CN1362077A - Nano thrombus treating xinmaining medicine and its preparation - Google Patents
Nano thrombus treating xinmaining medicine and its preparation Download PDFInfo
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- CN1362077A CN1362077A CN 01100042 CN01100042A CN1362077A CN 1362077 A CN1362077 A CN 1362077A CN 01100042 CN01100042 CN 01100042 CN 01100042 A CN01100042 A CN 01100042A CN 1362077 A CN1362077 A CN 1362077A
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Abstract
The invention discloses a nano preparation for relieving thrombus and heart vessel. It comprises materials such as nano ligusticum wallichii, nano sophora flower-bud, nano root of red-rooted salvia, nano leech, nano ilex pubescens, nano bezoar, nanomusk, nano borneol, nanosenso, etc. and makes up in accordance with proportion and to be fabricated into new medical preparation. Its particle fineness in 1200-1500 mesh, and its particle size 0.1-200nm, most of the particle size is shorter than 100nm and has new material properties. It is fabricated through steps such as microwave extraction, decompression and concentration, supersonic jet and spray drying.
Description
The present invention relates to a kind of causing resuscitation with aromatic drugs, promoting blood circulation to remove blood stasis, cure mainly the nano thrombus sumalin preparation medicine that cerebral thrombosis, coronary heart disease, angina pectoris belong to syndrome of qi stagnation and blood stasis, the invention still further relates to the method for this medication preparation.
The XUESHUANXINMAINING capsule is a kind of classical Chinese patent medicine, mainly contains effects such as causing resuscitation with aromatic drugs, promoting blood circulation to remove blood stasis, is used for cerebral thrombosis, coronary heart disease, angina pectoris and belongs to syndrome of qi stagnation and blood stasis.But traditional XUESHUANXINMAINING capsule absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano thrombus sumalin preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano thrombus sumalin preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Chuanxiong 50-500 part nanometer Flos Sophorae Immaturus 100-600 part nano red sage 100-600 part
Nanometer Hirudo 50-500 part nanometer Radix Ilicis Pubescentis 30-500 part nano bezoar 3-25 part
Nano musk 1-10 part nano ginseng stem and leaf Saponin 50-300 part
Nanometer Borneolum Syntheticum 1-10 part nanometer Venenum Bufonis 1-10 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Chuanxiong 100-300 part nanometer Flos Sophorae Immaturus 150-500 part nano red sage 150-500 part
Nanometer Hirudo 100-300 part nanometer Radix Ilicis Pubescentis 50-300 part nano bezoar 5-20 part
Nano musk 3-8 part nano ginseng stem and leaf Saponin 100-200 part
Nanometer Borneolum Syntheticum 3-8 part nanometer Venenum Bufonis 3-8 part
The optimum weight proportioning of medicine of the present invention is:
250 parts of 250 parts of nano red sages of 200 portions of nanometer Flos Sophorae Immaturus of nanometer Rhizoma Chuanxiong
10 parts of 150 parts of nano bezoars of 200 parts of nanometer Radix Ilicis Pubescentiss of nanometer Hirudo
150 parts of 5 parts of nano ginseng stem and leaf of nano musk Saponins
10 parts of 5 parts of nanometer Venenum Bufoniss of nanometer Borneolum Syntheticum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get XUESHUANXINMAINING preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano thrombus sumalin preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common XUESHUANXINMAINING capsule preparations material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano thrombus sumalin preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for cerebral thrombosis, coronary heart disease, angina pectoris and belongs to treatment of conditions such as syndrome of qi stagnation and blood stasis, and clinical efficacy significantly is better than traditional XUESHUANXINMAINING capsule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
250 parts of 250 parts of nano red sages of 200 portions of nanometer Flos Sophorae Immaturus of nanometer Rhizoma Chuanxiong
10 parts of 150 parts of nano bezoars of 200 parts of nanometer Radix Ilicis Pubescentiss of nanometer Hirudo
150 parts of 5 parts of nano ginseng stem and leaf of nano musk Saponins
10 parts of 5 parts of nanometer Venenum Bufoniss of nanometer Borneolum Syntheticum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
250 parts of 250 parts of nano red sages of 200 portions of nanometer Flos Sophorae Immaturus of nanometer Rhizoma Chuanxiong
10 parts of 150 parts of nano bezoars of 200 parts of nanometer Radix Ilicis Pubescentiss of nanometer Hirudo
150 parts of 5 parts of nano ginseng stem and leaf of nano musk Saponins
10 parts of 5 parts of nanometer Venenum Bufoniss of nanometer Borneolum Syntheticum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nano thrombus sumalin powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
250 parts of 250 parts of nano red sages of 200 portions of nanometer Flos Sophorae Immaturus of nanometer Rhizoma Chuanxiong
10 parts of 150 parts of nano bezoars of 200 parts of nanometer Radix Ilicis Pubescentiss of nanometer Hirudo
150 parts of 5 parts of nano ginseng stem and leaf of nano musk Saponins
10 parts of 5 parts of nanometer Venenum Bufoniss of nanometer Borneolum Syntheticum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nano thrombus sumalin membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: chest, cervical region.
Claims (6)
1, a kind of nano thrombus sumalin preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Chuanxiong 50-500 part nanometer Flos Sophorae Immaturus 100-600 part nano red sage 100-600 part
Nanometer Hirudo 50-500 part nanometer Radix Ilicis Pubescentis 30-500 part nano bezoar 3-25 part
Nano musk 1-10 part nano ginseng stem and leaf Saponin 50-300 part
Nanometer Borneolum Syntheticum 1-10 part nanometer Venenum Bufonis 1-10 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano thrombus sumalin preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Chuanxiong 100-300 part nanometer Flos Sophorae Immaturus 150-500 part nano red sage 150-500 part
Nanometer Hirudo 100-300 part nanometer Radix Ilicis Pubescentis 50-300 part nano bezoar 5-20 part
Nano musk 3-8 part nano ginseng stem and leaf Saponin 100-200 part
Nanometer Borneolum Syntheticum 3-8 part nanometer Venenum Bufonis 3-8 part
3, nano thrombus sumalin preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
250 parts of 250 parts of nano red sages of 200 portions of nanometer Flos Sophorae Immaturus of nanometer Rhizoma Chuanxiong
10 parts of 150 parts of nano bezoars of 200 parts of nanometer Radix Ilicis Pubescentiss of nanometer Hirudo
150 parts of 5 parts of nano ginseng stem and leaf of nano musk Saponins
10 parts of 5 parts of nanometer Venenum Bufoniss of nanometer Borneolum Syntheticum
4, according to claim 1 or 2 or 3 described nano thrombus sumalin preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano thrombus sumalin preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100042 CN1362077A (en) | 2001-01-05 | 2001-01-05 | Nano thrombus treating xinmaining medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100042 CN1362077A (en) | 2001-01-05 | 2001-01-05 | Nano thrombus treating xinmaining medicine and its preparation |
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| CN1362077A true CN1362077A (en) | 2002-08-07 |
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| CN 01100042 Pending CN1362077A (en) | 2001-01-05 | 2001-01-05 | Nano thrombus treating xinmaining medicine and its preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342238B (en) * | 2008-08-27 | 2012-02-08 | 吉林华康药业股份有限公司 | Medicinal composition for treating cardiovascular and cerebrovascular diseases |
| CN102507843A (en) * | 2011-11-13 | 2012-06-20 | 吉林华康药业股份有限公司 | Method for testing effective contents of Xueshuan xinmaining tablet |
| CN102507844A (en) * | 2011-11-13 | 2012-06-20 | 吉林华康药业股份有限公司 | Testing method for Xueshuan xinmaining tablet |
-
2001
- 2001-01-05 CN CN 01100042 patent/CN1362077A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342238B (en) * | 2008-08-27 | 2012-02-08 | 吉林华康药业股份有限公司 | Medicinal composition for treating cardiovascular and cerebrovascular diseases |
| CN102507843A (en) * | 2011-11-13 | 2012-06-20 | 吉林华康药业股份有限公司 | Method for testing effective contents of Xueshuan xinmaining tablet |
| CN102507844A (en) * | 2011-11-13 | 2012-06-20 | 吉林华康药业股份有限公司 | Testing method for Xueshuan xinmaining tablet |
| CN102507844B (en) * | 2011-11-13 | 2013-10-16 | 吉林华康药业股份有限公司 | Testing method for Xueshuan xinmaining tablet |
| CN102507843B (en) * | 2011-11-13 | 2014-01-08 | 吉林华康药业股份有限公司 | Method for testing effective contents of Xueshuan xinmaining tablet |
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