CY1116295T1 - Αναστολεις της κινασης τυροσινης toy bruton - Google Patents
Αναστολεις της κινασης τυροσινης toy brutonInfo
- Publication number
- CY1116295T1 CY1116295T1 CY20151100453T CY151100453T CY1116295T1 CY 1116295 T1 CY1116295 T1 CY 1116295T1 CY 20151100453 T CY20151100453 T CY 20151100453T CY 151100453 T CY151100453 T CY 151100453T CY 1116295 T1 CY1116295 T1 CY 1116295T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tyrosine kinase
- disclosed
- bruton
- toy
- suspensions
- Prior art date
Links
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940124291 BTK inhibitor Drugs 0.000 abstract 2
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 abstract 1
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
Γνωστοποιούνται στο παρόν ενώσεις οι οποίες σχηματίζουν ομοιοπολικούς δεσμούς με κινάση τυροσίνης του Bruton (Btk). Επίσης περιγράφονται στο παρόν μη-αντιστρεπτοί αναστολείς της Btk. Μέθοδοι για την παρασκευή των ενώσεων γνωστοποιούνται. Επίσης γνωστοποιούνται φαρμακευτικές συνθέσεις οι οποίες περιλαμβάνουν τις ενώσεις. Μέθοδοι χρήσης των Btk αναστολέων γνωστοποιούνται, μόνων ή σε συνδυασμό με άλλους θεραπευτικούς παράγοντες, για την αντιμετώπιση διαταραχών του πολλαπλασιασμού των Β-κυττάρων.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82672006P | 2006-09-22 | 2006-09-22 | |
US82859006P | 2006-10-06 | 2006-10-06 | |
EP12166301.7A EP2526933B1 (en) | 2006-09-22 | 2006-12-28 | Inhibitors of Bruton's tyrosine kinase |
Publications (1)
Publication Number | Publication Date |
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CY1116295T1 true CY1116295T1 (el) | 2017-02-08 |
Family
ID=39225888
Family Applications (11)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100100T CY1112513T1 (el) | 2006-09-22 | 2012-01-27 | Αναστολεις της κινασης τυροσινης του bruton |
CY2015016C CY2015016I2 (el) | 2006-09-22 | 2015-04-03 | Αναστολεις της κινασης τυροσινης του bruton |
CY20151100453T CY1116295T1 (el) | 2006-09-22 | 2015-05-20 | Αναστολεις της κινασης τυροσινης toy bruton |
CY20161100196T CY1117587T1 (el) | 2006-09-22 | 2016-03-07 | Αναστολεις κινασης τυροσινης bruton |
CY20161100734T CY1117840T1 (el) | 2006-09-22 | 2016-07-26 | Αναστολεις κινασης τυροσινης bruton |
CY20161100765T CY1117897T1 (el) | 2006-09-22 | 2016-08-03 | Αναστολεις κινασης τυροσινης bruton |
CY2016041C CY2016041I1 (el) | 2006-09-22 | 2016-11-15 | Αναστολεις κινασης τυροσινης bruton |
CY20161101348T CY1119209T1 (el) | 2006-09-22 | 2016-12-27 | Αναστολεις κινασης τυροσινης bruton |
CY20171100248T CY1118666T1 (el) | 2006-09-22 | 2017-02-22 | Αναστολεις κινασης τυροσινης bruton |
CY2017012C CY2017012I2 (el) | 2006-09-22 | 2017-03-31 | Αναστολεις κινασης τυροσινης bruton |
CY20181100404T CY1120135T1 (el) | 2006-09-22 | 2018-04-17 | Αναστολεις κινασης τυροσινης bruton |
Family Applications Before (2)
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CY20161100196T CY1117587T1 (el) | 2006-09-22 | 2016-03-07 | Αναστολεις κινασης τυροσινης bruton |
CY20161100734T CY1117840T1 (el) | 2006-09-22 | 2016-07-26 | Αναστολεις κινασης τυροσινης bruton |
CY20161100765T CY1117897T1 (el) | 2006-09-22 | 2016-08-03 | Αναστολεις κινασης τυροσινης bruton |
CY2016041C CY2016041I1 (el) | 2006-09-22 | 2016-11-15 | Αναστολεις κινασης τυροσινης bruton |
CY20161101348T CY1119209T1 (el) | 2006-09-22 | 2016-12-27 | Αναστολεις κινασης τυροσινης bruton |
CY20171100248T CY1118666T1 (el) | 2006-09-22 | 2017-02-22 | Αναστολεις κινασης τυροσινης bruton |
CY2017012C CY2017012I2 (el) | 2006-09-22 | 2017-03-31 | Αναστολεις κινασης τυροσινης bruton |
CY20181100404T CY1120135T1 (el) | 2006-09-22 | 2018-04-17 | Αναστολεις κινασης τυροσινης bruton |
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