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CU24663B1 - Dominio de unión a antígeno anti-trbc1, receptor de antígeno quimérico, anticuerpo y acoplador biespecífico de células t que comprenden el mismo - Google Patents

Dominio de unión a antígeno anti-trbc1, receptor de antígeno quimérico, anticuerpo y acoplador biespecífico de células t que comprenden el mismo

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Publication number
CU24663B1
CU24663B1 CU2019000099A CU20190099A CU24663B1 CU 24663 B1 CU24663 B1 CU 24663B1 CU 2019000099 A CU2019000099 A CU 2019000099A CU 20190099 A CU20190099 A CU 20190099A CU 24663 B1 CU24663 B1 CU 24663B1
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CU
Cuba
Prior art keywords
seq
binding domain
antibody
trbc1
coupler
Prior art date
Application number
CU2019000099A
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English (en)
Other versions
CU20190099A7 (es
Inventor
Shaun Cordoba
Ram Jha
Wen Chean Lim
Shimobi Onuoha
Simon Thomas
Original Assignee
Autolus Ltd
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Publication date
Application filed by Autolus Ltd filed Critical Autolus Ltd
Publication of CU20190099A7 publication Critical patent/CU20190099A7/es
Publication of CU24663B1 publication Critical patent/CU24663B1/es

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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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Abstract

<p>La presente invención proporciona un dominio de unión a antígeno anti-TRBC1 el cual comprende:</p> <p>a) un dominio VH que tienen una secuencia de aminoácidos de SEQ ID No. 9, que comprende una HCDR1 de SEQ ID No: 37 (GYVMH), una HCDR2 de SEQ ID No: 38 (FINPYNDDIQSNERFRG) y una HCDR3 de SEQ ID No: 39 (GAGYNFDGAYRFFDF); y un dominio VL que tiene una secuencia de aminoácidos de SEQ ID No. 19, que comprende una HCDR1 de SEQ ID No: 40 (RSSQRLVHSNGNTYLH), una HCDR2 de SEQ ID No: 41 (RVSNRFP) y una HCDR3 de SEQ ID No: 42 (SQSTHVPYT); o</p> <p>b) un dominio VH que tiene una secuencia de aminoácidos de SEQ ID No. 13, que comprende una HCDR1 de SEQ ID No: 37 (GYVMH), una HCDR2 de SEQ ID No: 38 (FINPYNDDIQSNERFRG) y una HCDR3 de SEQ ID No: 39 (GAGYNFDGAYRFFDF); y un dominio VL que tiene una secuencia de aminoácidos de SEQ ID No. 19, que comprende una HCDR1 de SEQ ID No: 40 (RSSQRLVHSNGNTYLH), una HCDR2 de SEQ ID No: 41 (RVSNRFP) y una HCDR3 de SEQ ID No: 42 (SQSTHVPYT)</p> <p>La presente invención también proporciona un receptor de antígeno quimérico, un anticuerpo, y un acoplador biespecífico de células T que comprende a dicho dominio de unión a antígeno anti-TRBC1.</p>
CU2019000099A 2017-06-09 2018-06-08 Dominio de unión a antígeno anti-trbc1, receptor de antígeno quimérico, anticuerpo y acoplador biespecífico de células t que comprenden el mismo CU24663B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1709203.2A GB201709203D0 (en) 2017-06-09 2017-06-09 Antigen-binding domain
PCT/GB2018/051570 WO2018224844A1 (en) 2017-06-09 2018-06-08 Anti trbc1 antigen binding domains

Publications (2)

Publication Number Publication Date
CU20190099A7 CU20190099A7 (es) 2020-10-20
CU24663B1 true CU24663B1 (es) 2023-05-11

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US (3) US11440961B2 (es)
EP (1) EP3635006A1 (es)
JP (2) JP7177794B2 (es)
KR (1) KR20200015713A (es)
CN (2) CN110741018B (es)
AU (1) AU2018282038A1 (es)
BR (1) BR112019025990A2 (es)
CA (1) CA3065006A1 (es)
CL (1) CL2019003536A1 (es)
CO (1) CO2019013614A2 (es)
CU (1) CU24663B1 (es)
GB (1) GB201709203D0 (es)
IL (1) IL270731B2 (es)
MX (1) MX2019013387A (es)
PE (1) PE20191717A1 (es)
PH (1) PH12019502785A1 (es)
WO (1) WO2018224844A1 (es)
ZA (1) ZA201907524B (es)

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US11982672B2 (en) 2014-03-05 2024-05-14 Autolus Limited Methods
US11385233B2 (en) 2015-03-05 2022-07-12 Autolus Limited Methods of depleting malignant T-cells
GB201709203D0 (en) * 2017-06-09 2017-07-26 Autolus Ltd Antigen-binding domain
GB201800298D0 (en) 2018-01-09 2018-02-21 Autolus Ltd Method
GB201817172D0 (en) 2018-10-22 2018-12-05 Autolus Ltd Antibody
US20220041718A1 (en) * 2018-10-31 2022-02-10 Autolus Limited Binding domain
EP3927744A1 (en) * 2019-02-21 2021-12-29 Marengo Therapeutics, Inc. Multifunctional molecules that bind to t cell related cancer cells and uses thereof
WO2021188454A1 (en) * 2020-03-16 2021-09-23 Marengo Therapeutics, Inc. Engineered cell compositions and methods of use thereof
GB202004263D0 (en) * 2020-03-24 2020-05-06 Autolus Ltd Antibody conjugate
GB202005216D0 (en) 2020-04-08 2020-05-20 Autolus Ltd Cell
JP2021175722A (ja) 2020-04-22 2021-11-04 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
KR20230028242A (ko) * 2020-04-24 2023-02-28 마렝고 테라퓨틱스, 인크. T 세포 관련 암 세포에 결합하는 다중기능성 분자 및 그것의 용도
JP2022008152A (ja) 2020-06-25 2022-01-13 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
JP2022013736A (ja) 2020-07-01 2022-01-18 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
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