CO5650252A2 - Inhibidores de quinesina mitotica - Google Patents
Inhibidores de quinesina mitoticaInfo
- Publication number
- CO5650252A2 CO5650252A2 CO06013574A CO06013574A CO5650252A2 CO 5650252 A2 CO5650252 A2 CO 5650252A2 CO 06013574 A CO06013574 A CO 06013574A CO 06013574 A CO06013574 A CO 06013574A CO 5650252 A2 CO5650252 A2 CO 5650252A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- alkynyl
- cycloalkyl
- alkenyl
- quinesine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Structural Engineering (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
1.- Un compuesto de fórmula I: o una sal o estereoisómero farmacéuticamente aceptable del mismo,en la que: a es 0 ó 1; b es 0 ó 1; m es 0, 1, ó 2; n es 0, 1, 2 ó 3; r es 0 ó 1 ; s es 0 ó 1; t es 0, 1 ó 2;R1 y R2 se seleccionan independientemente de: H, alquilo C1-C6, arilo, heterociclilo y cicloalquilo C3-C6, opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados de R7; R3 se selecciona de:1) hidrógeno;2) alquilo C1-C10;3) alquil C1-C10-O-Rd,4) alquenil C2-C10-O-Rd, 5) alquinil C2-C10-O-Rd, 6) (alquilen C1-C6)n-cicloalquil C3-C8-O-Rd,7) alquil C1-C10-(C=O)b-NRCRCAND#39, 8) alquenil C2-C10-(C=O)bNRCRCAND#39, 9) alquinil C2-C10-(C=O)bNRCRCAND#39, 10) (alquilen C1-C6)n-cicloalquil C3-C8-(C=O)bNRCRCAND#39, 11) alquil C1-C10-S(O)m-Rd, 12) alquenil C2-C10-S(O)m-Rd, 13) alquinil C2-C10-S(O)m-Rd, 14) (alquilen C1-C6)n-cicloalquil C3-C8-S(O)m-Rd, estando opcionalmente sustituidos dichos alquilo, alquenilo, alquinilo y cicloalquilo con uno o más sustituyentes seleccionados de R6;R4 se selecciona independientemente de:1) (C=O)aOb-alquilo C1-C10, 2) (C=O)aObarilo, 3) CO2H, 4) halo, ...
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49563703P | 2003-08-15 | 2003-08-15 | |
US51268003P | 2003-10-20 | 2003-10-20 | |
US56358604P | 2004-04-19 | 2004-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5650252A2 true CO5650252A2 (es) | 2006-06-30 |
Family
ID=34222358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO06013574A CO5650252A2 (es) | 2003-08-15 | 2006-02-10 | Inhibidores de quinesina mitotica |
Country Status (13)
Country | Link |
---|---|
US (1) | US20050038074A1 (es) |
KR (1) | KR20060058716A (es) |
AR (1) | AR045342A1 (es) |
BR (1) | BRPI0413580A (es) |
CO (1) | CO5650252A2 (es) |
EC (1) | ECSP066362A (es) |
IL (1) | IL173513A0 (es) |
IS (1) | IS8276A (es) |
MA (1) | MA27986A1 (es) |
NO (1) | NO20061194L (es) |
PE (1) | PE20050730A1 (es) |
TW (1) | TW200510380A (es) |
WO (1) | WO2005019205A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003276005B2 (en) | 2002-06-14 | 2009-01-15 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
CN100421665C (zh) | 2002-06-14 | 2008-10-01 | 麦克公司 | 有丝分裂驱动蛋白抑制剂 |
CA2534729A1 (en) | 2003-08-15 | 2005-02-24 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
SI1664026T1 (sl) * | 2003-08-15 | 2009-04-30 | Merck & Co Inc | Inhibitorji mitotiäśnega kinezina |
CN1835756A (zh) | 2003-08-15 | 2006-09-20 | 默克公司 | 有丝分裂驱动蛋白抑制剂 |
JP2007533762A (ja) * | 2004-04-19 | 2007-11-22 | メルク エンド カムパニー インコーポレーテッド | 2,2−二置換ピロールの調製方法 |
EP1888050B1 (en) | 2005-05-17 | 2012-03-21 | Merck Sharp & Dohme Ltd. | cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer |
EP2001880A2 (en) * | 2006-03-07 | 2008-12-17 | Array Biopharma, Inc. | Heterobicyclic pyrazole compounds and methods of use |
BRPI0818605A2 (pt) | 2007-10-19 | 2015-04-22 | Schering Corp | Derivados de 1,3,4-tiadiazl espiro-condensados para inibir a atividade de ksp cinesima |
EP2413932A4 (en) | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | INHIBITORS OF AKT ACTIVITY |
JP5099731B1 (ja) | 2009-10-14 | 2012-12-19 | メルク・シャープ・アンド・ドーム・コーポレーション | p53活性を増大する置換ピペリジン及びその使用 |
US8999957B2 (en) | 2010-06-24 | 2015-04-07 | Merck Sharp & Dohme Corp. | Heterocyclic compounds as ERK inhibitors |
CN103068980B (zh) | 2010-08-02 | 2017-04-05 | 瑟纳治疗公司 | 使用短干扰核酸(siNA)的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1(CTNNB1)基因表达的抑制 |
WO2012024170A2 (en) | 2010-08-17 | 2012-02-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
DK2632472T3 (en) | 2010-10-29 | 2018-03-19 | Sirna Therapeutics Inc | RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
WO2013063214A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
WO2013165816A2 (en) | 2012-05-02 | 2013-11-07 | Merck Sharp & Dohme Corp. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
WO2014052563A2 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
RU2660349C2 (ru) | 2012-11-28 | 2018-07-05 | Мерк Шарп И Доум Корп. | Композиции и способы для лечения злокачественной опухоли |
EP2935263B1 (en) | 2012-12-20 | 2018-12-05 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
EP2951180B1 (en) | 2013-01-30 | 2018-05-02 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
WO2018071283A1 (en) | 2016-10-12 | 2018-04-19 | Merck Sharp & Dohme Corp. | Kdm5 inhibitors |
MX2019012233A (es) | 2017-04-13 | 2020-01-14 | Aduro Biotech Holdings Europe Bv | Anticuerpos anti-sirpa. |
EP3706747A4 (en) | 2017-11-08 | 2021-08-04 | Merck Sharp & Dohme Corp. | PRMT5 INHIBITORS |
WO2019094311A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
WO2019148412A1 (en) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
EP3833668A4 (en) | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme Corp. | PRMT5 INHIBITORS |
US20230108452A1 (en) | 2019-12-17 | 2023-04-06 | Merck Sharp & Dohme Llc | Prmt5 inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057342A (en) * | 1996-08-16 | 2000-05-02 | Dupont Pharmaceutical Co. | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof |
US6440686B1 (en) * | 2000-06-15 | 2002-08-27 | Cytokinetics, Inc. | Methods for screening and therapeutic applications of kinesin modulators |
EP1458726B1 (en) * | 2001-12-06 | 2009-07-15 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
CN100421665C (zh) * | 2002-06-14 | 2008-10-01 | 麦克公司 | 有丝分裂驱动蛋白抑制剂 |
AU2003276005B2 (en) * | 2002-06-14 | 2009-01-15 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
CA2500848A1 (en) * | 2002-10-18 | 2004-05-06 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
-
2004
- 2004-08-06 PE PE2004000762A patent/PE20050730A1/es not_active Application Discontinuation
- 2004-08-06 AR ARP040102815A patent/AR045342A1/es not_active Application Discontinuation
- 2004-08-11 KR KR1020067003087A patent/KR20060058716A/ko not_active Application Discontinuation
- 2004-08-11 BR BRPI0413580-6A patent/BRPI0413580A/pt not_active Application Discontinuation
- 2004-08-11 WO PCT/US2004/025980 patent/WO2005019205A1/en active Application Filing
- 2004-08-11 US US10/916,096 patent/US20050038074A1/en not_active Abandoned
- 2004-08-13 TW TW093124289A patent/TW200510380A/zh unknown
-
2006
- 2006-01-31 IS IS8276A patent/IS8276A/is unknown
- 2006-02-02 IL IL173513A patent/IL173513A0/en unknown
- 2006-02-08 MA MA28785A patent/MA27986A1/fr unknown
- 2006-02-10 CO CO06013574A patent/CO5650252A2/es not_active Application Discontinuation
- 2006-02-13 EC EC2006006362A patent/ECSP066362A/es unknown
- 2006-03-14 NO NO20061194A patent/NO20061194L/no unknown
Also Published As
Publication number | Publication date |
---|---|
IL173513A0 (en) | 2006-07-05 |
AR045342A1 (es) | 2005-10-26 |
KR20060058716A (ko) | 2006-05-30 |
IS8276A (is) | 2006-01-31 |
NO20061194L (no) | 2006-05-05 |
TW200510380A (en) | 2005-03-16 |
US20050038074A1 (en) | 2005-02-17 |
PE20050730A1 (es) | 2005-09-20 |
MA27986A1 (fr) | 2006-07-03 |
ECSP066362A (es) | 2006-10-31 |
WO2005019205A1 (en) | 2005-03-03 |
BRPI0413580A (pt) | 2006-10-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO5650252A2 (es) | Inhibidores de quinesina mitotica | |
RS52397B (en) | PYRIDO / 2,1-A / ISOCHINOLINE DERIVATIVES AS DPP-IV INHIBITORS | |
AR047076A1 (es) | Compuestos de pirrolotriazina como inhibidores de tirosina quinasas, composiciones farmaceuticas | |
MX2009005219A (es) | Inhibidores macrociclicos del virus de hepatitis c. | |
RS51101B (sr) | Inhibitori hcv ns3 proteaze | |
ECSP088150A (es) | Inhibidores macrociclicos del virus de la hepatitis c | |
DE60217186D1 (de) | Dpiv-inhibitoren auf glutaminbasis | |
HK1110868A1 (en) | Heterocyclic compounds as ccr2b antagonists | |
TW200730501A (en) | Heterocyclic derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase I | |
AR061008A1 (es) | Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo | |
AR065810A1 (es) | Derivados de isoindolina 4'-o-sustituidos,composiciones farmaceuticas que los comprenden y usos de los mismos en el tratamiento del cancer y en otros trastornos donde es necesario el control de la angiogenesis o la inhibicion de citoquinas, incluyendo tnf-alfa. | |
ES2476422T3 (es) | Compuestos de piperidina 3,5-sustituida como inhibidores de renina | |
EA200501617A1 (ru) | Новые гетероциклические соединения, применяемые для лечения нарушений аллергической или воспалительной природы: способы синтеза и содержащие их фармацевтические составы | |
HUP0201088A2 (hu) | Új alfa-aminosav-szulfonil-vegyületek, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények | |
HRP20120523T1 (hr) | Inhibitori virusa hepatitisa c | |
MY144718A (en) | Viral polymerase inhibitors. | |
TN2009000012A1 (en) | Amino-piperidine derivatives as cetp inhibitors | |
EA200601830A1 (ru) | Ортозамещённые арильные или гетероарильные амидные соединения | |
BRPI0014526B8 (pt) | compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo | |
PE20080209A1 (es) | Derivados de glicina como inhibidores de prolil hidroxilasa | |
CO6270320A2 (es) | Derivados de piperidina utiles como antagonistas del receptor orexina | |
PE20091573A1 (es) | Derivados heterociclicos de urea como inhibidores de adn girasa y/o topoisomerasa | |
RS52978B (en) | FUSIONED AMINO PIRIDIN AS HSP90 INHIBITORS | |
CO5320599A1 (es) | Inhibidores no peptidilicos de la union a las celulas depen dientes de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias | |
MX2010000658A (es) | Derivados de pirimidina 934. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |