CN113081933A

CN113081933A - Acne-removing composition and preparation method and application thereof

Info

Publication number: CN113081933A
Application number: CN202110388109.7A
Authority: CN
Inventors: 郝姗姗; 陈明霞; 段行武; 韩雅慧; 易斌
Original assignee: Jianchangbang Pharmacy Co ltd
Current assignee: Jianchangbang Pharmacy Co ltd
Priority date: 2021-04-12
Filing date: 2021-04-12
Publication date: 2021-07-09

Abstract

The invention relates to the technical field of traditional Chinese medicines and traditional Chinese medicine cosmetics, and particularly relates to an acne-removing composition and a preparation method and application thereof. The acne-removing composition comprises the following components in parts by weight: 0.01-0.5 part of turmeric extract, 0.01-0.3 part of clove extract, 0.02-1 part of salvia miltiorrhiza extract and 0.01-0.3 part of cacumen biotae extract. The composition has high safety, and can not cause skin dryness, desquamation, allergy, and dependence. Meanwhile, the composition has a remarkable acne removing effect and has the effects of moisturizing and acne mark fading. The prepared active extract has light color and good stability, and can achieve the effect by low-content application. The acne-removing traditional Chinese medicine composition is simple and convenient to apply, can be directly applied to cosmetics in various formulations, is not limited to products such as face cleaning products, water products, emulsion products, face cream products, essence products and the like, is low in formula cost, and has wide application prospects.

Description

Acne-removing composition and preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines and traditional Chinese medicine cosmetics, and particularly relates to an acne-removing composition and a preparation method and application thereof.

Background

Acne, commonly referred to as acne, is a chronic inflammatory skin disease that occurs well in adolescence and mainly involves the pilosebaceous unit of the face. The pathogenesis of acne has not yet been fully elucidated, and the currently known pathogenesis is mainly the following four: 1 hormone-induced excessive secretion of lipids from sebaceous glands in a genetic background; 2 follicular sebaceous gland duct keratosis; 3, breeding hair follicle microorganisms such as propionibacterium acnes; inflammation and immune response.

Cosmetics developed for acne are generally called acne-removing cosmetics. Aiming at the pathogenesis, the current commercially available acne-removing cosmetics usually achieve the effect by adding vitamin A and chemical bacteriostat (such as sulfur and salicylic acid). However, these ingredients tend to cause dryness, irritation or damage to the normal flora of the skin, and have poor consumer compliance. Moreover, the effect is achieved by adding forbidden substances (such as antibiotics such as chloramphenicol and the like, heavy metals and the like), and deeper damage is brought to the skin and even the mind of consumers.

The traditional Chinese medicine for treating acne has a long history in China, has wide sources of raw materials, low price and small toxic and side effects, and has obvious advantages in preparation of acne medicines. Therefore, the application of the traditional Chinese medicine in the acne-removing cosmetics is also an industrial research and development hotspot. However, the content of effective substances and the function condition of the acne removing efficacy of the acne removing cosmetics using the traditional Chinese medicine extract in the current market are not proved by scientific and rigorous data. Most of the acne removing cosmetics only stay at the level of concept addition, and whether the acne removing products have remarkable efficacy and whether the acne removing cosmetics are safe for human bodies cannot be guaranteed. The traditional Chinese medicine composition is mostly dark or light, but has poor stability, and can change color with time to cause inactivation. In addition, the addition amount of the traditional Chinese medicine composition in the cosmetic really having the acne removing effect is large, the cost is high, and the application is limited.

In view of the above, the present invention is particularly proposed.

Disclosure of Invention

In order to achieve the above purpose of the present invention, the following technical solutions are adopted:

the first aspect of the invention relates to an acne-removing composition which comprises the following components in parts by weight:

0.01-0.5 part of turmeric extract, 0.01-0.3 part of clove extract, 0.02-1 part of salvia miltiorrhiza extract and 0.01-0.3 part of cacumen biotae extract.

Optionally, the acne-removing composition comprises the following components by weight:

0.1-0.2 part of turmeric extract, 0.05-0.15 part of clove extract, 0.1-0.5 part of salvia miltiorrhiza extract and 0.05-0.15 part of cacumen biotae extract.

Optionally, in the acne-removing composition, the turmeric extract is a microbial fermentation product using turmeric as a substrate, and the total amount of curcumin and turmerone is more than or equal to 10% (w/w);

the clove extract is an alcohol extract, and the volatile oil is more than or equal to 8 percent;

the red sage root extract is an alcohol extract, and the tanshinone content is more than or equal to 5 percent;

the cacumen biotae extract is an alcohol extract, and the flavonoid substance is more than or equal to 3 percent.

Optionally, the acne-removing composition as described above further comprises the following components by weight:

0.01 to 0.5 part of rhizoma atractylodis extract, 0.01 to 0.5 part of rhubarb extract, 0.01 to 0.7 part of radix sophorae flavescentis extract and 0.01 to 0.3 part of rhizoma cyperi extract.

0.1-0.2 part of rhizoma atractylodis extract, 0.1-0.2 part of rhubarb extract, 0.1-0.3 part of radix sophorae flavescentis extract and 0.05-0.15 part of rhizoma cyperi extract.

Optionally, in the acne-removing composition, the rhizoma atractylodis extract is steam distillate, and the volatile oil is more than or equal to 5%;

the rhubarb extract is an alcohol extract, and anthraquinone substances are more than or equal to 1 percent;

the sophora flavescens extract is an alcohol extract, and the matrine content is more than or equal to 1.5 percent;

the rhizoma cyperi extract is an alcohol extract, and the volatile oil is more than or equal to 2 percent.

Optionally, the acne-removing composition further comprises pharmaceutically acceptable auxiliary materials.

A second aspect of the invention relates to a skin care composition comprising an anti-acne composition as described above.

Optionally, the skin care composition as described above is a lotion, mask, lotion, essence, or cream.

A third aspect of the invention relates to the use of an anti-acne composition as described above for the preparation of a medicament for the treatment of acne.

The composition has high safety, and can not cause skin dryness, desquamation, allergy, and dependence. Meanwhile, the composition has a remarkable acne removing effect and has the effects of moisturizing and acne mark fading. The prepared active extract has light color and good stability, and can achieve the effect by low-content application. The acne-removing traditional Chinese medicine composition is simple and convenient to apply, can be directly applied to cosmetics in various formulations, is not limited to products such as face cleaning products, water products, emulsion products, face cream products, essence products and the like, is low in formula cost, and has wide application prospects.

Detailed Description

Reference will now be made in detail to embodiments of the invention, one or more examples of which are described below. Each example is provided by way of explanation, not limitation, of the invention. In fact, it will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the scope or spirit of the invention. For instance, features illustrated or described as part of one embodiment, can be used on another embodiment to yield a still further embodiment.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

The invention relates to an acne-removing composition which comprises the following components in parts by weight:

In some embodiments, the acne-removing composition of the present invention comprises the following components by weight:

0.15 part of turmeric extract, 0.1 part of clove extract, 0.3 part of salvia extract and 0.1 part of cacumen biotae extract.

In some embodiments, the acne-removing composition of the present invention further comprises the following components by weight:

0.15 part of rhizoma atractylodis extract, 0.15 part of rhubarb extract, 0.2 part of radix sophorae flavescentis extract and 0.1 part of rhizoma cyperi extract.

The properties of the raw materials (components) are as follows:

turmeric: pungent and bitter with warm nature. It enters spleen and liver meridians. The functional indications are as follows: break blood and move qi, dredge meridians to alleviate pain. Can be used for treating chest and hypochondrium stabbing pain, thoracic obstruction, cardialgia, dysmenorrhea, amenorrhea, abdominal mass, rheumatism, shoulder and arm pain, and traumatic injury with swelling and pain. In the present invention, turmeric exerts its excellent anti-inflammatory ability, and can prevent the occurrence and deterioration of pox; can soften and moisten skin and delay skin aging; can reduce acne marks and reduce acne aggravation caused by sunlight. The turmeric extract adopted by the invention is preferably a microbial fermentation product (particularly a lactobacillus fermentation product) taking turmeric as a substrate, and further, the total amount of the curcumin and the turmerone is more than or equal to 10 percent (w/w); the amount of the surfactant may be 0.01 to 0.5 parts by weight, for example, 0.05, 0.1, 0.2, 0.3 or 0.4 parts by weight.

Clove: pungent flavor and warm nature. It enters spleen, stomach, lung and kidney meridians. The functional indications are as follows: to warm the middle-jiao and descend the adverse flow of qi, tonify the kidney and strengthen yang. Can be used for treating deficiency-cold of spleen and stomach, singultus emesis, anorexia vomiting and diarrhea, psychroalgia of heart and abdomen, and sexual impotence due to kidney deficiency. In the invention, clove can inhibit the activity of 5 alpha-reductase, reduce the grease secretion caused by higher androgen, and can be used for preventing and treating pox by combining the antibacterial property and the anti-inflammatory property of the clove. Flos Caryophylli has effects of inhibiting collagenase activation, scavenging free radicals, resisting oxidation, and resisting wrinkle and aging. The clove extract adopted by the invention is preferably an alcohol extract, and further, the volatile oil is more than or equal to 8 percent; the amount of the surfactant may be 0.01 to 0.3 parts by weight, for example, 0.05, 0.1, 0.15, 0.2 or 0.25 parts by weight.

Red sage root: bitter in taste and slightly cold in nature. It enters heart and liver meridians. The functional indications are as follows: promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and eliminating carbuncle. Can be used for treating thoracic obstruction, cardialgia, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain. In the present invention, Salvia miltiorrhiza has an antiandrogenic effect and can inhibit sebum secretion. And can inhibit activity of Propionibacterium acnes, reduce skin inflammation, and supplement skin trace elements. The salvia miltiorrhiza extract adopted by the invention is preferably an alcohol extract, and further, the tanshinone content is more than or equal to 5 percent; the amount may be 0.02 to 1 part by weight, for example, 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 part by weight.

Cacumen biotae: bitter and astringent taste, cold in nature. It enters lung, liver and spleen meridians. The functional indications are as follows: cool blood to stop bleeding, resolve phlegm to stop cough, promote hair growth and blacken hair. Can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, metrostaxis, cough due to lung heat, alopecia due to blood heat, and premature gray hair. In the invention, the cacumen biotae has obvious antibacterial effect and anti-inflammatory activity, and can help skin to lock moisture, shrink pores and maintain the moist and fine state of the skin. The adopted cacumen biotae extract is preferably an alcohol extract, and further, the flavonoid substance is more than or equal to 3 percent; the addition amount of cacumen Platycladi may be 0.01-0.3 parts by weight, for example, 0.05, 0.1, 0.15, 0.2, 0.25 parts by weight.

Rhizoma atractylodis: pungent and bitter with warm nature. It enters spleen, stomach and liver meridians. The functional indications are as follows: dry dampness and invigorate spleen, dispel wind and cold, improve vision. Can be used for treating damp obstruction of middle warmer, abdominal distention, diarrhea, edema, tinea pedis atrophy 36484m, rheumatalgia, wind-cold type common cold, night blindness, dim eyesight, and astringency. In the invention, the rhizoma atractylodis has antibacterial effect on various bacteria, and can prevent and treat acnes; has effects in inhibiting tyrosinase, and can be combined with its antioxidant effect to reduce acne marks. The rhizoma atractylodis extract adopted by the invention is preferably steam distillate, and further, the volatile oil is more than or equal to 5 percent; the amount of rhizoma Atractylodis can be 0.01-0.5 weight parts, such as 0.05, 0.1, 0.2, 0.3, 0.4 weight parts.

Rhubarb: bitter taste and cold nature. It enters spleen, stomach, large intestine, liver and pericardium meridians. The functional indications are as follows: purgation and eliminating accumulation, clearing heat and purging fire, cooling blood and removing toxicity, removing blood stasis and dredging channels, promoting diuresis and eliminating jaundice. Can be used for treating constipation due to excessive heat accumulation, hematemesis, epistaxis, conjunctival congestion, pharyngeal swelling, carbuncle, sore, intestinal carbuncle, abdominal pain, blood stasis, amenorrhea, puerperal blood stasis, traumatic injury, damp-heat dysentery, jaundice, dark urine, stranguria, and edema; it can be used for external treatment of burn and scald. In the invention, the rhubarb plays roles of moisturizing, anti-inflammation and bacteriostasis. The rhubarb extract adopted by the invention is preferably an alcohol extract, and further, anthraquinone substances are more than or equal to 1 percent; the amount of rhubarb added may be 0.01 to 0.5 parts by weight, for example, 0.05, 0.1, 0.2, 0.3, 0.4 parts by weight.

Flavescent sophora root: bitter taste and cold nature. It enters heart, liver, stomach, large intestine and bladder meridians. The functional indications are as follows: clear heat and dry dampness, kill parasites and induce diuresis. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, and leprosy; it can be used for treating trichomonas vaginitis. In the invention, the sophora flavescens has the functions of moisturizing, anti-inflammation and bacteriostasis. The sophora flavescens extract adopted by the invention is preferably an alcohol extract, and furthermore, the matrine is more than or equal to 1.5%; the addition amount of the sophora flavescens can be 0.01 to 0.7 part by weight, for example, 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6 part by weight.

Rhizoma cyperi: pungent, slightly bitter, slightly sweet and neutral in nature. It enters liver, spleen and triple energizer meridians. The functional indications are as follows: to soothe the liver, relieve depression, regulate qi, relieve epigastric distention, regulate menstruation and alleviate pain. Can be used for treating stagnation of qi due to depression of the liver, distending pain in chest and hypochondrium, hernia pain, breast pain, stagnation of qi in spleen and stomach, abdominal distention, fullness and pain, menoxenia, amenorrhea, and dysmenorrhea. In the invention, the rhizoma cyperi can effectively calm the skin, thereby achieving the effect of conditioning the skin, strengthening the natural defense system of the skin and ensuring the skin to be moist and comfortable. The rhizoma cyperi extract adopted by the invention is preferably an alcohol extract, and further, the volatile oil is more than or equal to 2 percent; the addition amount of rhizoma Cyperi may be 0.01-0.3 parts by weight, such as 0.05, 0.1, 0.15, 0.2, 0.25 parts by weight.

The raw materials can also contain pharmaceutically acceptable auxiliary materials.

Examples of the pharmaceutically acceptable auxiliary ingredient include binders (syrup, gum arabic, gelatin, sorbitol, tragacanth (tragacanth), polyvinylpyrrolidone and the like), fillers (lactose, sucrose, starch, calcium phosphate, sorbitol, glycine and the like), lubricants (magnesium stearate, talc, polyethylene glycol and the like), disintegrants (starch, microcrystalline cellulose (microcrystalline cellulose), and the like), wetting agents (sodium lauryl sulfate, and the like), suspending agents (sorbitol, syrup, methyl cellulose, glucose syrup, gelatin, hydrogenated edible fat and the like), emulsifiers (lecithin, sorbitol monooleate, gum arabic and the like), non-aqueous carriers (almond oil, fractionated coconut oil, hydrophobic esters of glycerin, propylene glycol, ethanol and the like), preservatives (methyl p-hydroxybenzoate or propyl p-hydroxybenzoate, sodium p-hydroxybenzoate and the like), preservatives (lecithin, sorbitol monooleate, gum arabic and the like), and the like, Sorbic acid, etc.), an aromatic agent (synthetic flavor, natural flavor, etc.), a sweetener (sucrose, stevia, xylitol, etc.), a pH adjuster (sodium hydrogen carbonate, potassium carbonate, etc.), a coloring agent (pigment, dye, etc.), a thickener (gum arabic, methyl cellulose, etc.), an antioxidant (vitamin C, vitamin E, etc.), and the like.

The acne-removing composition can be in various dosage forms, and the preferred dosage forms are ointment, cataplasm or gel.

The ointment is one of the pharmaceutical dosage forms. The unguent is prepared by decocting the above materials with water or vegetable oil, and concentrating. There are oral and external application. The topical ointment includes ointment and plaster. The ointment for external use is called ointment, and is generally prepared by adding beeswax into cottonseed oil or peanut oil, heating to melt, adding the applied medicine fine powder while heating, continuously stirring, and condensing. The ointment is preferably an ointment, cream or patch.

The present invention is preferably an external ointment.

Cataplasm (cataplasma) is a novel external preparation, and is an external preparation for skin application, which is prepared by dissolving or mixing medicines in a water-soluble high polymer material matrix and spreading the mixture on a backing material.

The gel is thick liquid or semisolid preparation prepared by the drug and auxiliary materials capable of forming gel and prepared into solution, suspension or emulsion. Gels are typically topically applied to the skin and body cavities (e.g., nasal, vaginal, and rectal).

The invention also provides a skin care composition containing the acne removing composition.

The acne-removing composition according to the invention may be present in the skin care composition according to the invention in an amount which may be between 0.001% and 10% by weight, preferably between 0.1% and 5% by weight, preferably between 0.5% and 3% by weight, more preferably between 1% and 2% by weight, relative to the total weight of the composition.

In one embodiment, the skin care composition further comprises a physiologically acceptable medium and at least one compound selected from the group consisting of: thickeners, preservatives, fragrances, bactericides, solvents [ e.g. water, alcohols (e.g. ethanol, glycerol, propylene glycol), oils (e.g. mineral, vegetable or animal oils), including in particular C1-C6 alcohols and C2-C10 carboxylic esters ], and carbon-based oils and/or silicone oils (whether of mineral, animal and/or vegetable origin).

The skin care composition additionally comprises a physiologically acceptable medium, i.e., a medium that is free of unpleasant odor, color, or appearance, and does not cause any discomfort (e.g., unacceptable stinging or tautness) to the user. In particular, the composition is suitable for topical application to the skin.

Thus, a "physiologically acceptable medium" is understood to mean a medium compatible with human keratin materials, and in particular with the skin of the body or face.

The compositions according to the invention may comprise any cosmetic adjuvant conventionally used in the fields of application envisaged.

The composition according to the invention may be substantially fluid and may have the appearance of a white or coloured cream, ointment, cream, body cream, lotion (in particular facial cleanser, bath foam), essence, paste, gel or foam. It may optionally be administered in aerosol form. It can also be in solid form, and in particular in the form of a stick. It may also be on a support, for example on a wipe (such as a make-up removal wipe); also for example a face mask.

In particular, in a specific embodiment, the invention also provides a preparation method of the acne-removing essence, which comprises the following steps:

keeping the temperature of the mixed solution of butanediol, glycerol and xanthan gum at 80-100 ℃ for 20-40 min;

adding EDTA salt, allantoin and antiseptic, stirring and cooling to 40-50 deg.C, adding hexanediol and the above-mentioned acne-removing composition.

In some embodiments, the preservative is p-hydroxyacetophenone.

In some embodiments, the acne removing essence comprises 1 to 3 parts by weight of butanediol, 1 to 3 parts by weight of glycerin, 0.1 to 0.2 part by weight of xanthan gum, 0.01 to 0.03 part by weight of EDTA salt, 0.05 to 0.15 part by weight of allantoin and 0.3 to 0.5 part by weight of p-hydroxyacetophenone based on 100 parts by weight of the total amount of the acne removing essence. The addition amount of the acne-removing composition is added according to the weight parts, such as 0.01-0.5 part of turmeric extract, 0.01-0.3 part of clove extract, 0.02-1 part of salvia miltiorrhiza extract, 0.01-0.3 part of cacumen biotae extract, and optionally: 0.01 to 0.5 part of rhizoma atractylodis extract, 0.01 to 0.5 part of rhubarb extract, 0.01 to 0.7 part of radix sophorae flavescentis extract and 0.01 to 0.3 part of rhizoma cyperi extract. The balance being a solvent such as water.

The invention also relates to application of the acne-removing composition in preparation of a medicine for treating acne.

The invention also relates to a method of treating acne comprising topically contacting the skin, and more particularly administering to the facial skin, with an acne-removing composition as described above.

As used herein, the term "treating" includes inhibiting a pathological state, disorder or disease, e.g., arresting or reducing the development of the pathological state, disorder or disease or clinical symptoms thereof; or alleviating the pathological state, disorder or disease, e.g., causing regression of the pathological state, disorder or disease or clinical symptoms thereof. These terms also encompass treatments and cures. Treatment means any manner of ameliorating or otherwise beneficially altering the symptoms of a pathological condition, disorder, or disease. Preferably, the subject in need of such treatment is a mammal, more preferably a human.

For the purposes of the present invention, the term "acne" is intended to mean skin exhibiting acne with an ECLA score of 1 to 36.

Embodiments of the present invention will be described in detail with reference to examples.

Examples

Examples 1 to 8

A traditional Chinese medicine composition for removing acne comprises the following components:

comparative examples 1 to 5

Preparation of a test sample acne removing essence:

1. uniformly dispersing 0.15 part by weight of xanthan gum by using 2 parts by weight of butanediol and 2 parts by weight of glycerol, adding 50 parts by weight of deionized water, heating and stirring to 90 ℃, and preserving heat for 30min to obtain colorless transparent liquid;

2. sequentially adding 0.02 weight part of EDTA disodium, 0.1 weight part of allantoin and 0.4 weight part of p-hydroxyacetophenone, stirring until the EDTA disodium, the allantoin and the p-hydroxyacetophenone are dissolved, and then cooling;

3. cooling to 45 ℃, sequentially adding 0.5 part by weight of hexanediol, the traditional Chinese medicine compositions of the examples 1-8 and the comparative examples 1-5 and the rest of deionized water (the whole formula is 100 parts by weight), and uniformly stirring;

4. cooling to 35 ℃ to obtain the acne removing essence 1-8 and the comparative examples 6-10.

Comparative example 11: the traditional Chinese medicine acne removing essence is commercially available.

Wherein the acne removing essence 1-8 and the comparative examples 6-10 are transparent colorless liquids, and the comparative example 11 is a brown yellow transparent liquid.

Safety

Skin occlusion patch test:

420 volunteers meeting the enrollment criteria were selected for the trial and randomized into 14 groups of 30 individuals each.

Inclusion volunteer criteria were: 1) the age is between 15 and 60 years old, and both men and women can use the health care tea; 2) no serious diseases, no immunodeficiency or autoimmune diseases, and no skin treatment and beauty treatment on the tested part; 3) no active allergic disease; 4) the tested part is not applied with any anti-inflammatory drugs in the last two months; 5) one week later with antihistamine or one month later without immunosuppressant. 6) Those who did not perform the patch test within a month.

Exclusion criteria: 1) pregnant or lactating women; 2) patients with severe diseases of heart, lung, cerebral vessels, liver, kidney and hemopoietic system and mental disease; 3) patients suffering from asthma or other chronic respiratory diseases are being treated.

Abort and exit criteria: during the test, the test sample was not applied as required or the record was not recalled as required.

All volunteers need to sign their informed consent. Marking sample serial numbers on the back surfaces of all spot testers, adding an equal amount of acne-removing essence, taking 0.025ml of sample by using an injector, placing the sample in a medicine chamber of a spot testing adhesive tape, immediately and longitudinally sticking the spot testing adhesive tape with the sample on normal skin of a left forearm from the lower part, and slightly pressing the medicine chamber one by one to expel air so as to uniformly distribute the test substances. The test site is marked for easy observation. Three groups of parallel lines and a blank group are set, the patch is applied once every 24 hours, and the patch is uncovered for a second half hour, and then the examination is performed according to the grading standard. The patch test was performed 6 times in total, and on day 6 after completion of the skin application, additional examination was performed to observe delayed reactions.

Closed patch test skin adverse reaction grading standard

The criteria for the skin irritation test are shown in the table.

The results are shown in the table:

essence 1-8

Comparative examples 6 to 11

And (4) conclusion:

no adverse reaction of human bodies occurs in 1-8 parts of essence and 6-10 parts of comparative examples, and the safety is high. Comparative example 11 three 2-stage reactions occurred. The composition of the invention has mild property and high safety.

(II) stability

And (3) placing the essence 1-8 and the comparative examples 6-11 under different storage conditions for stability observation for 3 months.

The results are shown in the table

Essence 1-8

Storage conditions

Essence 1

Essence 2

Essence 3

Essence 4

Essence 5

Essence 6

Essence 7

Essence 8

50℃

Without change

Is not changedTransforming

Without change

40℃

Without change

25℃

Without change

5℃

Without change

-18℃

Without change

Natural illumination of light

Without change

Comparative examples 6 to 11

Storage conditions

Comparative example 6

Comparative example 7

Comparative example 8

Comparative example 9

Comparative example 10

Comparative example 11

50℃

Darkening of color

The color is very dark

40℃

Darkening of color

Without change

Darkening of color

25℃

Without change

5℃

Without change

A small amount of precipitate is separated out

-18℃

Precipitate is separated out

A small amount of precipitate is separated out

Without change

A small amount of precipitate is separated out

Precipitate is separated out

Natural illumination of light

Without change

Color lightening

And (4) conclusion:

the essence 1-8 has no color or state change, and is high in stability. Comparative examples 6-11 all showed stability problems of different degrees, especially comparative example 11 showed high temperature, discoloration under illumination and low temperature precipitation. Since comparative example 11 is a brownish yellow transparent liquid, it is suspected that this may be caused by adding a high content of traditional Chinese medicine acne-removing ingredients to the formula to achieve a significant acne-removing effect. The traditional Chinese medicine extract has high ion concentration, and the system is unstable due to high content of the traditional Chinese medicine extract, and meanwhile, the long-term stability of the traditional Chinese medicine extract in a formula system is difficult to ensure due to improper proportion, and discoloration or precipitation occurs. Meanwhile, the comparative examples 6-10 also show state changes of different degrees, and compared with the essence 1-8, the results show that the turmeric extract, the clove extract, the salvia miltiorrhiza extract and the cacumen biotae extract are reasonably matched and have synergistic effect, so that a formula system is more stable.

(III) efficacy

Acne removing, moisturizing and acne mark fading efficacy test

450 volunteers meeting the selection criteria were selected for the trial, and all volunteers were randomly divided into 15 groups of 30 individuals each. The essence is used for 1-8 of all groups of volunteers respectively, the proportion is 6-11, one group of volunteers can normally care skin, no efficacy type skin care product is used, and the group is blank.

Inclusion volunteer criteria were: the age is 20-45 years old, and the nature is not limited; oily and mixed skin, and face with acne; hormone drugs and immunosuppressants have not been used in the last month; the tested part does not participate in other clinical testers at present or in nearly 30 days; can be matched with testers well; the system can read and understand all contents of the informed consent and voluntarily sign the informed consent; during the test period, the consent was not to use any cosmetics, drugs and nutraceuticals that have an impact on the outcome.

Exclusion criteria: open wound or erosion face at the acne affected part; those with high allergic constitution; those with a history of cosmetic allergy; a female who is pregnant, lactating, or intended to be pregnant during the test; severe center of gravity, liver and kidney function damage and severe immunologic hypofunction; those with mental disorders, severe endocrine disorders, and oral contraceptives; the patients who participate in the drug clinical testers or other testers within 30 days, or the patients who have systemic drugs which have influence on the test results within about 1 week; those who had oral and topical cosmetic products within 2 weeks that may have an effect on the outcome of the test; the investigator considered not appropriate for attending the investigator.

Abort and exit criteria: smearing the tested sample or recording the revisit according to the requirement during the test period; has serious diseases or serious adverse reactions during the use period.

All volunteers need to sign their informed consent. The volunteers applied the product on their whole face for 28 days after cleansing the face in the morning and evening each day. The clinical evaluation of the acne removing efficacy of a dermatologist is adopted to obtain the effective number and the cure number of the acne removing patients. Evaluation criteria: 1) and (3) curing: disappearance of clinical symptoms, elimination of pox and pox; 2) the method has the following advantages: the clinical symptoms are relieved, the pox part is eliminated or disappeared, and the reduction or reduction is realized; 3) and (4) invalidation: the clinical symptoms and pox are not improved.

Meanwhile, the volunteers are required to evaluate the effects of moisturizing and acne mark fading by themselves, the score is 0-9 according to the using effect, the score is the best when 9 is the best, and the score is the worst when 0 is the worst, and the average value is taken. Recording the number of effective people for removing acne, moisturizing and removing acne marks on days 1, 3, 7, 14 and 28 after sample trial, and recording the number of cured people on day 28.

The evaluation results of acne-removing efficacy are shown in Table 1

The scoring results of the moisturizing and acne mark removing effects are shown in Table 2

And (4) conclusion:

as can be seen from tables 1 and 2, the acne-removing traditional Chinese medicine composition provided by the essence 1-8 has the remarkable effects of removing acne, preserving moisture and removing acne marks, is quick in acne-removing effect and high in cure rate, and can improve the moisture of skin and remove acne marks after being used for a long time. Compared with the comparative examples 6-11 and the blank group, the essence 3 has a synergistic effect by reasonably proportioning the turmeric extract, the clove extract, the salvia miltiorrhiza extract and the cacumen biotae extract. The comparison of the essence 1-8 shows that the addition of any one or more of the rhizoma atractylodis extract, the rheum officinale extract, the radix sophorae flavescentis extract and the rhizoma cyperi extract can further enhance the effects of removing acnes, preserving moisture and fading acne marks.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. The acne-removing composition is characterized by comprising the following components in parts by weight:

2. The acne-removing composition according to claim 1, which comprises the following components in parts by weight:

3. The acne-removing composition according to claim 1, wherein:

the turmeric extract is a microbial fermentation product taking turmeric as a substrate, and the total amount of curcumin and turmerone is more than or equal to 10% (w/w);

4. The acne-removing composition according to claim 1, further comprising the following components by weight:

5. The acne-removing composition according to claim 4, further comprising the following components by weight:

6. The acne-removing composition according to claim 4, wherein:

the rhizoma atractylodis extract is steam distillate, and the volatile oil is more than or equal to 5 percent;

7. The acne removal composition according to claim 6, further comprising a pharmaceutically acceptable adjuvant.

8. A skin care composition comprising the acne treatment composition according to any one of claims 1 to 7.

9. The skin care composition according to claim 8, which is a lotion, a mask, a lotion, a serum, and a cream.

10. Use of the acne-removing composition according to any one of claims 1 to 7 in the preparation of a medicament for treating acne.