CN110123715B

CN110123715B - Chinese herbal medicine refined additive solution for sanitary care products, and preparation and application thereof

Info

Publication number: CN110123715B
Application number: CN201910477295.4A
Authority: CN
Inventors: 胡伟
Original assignee: Kingdom Healthcare Holdings Ltd Guangdong
Current assignee: Kingdom Healthcare Holdings Ltd Guangdong
Priority date: 2019-06-03
Filing date: 2019-06-03
Publication date: 2022-01-07
Anticipated expiration: 2039-06-03
Also published as: CN110123715A

Abstract

The invention discloses a Chinese herbal medicine refined additive solution for sanitary care products, which comprises the following components in percentage by weight: 1-3% of naringenin, 0.2-1.5% of clove essential oil, 2-3% of grape seed oil, 0.5-1% of angelica essential oil, 0.2-0.6% of argy wormwood leaf essential oil, 0.2-0.6% of ligusticum wallichii essential oil, 0.1-0.3% of rhizoma cyperi extract, 0.1-0.3% of sophora flavescens extract, 1-5% of fructan, 0.2-1% of bisabolol, 0.1-1% of pH regulator, 3-6% of hydrogenated castor oil and the balance of purified water, wherein the effective components of argy wormwood leaf, angelica, ligusticum wallichii, nutgrass galingale rhizome and the like are added and crushed to realize the synergistic effect among the components, then the volatile effective components are included by the hydrogenated castor oil to realize the effect of sustained slow release, the volatilization of the essential oil is not influenced by menstrual blood or blood clots, the effective components can reach private parts, and the effects of resisting bacteria, whitening skin, relieving and nourishing the pudendum can be realized, the menstrual period health is cared, the original disease of private parts can not be aggravated, and meanwhile, the invention has a certain auxiliary treatment effect.

Description

Chinese herbal medicine refined additive solution for sanitary care products, and preparation and application thereof

Technical Field

The invention relates to the field of daily chemical articles, in particular to a Chinese herbal medicine pure additive solution for a sanitary nursing article, and also relates to preparation, application and application methods thereof.

Background

The skin of the female vulva part is delicate, sweat glands are rich, wrinkles are many, the female vulva part is hidden and not exposed, the female vulva part has poor air permeability and is easy to be attacked by germs, and the vaginal orifice is close to the urethral orifice and the anus and is easy to be infected by urine and excrement to breed germs.

It can be known from the above that the female private parts are physiological structures which are easy to breed bacteria, and during menstruation, the use of the sanitary towel (pad) can lead the private parts to be in a hot and humid environment for a long time, which is easy to cause various private part health problems, and if the private parts of users already suffer from diseases (such as vulvitis, vaginitis and the like), the use of the sanitary towel (pad) can also aggravate the diseases; on the other hand, many women are afflicted with dysmenorrhea, and the severer may affect work and learning.

With the improvement of living standard, more and more women are aware of the importance of nursing private parts, and modern women pay more and more attention to the beauty of private parts, therefore, in order to solve the problems, many sanitary napkins (pads) added with single or compound materials are appeared on the market, and the single or compound materials are made into powder or chips which are clamped between the structural layers of the sanitary napkins (pads), but in the structure, the powder or the chips are not in direct contact with the vulva, and are easily covered by menstrual blood or blood clots, so that the ideal effect of nursing the pudendum is difficult to obtain.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention discloses a Chinese herbal medicine refined additive solution for a sanitary care product, and a preparation method and an application thereof.

The technical scheme adopted by the invention for solving the technical problems is as follows:

a Chinese herbal medicine refined additive solution for sanitary care products comprises the following components in percentage by weight: 1-3% of free radical scavenger, 0.2-1.5% of tyrosinase inhibitor, 2-3% of grape seed oil, 0.5-1% of angelica essential oil, 0.2-0.6% of argy wormwood leaf essential oil, 0.2-0.6% of ligusticum wallichii essential oil, 0.1-0.3% of rhizoma cyperi extract, 0.1-0.3% of bacteriostatic agent, 1-5% of humectant, 0.2-1% of anti-allergic agent, 0.1-1% of pH regulator, 3-6% of embedding material and the balance of purified water.

The naringenin is used as a hydrogen donor, can effectively remove free radicals, has strong antioxidation, and protects cells of the vulva from being damaged by the free radicals and toxic wastes in vivo, thereby maintaining the stability of cell membranes and organelles, improving the blood circulation of the pudendum and delaying the aging of the pudendum.

Tyrosinase is a key enzyme for melanin synthesis, the activity of the enzyme determines the amount of melanin formation, namely the skin color of the vulva is represented, and eugenol which is the main component in the clove essential oil in the additive solution can effectively inhibit the activity of the tyrosinase and prevent the skin color of the vulva from being further deepened. On the other hand, clove oil has a significant anti-candida albicans effect, and candida albicans is one of the most common pathogens of female urogenital infections.

The grape seed oil is rich in vitamin E, has strong oxidation resistance, can effectively prolong the shelf life of the invention, and prevents oxidation rancidity caused by illumination, heat radiation and contact with air.

The angelica essential oil has obvious pharmacological effects of resisting inflammation, easing pain and the like, dysmenorrhea is mainly caused by severe contraction of uterine smooth muscle, has an inhibition effect on normal and pathological uterine smooth muscle, has a strong uterine smooth muscle spasm resistance effect, and can effectively relieve dysmenorrhea.

The wormwood essential oil has the antibacterial and insecticidal effects and has special aromatic smell, so that the wormwood essential oil can emit fragrance to cover the menstrual blood peculiar smell, and embarrassment and inconvenience caused by the peculiar smell of a user are avoided.

Pharmacological experiments of the main component ligustilide in the ligusticum wallichii essential oil show strong biological activities of analgesia and spasmolysis, and simultaneously has activities of antivirus, antibiosis and the like; the rhizoma cyperi extract contains compounds such as alpha-cyperone, beta-cyperone, cyperol, cyperene and the like, has the effects of promoting qi circulation, resolving depression, regulating menstruation and relieving pain, and has better analgesic effect when the alpha-cyperone, the beta-cyperone, the cyperol, the cyperene and the like are used in a matching way.

The main components of the sophora flavescens extract are alkaloids and flavonoids, the main active component of the alkaloids is the matrine which has obvious antibacterial effect, has good inhibitory effect on staphylococcus aureus, escherichia coli, candida albicans and the like, and also has the effects of resisting trichomonas and amoeba, and trichomonas vaginitis can be caused by the trichomonas and the amoeba, and the sophora flavescens extract also has certain curative effect on vulva eczema; on the other hand, the flavonoid component is a non-competitive inhibitor of tyrosinase, assists the action of the tyrosinase inhibitor, and further reduces the production of melanin.

The fructan is present in plant cells and functions to store water, immobilize the active ingredients in the cells, and function to protect the cells, according to which the present invention maintains vulvar skin water by fructan and immobilizes the active ingredients of the present invention in the vulvar cells, and further, the fructan functions as an emulsifier, a thickener, in the following preparation method.

The bisabolol has the main effects of relieving and resisting allergy, can protect and care allergic skin, has certain anti-inflammatory and antibacterial effects, and is beneficial to further enhancing the efficacy of the invention.

The hydrogenated castor oil is used as an embedding material and has high safety to skin. Since the invention is composed of a plurality of essential oils, and the volatilization speed of the essential oils is extremely high, the hydrogenated castor oil is used for coating the essential oils to form a slow release effect, so as to improve the stability, the dispersibility and the utilization rate of the volatile components of the invention.

The pH value regulator is lactic acid with mild performance. Another role of the lactic acid is: the additive solution is sprayed on the surface layer of the absorbent sanitary product and needs to be dried, and the lactic acid can prevent the additive solution from being dried and cracked after the surface layer is formed.

The preparation method of the Chinese herbal medicine extract additive solution for the sanitary care products comprises the following steps:

1) heating the hydrogenated castor oil to 50-65 ℃, stirring at the rotating speed of 30-50 r/min for dissolving, sequentially adding the clove essential oil, the naringenin, the grape seed oil, the angelica essential oil, the ligusticum wallichii essential oil, the folium artemisiae argyi essential oil and the bisabolol, keeping the stirring state, and clathrating the various essential oils by the hydrogenated castor oil, wherein the bisabolol is insoluble in water, so that the bisabolol is dispersed and dissolved in the step.

2) Dissolving the sophora flavescens extract and the aconite extract in a proper amount of pure water in advance, adding the mixture into the mixed solution prepared in the step 1), continuously stirring for 10-15 minutes until the sophora flavescens extract and the aconite extract are completely dissolved, and keeping the stirring state.

3) Adding the levan into the mixed solution prepared in the step 2), and continuing to stir for 5-10 minutes until the mixed solution is in a uniform gel state, wherein the levan is a water-soluble and viscous high-molecular polysaccharide, and has the functions of an emulsifier and a thickener in the step in addition to the moisturizing function, so that the oily mixed solution in the step 1) and the aqueous mixed solution in the step 2) are mixed more uniformly.

4) The mixed liquid in the gel state prepared in the step 3) is difficult to be uniformly sprayed on the surface layer of the sanitary product through a nozzle, so that the mixed liquid prepared in the step 3) is transferred into a container of a homogenizer, the pH value regulator is added and the purified water is replenished, the homogenizer is started, the rotating speed is adjusted to be 2500 plus materials at 3000r/min, and the mixture is homogenized for 10-15 minutes, thus the additive liquid capable of maintaining the pudendum is prepared.

The application of the Chinese herbal medicine refined additive solution for the sanitary care products is to apply the additive solution to various absorbent sanitary products, such as sanitary towels, panty liners, adult diapers, tampons and the like.

The application method of the Chinese herbal medicine refined additive solution for the sanitary care products comprises the steps of spraying the additive solution on surface layer sheets of various absorbent sanitary products contacting with skin, extruding the surface layer sheets, drying and evaporating water to enable the surface layer sheets to contain effective ingredients of the additive solution.

The invention has the beneficial effects that: the essential oil is volatilized without being influenced by menstrual blood or blood clots, so that the effective components can reach private parts, the effects of resisting bacteria, whitening, relieving dysmenorrheal and nourishing the private parts are realized, the menstrual period health is cared, the original diseases of the private parts cannot be aggravated, and meanwhile, a certain auxiliary treatment effect is achieved.

Detailed Description

The following examples further illustrate the practice and advantages of the present invention, and should not be construed as limiting the scope of the invention.

Example 1:

the composition of the present example is expressed in weight percent: naringenin 1%, clove essential oil 0.2%, grape seed oil 2%, angelica essential oil 0.5%, folium artemisiae argyi essential oil 0.2%, ligusticum wallichii essential oil 0.2%, rhizoma cyperi extract 0.1%, radix sophorae flavescentis extract 0.1%, levan 1%, bisabolol 0.2%, lactic acid 0.1%, hydrogenated castor oil 3%, and the balance of purified water.

The preparation method of the embodiment comprises the following steps:

4) The mixed liquid in the gel state prepared in the step 3) is difficult to be uniformly sprayed on the surface layer of the sanitary product through a nozzle, so that the mixed liquid prepared in the step 3) is transferred into a container of a homogenizer (model LM-S-ZRG-D, Union mechanical equipment, Inc., Guangzhou city), the lactic acid is added and the purified water is replenished, the homogenizer is started, the rotating speed is adjusted to 2500 + 3000r/min, and the mixture is homogenized for 10-15 minutes, thus obtaining the additive liquid capable of maintaining the pudendum.

The additive solution prepared by the embodiment is sprayed on a surface layer sheet of the sanitary towel contacting with skin, then the surface layer sheet is extruded, dried to evaporate water, so that the surface layer sheet contains the active ingredients of the additive solution, and then the surface layer sheet is combined with other sheets according to the conventional production process in the field to prepare the sanitary towel.

Example 2:

the composition of the present example is expressed in weight percent: naringenin 2%, clove essential oil 0.8%, grape seed oil 2.5%, angelica essential oil 0.8%, folium artemisiae argyi essential oil 0.4%, ligusticum wallichii essential oil 0.4%, rhizoma cyperi extract 0.2%, radix sophorae flavescentis extract 0.2%, levan 3%, bisabolol 0.6%, lactic acid 0.5%, hydrogenated castor oil 5%, and the balance of purified water.

The preparation method of this example is the same as example 1.

Example 3:

the composition of the present example is expressed in weight percent: 3% of naringenin, 1.5% of clove essential oil, 3% of grape seed oil, 1% of angelica essential oil, 0.6% of argy wormwood leaf essential oil, 0.6% of ligusticum wallichii essential oil, 0.3% of rhizoma cyperi extract, 0.3% of radix sophorae flavescentis extract, 5% of fructan, 1% of bisabolol, 1% of lactic acid, 6% of hydrogenated castor oil and the balance of purified water.

The preparation method of this example is the same as example 1.

And (3) bacteriostatic performance detection test:

the experimental results show that the difference between the bacteriostatic rate of the tested sample group and the bacteriostatic rate of the control sample group is more than 26 percent and reaches the evaluation standard specified in GB15979-2002 appendix C5, and the results are as follows:

the table data shows that the invention has antibacterial effect.

Effect on tyrosinase activity:

the test method comprises the following steps: in a 2mL reaction system, adding L-dopa (1mmol/L) and phosphate buffer (PBS, 0.03mol/L, pH 6.8), after incubation in a 37 ℃ water bath for 10min, respectively adding 0.5mL of the additive solution of examples 1-3, respectively, adding 200U/mL of tyrosinase solution and immediately and thoroughly mixing at 25 ℃, measuring absorbance at 475nm, using 1mg/mL arbutin as a positive control, and calculating the tyrosinase activity inhibition rate as follows:

in the formula: a. the₁: absorbance of the mixture without the addition of the enzyme;

A₂: absorbance of the mixture solution to which the enzyme was added without adding the example;

A₃: absorbance of the mixture without enzyme added in the example;

A₄: the absorbance of the mixture of the example and the enzyme was added.

Data processing and statistical analysis method: each set of experiments was repeated at least 3 times, and all data were averaged ± sd. The test results are shown in the following table:

from the table data, it can be seen that the additive solutions of examples 1 to 3 can inhibit tyrosinase activity in vitro, and the present invention can prevent further deepening of vulvar skin color and has certain whitening efficacy. In addition, the effective component ratios of the examples 1 to 3 are increased, so that the inhibition rate of the tyrosinase and the effective component ratio are in positive correlation and concentration dependence. The inhibition rate of the additive liquid of the examples 2 and 3 on the tyrosinase activity is higher than 1mg/mL arbutin.

Vaginal mucosa irritation test:

the additive solutions of examples 1 to 3 were subjected to a vaginal mucosa irritation test according to the second part of the "Disinfection Specification" (2002 edition of Ministry of health) -2.2.5, and the vaginal mucosa irritation intensity was graded as shown in the following table:

index of irritation of vaginal mucosa	＜1	1～＜5	5～＜9	9～＜12	≥12
						Intensity of vaginal mucosa irritation response	Is free of	Is extremely light	Mild degree of	Of moderate degree	Severe degree

The test results are shown in the following table:

vaginal mucosa stimulation response recording table for 24h dissection observation

Examples	Congestion of blood	Edema (edema)	Swelling/atrophy	Accumulated pus	Others
						1	Whether or not	Whether or not	Whether or not	Whether or not	Whether or not
2	Whether or not	Whether or not	Whether or not	Whether or not	Whether or not
						3	Whether or not	Whether or not	Whether or not	Whether or not	Whether or not
Control group	Whether or not	Whether or not	Whether or not	Whether or not	Whether or not

24h pathological observation vagina mucosa irritation response scoring table

From the data in the table, the addition solutions of examples 1 to 3 have very low stimulation intensity to the vaginal mucosa of white rabbits in vitro, i.e., the formula of the invention is mild.

Actual use test of volunteers:

volunteers are recruited in a gynecological clinic of a certain hospital, and the conditions of the recruited volunteers are as follows: the test group 1 uses the sanitary napkins made in the examples 1-3, the test group 2 uses the foreign brand certain antibacterial sanitary napkins, and the number of samples is counted according to the physiological period of three months.

The sanitary napkins used in the test have the marked substances such as trademarks and the like torn off, so that volunteers do not know the type of sanitary napkins used by the volunteers, and the volunteers need to provide self use feeling to experimenters after menstruation ends. The use experience comprises: whether the pudendum is fresh and cool, whether the vagina is painful and itchy, whether leucorrhea is reduced, whether pain is relieved, whether melanin can be lightened, whether private parts are tender and have irritation and whether friction feeling with the sanitation is experienced to grade, each fragrance is fully divided into 10 points, the grade is higher when the fragrance is better, and the average score of three times of three months of each group of volunteers is calculated. The test results are shown in the following table:

from the table data, it can be seen that: the test group 1 using the sanitary napkins of examples 1 to 3 was significantly superior to the test group 2 in lightening melanin, tendering private parts, relieving pain, itching, leucorrhea, and the like.

The above embodiments do not limit the scope of the present invention, and those skilled in the art can make equivalent modifications and variations without departing from the overall concept of the present invention.

Claims

1. A Chinese herbal medicine refined additive solution for sanitary care products is characterized by comprising the following components in percentage by weight: 1-3% of naringenin, 0.2-1.5% of clove essential oil, 2-3% of grape seed oil, 0.5-1% of angelica essential oil, 0.2-0.6% of argy wormwood leaf essential oil, 0.2-0.6% of ligusticum wallichii essential oil, 0.1-0.3% of rhizoma cyperi extract, 0.1-0.3% of radix sophorae flavescentis extract, 1-5% of levan, 0.2-1% of bisabolol, 0.1-1% of pH regulator, 3-6% of hydrogenated castor oil and the balance of purified water.

2. The Hanfang plant essence additive solution for use in sanitary care products of claim 1, wherein the pH regulator is lactic acid.

3. A method for preparing the chinese herbal extract additive solution for health care products according to any one of claims 1 or 2, comprising the steps of:

1) heating the hydrogenated castor oil to 50-65 ℃, stirring at the rotating speed of 30-50 r/min for dissolving, sequentially adding the clove essential oil, the naringenin, the grape seed oil, the angelica essential oil, the ligusticum wallichii essential oil, the argyi leaf essential oil and the bisabolol, and keeping the stirring state;

2) dissolving the radix Sophorae Flavescentis extract and herba Achilleae extract in pure water, adding into the mixture obtained in step 1), stirring for 10-15 min until completely dissolved, and keeping stirring state;

3) adding the fructan into the mixed liquid prepared in the step 2), and continuing to stir for 5-10 minutes until the mixed liquid is in a uniform jelly state;

4) transferring the mixed solution prepared in the step 3) into a container of a homogenizer, adding the pH regulator and supplementing the purified water, starting the homogenizer, adjusting the rotation speed to 2500-.

4. Use of the chinese herbal extract additive solution for use in sanitary care products according to any one of claims 1 or 2, wherein the additive solution is used in absorbent sanitary products of various types.

5. The application method of the Chinese herbal medicine extract additive solution for the sanitary care products as claimed in any one of claims 1 or 2, wherein the additive solution is sprayed on a surface layer sheet of each type of absorbent sanitary products which is in contact with the skin, and then the surface layer sheet is extruded and dried.