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CO5720998A2 - Antranilamidopirimidinas que inhiben vegfr-2 y vegfr-3 - Google Patents

Antranilamidopirimidinas que inhiben vegfr-2 y vegfr-3

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Publication number
CO5720998A2
CO5720998A2 CO05017954A CO05017954A CO5720998A2 CO 5720998 A2 CO5720998 A2 CO 5720998A2 CO 05017954 A CO05017954 A CO 05017954A CO 05017954 A CO05017954 A CO 05017954A CO 5720998 A2 CO5720998 A2 CO 5720998A2
Authority
CO
Colombia
Prior art keywords
alkyl
halo
group
so2r6
cycloalkyl
Prior art date
Application number
CO05017954A
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English (en)
Inventor
Andreas Huth
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10235690A external-priority patent/DE10235690A1/de
Priority claimed from DE10328036A external-priority patent/DE10328036A1/de
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of CO5720998A2 publication Critical patent/CO5720998A2/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

1.- Compuestos de la formula general I donde X es CH o N,W es hidrogeno o fl·or,A, B, D,E y Q son en cada caso, independientemente entre si, un atomo de nitrogeno o carbono, no pudiendo haber en el anillo mas de un maximo de dos atomos de nitrogeno, R1 es arilo o heteroarilo, el que puede estar mono- o polisustituido, en forma igual o diferente con halogeno, hidroxi, alquilo-C1-C12, cicloalquilo-C3-C6, alquenilo-C3-C6, alquinilo-C2-C6, aralquiloxi, alcoxi-C1-C12, halo-alquilo-C1-C6, ciano-alquilo-C1-C6 o con el grupo =0, -SO2R6 o -OR5, con lo cual alquilo-C1-C6 también puede estar sustituido por el grupo -OR5 o -NR9R10,Y y Z son, en cada caso, independientemente entre si, una union o el grupo =CO, =CS o =SO2, R2 y R3 son, independientemente entre si, hidrogeno o el grupo -CONR9R10, -SO2R6, -COR11, -CO-alquilo-C1-C6, -CO-alquilo-C1-C6-R11, NR9R10 o son alquilo-C1-C6, cicloalquilo-C3-C10, cicloalquenilo-C3-C6, arilo o heteroarilo que puede ser mono o polisustituido de manera igual o diferente con halogeno, ciano, C1-C12-alquilo-, C1-C12-alcoxi-, hidroxi-C1-C6-alquilo, halo-alquilo-C1-C6 o con el grupo -NR7R8, -OR5, alquilo-C1-C6-OR5, -SR4, -SOR4 o -SO2R6, R2, R3, yy Z forman junto con el atomo de nitrogeno, un anillo de 3-8 miembros, saturado o no saturado que puede contener otros heteroatomos en el anillo y puede ostar mono- o polisustituido de manera igual o diferente con halogeno, ciano, alquilo-C1-C12, alcoxi -C1-C12, halo-alquilo-C1-C6, hidroxi-alquilo-C1-C6 o con el grupo =0, -OR5, -SR4, -SOR4 o -SO2R6,R4 es alquilo-C1-C12, arilo o heteroarilo,R5 es hidrogeno, alquilo-C1-C12, cicloalquilo-C3-C10, alcoxi-C1-C12, halo-alquilo-C1-C12 o halo-cicloalquilo-C3-C6, R6 es hidrogeno, alquilo-C1-C12, halo-alquilo-C1-C12, ...
CO05017954A 2002-07-31 2005-02-25 Antranilamidopirimidinas que inhiben vegfr-2 y vegfr-3 CO5720998A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10235690A DE10235690A1 (de) 2002-07-31 2002-07-31 VEGFR-2 und VEGFR-3 inhibitorische Anthranylamidpyridinamide
DE10328036A DE10328036A1 (de) 2003-06-19 2003-06-19 VEGFR-2 und VEGFR-3 inhibitorische Anthranylamidpyridine

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CO5720998A2 true CO5720998A2 (es) 2007-01-31

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KR (1) KR20050026535A (es)
CN (1) CN1671666A (es)
AU (1) AU2003281855A1 (es)
BR (1) BR0313122A (es)
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HR (1) HRP20050187A2 (es)
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RS (1) RS20050084A (es)
RU (1) RU2005105683A (es)
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Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7615565B2 (en) 2002-07-31 2009-11-10 Bayer Schering Pharma Aktiengesellschaft VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
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KR20050100615A (ko) 2003-01-14 2005-10-19 싸이토키네틱스, 인코포레이티드 화합물, 조성물 및 방법
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