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CN201421413Y - Liquid sample processing device - Google Patents

Liquid sample processing device Download PDF

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Publication number
CN201421413Y
CN201421413Y CN2009200268819U CN200920026881U CN201421413Y CN 201421413 Y CN201421413 Y CN 201421413Y CN 2009200268819 U CN2009200268819 U CN 2009200268819U CN 200920026881 U CN200920026881 U CN 200920026881U CN 201421413 Y CN201421413 Y CN 201421413Y
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cavity
reagent
piston
packed
liquid sample
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Expired - Lifetime
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CN2009200268819U
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Chinese (zh)
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何峰
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Individual
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Abstract

The utility model relates to a liquid sample processing device, which belongs to the technical field of the structure of liquid sample processing device. The liquid sample processing device is characterized by comprising at least one cavity which is filled with at least one type of reagent, the lower part of the cavity is provided with at least one capillary which is communicated with the cavity,the inside of each cavity is provided with at least one seal piston the upper part of which is provided with a push arm, the lower part of the each seal piston the upper part of which is provided withthe push arm is correspondingly provided with at least one sealing body, which is used for isolating the reagent, matched with the cavity, provided with a diversion channel, and applied in the mixingof a sample and the reagent through movement, the reagent is arranged between the seal piston and the sealing body, and the mixing of the reagent in the cavity and the sample in the capillary is realized through the diversion channel arranged in the cavity. The utility model has the advantages of reasonable structure, simple and convenient operation and applicability to various situations, makesthe detection simple, and is applied to the real-time test.

Description

Liquid sample processing device
One, technical field
The utility model relates to a kind of liquid sample processing device, particularly a kind of liquid sample collection, reagent store and with the two mix, the device of mixing, belong to the liquid sample processing device technical field of structures.
Two, background technology
(Point-of-Care Testing POCT), claims other check of bed or POCT again to real-time test, has the advantage that assay is offered immediately the doctor.And traditional laboratory is detected and the sample of gathering need be delivered to the laboratory, waits for that several hours time to several weeks could send the result to doctor.
Have only that operation steps is few, method of operating is simple, be easy to learn and use, and does not need the large automatic instrument to handle, and can become the real-time test project by the project that amateur docimaster such as nurse or patient oneself finish.
Large automatic instrument detecting sample is used in the laboratory basically now, need not artificial intervention.Before self-reacting device was widely used, a lot of test items were by manually finishing, and such method is still being used in some small test chamber now.Manual detection sample complex steps needs to operate through the docimaster of special training.As detect glucose in the blood, drawing sample with micro sample adding appliance earlier joins in the reaction cup, sample of every absorption need be changed the suction nozzle of sample injector to avoid cross pollution, draw the first component reagent in reaction cup with sample injector then, sway mixing, draw the second component reagent with sample injector again and add in the above-mentioned reaction cup, detect with photometer after swaying mixing once more.Some detectable is a dry powder for another example, needs to add quantitative water or reagent before use and makes working fluid and can use.Obviously so complicated operations has limited the application of a lot of test items in real-time test.
Three, summary of the invention
The purpose of this utility model is to solve the weak point that above-mentioned prior art exists, and provides a kind of and can save numerous and diverse operation steps, makes to detect the liquid sample processing device that becomes simple and easy to do and can be applied to real-time test.
The utility model is achieved through the following technical solutions:
Liquid sample processing device, special character is to comprise that at least one internal storage has the cavity 4 of at least a reagent, cavity 4 bottoms are provided with at least one and are communicated with kapillary 7 with it, be provided with the packed-piston 2 of at least one top band pusher arm 1 in each cavity 4, the bottom correspondence of the packed-piston 2 of each top band pusher arm 1 is provided with at least one and is used to isolate reagent, with cavity supporting belt water conservancy diversion channel, can be by motion with the obturator of sample and reagent mix, reagent between packed-piston 2 and obturator, mixing between the samples in reagent and the kapillary 7 in the cavity 4 by water conservancy diversion channels realizations set in the cavity 4;
Described cavity 4 bottoms are communicated with kapillary 7 by the bottom of the cone-shaped cavity 5 that is attached thereto;
It is liquid reagent that the described reagent 8 that is stored in the cavity 4 has at least a kind of, and it is stored between packed-piston 2 and the obturator, and other kinds reagent is dry powder or liquid; Store between reagent and the packed-piston air or other kinds gas such as nitrogen etc. are arranged.
Described obturator is to be used with the water conservancy diversion channel, fit tightly with cavity 4 inwalls, be used to isolate reagent 8 and make it to seal the packed-piston 9 that is stored in the cavity 4, the water conservancy diversion channel is set at least 1 diversion trench 12 of cavity 4 lower cavity inwalls, when the packed-piston 2 of pusher arm 1 drive bottom presses down, under pressure, the packed-piston 9 of bottom also moves down thereupon, when moving to diversion trench 12 places, packed-piston 9 stops to move down, this moment, the pusher arm 1 drive packed-piston on top continued to move down, reagent 8 between packed-piston 9 and the packed-piston 2 enters in the cone-shaped cavity 5 and by the kapillary 7 injection reaction cup of cone-shaped cavity 5 bottoms along diversion trench 12 and mixes with sample, continue to promote pusher arm 1 this moment, make packed-piston 2 continue to move down, until reagent 8 and air are injected reaction cup fully, the pressure that injects the process of reaction cup at reagent and air can be fully with reagent and sample mixing;
Described obturator is the diaphragm seal 18 in cavity 4 bottoms being used for of being tightly connected reagent 8 sealings being stored in, the puncturing lever 16 of water conservancy diversion channel for inserting into the inner by cavity 4 tops, diaphragm seal 18 realizations that penetrate cavity 4 bottoms by moving down of puncturing lever 16 that mix of reagent and sample; During use, move down earlier diaphragm seal 18 is punctured, realize being communicated with between cavity 4 and the cone-shaped cavity 5, promote pusher arm 1 more at this moment and press down by puncturing lever 16, reagent 8 in the cavity 4 enters in the cone-shaped cavity 5 by the diaphragm seal 18 of breakage under pressure, and realization reagent mixes with sample;
Be provided with between described pusher arm 1 and cavity 4 outer walls and be used to the locking system 3 that makes packed-piston 2 be in lockup state, the bottom of cone-shaped cavity 5 has the kapillary 7 that is used to draw the quantitative liquid sample, and kapillary 7 is provided with cone-shaped cavity 5 places of connection can stop the platform 15 that kapillary 7 samples are drawn automatically;
Described locking system 3 is the draw and insert-type rhabodoids that are interspersed between cavity 4 outer walls and the pusher arm 1, only needs when removing locking its extraction and pusher arm 1 disengaging are got final product;
Described locking system 3 is the rhabodoids that are fixed between cavity 4 outer walls and the pusher arm 1, and it inserts cavity 4 parts and can fracture under the following acting force of pusher arm 1, removes its locking to pusher arm 1;
The set diversion trench of the packed-piston that is used for store reagents in the described cavity and its underpart cavity inner wall is used, the sequencing that described different reagent mixes with sample is regulated and control to the spacing between the lower guide chute by packed-piston, thereby realizes the purpose of mixing of different reagent and sample;
The quantity of described diversion trench, the degree of depth and width can be provided with 1-6 with the need;
In order to realize that more kinds of reagent mix with sample, described cavity 4 can be combined by a plurality of single cavity of the shared connection cone-shaped cavity 5 in bottom, each single cavity has the independently packed-piston 2 of top band pusher arm 1 respectively, can need set the packed-piston 9 of varying number and the diversion trench 12 that matches in its underpart with reagent type in single cavity;
In order to realize that reagent mixes with multiple sample, described cavity 4 can be communicated with a plurality of single cavity that has kapillary 7 separately by the bottom and combine, each single cavity has the packed-piston 2 that top independently has pusher arm 1 respectively, can need set the packed-piston 9 of varying number and the diversion trench 12 that matches in its underpart with reagent type in single cavity.
The utility model liquid sample processing device, rational in infrastructure, easy to operate, be applicable to multiple different situation needs, can save operation steps numerous and diverse in the prior art, make to detect to become simple and easy to do and can be applied to real-time test.
Four, description of drawings
Fig. 1: the structural representation of embodiment 1 liquid sample processing device of the present utility model;
The planar structure synoptic diagram of Fig. 1-A: Fig. 1; The axial section of Fig. 1-B: Fig. 1-A;
Fig. 1-D: the A-A sectional view among Fig. 1-B;
Fig. 2: the structural representation of embodiment 2 liquid sample processing devices of the present utility model;
The planar structure synoptic diagram of Fig. 2-A: Fig. 2; The axial section of Fig. 2-B: Fig. 2-A;
Fig. 3: the structural representation of embodiment 3 liquid sample processing devices of the present utility model;
The planar structure synoptic diagram of Fig. 3-A: Fig. 3; The axial section of Fig. 3-B: Fig. 3-A;
Fig. 3-D: B-B sectional view among Fig. 3-B; Fig. 3-E: C-C sectional view among Fig. 3-B;
Fig. 4: the structural representation of embodiment 4 liquid sample processing devices of the present utility model;
The planar structure synoptic diagram of Fig. 4-A: Fig. 4; The axial section of Fig. 4-B: Fig. 4-A;
Fig. 4-D: D-D sectional view among Fig. 4-B; Fig. 4-E: E-E sectional view among Fig. 4-B;
Fig. 5: the structural representation of embodiment 5 liquid sample processing devices of the present utility model;
The planar structure synoptic diagram of Fig. 5-A: Fig. 5; The axial section of Fig. 5-B: Fig. 5-A;
Fig. 5-D: F-F sectional view among Fig. 5-B;
Fig. 6: the structural representation of embodiment 6 liquid sample processing devices of the present utility model;
The planar structure synoptic diagram of Fig. 6-A: Fig. 6; The axial section of Fig. 6-B: Fig. 6-A;
Fig. 6-D: G-G sectional view among Fig. 6-B; Fig. 6-E: H-H sectional view among Fig. 6-B;
Five, embodiment
Following with reference to accompanying drawing, provide embodiment of the present utility model, be used for formation of the present utility model is further specified.
Embodiment 1
The liquid sample processing device of present embodiment is with reference to figure 1, Fig. 1-A, Fig. 1-B, Fig. 1-D, there is a kapillary 7 to be used to draw quantitative liquid sample, kapillary 7 has platform 15 with cone-shaped cavity 5 places of connection, and platform 15 can stop the sample of kapillary 7 automatically and draw; A cavity 4 is connected with cone-shaped cavity 5, has a packed-piston 9 to be used for isolating reagent in the cavity 4 and makes reagent 8 be stored in cavity; The packed-piston 2 that links to each other with pusher arm 1 can move axially along cavity, and storing between reagent 8 and the packed-piston 2 has air; Locking system 3 fixedly pusher arm 1 makes packed-piston 2 and packed-piston 9 be in lockup state, locking system 3 can be the rhabodoid that when using pusher arm 1, takes out also can be formula easy to break apply certain pressure in pusher arm 1 time can fracture; Four diversion trenchs 11,12,13 and 14 are arranged on the wall of cavity 4.During use, kapillary 7 is contacted with liquid sample, can be full of kapillary 7 automatically by the capillarity sample, take out or backfin locking system 3, bring pressure to bear on pusher arm 1, the pressure that packed-piston 2 and packed-piston 9 move down generation injects reaction cup with the sample in the kapillary 7, when moving to the diversion trench position, packed-piston 9 can stop, reagent 8 enters cone-shaped cavity 5 along diversion trench also to be mixed with sample by kapillary 7 injection reaction cup, continue to promote pusher arm 1, make packed-piston 2 continue to move down, until reagent 8 and air are injected reaction cup fully, the pressure that injects the process of reaction cup at reagent and air can be fully with reagent and sample mixing.
Embodiment 2
The liquid sample processing device of present embodiment has a kapillary 7 to be used to draw quantitative liquid sample with reference to figure 2, Fig. 2-A, Fig. 2-B, and kapillary 7 has platform 15 with cone-shaped cavity 5 places of connection, and platform 15 can stop the sample of kapillary 7 automatically and draw; A cavity 4, the bottom of cavity 4 have a diaphragm seal 18 to be used for isolating reagent to make reagent 8 be stored in cavity; Cone-shaped cavity 5 is tightly connected by screw thread 17 with cavity 4; The packed-piston 2 that links to each other with pusher arm 1 can move axially along cavity, and storing between reagent 8 and the packed-piston 2 has air; Puncturing lever 16 is used for puncture through seal film 18; Locking system 3 fixedly pusher arm 1 makes packed-piston 2 be in lockup state, locking system 3 can be the rhabodoid that when using pusher arm 1, takes out also can be formula easy to break apply certain pressure in pusher arm 1 time can fracture.During use, kapillary 7 is contacted with liquid sample, can be full of kapillary 7 automatically by the capillarity sample, promote puncturing lever puncture through seal film 18, cavity 4 can be communicated with cone-shaped cavity 5, take out or backfin locking system 3, bring pressure to bear on pusher arm 1, the pressure that packed-piston 2 moves down generation injects the reaction cup mixing with sample in the kapillary 7 and reagent 8, continue to promote pusher arm 1, make packed-piston 2 continue to move down, until reagent 8 and air are injected reaction cup fully, the pressure that injects the process of reaction cup at reagent and air can be fully with reagent and sample mixing.
Embodiment 3
The liquid sample processing device of present embodiment is with reference to figure 3, Fig. 3-A, Fig. 3-B, Fig. 3-D, Fig. 3-E, and the key distinction of present embodiment and embodiment 1 is to store two kinds of reagent in the cavity 4.Have a kapillary 7 to be used to draw quantitative liquid sample, kapillary 7 has platform 15 with cone-shaped cavity 5 places of connection, and platform 15 can stop the sample of kapillary 7 automatically and draw; A cavity 4, be connected with cone-shaped cavity 5, packed-piston 9-1 is used to isolate reagent liquid 8-1 and reagent 8-2 in the cavity 4, and reagent 8-2 can be that liquid reagent also can be a powdered reagent, is that powdered reagent should be designed so that then reagent 8-1 mixes with sample earlier with after 8-2 mixes again as 8-2; Packed-piston 9-2 is used for isolating reagent 8-2 and is stored in cavity 4 in the cavity 4; The packed-piston 2 that links to each other with pusher arm 1 can move axially along cavity, and all storing between reagent 8-2 and the packed-piston 9-1 and between reagent 8-1 and the packed-piston 2 has air; Locking system 3 fixedly pusher arm 1 makes packed-piston 2 and packed-piston 9 be in lockup state, locking system 3 can be the rhabodoid that when using pusher arm 1, takes out also can be formula easy to break apply certain pressure in pusher arm 1 time can fracture; Two groups of diversion trenchs are up and down arranged on the wall of cavity 4, and the quantity of every group of diversion trench is more than one, and 3 diversion trench 12-1,11-1,13-1 are used in present embodiment B-B cross section, and 2 diversion trench 12-2,14-2 are used in the C-C cross section; Gap by adjusting packed-piston 9-1 and diversion trench can set the sequencing that two kinds of reagent mix with sample apart from the gap of 10-1 and packed-piston 9-2 and diversion trench apart from 10-2, as 10-1 less than 10-2 then reagent 8-1 and reagent 8-2 mix with sample again after mixing earlier, as 10-1 greater than 10-2 then reagent 8-2 first with mix with reagent 8-1 again after sample mixes; During use, kapillary 7 is contacted with liquid sample, can be full of kapillary 7 automatically by the capillarity sample, take out or backfin locking system 3, bring pressure to bear on pusher arm 1, the pressure that packed-piston 2 and packed-piston 9-1 and 9-2 move down generation injects reaction cup with sample in the kapillary 7 and the reagent in the cavity, and according to big young pathbreaker's reagent 8-1 of 10-1 and 10-2 and reagent 8-2 successively and sample mixing mixing.
Embodiment 4
The liquid sample processing device of present embodiment is with reference to figure 4, Fig. 4-A, Fig. 4-B, Fig. 4-D, Fig. 4-E, present embodiment can be regarded the set of the device of embodiment 1 and embodiment 3 as, and cavity 4 and two pusher arm 1-1,1-2 of a kapillary 7 and two store reagents are arranged.Have a kapillary 7 to be used to draw quantitative liquid sample, kapillary 7 has platform 15 with cone-shaped cavity 5 places of connection, and platform 15 can stop the sample of kapillary 7 automatically and draw; Two cavity 4-1 and 4-2 are connected with cone-shaped cavity 5, and two pusher arm 1-1 and 1-2 have a packed-piston 9-3 to be used for isolating reagent and make reagent 8-3 be stored in cavity among the cavity 4-1; The packed-piston 2-1 that links to each other with pusher arm 1-1 can move axially along cavity, and storing between reagent 8-3 and the packed-piston 2-1 has air; Packed-piston 9-1 is used to isolate reagent 8-1 and reagent 8-2 among the cavity 4-2, and packed-piston 9-2 is used for isolating reagent 8-2 and is stored in cavity 4-2 among the cavity 4-2; The packed-piston 2-2 that links to each other with pusher arm 1-2 can move axially along cavity, and all storing between reagent 8-2 and the packed-piston 9-1 and between reagent 8-1 and the packed-piston 2-2 has air; Locking system 3-1 is pusher arm 1-1 fixedly, and locking system 3-2 is pusher arm 1-2 fixedly.The packed-piston 9-2 cavity inner wall of packed-piston 9-1 and bottom is provided with diversion trench 11-1,12-1,13-1,14-1 among the cavity 4-2, be respectively equipped with diversion trench 11-3,12-3,13-3,14-3 and diversion trench 11-2,12-2,13-2,14-2 among the cavity 4-1 among packed-piston 9-3 and the cavity 4-2 on the lower cavity inwall of packed-piston 9-2, the gap by adjusting each packed-piston and corresponding diversion trench can set the sequencing that each reagent mixes with sample apart from 10-1,10-2 and 10-3.
Embodiment 5
The liquid sample processing device of present embodiment is with reference to figure 5, Fig. 5-A, Fig. 5-B, Fig. 5-D, present embodiment can be regarded the set of the device of two embodiment 3 as, and cavity 4-1,4-2 and two pusher arm 1-1,1-2 that have packed-piston 2-1,2-2 of two kapillary 7-1,7-2 and two store reagents are arranged.Kapillary 7-1,7-2 have platform 15-1,15-2 with the lower cavity place of connection, and platform 15-1,15-2 can stop the sample of kapillary 7-1,7-2 automatically and draw; Be respectively equipped with locking system 3-1,3-2 between pusher arm 1-1,1-2 and cavity 4-1, the 4-2, kapillary 7-1 is communicated with cavity 4-1, and kapillary 7-2 is connected with cavity 4-2; Cavity 4-1 is interior by packed-piston 9-4,9-5 stores two kinds of reagent 8-4,8-5, packed-piston 9-4 in the cavity 4-1, each correspondence of the bottom of 9-5 is provided with diversion trench 11-4,12-4,13-4 and diversion trench 11-5,12-5,13-5, packed-piston 9-4, spacing between 9-5 and the lower guide chute is respectively 10-4,10-5, cavity 4-2 is interior by packed-piston 9-1,9-2,9-3 stores three kinds of reagent 8-1,8-2,8-3, packed-piston 9-1 in the cavity 4-2,9-2,9-3 bottom correspondence is provided with diversion trench 11-1,12-1,13-1, diversion trench 11-2,12-2,13-2 and diversion trench 11-3,12-3,13-3, packed-piston 9-1,9-2, spacing between 9-3 and the lower guide chute is 10-1,10-2,10-3, this device can be handled two liquid samples simultaneously.
Embodiment 6
The liquid sample processing device of present embodiment is with reference to figure 6, Fig. 6-A, Fig. 6-B, Fig. 6-D, Fig. 6-E, and present embodiment can be regarded the set of the device of two embodiment 4 as, and cavity and four pusher arms of two kapillaries and four store reagents are arranged.Each kapillary is connected with 2 cavitys, be used for handling simultaneously two liquid samples, and each sample needs plurality of reagents to handle.

Claims (10)

1, liquid sample processing device, the feature part is to comprise that at least one internal storage has the cavity (4) of at least a reagent, cavity (4) bottom is provided with at least one and is communicated with kapillary (7) with it, be provided with the packed-piston (2) of at least one top band pusher arm (1) in each cavity (4), the bottom correspondence of the packed-piston (2) of each top band pusher arm is provided with at least one and is used to isolate reagent, with cavity supporting belt water conservancy diversion channel, can be by motion with the obturator of sample and reagent mix, reagent is positioned between packed-piston (2) and the obturator, and mixing by water conservancy diversion channel set in the cavity (4) between the interior reagent of cavity (4) and the interior sample of kapillary (7) realizes.
2,, it is characterized in that described cavity (4) bottom is communicated with kapillary (7) by the bottom of the cone-shaped cavity (5) that is attached thereto according to the described liquid sample processing device of claim 1.
3, according to the described liquid sample processing device of claim 1, it is characterized in that
It is liquid reagent that the described reagent (8) that is stored in the cavity (4) has at least a kind of, and it is stored between packed-piston (2) and the obturator, and storing between reagent and the packed-piston has air or other kinds gas.
4, according to claim 1 or 2 or 3 described liquid sample processing devices, it is characterized in that
Described obturator for that be used with the water conservancy diversion channel, that fit tightly with cavity (4) inwall, be used to isolate reagent (8) and make it sealing and be stored in packed-piston (9) in the cavity (4), the water conservancy diversion channel is set (1) at least individual diversion trench (12) of cavity (4) lower cavity inwall.
5, according to claim 1 or 2 or 3 described liquid sample processing devices, it is characterized in that
Described obturator is the diaphragm seal (18) in cavity (4) bottom being used for of being tightly connected reagent (8) sealing being stored in, the puncturing lever (16) of water conservancy diversion channel for being inserted into the inner by cavity (4) top.
6, according to claim 1 or 2 or 3 described liquid sample processing devices, it is characterized in that
Be provided with between described pusher arm (1) and cavity (4) outer wall and be used to make packed-piston (2) to be in the locking system (3) of lockup state, the bottom of cone-shaped cavity (5) has the kapillary (7) that is used to draw the quantitative liquid sample, and kapillary (7) is provided with cone-shaped cavity (5) place of connection can stop the platform (15) that kapillary (7) sample is drawn automatically.
7, according to the described liquid sample processing device of claim 6, it is characterized in that described
Locking system (3) is the draw and insert-type rhabodoid that is interspersed between cavity (4) outer wall and the pusher arm (1).
8, according to the described liquid sample processing device of claim 6, it is characterized in that described
Locking system (3) is to be fixed in rhabodoid between cavity (4) outer wall and the pusher arm (1), that its insertion cavity (4) part fractures under the following acting force of pusher arm (1).
9, according to claim 2 or 3 described liquid sample processing devices, it is characterized in that described
Cavity (4) is combined by a plurality of single cavity of the shared connection cone-shaped cavity in bottom (5), and each single cavity has the independently packed-piston (2) of top band pusher arm (1) respectively.
10, according to claim 1 or 2 or 3 described liquid sample processing devices, it is characterized in that described
Cavity (4) is communicated with separately a plurality of single cavity that has kapillary (7) by the bottom and combines, and each single cavity has the packed-piston (2) that top independently has pusher arm (1) respectively.
CN2009200268819U 2009-06-05 2009-06-05 Liquid sample processing device Expired - Lifetime CN201421413Y (en)

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Application Number Priority Date Filing Date Title
CN2009200268819U CN201421413Y (en) 2009-06-05 2009-06-05 Liquid sample processing device

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Application Number Priority Date Filing Date Title
CN2009200268819U CN201421413Y (en) 2009-06-05 2009-06-05 Liquid sample processing device

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CN201421413Y true CN201421413Y (en) 2010-03-10

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102445558A (en) * 2011-12-16 2012-05-09 苏州生水医学科技有限公司 Multi-piston trace reagent charging device
CN101581729B (en) * 2009-06-05 2012-06-27 何峰 Liquid sample processing device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101581729B (en) * 2009-06-05 2012-06-27 何峰 Liquid sample processing device
CN102445558A (en) * 2011-12-16 2012-05-09 苏州生水医学科技有限公司 Multi-piston trace reagent charging device

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Granted publication date: 20100310

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