CN220932495U

CN220932495U - Kit integrating convenient sampling and detection

Info

Publication number: CN220932495U
Application number: CN202322725122.4U
Authority: CN
Inventors: 喻冬志; 顾易凡; 顾佳; 王致明; 冯澄宇
Original assignee: Hicomp Microtech Suzhou Co ltd
Current assignee: Hicomp Microtech Suzhou Co ltd
Priority date: 2023-10-11
Filing date: 2023-10-11
Publication date: 2024-05-10
Anticipated expiration: 2033-10-11

Abstract

The utility model relates to the technical field of ophthalmic detection, in particular to a kit integrating convenient sampling and detection, which comprises a shell, a test strip, a sampling area, a reaction area, an indication area and a quality control area; the test strip is fixed in the shell; the sampling area is positioned at one side of the shell and is used for collecting tear samples of a person to be detected; the reaction area is positioned on the test strip and is used for placing a reagent and reacting; the indication area is positioned on the shell and comprises a preset biomarker detection area, the detection area is provided with a plurality of detection reagents aiming at different biomarkers, and after tear is acquired, the biomarkers in the tear are detected; the quality control area is positioned on the shell and comprises a standard reference area, wherein the standard reference area is provided with standard reference objects with known concentrations and used for comparing and calibrating detection results. The utility model combines the quantitative tear collection and the tear index detection to realize the rapid and accurate detection of tear parameters, and has relatively convenient operation.

Description

Kit integrating convenient sampling and detection

Technical Field

The utility model relates to the technical field of ophthalmic detection, in particular to a kit integrating convenient sampling and detection.

Background

Tears are important secretions of the eye and have important significance for diagnosis and treatment of eye diseases. However, the existing tear collection and detection method is that liquid is required to be collected by a dropper during collection and then dripped on a test strip, and then the degree of color change is observed to determine the tear quality by comparing with a standard color card. The tear collection and detection method has the problems of relatively complicated operation, influence of a plurality of operation steps, unstable detection results and the like, and the wide clinical application of the tear collection and detection method is limited. Therefore, it is of great practical importance to develop a detection cartridge capable of simultaneously performing quantitative tear collection and tear index detection.

Disclosure of utility model

The utility model aims to provide a reagent kit integrating convenient sampling and detection into a whole, so as to solve the problems in the background technology.

In order to achieve the above purpose, the present utility model provides the following technical solutions:

A kit integrating convenient sampling and detection, comprising:

the shell is formed by covering an upper cover and a lower cover;

The test strip is fixed in the shell;

The sampling area is positioned at one side of the shell and is used for collecting tear samples of a person to be detected;

The reaction zone is positioned on the test strip, is adjacent to the sampling zone and is used for placing a reagent and carrying out reaction;

The indication area is positioned on the shell and comprises a preset biomarker detection area, the detection area is provided with a plurality of detection reagents aiming at different biomarkers, and after the tears are obtained, the biomarkers in the tears are detected;

The quality control area is positioned on the shell and comprises a standard reference area, and the standard reference area is provided with standard reference objects with known concentration and used for comparing and calibrating detection results.

Further, the upper cover and the lower cover are combined in an interference fit mode through the positioning column and the positioning hole, and the test strip is pressed and fixed inside.

Further, the sampling area is inclined outwards, and the inside of the sampling area is conical, and is provided with a capillary tube for flowing tear sample to a reaction area on the test strip.

Furthermore, the upper cover and the lower cover are both provided with slope structures for ensuring that the reagent strips are in a compression state inside and are in complete contact with the capillary outlet of the capillary.

Further, the slope structure includes two protruding portions that set up on upper cover and lower cover and be located the capillary between two protruding portions, the capillary export has the inclined plane, and after upper cover and lower cover lid were closed, the test paper strip card was between two protruding portions to compress tightly the reagent strip inside the casing through two inclined planes.

Further, the test strip comprises a back plate, a sample chromatographic layer, a sample processing pad and a marking pad, wherein the sample processing pad and the sample chromatographic layer are positioned on the back plate, the sample processing pad is pressed at two ends of the sample chromatographic layer, and one end of the sample processing pad is pressed through the marking pad.

Further, the sample processing pad and the marking pad each have a crimp portion, wherein the crimp portion of one sample processing pad is crimped onto the marking pad, the crimp portion of the marking pad is crimped onto one end of the sample chromatographic layer, and the crimp portion of the other sample processing pad is directly crimped onto the other end of the sample chromatographic layer.

Further, the sample processing pad serves as a water absorption region except for the crimping portion, and the sample chromatographic layer serves as a reaction region except for a portion of which both end portions are pressed by the crimping portion.

Compared with the prior art, the utility model has the beneficial effects that:

The utility model relates to a detection card box combining tear quantitative collection and tear index detection, so as to realize rapid and accurate detection of tear parameters, and the operation is relatively convenient.

The detection cartridge of the utility model combines the dropper function, and the collected liquid is conveyed to the test strip through the internal capillary structure, thereby providing a more convenient solution.

Drawings

FIG. 1 is a schematic diagram of the overall structure of the present utility model.

Fig. 2 is a schematic diagram of an explosive structure according to the present utility model.

Fig. 3 is a schematic perspective view of the present utility model.

FIG. 4 is a schematic view of the sample area of the present utility model on the upper cover.

Fig. 5 is a schematic view of the inner side structure of the upper cover of the present utility model.

FIG. 6 is a schematic diagram of a test strip according to the present utility model.

FIG. 7 is an exploded schematic view of the test strip of the present utility model.

FIG. 8 is a schematic cross-sectional view of the utility model at A-A of FIG. 1.

In the figure: 1-casing, 2-upper cover, 3-lower cover, 4-locating hole, 5-test strip, 6-backplate, 7-sample chromatography layer, 8-sample processing pad, 9-mark pad, 10-sampling area, 11-capillary, 12-indication area, 13-matter control area, 14-reaction area, 15-slope structure, 16-protrusion, 17-inclined plane, 18-reference column, 19-capillary export.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

In the description of the present utility model, it should be noted that the terms "upper end," "lower end," "inner," "outer," "front end," "rear end," "both ends," "one end," "the other end," and the like indicate an azimuth or a positional relationship based on that shown in the drawings, merely for convenience of description and simplification of the description, and do not indicate or imply that the apparatus or element to be referred to must have a specific azimuth, be configured and operated in a specific azimuth, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "configured," "sleeved," "connected," and the like are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

Referring to fig. 1 to 8, the present utility model provides a technical solution:

A detection card box combining quantitative tear collection and tear index detection is used for realizing rapid and accurate detection of tear parameters. In order to achieve the above object, the following technical scheme is adopted, including:

The shell 1 is formed by covering an upper cover 2 and a lower cover 3;

The test strip 5 is fixed in the shell 1;

The sampling area 10 is positioned at one side of the shell 1 and is used for collecting tear samples of a person to be detected;

a reaction zone 14, wherein the reaction zone 14 is positioned on the test strip 5 and adjacent to the sampling zone 10, and is used for placing a reagent and performing a reaction;

An indicator zone (T) 12, said indicator zone 12 being located on the housing 1 and comprising a preset biomarker detection zone provided with a plurality of detection reagents for different biomarkers, so that the biomarkers in the tear can be detected immediately after the tear is obtained;

A quality control zone (C) 13, said quality control zone 13 being located on the housing 1 and comprising a standard reference area provided with a standard reference of known concentration for comparing and calibrating the results of the detection.

It should be noted that the upper cover 2 and the lower cover 3 are covered and combined to form a relatively sealed shell 1, the indication area (T) and the quality control area (C) can be engraved on the mold through integral injection molding, and can also be marked by means of code spraying, laser etching and the like, the reaction of the test strip 5 is finished, and the test result can be checked through the reaction area 14.

Specifically, as shown in fig. 2 to 3, the upper cover 2 and the lower cover 3 are combined in an interference fit manner with the positioning posts 18 and the positioning holes 4, so as to compress and fix the test strip 5 inside.

Specifically, as shown in fig. 2 to 3, the sampling area 10 is inclined outward in shape and tapered in inside, and has a capillary 11 for flowing a tear sample to a reaction area 14 on the test strip 5.

Specifically, as shown in fig. 5, the upper cover 2 and the lower cover 3 are both provided with a slope structure 15 for ensuring that the reagent strip 5 is in a compressed state inside and is in complete contact with the capillary outlet 19 of the capillary 11.

Specifically, as shown in fig. 8, the slope structure 15 includes two protruding parts 16 disposed on the upper cover 2 and the lower cover 3, and a capillary tube 11 located between the two protruding parts 16, the capillary tube outlet 19 has an inclined surface 17, and when the upper cover 2 and the lower cover 3 are covered, the test strip 5 is clamped between the two protruding parts 16, and the reagent strip is pressed inside the housing 1 through the two inclined surfaces 17. The ramp structures 15 may be one or a pair near the sampling area 10, only one being shown in this embodiment.

Specifically, the test strip 5 includes a back plate 6, a sample chromatographic layer 7, a sample processing pad 8 and a labeling pad 9, the sample processing pad 8 and the sample chromatographic layer 7 are located on the back plate 6, and the sample processing pad 8 is pressed at two ends of the sample chromatographic layer 7, one end of which is pressed by the labeling pad 9.

Specifically, as shown in fig. 7, the sample processing pad 8 and the marking pad 9 each have a pressure-bonding section, namely, a pressure-bonding section a of the marking pad 9 and a pressure-bonding section b of the sample processing pad 8, respectively, wherein the pressure-bonding section b of one sample processing pad 8 is pressed against the marking pad 9, the pressure-bonding section a of the marking pad 9 is pressed against one end portion of the sample chromatographic layer 7, and the pressure-bonding section b of the other sample processing pad 8 is directly pressed against the other end portion of the sample chromatographic layer 7.

Specifically, as shown in fig. 6, the sample processing pad 8 serves as a water absorbing region except for the pressure-bonding section b, and the sample chromatographic layer 7 serves as a reaction region 14 except for the portions of both end portions pressed by the pressure-bonding sections a and b.

The utility model specifically comprises the following steps:

1. The upper cover 2 and the lower cover 3 are combined in an interference fit mode through the positioning column 18 and the positioning hole 4, so that the test strip 5 is pressed and fixed inside;

2. the volume of the sampling area 10 can accommodate 90ul of liquid volume, the appearance is inclined outwards, the liquid is conveniently collected, the interior is conical, and the liquid is conveniently collected to the capillary 11;

3. The diameter of the capillary tube 11 is 0.5 mm-1.0 mm, so that capillary action can be realized and the feasibility requirement of the injection mold can be met;

4. The upper cover 2 and the lower cover 3 are both provided with slope structures 15, so that the reagent strips 5 can be ensured to be in a compression state inside and completely contact with the capillary outlet 19;

5. The test strip 5 is divided into a back plate 6, a sample processing pad 8, a marking pad, a sample chromatography (area) layer 7, a water absorption area, and two lines of the sample chromatography area, namely an indication area 12 and a quality control area 13;

6. the marking pad 9 can be made of colloidal gold particles, latex microspheres, fluorescent microspheres and quantum dots for marking detection reagents of different biomarkers so as to detect different indexes;

7. The indication area 12 of the sample chromatography (area) layer 7 can be coated with a plurality of detection reagents aiming at different biological markers so as to capture different biological markers combined with colloidal gold particles, latex microspheres, fluorescent microspheres and quantum dots;

8. The reaction zone 14 is not covered by the label pad 6 and the water-absorbing zone in the sample chromatography layer 7, but is the region that can be observed during the reaction.

9. The back plate 6 and the marking pad 9 are made of glass fiber and polyester film, the sample chromatography layer 7 is nitrocellulose film, and the sample treatment pad 8 is a water-absorbent paper, and is a mixture of paper and cotton. Of course, the prior art Schirmer's filter paper may be used as long as it is sufficient to collect a tear sample of the subject to be tested, which can be adsorbed to the reaction zone 14 by capillary action through the capillary outlet 19 of the capillary tube 11.

According to the utility model, the dropper function is combined, and the collected liquid (for collecting the tear sample of the person to be detected) is conveyed to the test strip 5 through the internal capillary structure, so that a more convenient solution is provided.

The application process of the utility model is as follows:

During testing, the liquid is sampled and waits for a few seconds; the capillary 11 transfers liquid from the inlet to the capillary outlet 19; the test strip 5 at the capillary outlet 19 is contacted with liquid, the liquid is slowly sucked away, and the liquid in the sampling area 10 is continuously transferred to the test strip 5 through the capillary 11; the reaction of the test strip 5 is completed, and the result is checked through the reaction area 14.

The utility model, not described in detail, is well known or known in the art.

Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. Collect convenient sampling and detect kit as an organic whole, its characterized in that includes:

The shell (1), the said shell (1) is covered by upper cover (2) and lower cover (3);

the test strip (5) is fixed in the shell (1);

the sampling area (10) is positioned at one side of the shell (1) and is used for collecting tear samples of a person to be detected;

The reaction zone (14) is positioned on the test strip (5), is adjacent to the sampling zone (10) and is used for placing a reagent and carrying out reaction;

The indication area (12) is positioned on the shell (1) and comprises a preset biomarker detection area, wherein the detection area is provided with a plurality of detection reagents aiming at different biomarkers, and the biomarkers in the tear are detected after the tear is acquired;

And the quality control area (13) is positioned on the shell (1) and comprises a standard reference area, wherein the standard reference area is provided with standard reference objects with known concentration and used for comparing and calibrating detection results.

2. A kit integrating convenient sampling and detection as claimed in claim 1, wherein the upper cover (2) and the lower cover (3) are combined with the positioning hole (4) through the positioning column (18) in an interference fit manner, so that the test strip (5) is pressed and fixed inside.

3. A kit for integrated convenient sampling and testing as claimed in claim 1, wherein said sampling zone (10) is outwardly inclined in shape and tapered internally and has a capillary (11) for flowing the tear sample to a reaction zone (14) on the strip (5).

4. A kit for integrated convenient sampling and testing as claimed in claim 3, wherein the upper cover (2) and the lower cover (3) are provided with ramp structures (15) for ensuring that the reagent strip (5) is in a compressed state inside and is in complete contact with the capillary outlet (19) of the capillary tube (11).

5. A kit as claimed in claim 4, wherein the ramp structure (15) comprises two protrusions (16) arranged on the upper cover (2) and the lower cover (3) and a capillary tube (11) arranged between the two protrusions (16), the capillary tube outlet (19) is provided with an inclined surface (17), and the test strip (5) is clamped between the two protrusions (16) after the upper cover (2) and the lower cover (3) are covered, and the reagent strip is pressed inside the casing (1) through the two inclined surfaces (17).

6. A kit integrating convenient sampling and detection as claimed in claim 1, wherein the test strip (5) comprises a back plate (6), a sample chromatographic layer (7), a sample processing pad (8) and a marking pad (9), the sample processing pad (8) and the sample chromatographic layer (7) are positioned on the back plate (6), and the sample processing pad (8) is pressed at two ends of the sample chromatographic layer (7), one end of the sample processing pad is pressed by the marking pad (9).

7. A kit integrating convenient sampling and detection as claimed in claim 6, wherein the sample processing pad (8) and the label pad (9) each have a crimp portion, wherein the crimp portion of one sample processing pad (8) is pressed against the label pad (9), the crimp portion of the label pad (9) is pressed against one end of the sample chromatographic layer (7), and the crimp portion of the other sample processing pad (8) is directly pressed against the other end of the sample chromatographic layer (7).

8. A kit integrating convenient sampling and testing as claimed in claim 7, wherein said sample processing pad (8) is used as a water absorption zone except for a press-contact part, and said sample chromatographic layer (7) is used as a reaction zone (14) except for a part of which both ends are pressed by the press-contact part.