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CY1116178T1 - Αναστολεις των lox και loxl2 και χρησεις εξ' αυτων - Google Patents

Αναστολεις των lox και loxl2 και χρησεις εξ' αυτων

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Publication number
CY1116178T1
CY1116178T1 CY20151100310T CY151100310T CY1116178T1 CY 1116178 T1 CY1116178 T1 CY 1116178T1 CY 20151100310 T CY20151100310 T CY 20151100310T CY 151100310 T CY151100310 T CY 151100310T CY 1116178 T1 CY1116178 T1 CY 1116178T1
Authority
CY
Cyprus
Prior art keywords
fibrosis
lox
conditions
loxl
angiogenesis
Prior art date
Application number
CY20151100310T
Other languages
English (en)
Inventor
Victoria Smith
Scott Ogg
Vlasselaer Peter Van
Vivian E Barry
Derek Marshall
Alison Kay Holzer
Hector Rodriguez
Miho Oyasu
Scott Alan Mccauley
Carlos Aurelio Garcia
Donna Hiroko Tokuoka Biermann
Original Assignee
Gilead Biologics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Biologics, Inc. filed Critical Gilead Biologics, Inc.
Publication of CY1116178T1 publication Critical patent/CY1116178T1/el

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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

Η παρούσα αποκάλυψη παρέχει καινοτόμο μεθοδολογία και σχετικές συνθέσεις και κιτ για την πρόληψη και αγωγή διαφόρων παθήσεων που συσχετίζονται με μη-φυσιολογική υπερπλασία κυττάρων, αγγειογένεση και ίνωση, χρησιμοποιώντας έναν αναστολέα των επεξεργασμένων μορφών της οξειδάσης λυσυλίου ή των παρόμοιων με οξειδάση λυσυλίου πρωτεϊνών, αναστολέα του LOX και αναστολέα LOXL, ή συνεργιστικό συνδυασμό αναστολέα από LOX ή LOXL συνδυασμένο με άλλους θεραπευτικούς παράγοντες. Επίσης παρέχονται και καινοτόμες μέθοδοι για την επιλογή παραγόντων που αποτρέπουν ή αναστέλλουν την εισβολή όγκων, την αγγειογένεση και την μετάσταση, φέροντας σε επαφή κύτταρα που είναι σε μια κατάσταση επιθηλιακής-μεσεγχυματικής μετάπτωσης (ΕΜΤ) με υποψήφιο παράγοντα και ανίχνευσης αλλαγής στην κατάσταση ΕΜΤ των κυττάρων. Μέθοδοι και σχετικές συνθέσεις και κιτ για την διάγνωση ή επιτήρηση διαφόρων παθήσεων που συσχετίζονται με μη-φυσιολογική υπερπλασία κυττάρων, αγγειογένεση και ίνωση, χρησιμοποιώντας μόρια ή παράγοντες που αναγνωρίζουν συγκεκριμένα επεξεργασμένες μορφές των LOX ή LOXL παρέχονται επίσης. Επίσης παρέχονται εις το παρόν και μέθοδοι και σχετικές συνθέσεις, ιατροτεχνολογικές συσκευές, συστήματα και κιτ για την πρόληψη ή αγωγή διαφόρων παθήσεων και καταστάσεων που συσχετίζονται με ίνωση με τις συνθέσεις που περιλαμβάνουν αναστολείς των LOX ή LOXL. Τέτοιες παθήσεις ή καταστάσεις συμπεριλαμβάνουν παθολογικές καρδιαγγειακές καταστάσεις και παθήσεις όπως είναι η υπέρταση, η υπερτασική πάθηση της καρδιάς, το έμφραγμα του μυοκαρδίου, η αθηροσκλήρυνση, και η επαναστένωση, η ίνωση του ήπατος, η ίνωση των νεφρών, η ίνωση των πνευμόνων, η δερματική ουλοποίηση, ο σχηματισμός
CY20151100310T 2007-08-02 2015-03-30 Αναστολεις των lox και loxl2 και χρησεις εξ' αυτων CY1116178T1 (el)

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US96324807P 2007-08-02 2007-08-02
US96328207P 2007-08-02 2007-08-02
US96321407P 2007-08-02 2007-08-02
US96324907P 2007-08-02 2007-08-02
US96324607P 2007-08-02 2007-08-02
EP08830207.0A EP2185198B1 (en) 2007-08-02 2008-08-01 Lox and l0xl2 inhibitors and uses thereof

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CY1116178T1 true CY1116178T1 (el) 2017-02-08

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CY20131100280T CY1113897T1 (el) 2007-08-02 2013-04-03 Μεθοδοι και συνθεσεις για θεραπεια και διαγνωση ινωσης
CY20151100310T CY1116178T1 (el) 2007-08-02 2015-03-30 Αναστολεις των lox και loxl2 και χρησεις εξ' αυτων

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US (10) US8679485B2 (el)
EP (4) EP2543389A3 (el)
JP (8) JP5312459B2 (el)
CN (6) CN110372795A (el)
AU (4) AU2008282739B2 (el)
CA (2) CA2693208A1 (el)
CY (2) CY1113897T1 (el)
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ES (3) ES2700141T3 (el)
HK (2) HK1143543A1 (el)
HR (2) HRP20130287T1 (el)
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PT (3) PT2185198E (el)
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