CN112867733A - 抗cd137抗体及其应用 - Google Patents
抗cd137抗体及其应用 Download PDFInfo
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- CN112867733A CN112867733A CN201880098756.0A CN201880098756A CN112867733A CN 112867733 A CN112867733 A CN 112867733A CN 201880098756 A CN201880098756 A CN 201880098756A CN 112867733 A CN112867733 A CN 112867733A
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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Abstract
提供了一种可以特异性结合CD137的抗体或其抗原结合片段，其轻链可变区和重链可变区包括一个或多个突变。还提供了所述抗体或其抗原结合片段在制备药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (41)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2018/111086 WO2020077635A1 (zh) | 2018-10-19 | 2018-10-19 | 抗cd137抗体及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112867733A true CN112867733A (zh) | 2021-05-28 |
| CN112867733B CN112867733B (zh) | 2023-01-06 |
Family
ID=70283644
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880098756.0A Active CN112867733B (zh) | 2018-10-19 | 2018-10-19 | 抗cd137抗体及其应用 |
| CN201980068277.9A Active CN112867737B (zh) | 2018-10-19 | 2019-09-12 | 抗cd137抗体及其应用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980068277.9A Active CN112867737B (zh) | 2018-10-19 | 2019-09-12 | 抗cd137抗体及其应用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210380708A1 (zh) |
| EP (1) | EP3885364A4 (zh) |
| JP (1) | JP7466930B2 (zh) |
| CN (2) | CN112867733B (zh) |
| WO (2) | WO2020077635A1 (zh) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040105855A1 (en) * | 2002-07-30 | 2004-06-03 | Kunkel Maria Jure | Humanized antibodies against human 4-1BB |
| EP1670828A1 (en) * | 2003-10-10 | 2006-06-21 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1bb (cd137) |
| CN1867585A (zh) * | 2003-10-10 | 2006-11-22 | 布里斯托尔-迈尔斯·斯奎布公司 | 抗人4－1bb(cd137)的完全人抗体 |
| CN108026169A (zh) * | 2015-09-22 | 2018-05-11 | 苏州丁孚靶点生物技术有限公司 | 抗人cd137的完全人抗体及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000034847A (ko) * | 1998-11-17 | 2000-06-26 | 성재갑 | 인간 4-1비비 분자에 대한 인간화 항체 및 이를 포함하는 약학조성물 |
| CN1289668C (zh) * | 2003-06-12 | 2006-12-13 | 北京安波特基因工程技术有限公司 | 一种用于抗体改形的体外分子定向进化方法 |
| WO2006088447A1 (en) * | 2005-02-15 | 2006-08-24 | Gtc Biotherapeutics, Inc. | An anti-cd137 antibody as an agent in the treatement of cancer and glycosylation variants thereof |
| US10624974B2 (en) * | 2015-10-15 | 2020-04-21 | Dingfu Biotarget Co., Ltd. | Anti-OX40 antibody and application thereof |
| BR112019000512A2 (pt) * | 2016-07-14 | 2019-04-24 | Genmab A/S | anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, composição, métodos de tratamento de uma doença, para produzir um anticorpo biespecífico e para detectar se a reticulação entre as células que expressam cd40 e cd137 ocorre em uma amostra, uso de um anticorpo multiespecífico, e, kit |
| EP3544628A4 (en) * | 2016-11-23 | 2020-11-18 | Immunoah Therapeutics, Inc. | 4-1BB BINDING PROTEINS AND THEIR USES |
| SG10201914064QA (en) * | 2017-01-06 | 2020-03-30 | Eutilex Co Ltd | Anti-human 4-1 bb antibodies and use thereof |
-
2018
- 2018-10-19 CN CN201880098756.0A patent/CN112867733B/zh active Active
- 2018-10-19 WO PCT/CN2018/111086 patent/WO2020077635A1/zh active Application Filing
-
2019
- 2019-09-12 US US17/285,760 patent/US20210380708A1/en active Pending
- 2019-09-12 EP EP19873484.0A patent/EP3885364A4/en active Pending
- 2019-09-12 WO PCT/CN2019/105537 patent/WO2020078149A1/zh unknown
- 2019-09-12 CN CN201980068277.9A patent/CN112867737B/zh active Active
- 2019-09-12 JP JP2021521057A patent/JP7466930B2/ja active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040105855A1 (en) * | 2002-07-30 | 2004-06-03 | Kunkel Maria Jure | Humanized antibodies against human 4-1BB |
| EP1670828A1 (en) * | 2003-10-10 | 2006-06-21 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1bb (cd137) |
| CN1867585A (zh) * | 2003-10-10 | 2006-11-22 | 布里斯托尔-迈尔斯·斯奎布公司 | 抗人4－1bb(cd137)的完全人抗体 |
| US20090068192A1 (en) * | 2003-10-10 | 2009-03-12 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
| CN108026169A (zh) * | 2015-09-22 | 2018-05-11 | 苏州丁孚靶点生物技术有限公司 | 抗人cd137的完全人抗体及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020078149A1 (zh) | 2020-04-23 |
| EP3885364A1 (en) | 2021-09-29 |
| CN112867733B (zh) | 2023-01-06 |
| CN112867737A (zh) | 2021-05-28 |
| JP2022512724A (ja) | 2022-02-07 |
| US20210380708A1 (en) | 2021-12-09 |
| EP3885364A4 (en) | 2022-09-07 |
| JP7466930B2 (ja) | 2024-04-15 |
| CN112867737B (zh) | 2023-01-06 |
| WO2020077635A1 (zh) | 2020-04-23 |
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