CN1362074A - Nano heart proteoting medicine and its preparation - Google Patents
Nano heart proteoting medicine and its preparation Download PDFInfo
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- CN1362074A CN1362074A CN 01100039 CN01100039A CN1362074A CN 1362074 A CN1362074 A CN 1362074A CN 01100039 CN01100039 CN 01100039 CN 01100039 A CN01100039 A CN 01100039A CN 1362074 A CN1362074 A CN 1362074A
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Abstract
The invention discloses a nano preparation for protection of heart. It comprises materials such as nano datura flower, nanoginseng, nano Cinnamonum cassia, nanomonkshood, nano pilose deer horn, nanoborneol, nanomusk, nano pseudo-ginseng, nanosenso, and makes up in accordance with proportion, then fabricates into n new medical preparation. Its particle fineness reaches 1200-1500 mesh; and particle size 0.1-200nm, most of the particle size is less than 100nm and has new material properties. It is fabricated through steps such as microwave extraction, decompression and concentration, supersonic jet and spray drying.
Description
The present invention relates to a kind of warming YANG, QI invigorating, invigorate blood circulation, cure mainly sick sinus syndrome, angina pectoris, myocardial ischemia, and the nanometer heart of cardiac insufficiency protect preparation medicine, the invention still further relates to the method for this medication preparation.
It is a kind of classical Chinese patent medicine that the heart is protected ball, mainly contains heart tonifying, increase coronary flow, anti-hypoxia and improves the effects such as consumption that aconitine brings out asystole, is used for sick sinus syndrome, angina pectoris, myocardial ischemia, reaches cardiac insufficiency.It is slower that but traditional heart is protected the ball disintegrate, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully, and the nanometer heart of increase evident in efficacy is protected preparation medicine.
Another object of the present invention provides this nanometer heart to protect the preparation method of preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Flos Daturae 30-300 part nano ginseng 50-500 part nanometer Cortex Cinnamomi 30-300 part
Nanometric Radix Aconiti Lateralis Preparata 30-300 part nano-antler 1-10 part nanometer Borneolum Syntheticum 1-10 part
Nano musk 1-10 part nanometer Radix Notoginseng 50-500 part nanometer Venenum Bufonis 30-300 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Flos Daturae 50-200 part nano ginseng 100-300 part nanometer Cortex Cinnamomi 50-200 part
Nanometric Radix Aconiti Lateralis Preparata 50-200 part nano-antler 3-8 part nanometer Borneolum Syntheticum 3-8 part
Nano musk 3-8 part nanometer Radix Notoginseng 100-300 part nanometer Venenum Bufonis 50-200 part
The optimum weight proportioning of medicine of the present invention is:
100 parts of 150 parts of nanometer Cortex Cinnamomis of 100 parts of nano ginsengs of nanometer Flos Daturae
5 parts of 5 parts of nanometer Borneolum Syntheticums of 100 parts of nano-antlers of nanometric Radix Aconiti Lateralis Preparata
100 parts of 150 parts of nanometer Venenum Bufoniss of 5 parts of nanometer Radix Notoginseng of nano musk
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the heart and protect the preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer heart guarantor preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the common heart is protected the pill material and is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the nanometer heart and has protected the new drug formulation that the powder of preparation medicine, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution etc. are had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for sick sinus syndrome, angina pectoris, myocardial ischemia, and treatment of conditions such as cardiac insufficiency, and clinical efficacy significantly is better than traditional heart and protects ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 150 parts of nanometer Cortex Cinnamomis of 100 parts of nano ginsengs of nanometer Flos Daturae
5 parts of 5 parts of nanometer Borneolum Syntheticums of 100 parts of nano-antlers of nanometric Radix Aconiti Lateralis Preparata
100 parts of production methods of 150 parts of nanometer Venenum Bufoniss of 5 parts of nanometer Radix Notoginseng of nano musk are as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of 150 parts of nanometer Cortex Cinnamomis of 100 parts of nano ginsengs of nanometer Flos Daturae
5 parts of 5 parts of nanometer Borneolum Syntheticums of 100 parts of nano-antlers of nanometric Radix Aconiti Lateralis Preparata
100 parts of production methods of 150 parts of nanometer Venenum Bufoniss of 5 parts of nanometer Radix Notoginseng of nano musk are as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the nanometer heart and protect powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
100 parts of 150 parts of nanometer Cortex Cinnamomis of 100 parts of nano ginsengs of nanometer Flos Daturae
5 parts of 5 parts of nanometer Borneolum Syntheticums of 100 parts of nano-antlers of nanometric Radix Aconiti Lateralis Preparata
100 parts of 150 parts of nanometer Venenum Bufoniss of 5 parts of nanometer Radix Notoginseng of nano musk
Production method is as follows:
In the 6MP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer heart and protect membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: chest.
Claims (6)
1, a kind of nanometer heart is protected preparation medicine, it is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Flos Daturae 30-300 part nano ginseng 50-500 part nanometer Cortex Cinnamomi 30-300 part
Nanometric Radix Aconiti Lateralis Preparata 30-300 part nano-antler 1-10 part nanometer Borneolum Syntheticum 1-10 part
Nano musk 1-10 part nanometer Radix Notoginseng 50-500 part nanometer Venenum Bufonis 30-300 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, the nanometer heart according to claim 1 is protected preparation medicine, and wherein the weight proportion of each nano raw material is:
Nanometer Flos Daturae 50-200 part nano ginseng 100-300 part nanometer Cortex Cinnamomi 50-200 part
Nanometric Radix Aconiti Lateralis Preparata 50-200 part nano-antler 3-8 part nanometer Borneolum Syntheticum 3-8 part
Nano musk 3-8 part nanometer Radix Notoginseng 100-300 part nanometer Venenum Bufonis 50-200 part
3, the nanometer heart according to claim 1 is protected preparation medicine, and wherein the weight proportion of each nano raw material is:
100 parts of 150 parts of nanometer Cortex Cinnamomis of 100 parts of nano ginsengs of nanometer Flos Daturae
5 parts of 5 parts of nanometer Borneolum Syntheticums of 100 parts of nano-antlers of nanometric Radix Aconiti Lateralis Preparata
100 parts of 150 parts of nanometer Venenum Bufoniss of 5 parts of nanometer Radix Notoginseng of nano musk
4, protect preparation medicine according to the claim 1 or the 2 or 3 described nanometer hearts, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer hearts guarantor preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100039 CN1362074A (en) | 2001-01-05 | 2001-01-05 | Nano heart proteoting medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100039 CN1362074A (en) | 2001-01-05 | 2001-01-05 | Nano heart proteoting medicine and its preparation |
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| CN1362074A true CN1362074A (en) | 2002-08-07 |
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| CN 01100039 Pending CN1362074A (en) | 2001-01-05 | 2001-01-05 | Nano heart proteoting medicine and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114127B (en) * | 2009-06-30 | 2015-04-15 | 广东太安堂药业股份有限公司 | Multifunctional good medicine for heart and preparation method thereof |
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2001
- 2001-01-05 CN CN 01100039 patent/CN1362074A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114127B (en) * | 2009-06-30 | 2015-04-15 | 广东太安堂药业股份有限公司 | Multifunctional good medicine for heart and preparation method thereof |
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