharma Cocristal que comprende vx-950 y un formador de cocristal seleccionado de acido 3-metoxi-4hidroxibenzoico,acido 2,4-dihidroxibenzoico y acido 2,5-dihidroxibenzoico; metodo de preparacion; composicion farmaceutica que comprende el cocristal, util como agente antiviral en el tratamiento del hcv.
MX2012002605A (es) 2009-08-29 2012-04-02 Abbott Lab Proteinas terapeutico de union a dll4.
MX348312B (es) 2010-03-02 2017-06-06 Abbvie Inc Proteínas terapéuticas de enlace dll4.
MX341579B (es) 2010-08-03 2016-08-25 Abbvie Inc * Inmunoglobulinas de dominio variable doble y usos de las mismas.
BR112015009961B1 (pt) 2012-11-01 2020-10-20 Abbvie Inc. proteína de ligação capaz de se ligar a dll4 e vegf, bem como composição que a compreende como composição que a compreende
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
MX2021015894A (es) * 2019-07-01 2022-02-03 Basf Se Peptidos acetales para estabilizar enzimas.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787249A (fr) 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
US3935280A (en) 1975-01-10 1976-01-27 Aldrich-Boranes, Inc. Reduction of amino acids in the presence of boron trifluoride
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
DE3481913D1 (de) 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives

Also Published As

Publication number Publication date
ES557734A0 (es) 1988-11-16
EP0204571A2 (de) 1986-12-10
FI862434A0 (fi) 1986-06-06
FI862434A (fi) 1986-12-08
IE861513L (en) 1986-12-07
NO862269D0 (no) 1986-06-06
EP0204571B1 (de) 1992-01-22
ES557735A0 (es) 1988-05-01
NZ216437A (en) 1990-06-26
GR861488B (en) 1986-09-05
ES8802321A1 (es) 1988-05-01
AU5845486A (en) 1986-12-18
FI86859C (fi) 1992-10-26
ES8802619A1 (es) 1988-09-01
ES8900051A1 (es) 1988-11-16
HU208438B (en) 1993-10-28
DK267686D0 (da) 1986-06-06
ATE71934T1 (de) 1992-02-15
ES8801305A1 (es) 1987-12-16
EP0204571A3 (en) 1988-09-21
FI86859B (fi) 1992-07-15
NO862269L (no) 1986-12-08
IL79049A0 (en) 1986-09-30
NO170585B (no) 1992-07-27
PT82724B (pt) 1988-12-15
US4880780A (en) 1989-11-14
DK267686A (da) 1986-12-08
ES557733A0 (es) 1988-09-01
AU594683B2 (en) 1990-03-15
IE59146B1 (en) 1994-01-12
HUT40811A (en) 1987-02-27
JPS6253951A (ja) 1987-03-09
JPH07116159B2 (ja) 1995-12-13
ES555826A0 (es) 1987-12-16
PT82724A (en) 1986-07-01
NO170585C (no) 1992-11-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee