CN1100651A - Chinese herbal prepn. for curing chronic gastroenteritis and peptic gastric ulcer - Google Patents
Chinese herbal prepn. for curing chronic gastroenteritis and peptic gastric ulcer Download PDFInfo
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- CN1100651A CN1100651A CN 94101997 CN94101997A CN1100651A CN 1100651 A CN1100651 A CN 1100651A CN 94101997 CN94101997 CN 94101997 CN 94101997 A CN94101997 A CN 94101997A CN 1100651 A CN1100651 A CN 1100651A
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Abstract
The prescription consists of dandelion, tuber of corydalis, licorice root, white peony root, rhizome of nutgrass flatsedge, tuber of bletilla and cuttle fish bone, it has notable effect of treating gastroenteralgia, chronic gastritis, duodenal ulcer and gastric neurosis.
Description
The present invention relates to the Chinese medicine preparation of one group of treatment acute or chronic gastritis and peptic ulcer.
Chronic gastritis and peptic ulcer are commonly encountered diseases, frequently-occurring disease, and its cause of disease and pathogeny are not illustrated so far yet fully.Since the relation of nineteen eighty-three Australia scholar Warren and Marshall discovery campylobacter pyloridis (HP) and chronic gastritis and peptic ulcer, Chinese scholars competitively conducts a research, obtained remarkable progress, domestic in recent years application Chinese medicine prevention HP infected gastric disease has also been obtained certain advantage, for laying a good foundation with this type of disease of Chinese medicine prevention, chronic gastritis and peptic ulcer belong to " gastric abscess ", " noisy ", " acid regurgitation " category in Chinese Internal Medicine.Think that weakness of the spleen and stomach is this sick pathogenesis basis, qi depression to blood stasis is common pathogenesis more, and the damage of stomach network is basic lesion, thereby ascending YANG and invigorating QI, stomach reinforcing spleen invigorating, blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain, let out liver-heat clearly, method of treatment such as convergence life etc. is often by being used in this type of disease treatment, but present treatment also rests on the experience stage, to effect a radical cure the cause of disease rapidly, diminish inflammation, make ulcer healing and control recurrence rapidly, be still the still unresolved treatment difficult problem of present this type of disease of treatment.The objective of the invention is under instruction of Chinese Medicine theory, in conjunction with the understanding of modern medicine to such disease, develop the characteristic of Chinese medicine, develop one group of determined curative effect, side effect is little, ulcer healing rate height, the new Chinese medicine compound that relapse rate is low.
The object of the present invention is achieved like this, select Herba Taraxaci, Rhizoma Corydalis, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), seven kinds of medicines of Endoconcha Sepiae for use, form basic prescription, reach heat-clearing and toxic substances removing, relieving spasm to stop pain, be good for the stomach calm the nerves, the effect of hemostasia and detumescence, promoting tissue regeneration and ulcer healing, from the modern medicine viewpoint, definite pharmacological action such as this side's tool spasmolytic, pain relieving, antiinflammatory, antibiotic, antiulcer.Herba Taraxaci energy heat-clearing and toxic substances removing, medicinal powder for relieving pain knot in the side, hemostasis and pain-relieving preventing or arresting vomiting and elimination flatulence, appetite stimulator, modern medicine study think that it has broad-spectrum antibacterial action, particularly helicobacter pylori are had stronger killing action, its effect is similar to ampicillin.The reported literature list also can make the cloudy commentaries on classics of helicobacter pylori with this product treatment peptic ulcer, the ulcer surface healing, and pain stops, effective percentage reaches 94.4%(Chinese medicine journal, 41 pages of 1991, the 1 phases).Rhizoma Corydalis has the promoting blood circulation to remove blood stasis regulating QI to relieve pain, and calmness is stable to wait effect, and significantly gastric acid inhibitory is secreted and reduced free acid and total acidity, and the pepsin acid activity is reduced, and we get the advantage of its calm neuroleptanalgesiss.Radix Glycyrrhizae also can relieving spasm to stop pain, and the gastric acid inhibitory secretion also has the effect that promotes ulcer healing.The Radix Paeoniae Alba also has the effect of obvious suppression gastric secretion, and significant calmness, spasmolytic and antiinflammatory action are arranged, and with Radix Glycyrrhizae 5 usefulness the obvious synergistic effect is arranged.Rhizoma Cyperi can depressed liver-energy dispersing and QI regulating be good for the stomach (motor function of adjusting stomach), eliminates the digestive tract pneumatosis, and relieving spasm to stop pain is arranged, anti-inflammation detoxifcation and neuroleptoanalgesia effect.Pseudobulbus Bletillae (Rhizoma Bletillae) hemostasia and detumescence, promoting tissue regeneration and ulcer healing.The Endoconcha Sepiae relieving gastric hyperacidity to alleviate stomachache, dredge the meridian passage, convergence granulation promoting.Above seven flavor medicine is formed compound preparation, and its pharmacological action strengthens mutually, the effect multiplication.Through clinical observation, determined curative effect, side effect is little, can be the good recipe of one group of treatment chronic gastritis and peptic ulcer.
Medicine optimal proportion of the present invention is a Herba Taraxaci 1~3: Rhizoma Corydalis 1~1.5: the Radix Paeoniae Alba 1~1.5: Radix Glycyrrhizae 1~1.5, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1~1.5: Endoconcha Sepiae 1~1.5: Rhizoma Cyperi 1~1.5.
This compound preparation can be by following SOME METHODS preparation.
1, gets above-mentioned Chinese medicine, pulverize, with 75~95% soak with ethanol 24h, filter, reclaim ethanol, it is standby to get ethanol extract, medicinal residues add the water steaming and decocting three times again, merge three filtrates and filter, filtrate is concentrated in right amount, adds suitable adjuvant and aforesaid ethanol extract, dry, pulverizing adds appropriate amount of auxiliary materials, make granule, tabletting sugar coating or promptly encapsulated
2, get above-mentioned Chinese medicine and pulverize, decoct with water three times, boiled back 1 hour at every turn, filter, merges three times filtrate, concentrate sticking paste, directly make granule through vacuum drying (70~80 ℃), adding appropriate amount of auxiliary materials, tabletting sugar coating or promptly encapsulated.
3, get Herba Taraxaci, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Corydalis and extract the Herba Taraxaci Saponin by known technology respectively, paeoniflorin, glycyrrhizin and Rhizoma Corydalis alkaloid, add other Chinese medicine extract that do not contain mentioned component of making by 1 method or 2 method technologies again, concentrate, dry, evenly add suitable adjuvant, make granule, tabletting sugar coating or divide promptly encapsulated.
The goods that adopt said method to make through pharmacology and toxicologic study, prove to truly have curative effect and avirulence.It is the special good medicine of preventing and treating chronic gastritis and peptic ulcer.
This preparation is added some Chinese prescription, and to some common property, effects such as intractable chronic gastritis, gastric and duodenal ulcers are better, now are exemplified below:
One, to being the optimum formula of various acute or chronic gastritis, gastroduodenal ulcer and the stomach neurosis of primary symptom with " gastric abscess ", " stomachache ".
Optimum formula (1) is serving as on the basis of basis side with above-mentioned Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, add Bulbus Fritillariae Thunbergii, Cortex Ilicis Rotundae, the Rhizoma Atractylodis Macrocephalae, Folium Et Cacumen Murrayae, Radix Zanthoxyli, forge Concha Arcae and form optimum formula, its optimal proportion is followed successively by (2~3: 1~1.5: 1: 1: 1: 1: 1 ,~1.5: 1.5: 1~1.6: 1: 1: 1: 1).Make " treasured is good for the stomach " with we with aforementioned technology, clinical practice is taken medicine to the pain disease due to the various gastritis such as " gastric abscesss " can produce tangible analgesic effect in back about 5 minutes, serve on to make the disease recovery from illness 2 to 4 weeks, and physical rehabilitation has no adverse reaction.Effective percentage reaches more than 90%.
Two, to the optimum formula of chronic atrophic gastritis achlorhydria
Optimum formula (2): serving as on the basis of basis side with above-mentioned Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), adding Radix Et Rhizoma Rhei, Radix Notoginseng, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Codonopsis, Ramulus Cinnamomi, Fructus Mume, Cortex Magnoliae Officinalis, Endothelium Corneum Gigeriae Galli composition.This side's optimal proportion is (2: 1: 0.5: 0.5: 1: 1: 1: 0.5: 1: 2: 2: 1: 2: 1: 2).We are based on heat clearing and blood stasis dispersing, and to chronic atrophic gastritis, it is good that differential diagnosis in tcm belongs to " gastric heat type " person's curative effect spy." spirit of the being good for the stomach " clinical research of making by aforementioned technology with we shows, we to how based on the patient of " damp and hot ", " blood stasis ", take this product after 2~4 weeks, clinical symptoms is eliminated, and gastroscopy atrophy phenomenon disappears, and changes superficial gastritis into, pathological symptom improves, HP transfers feminine gender to by the positive, not recurrence after 1 year, and effective percentage reaches more than 90%.
Three, the optimum formula of treatment peptic ulcer
Optimum formula (3): serving as on the basis of basis side with above-mentioned Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, adding Radix Codonopsis, Rhizoma Coptidis, Radix Notoginseng, the Radix Astragali, Radix Puerariae, Fructus Mume composition again.Each medicine of the ratio of each medicine in we is all between 0.5~1.5.We are good to peptic ulcer companion helicobacter pylori positive person curative effect spy.
Optimum formula (4): serving as on the basis of basis side with above-mentioned Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, the compound recipe that adds Rhizoma Coptidis, Radix Scutellariae, Fructus Aurantii, Radix Angelicae Sinensis, the Radix Aucklandiae, Fructus Amomi, Radix Codonopsis seven flavor compositions again, or add Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, the Radix Astragali, Radix Codonopsis, Herba Asari seven flavors again and form optimum formula (5) altogether, this compound recipe is the same with the place ahead, clinical research shows that gastritis and peptic ulcer are all had splendid curative effect.
Four, the optimum formula of tcm syndrome typing for the peptic ulcer of " Qi-stagnation type " pressed in treatment
Optimum formula (6): serving as on the basis of basis side with above-mentioned Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, adding Radix Bupleuri, Rhizoma Chuanxiong, the Radix Astragali, Cortex Magnoliae Officinalis, the Radix Linderae, Semen Raphani again, wide wood is defended the optimum formula of forming treatment " Qi-stagnation type " gastric abscess.Prove that through clinical observation originally can remove clinical symptoms such as gastral cavilty distending pain, two side of body feeling of distension and oppression, belch, general acid regurgitation water, bitter taste are dizzy, lack of appetite uncomfortable in chest rapidly, effective percentage reaches more than 90%.
Five, the optimum formula of tcm syndrome typing for the peptic ulcer of " stagnated heat type " pressed in treatment
Optimum formula (7): serving as on the basis of basis side with above-mentioned Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, the optimum formula that adds the peptic ulcer of Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Radix Adenophorae (Radix Glehniae), Fructus Mume composition treatment " stagnated heat type " again, prove through clinical observation, originally can remove the urgent pain of gastral cavilty, burning sensation rapidly, eat that pain is more obvious, xerostomia and stagnated heat type symptoms such as hardship, acid regurgitation, noisy, irritated irritability, constipation, effective percentage reaches more than 90%.
Six, the optimum formula of tcm syndrome typing for the peptic ulcer of " YIN-deficiency type " and " asthenic cold type " pressed in treatment
Optimum formula (8): serving as on the basis of basis side with above-mentioned Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, add the optimum formula of Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis, Fructus Lycii, Fructus Mume composition treatment " YIN-deficiency type " peptic ulcer again, or add the optimum formula (9) of the peptic ulcer of Ramulus Cinnamomi, the Radix Astragali, Rhizoma Alpiniae Officinarum, Rhizoma Atractylodis Macrocephalae composition treatment " asthenic cold type ".The place ahead (8) is to " YIN-deficiency type ", and rear (9) are good to " gastric abscess " the curative effect spy of " asthenic cold type ", and effective percentage is all more than 90%.
Seven, the optimum formula of tcm syndrome typing for the peptic ulcer of " blood stasis type " pressed in treatment
Optimum formula (10): serving as on the basis of basis side with above-mentioned Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, adding the optimum formula of Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Radix Curcumae, Rhizoma Curcumae, Radix Sangusorbae, Radix Notoginseng composition treatment " blood stasis type " peptic ulcer again.Prove through clinical observation, originally can alleviate rapidly " blood stasis type " patient violent stomachache, fixing pain, purplish tongue is dark or symptoms such as ecchymosis, hematemesis or melena, effective percentage reaches more than 90%.
Eight, the optimum formula of treatment gallbladder antiperspirant reflux gastritis
Optimum formula (11): serving as on the basis of basis side with above-mentioned Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, add Radix Curcumae, Radix Scutellariae, Semen Raphani, Pericarpium Citri Reticulatae, Herba Lysimachiae composition optimum formula (11) again: it is good that this side belongs to " heat symptom-complex " person curative effect spy to gallbladder antiperspirant reflux gastritis.Or add Radix Curcumae, Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Ramulus Cinnamomi, the Radix Astragali, because of Chen Zucheng optimum formula (12): this side is good to gallbladder antiperspirant reflux gastritis genus " sympotoms caused by cold factors person " curative effect spy.Confirm that through clinical observation this two side reaches more than 90% gallbladder antiperspirant reflux gastritis effective percentage.
In sum, with Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Cyperi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae is the compound preparation that the basis is formed, various chronic gastritiss and peptic ulcer had splendid therapeutic effect, add some other drugs on this basis, to some cause specific, such disease effects of characteristic symptom is better.
Above-mentioned 12 groups of optimum formulas enumerating, can make tablet or capsule confession oral application by aforementioned technology one, two or three, also can be made into application such as electuary, oral liquid, beverage, health product, partly preparation can be made injection and be used for clinical through further technological transformation.
Claims (10)
1, a kind of compound Chinese medicinal preparation for the treatment of gastritis and peptic ulcer is characterized in that said preparation is made up of Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cyperi, Endoconcha Sepiae; Its optimal proportion is a Herba Taraxaci 1~3; Other each medicines are 0.5~1.5, and said preparation can be by following three kinds of prepared:
A. get above-mentioned Chinese medicine and pulverize,, filter with 75~95% soak with ethanol 24h, reclaim ethanol, it is standby to get alcohol extract, and medicinal residues add the water steaming and decocting three times again, merge three times filtrate, filter, filtrate is concentrated in right amount, add suitable adjuvant and aforesaid ethanol extract, drying is pulverized, add appropriate amount of auxiliary materials, make granule, tabletting sugar coating or encapsulated, promptly;
B. get above-mentioned Chinese medicine and pulverize, decoct with water three times, filtrations in back 1 hour of at every turn boiling merges three times filtrate, and concentrated sticking paste is directly made granule through vacuum drying (70~80 ℃), the adding appropriate amount of auxiliary materials, and tabletting sugar coating or encapsulated, promptly;
C. get Herba Taraxaci, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Corydalis and extract the Herba Taraxaci Saponin by each technology respectively, paeoniflorin, glycyrrhizin and Rhizoma Corydalis alkaloid, add other Chinese medicine extract that do not contain mentioned component of making by 1 method or 2 method technologies again, concentrated, dry, evenly, add suitable adjuvant, make granule, the tabletting sugar coating or divide encapsulated, promptly.
2, the compound Chinese medicinal preparation of treatment gastritis as claimed in claim 1 and peptic ulcer, it is characterized in that its optimum formula is is serving as on the basis of basis side with Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cyperi, Endoconcha Sepiae, add Bulbus Fritillariae Thunbergii again, Cortex Ilicis Rotundae, the Rhizoma Atractylodis Macrocephalae, Folium Et Cacumen Murrayae, Radix Zanthoxyli, forge Concha Arcae, this side's optimal proportion begins to be followed successively by 2~3: 1~1.5 from Herba Taraxaci: 1: 1: 1: 1: 1~1.5: 1.5: 1~1.6: 1: 1: 1: 1.
3, the compound Chinese medicinal preparation of treatment gastritis as claimed in claim 1 and peptic ulcer, it is characterized in that its optimum formula is is serving as on the basis of basis side with Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cyperi, add Radix Et Rhizoma Rhei, Radix Notoginseng, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Codonopsis, Ramulus Cinnamomi again, Fructus Mume, Cortex Magnoliae Officinalis, Endothelium Corneum Gigeriae Galli are formed, and this side's optimal proportion began to be followed successively by 2: 1: 0.5 from Herba Taraxaci: 0.5: 1: 1: 1: 0.5: 1: 2: 2: 1: 2: 1: 2.
4, the compound Chinese medicinal preparation of treatment gastritis as claimed in claim 1 and peptic ulcer, it is characterized in that its optimum formula is is serving as on the basis of basis side with Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cyperi, Endoconcha Sepiae, add Radix Codonopsis, Rhizoma Coptidis, Radix Notoginseng, the Radix Astragali, Radix Puerariae, Fructus Mume again, its at each medicine of ratio of we all between 0.5~1.5.
5, the compound Chinese medicinal preparation of treatment gastritis as claimed in claim 1 and peptic ulcer, it is characterized in that its optimum formula is serving as on the basis of basis side with Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cyperi, Endoconcha Sepiae, adds Rhizoma Coptidis, Radix Scutellariae, Fructus Aurantii, Radix Angelicae Sinensis, the Radix Aucklandiae, Fructus Amomi, Radix Codonopsis again; Or add Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Rhei, the Radix Astragali, Radix Codonopsis, Herba Asari again.
6, the compound Chinese medicinal preparation of treatment gastritis as claimed in claim 1 and peptic ulcer, it is characterized in that its optimum formula is serving as on the basis of basis side with Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cyperi, Endoconcha Sepiae, adds Radix Bupleuri, Rhizoma Chuanxiong, the Radix Astragali, Cortex Magnoliae Officinalis, Semen Raphani, the Radix Linderae, Radix Aucklandiae (Radix Vladimiriae) again; Or add Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Radix Adenophorae (Radix Glehniae), Fructus Mume.
7, the compound Chinese medicinal preparation of treatment gastritis as claimed in claim 1 and peptic ulcer, it is characterized in that its optimum formula is serving as on the basis of basis side with Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cyperi, Endoconcha Sepiae, adds Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis, Fructus Lycii, Fructus Mume again; Or add Ramulus Cinnamomi, the Radix Astragali, Rhizoma Alpiniae Officinarum, the Rhizoma Atractylodis Macrocephalae.
8, the compound Chinese medicinal preparation of described treatment gastritis of claim 1 and peptic ulcer, it is characterized in that its optimum formula is serving as on the basis of basis side with Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cyperi, Endoconcha Sepiae, adds Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Radix Curcumae, Rhizoma Curcumae, Radix Sangusorbae, Radix Notoginseng again.
9, the compound Chinese medicinal preparation of treatment gastritis as claimed in claim 1 and peptic ulcer, it is characterized in that its optimum formula is is serving as on the basis of basis side with Herba Taraxaci, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cyperi, Endoconcha Sepiae, add Radix Curcumae, Radix Scutellariae, Semen Raphani, Pericarpium Citri Reticulatae, Herba Lysimachiae again, or add Radix Curcumae, Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Ramulus Cinnamomi, the Radix Astragali, Herba Artemisiae Scopariae.
10, as the compound Chinese medicinal preparation of described treatment gastritis of claim 1~9 and peptic ulcer, it is characterized in that these preparations can be made into tablet, capsule, electuary, oral liquid, beverage, health product, the part preparation can be made injection and be used for clinical through further technological transformation.
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