CN103007049A - Medicine for nursing duodenal ulcer - Google Patents
Medicine for nursing duodenal ulcer Download PDFInfo
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Abstract
The invention discloses a medicine for nursing duodenal ulcer, which belongs to the field of traditional Chinese medicine. The medicine comprises the following raw materials of effective components in parts by weight: 75-100 parts of liquorice, 70-90 parts bletilla striata, 65-85 parts of costus root, 60-80 parts of fructus citri skin, 60-75 parts of pericarpium citri reticulatae, 55-70 parts of perilla stem, 50-65 parts of toosendan fruit, 45-60 parts of manyleaf meadowure rhizome and root, 40-55 parts of rhizoma cyperi, 35-50 parts of fingered citron, 30-45 parts of rhizoma corydalis, 25-40 parts of cuttlebones, 20-35 parts of immature bitter orange, 15-30 parts of radix bupleuri, 10-25 parts of taraxacum and 5-20 parts of calcined concha arcae. The medicine disclosed by the invention is reasonable in material selection, and aims at the etiologies of middle energizer, deficient cold, stomach yang restraince, spleen-yang and stomach-yang deficiency, stagnancy of qi and blood stasis, and the like which cause the duodenal ulcer, thereby activating the organism immunity mechanism from enhancing digestive system activity, achieving the purposes of dispelling cold, warming the middle-jiao, stopping bleeding, dispersing stasis, relieving hyperacidity, stopping pain and dredging Yang spirit and remitting the ulcer symptoms; and the medicine is proved to have the advantages of good absorption, no toxic or side effect or adverse reaction and higher cure rate on duodenum through clinical use.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of medicine for the duodenal ulcer nursing.
Background technology
Peptic ulcer refers to the tissue injury that surpasses muscular layer of mucosa that gastrointestinal mucosa is caused by peptic digestion liquid autodigestion.Ulcer can betide gastral any position, and is wherein common with stomach and duodenum, i.e. gastric ulcer and duodenal ulcer, and its cause of disease, clinical symptoms and Therapeutic Method basic simlarity are clarified a diagnosis main by gastroscopy.Duodenal ulcer and gastric ulcer are similar, are the tissue injurys that surpasses muscular layer of mucosa that causes owing to the digested liquid autodigestion of intestinal mucosa, are more common in person between twenty and fifty, mainly rely on gastroscope to make a definite diagnosis.Think that at present the protection mechanism of normal person's gastroduodenal mucosa is enough to resist gastric acid and pepsic erosion.But, when some factor has damaged that certain link in the protection mechanism just may occur that gastric acid and protease corrode self mucosa and the formation that causes ulcer.When excessive gastric acid secretion also may cause ulcer to occur considerably beyond the defence of mucosa and repair.In recent years research shows, helicobacter pylori and NSAID (non-steroidal anti-inflammatory drug) be the infringement gastrointestinal protection mechanism most commonly encountered diseases that causes the ulcer morbidity because of, gastric acid plays a crucial role in ulcer.In addition, medicine, stress, hormone also can cause the generation of ulcer, but various psychological factor and bad dietetic life are accustomed to the appearance of induced ulcer.
The performance of the typical clinical of duodenal ulcer has upper abdominal pain and epigastric discomfort etc., and various dyspeptic symptoms can appear in most people, but have also without any symptom, until develop complications.Hemorrhage, perforation that its common complication mainly contains.Common gastrointestinal symptom and General Symptoms mainly contain burn feeling behind belch, acid regurgitation, big belly, the breastbone, feel sick, vomiting, poor appetite etc.Burn feeling is because cardiochalasia is felt sick, vomitted many reflection ulcer and may point out ulcer to be in active stage behind acid regurgitation and the breastbone.Some patients were has autonomic nervous dysfunction's symptoms such as insomnia, hyperhidrosis.
Treat clinically at present duodenal ulcer and mainly contain Drug therapy, eliminating pylorus treatment and operative therapy.Drug therapy mainly adopts gastric acid secretion inhibiting medicine, mucosa protective agent and digestive tract power reinforcing medicine; Eliminating pylorus needs drug combination, and the first-line treatment scheme is to add two kinds of antibiotic Triple therapy schemes as the basis take PPI; Operative therapy is mainly used in that the massive hemorrhage medicine can not be controlled, perforation, cicatricial pyloric obstruction, intractable ulcer that Drug therapy is invalid, highly suspect the situations such as canceration.There are the shortcomings such as treatment cycle is long, effect is unstable in the treatment with western method, and there is operation risk in operative treatment, and postoperation recovery waits weak point slowly.
An important feature of duodenal ulcer is that it is a kind of somatopsychic illness.Patient's stress is often larger, various indigestion symptom cross occurrence due to its clinical symptoms and the functional gastrointestinal disorder, therefore some patient is behind the eradication therapy of enough courses for the treatment of, confirm that through endoscopy ulcer heals, but it is not good enough that indigestion symptom is alleviated, and its main cause is that patient's mental burden is heavier, poor sleep, in the past for a long time, dyspeptic symptom only can be more and more serious.Traditional Chinese medical theory is thought, Stomach duodenum ulcer, caused by deficiency-cold in middle-JIAO, stagnation of stomach-YANG, YANG deficiency of the spleen and stomach, qi depression to blood stasis, to thoroughly eradicate gastroenteritic ulcer, need from start with at all, concoct with the activate yang Chinese crude drug compatibility of gas, hemostasia and dissipation blood stasis, relieving gastric hyperacidity to alleviate stomachache of cold expelling warming middle-JIAO, a surname, ask the effect of replenishing vital QI with drugs of warm nature taste, blood activating and promoting tissue regeneration, reach relief of symptoms, eradicate the purpose of sufferer.
Summary of the invention
The invention provides a kind of medicine for duodenal ulcer nursing, have the activate yang effect of gas of cold expelling warming middle-JIAO, hemostasia and dissipation blood stasis, relieving gastric hyperacidity to alleviate stomachache, a surname, cure the disease and ask the source treating both the principal and secondary aspects of a disease, the duodenal ulcer that a variety of causes is caused all has good curative effect.
For achieving the above object, technical scheme of the present invention is implemented as follows:
A kind of medicine for the duodenal ulcer nursing, raw material composition and the parts by weight of making described effective ingredient are:
60～80 parts of 65～85 parts of Pericarpium Citris of 70～90 portions of Radix Aucklandiae (Radix Vladimiriae) of 75～100 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Radix Glycyrrhizae
45～60 parts of 50～65 parts of Radix et Rhizoma Thalictri of 55～70 parts of Fructus Toosendans of 60～75 parts of Caulis Perillaes of Pericarpium Citri Reticulatae
25～40 parts of 30～45 parts of Os Sepiae of 35～50 parts of Rhizoma Corydalis of 40～55 portions of Fructus Citri Sarcodactylis of Rhizoma Cyperi
10～25 parts of 15～30 parts of Herba Taraxacis of 20～35 parts of Radix Bupleuri of Fructus Aurantii Immaturus are forged 5～20 parts of Concha Arcaes.
Raw material composition and the parts by weight of making described effective ingredient are:
63～78 parts of 68～82 parts of Pericarpium Citris of 72～88 portions of Radix Aucklandiae (Radix Vladimiriae) of 78～95 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Radix Glycyrrhizae
48～58 parts of 52～62 parts of Radix et Rhizoma Thalictri of 58～68 parts of Fructus Toosendans of 63～73 parts of Caulis Perillaes of Pericarpium Citri Reticulatae
28～38 parts of 32～43 parts of Os Sepiae of 38～48 parts of Rhizoma Corydalis of 43～52 portions of Fructus Citri Sarcodactylis of Rhizoma Cyperi
12～22 parts of 18～28 parts of Herba Taraxacis of 23～32 parts of Radix Bupleuri of Fructus Aurantii Immaturus are forged 6～18 parts of Concha Arcaes.
Raw material composition and the parts by weight of making described effective ingredient are:
65～75 parts of 70～80 parts of Pericarpium Citris of 75～85 portions of Radix Aucklandiae (Radix Vladimiriae) of 82～90 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Radix Glycyrrhizae
50～56 parts of 55～60 parts of Radix et Rhizoma Thalictri of 60～65 parts of Fructus Toosendans of 65～70 parts of Caulis Perillaes of Pericarpium Citri Reticulatae
30～36 parts of 34～40 parts of Os Sepiae of 42～46 parts of Rhizoma Corydalis of 45～50 portions of Fructus Citri Sarcodactylis of Rhizoma Cyperi
14～20 parts of 20～25 parts of Herba Taraxacis of 25～30 parts of Radix Bupleuri of Fructus Aurantii Immaturus are forged 8～15 parts of Concha Arcaes.
Raw material composition and the parts by weight of making described effective ingredient are:
68 parts of 73 parts of Pericarpium Citris of 78 portions of Radix Aucklandiae (Radix Vladimiriae) of 84 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Radix Glycyrrhizae
52 parts of 57 parts of Radix et Rhizoma Thalictri of 62 parts of Fructus Toosendans of 67 parts of Caulis Perillaes of Pericarpium Citri Reticulatae
32 parts of 36 parts of Os Sepiae of 44 parts of Rhizoma Corydalis of 47 portions of Fructus Citri Sarcodactylis of Rhizoma Cyperi
16 parts of 22 parts of Herba Taraxacis of 27 parts of Radix Bupleuri of Fructus Aurantii Immaturus are forged 10 parts of Concha Arcaes.
A kind of preparation method of the medicine for duodenal ulcer nursing comprises following processing step:
(1) with Radix et Rhizoma Thalictri, Os Sepiae, pulverize after forging Concha Arcae and mixing and grind into powder, cross 120 order fine powders, for subsequent use.
(2) Rhizoma Cyperi, Rhizoma Corydalis are mixed thoroughly with vinegar, infiltrated, after being exhausted fully to vinegar, fry to little dried with slow fire, grind into powder after the pulverizing, cross 120 order fine powders, for subsequent use.
(3) Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Aucklandiae (Radix Vladimiriae), Pericarpium Citri, Pericarpium Citri Reticulatae, Caulis Perillae, Fructus Toosendan, Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus, Radix Bupleuri, Herba Taraxaci are put into container, add the water of octuple amount, boil rear continuation and soaked 9～12 hours, get immersion; The water that adds again six times of amounts in remaining medicinal residues boils rear continuation and soaked 6～8 hours, gets immersion; Merge twice gained immersion, evaporation and concentration is the thick paste of relative density 1.15～1.20 under 60 ℃ of environment, and is for subsequent use.
(4) with the fine powder of step (1), step (2) gained, the thick paste that makes with step (3) mixes, and adds vaseline, and after Sucus Zingberis mediation evenly, quick-freezing becomes powder, is prepared as the tablet product with modern science technique.
The property of medicine of the used Chinese medicine of the present invention is as follows:
Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; The stomach warp.Invigorating the spleen and replenishing QI; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity.Compendium of Material Medica is carried: " Radix Glycyrrhizae is monarch in all medicines.Control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine meritorious." the modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; be widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, have in addition anti-gastric-ulcer, gastritis effect.
The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth; Sweet; Puckery; Cold nature.Enter lung; Liver; The stomach warp.Eliminating phlegm and stopping cough; Promoting blood circulation and hemostasis.Cure mainly cough with copious phlegm; Hemoptysis; Mastitis; Traumatic injury; Traumatic hemorrhage." Japan hanako materia medica " carries: " spasmolytic is evil, blood is evil, dysentery, and acute conjunctivitis, crux, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, the hemorrhoid wart, cutter arrow skin ulcer is pounced on damage, warm malaria, dysentery, sore due to scald and burn, granulation promoting pain relieving, migratory arthralgia." the modern medicine study confirmation, the Pseudobulbus Bletillae (Rhizoma Bletillae) is rich in colloid, starch, volatilization wet goods, effectively resists bacillus, suppresses the activity of plasmin, is widely used in all kinds of traumatic hemorrhage.
Radix Aucklandiae (Radix Vladimiriae): acrid in the mouth; Bitter; Cold in nature; Slightly poisonous.Enter lung; The stomach warp.Promoting the circulation of QI to relieve pain; Removing toxic substances and promoting subsidence of swelling; The suppressing the hyperactive liver blood pressure lowering.Cure mainly breast side of body epigastric pain; Colicky; Intestinal is scorching; Dysentery stomachache; The cough phlegm dyspnea; Snake bite and insect sting; The carbuncle furuncle; Eczema; Skin pruritus; Hypertension." book on Chinese herbal medicine meets former " carries: " control large intestine, control wind syndrome of head, pruritus, tinea alba." clinic study shows; the Radix Aucklandiae (Radix Vladimiriae) total alkaloids has in various degree inhibitory action to staphylococcus aureus, bacillus pyocyaneus, escherichia coli and modification bacillus; strengthen the peritoneal macrophage activate the phagocytic capacity, the enhancing body defensive enginery also has calm, emetic action in addition.
Pericarpium Citri: acrid in the mouth; Bitter; Acid; Warm in nature.Enter liver; Lung; Spleen channel.Regulating QI and lowering the adverseness; The chest stuffiness relieving reduces phlegm.Cure mainly the breast abdominal distention vexed; Distending pain over the hypochondrium; Cough with copious phlegm." book on Chinese herbal medicine is new again " carries: " diuretic that stimulates the menstrual flow is controlled the waist beriberi for suppressing the hyperactive liver Shu Yu, reason lung qi." modern medicine study confirms, the contained volatile oil of Pericarpium Citri has gentle stimulation to gastrointestinal tract, can promote wriggling and Digestive system composition in the intestines and stomach, gets rid of the enteral pneumatosis, and eliminate the phlegm, antiinflammatory, antiviral, and the effect of prevention cold injury and inhibition aldehyde reductase.
Pericarpium Citri Reticulatae: acrid in the mouth; Sweet; Cold in nature.Enter spleen; The stomach warp.The therapeutic method to keep the adverse QI flowing downwards; In the accent; Reduce phlegm; Relieving alcoholic intoxication.Cure mainly drinking and eating irregularly; Upper gas stuffy sensation with restlessness; Get sick from drinking too much wine thirsty." Japan hanako materia medica " carries: " skin is processed and is made soup, but alcoholic intoxication and wine are thirsty, typhoid fever diet recurrence caused by overexertion person, the dense juice clothes of frying in shallow oil." medicine clinical research shows; the contained Hesperidin of Pericarpium Citri Reticulatae can suppress gastric ulcer; reduce capillary permeability; have the gastrointestinal function of adjustment and antiinflammatory action; its volatile oil has eliminating the phlegm, relievings asthma, facilitating digestion liquid secretion and get rid of the effect such as enteral pneumatosis, also has in addition coronary artery dilator, reduces blood pressure and the effect such as function of gallbladder promoting.
Caulis Perillae: acrid in the mouth; Warm in nature.Return lung; Spleen channel.Pleasant helping digestion; Pain relieving; Antiabortive.Curing mainly dyspepsia does not change; Abdominal distention; Flu; Frequent fetal movement." Traditional Chinese Medicine in Sichuan will " carries: " expel flatulence and relieve chest stuffiness reduces phlegm in the row, helps digestion, control uncomfortable in chest, dysphagia and regurgitation and angina pectoris." modern medicine study confirms, Caulis Perillae can promote gastric secretion, strengthens gastrointestinal peristalsis, promotes the body sweating and heat resolving, the effect such as diuresis is arranged in addition, eliminate the phlegm.
Fructus Toosendan: bitter in the mouth; Cold in nature, slightly poisonous.Return liver; Small intestinal; Urinary bladder channel.Soothing the liver expelling the heat-evil; Promoting the circulation of QI to relieve pain; Parasite killing.Cure mainly the gastral cavity abdomen pain over the hypochondriac region; Hernia pain; Abdominal pain due to worm stagnation; Tinea capitis." it is former that book on Chinese herbal medicine is asked " carries: " control the gonorrhea pain in the penis and draw the side of body, seminal emission is gathered, all contrary rushing to, and the hematochezia of urinating, headache, gingival atrophy is hemorrhage, parasite killing." the modern medicine study confirmation, the contained Fructus Toosendan of Fructus Toosendan have the ascarifuge effect, and the central nervous system is had certain inhibitory action, also has in addition certain anti-botulism effect.
Radix et Rhizoma Thalictri: bitter in the mouth; Cold in nature.GUIXIN; Liver; Large intestine channel.Heat clearing and damp drying; Eliminating fire and detoxication.Cure mainly damp-heat dysentery; Jaundice; Sore swollen toxin; Conjunctival congestion and swelling pain; Cold, fever; Cancerous protuberance." Chinese herbal medicine is commonly used in Tibet " carries: " heat-clearing and toxic substances removing, the removing heat from blood that dispels the wind, anti-inflammtory anti-dysentery.Control conjunctivitis, infectious hepatitis, carbuncle furuncle, dysentery.Leaf, flower curing arthritis." the modern medicine study confirmation, the contained fetidine of Radix et Rhizoma Thalictri has hypotensive effect, and antiinflammatory, analgesia, cooling effect are arranged, and is widely used in clinically the diseases such as conjunctivitis, infectious hepatitis.
Rhizoma Cyperi: acrid in the mouth; Cold nature; Nontoxic.Return liver; Lung; Spleen; Stomach; Tri-jiao channel.The resolving depression of regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Cure mainly distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; The belch acid regurgitation; Vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement." detailed outline " carries: " the cold epidemic disease of loose seasonal epidemic pathogens, sharp three warmers, Xie Nvyu, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot; abdominal distention, beriberi is ended trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood; hematochezia, hematuria, married woman's bleeding not during menses, menoxenia, tire all kinds of diseases and ailments in front puerperal." modern medicine study proves, Rhizoma Cyperi can the nervous system regulation function, heart tonifying, decreased heart rate is arranged, reduce blood pressure, prevent and treat the effects such as hyperlipemia and atherosclerosis.
Fructus Citri Sarcodactylis: acrid in the mouth; Bitter; Warm in nature.Enter liver; Stomach; Spleen; Lung meridian.Liver-smoothing, qi-regulating; Stomach function regulating reduces phlegm.Cure mainly the hypochondriac pain of depression of liver-QI; Breast is vexed; Incoordination between the liver and stomach; The abdominal distention of stagnation of QI in spleen and stomach; Yuan gas; Feel sick; The chronic cough abundant expectoration." book on Chinese herbal medicine is new again " carries: " control the gas soothing liver-QI, stomach function regulating reduces phlegm, and removing mass is controlled dysphagia and regurgitation, eliminating mass abdominal mass scrofula." the modern medicine study confirmation; Fructus Citri Sarcodactylis has the phlegm-dispelling functions of relievining asthma; the antagonism trachea shrinks; the tension force of alleviating rapidly stomach, intestinal and gallbladder increases; prolong the convulsions time of origin, prevents arrhythmia, strengthens the resistance of hair and blood pipe; reduce the ascorbic discharge of adrenal gland, also has in addition the effect of antiinflammatory, antimicrobial acivity.
Rhizoma Corydalis: acrid in the mouth; Bitter; Warm in nature; Nontoxic.Enter liver; Stomach; The heart; Lung; Spleen channel.Invigorate blood circulation; Dissipating blood stasis; Regulate the flow of vital energy; Pain relieving.Cure mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints." detailed outline " carries: " stagnation of QI in the energy promoting the circulation of blood, stasis in the gas, thus all pains about specially controlling all over the body, among using, simply fantastic.Invigorate blood circulation promoting the circulation of QI, pain relieving, diuresis." modern medicine study shows, Rhizoma Corydalis has significant analgesia, calmness, hypnosis, stable effect, and excited gastrointestinal smooth muscle is significantly expanded coronary vasodilator, can cause the secretion of PATH, and muscle is had relaxation effect.
Os Sepiae: salty in the mouth; Puckery; Warm in nature.Enter liver; Kidney channel.Astringing to arrest bleeding; Treating spontaneous emission and leukorrhagia; Relieving gastric hyperacidity to alleviate stomachache; The removing dampness sore.Cure mainly haematemesis; Hematemesis; Metrorrhagia; Have blood in stool; Epistaxis; Have a stomachache noisy; Yuan gas pantothenic acid; Eczema ulcer." Bencao Jingshu " carries: " salty temperature enters Liver and kidney, promoting blood circulation and dispelling cold and dampness enters liver and gall, and Shu Yingqi, temperature and dampness, the many pus of main skin ulcer are also again." the modern medicine study confirmation, sepiellae seu sepiae decocting liquid has significant radiation resistance, can obviously promote the bone defect repair.
Fructus Aurantii Immaturus: bitter in the mouth; Hot; Cold in nature.Enter spleen; Stomach; Liver; Heart channel.The dispelling the stagnated QI removing food stagnancy; Reduce phlegm except painful abdominal mass.Cure mainly and stop in stagnant; The feeling of fullness distending pain; Constipation; Heavy behind the dysentery; Blocked-up chest; Gastroptosis." medicineization justice " carries: " Fructus Aurantii Immaturus is specially let out excess of the stomach, convinces hard knot by patient analysis, therefore the main middle part of gastric cavity is treated the interventral reality of umbilicus full to control blood system, the expectorant addiction is dispelled and cut off the water, by dyspepsia, broken blocked-up chest, relieving constipation is closed, non-this can not be also.If skin pruritus, because of hematocele stagnate in, can not nutrition flesh table, if diet do not think, can not transporting because of spleen pent-up, all get the power that its hot loose hardship is rushed down." Fructus Aurantii Immaturus can alleviate little enterospasm, increases gastrointestinal and shrinks the rhythm and pace of moving things, impels gallbladder contraction, increases Oddi's sphincter tension force, suppresses thrombosis, particularly has the antiulcer effect.
Radix Bupleuri: bitter in the mouth; Hot; Cold nature.Enter liver; Gallbladder meridian.Induce sweat and bring down a fever; Dispersing the stagnated live-QI to relieve the stagnation of QI; The elevate a turnable ladder yang-energy.Cure mainly fever caused by exogenous pathogens; Alternate attack of chill and fever; Malaria; The hypochondriac pain due to stagnation of liverQI mammary swelling; The headache dizziness; Gastroptosis." Japan hanako materia medica " carries: " mend five kinds of strain and seven kinds of impairment, relieving restlessness spasmolytic, expectorant antitussive, profit cardiopulmonary, breast side of body fullness caused by stagnant QI." modern medicine study shows, Radix Bupleuri contains the compositions such as volatile oil, fat, and its decoct has refrigeration function, and can suppress plasmodial growth promoter, and tubercule bacillus and influenza virus are also had inhibitory action.Especially the contained Saponin of Radix Bupleuri, the sedation and analgesia effect is arranged, and have anti-liver injury, prevent the function of steatosis and fibroplasia, transaminase lowering and function of gallbladder promoting, now be widely used in the illness such as acute hepatitis, biliary tract inflammation and intercostal neuralgia, certain curative effect is all arranged.
Herba Taraxaci: bitter in the mouth; Sweet; Cold in nature.Return liver; The stomach warp.Heat-clearing and toxic substances removing; The eliminating carbuncle eliminating stagnation.Cure mainly acute mastitis; Lung abscess; The intestinal carbuncle; Mumps; The furuncle carbuncle toxin; Conjunctival congestion and swelling pain; Cold, fever; Cough; Laryngopharynx swelling and pain; Stomach-fire; Intestinal is scorching; Dysentery; Hepatitis; Cholecystitis." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " control all pyogenic infections from tumour or sore, ruined tinea skin ulcer; Dispel the wind all sores that disappears, loose scrofula tuberculosis; End little having blood in stool, control the five types of stranguria difficulty in urination, sharp bladder." clinic study shows, the dandelion preparation can replace antibiotics to use to a certain extent, some disease is shown the effect of broad-spectrum antibiotic, and certain antiviral functions is arranged.
Forge Concha Arcae: sweet in the mouth; Salty; Property is put down.Enter liver; Spleen; The stomach warp.The expectorant blood stasis dispelling; Hard masses softening and resolving; Relieving gastric hyperacidity to alleviate stomachache.Cure mainly scrofula; The WEIJIA mass in the abdomen; The pertinacious phlegm chronic cough; The stomachache acid regurgitation; Ulcerative gingivitis; Traumatic hemorrhage; Chilblain and burn and scald." detailed outline " carries: " salty flavor acting on blood and softening the hard mass, thus the clot that can disappear, loose accumulation of phlegm." the modern medicine study confirmation, forging Concha Arcae has obvious curative effect for controlling Qi Xue WEIJIA, is rich in a large amount of calcium carbonate; a small amount of magnesium, ferrum, silicate, sulfate and chloride and organic matter; nucleic manganese is had special accumulation ability, be mainly used in clinically reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling.
The present invention compared with prior art has following beneficial effect:
Selection of the present invention is reasonable, for the deficiency-cold in middle-JIAO that causes duodenal ulcer, stagnation of stomach-YANG, YANG deficiency of the spleen and stomach, qi depression to blood stasis etc. pathogenic because of, start with from improving the digestive system vigor, activate the body immunologic mechanism, reach the activate yang purpose of gas of cold expelling warming middle-JIAO, hemostasia and dissipation blood stasis, relieving gastric hyperacidity to alleviate stomachache, a surname, alleviate the ulcer symptom, clinical use proves, good absorbing has no side effect and untoward reaction, and is higher to duodenal cure rate.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further elaborated.
Embodiment 1
The raw material of effective ingredient of the present invention forms and weight is:
Radix Glycyrrhizae 90g Pseudobulbus Bletillae (Rhizoma Bletillae) 85g Radix Aucklandiae (Radix Vladimiriae) 80g Pericarpium Citri 76g
Pericarpium Citri Reticulatae 72g Caulis Perillae 68g Fructus Toosendan 63g Radix et Rhizoma Thalictri 58g
Rhizoma Cyperi 53g Fructus Citri Sarcodactylis 47g Rhizoma Corydalis 42g Os Sepiae 38g
Fructus Aurantii Immaturus 32g Radix Bupleuri 28g Herba Taraxaci 22g forges Concha Arcae 18g.
The processing step of process for preparing medicine of the present invention is:
(1) with Radix et Rhizoma Thalictri, Os Sepiae, pulverize after forging Concha Arcae and mixing and grind into powder, cross 120 order fine powders, for subsequent use.
(2) Rhizoma Cyperi, Rhizoma Corydalis are mixed thoroughly with vinegar, infiltrated, after being exhausted fully to vinegar, fry to little dried with slow fire, grind into powder after the pulverizing, cross 120 order fine powders, for subsequent use.
(3) Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Aucklandiae (Radix Vladimiriae), Pericarpium Citri, Pericarpium Citri Reticulatae, Caulis Perillae, Fructus Toosendan, Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus, Radix Bupleuri, Herba Taraxaci are put into container, add the water of octuple amount, boil rear continuation and soaked 9～12 hours, get immersion; The water that adds again six times of amounts in remaining medicinal residues boils rear continuation and soaked 6～8 hours, gets immersion; Merge twice gained immersion, evaporation and concentration is the thick paste of relative density 1.15～1.20 under 60 ℃ of environment, and is for subsequent use.
(4) with the fine powder of step (1), step (2) gained, the thick paste that makes with step (3) mixes, and adds vaseline, and after Sucus Zingberis mediation evenly, quick-freezing becomes powder, is prepared as the tablet product with modern science technique.
Usage and dosage: adult every day 3 times, each oral 0.5～0.8g used warm water delivery service in one hour after meal, patient with severe symptoms every day 4 times, each oral 0.6～1.0g, general 1～3 onset course for the treatment of, 2～4 onsets course for the treatment of of patient with severe symptoms.
Embodiment 2
The raw material of effective ingredient of the present invention forms and weight is:
Radix Glycyrrhizae 88g Pseudobulbus Bletillae (Rhizoma Bletillae) 85g Radix Aucklandiae (Radix Vladimiriae) 78g Pericarpium Citri 75g
Pericarpium Citri Reticulatae 70g Caulis Perillae 66g Fructus Toosendan 60g Radix et Rhizoma Thalictri 56g
Rhizoma Cyperi 50g Fructus Citri Sarcodactylis 46g Rhizoma Corydalis 42g Os Sepiae 36g
Fructus Aurantii Immaturus 30g Radix Bupleuri 26g Herba Taraxaci 20g forges Concha Arcae 16g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
The raw material of effective ingredient of the present invention forms and weight is:
Radix Glycyrrhizae 86g Pseudobulbus Bletillae (Rhizoma Bletillae) 82g Radix Aucklandiae (Radix Vladimiriae) 75g Pericarpium Citri 70g
Pericarpium Citri Reticulatae 68g Caulis Perillae 64g Fructus Toosendan 58g Radix et Rhizoma Thalictri 54g
Rhizoma Cyperi 48g Fructus Citri Sarcodactylis 45g Rhizoma Corydalis 38g Os Sepiae 34g
Fructus Aurantii Immaturus 28g Radix Bupleuri 23g Herba Taraxaci 18g forges Concha Arcae 12g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
The raw material of effective ingredient of the present invention forms and weight is:
Radix Glycyrrhizae 84g Pseudobulbus Bletillae (Rhizoma Bletillae) 78g Radix Aucklandiae (Radix Vladimiriae) 73g Pericarpium Citri 68g
Pericarpium Citri Reticulatae 67g Caulis Perillae 62g Fructus Toosendan 57g Radix et Rhizoma Thalictri 52g
Rhizoma Cyperi 47g Fructus Citri Sarcodactylis 44g Rhizoma Corydalis 36g Os Sepiae 32g
Fructus Aurantii Immaturus 27g Radix Bupleuri 22g Herba Taraxaci 16g forges Concha Arcae 10g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case is selected
The duodenal ulcer patients 80 routine clinical observations of selecting my institute or outer court to make a definite diagnosis, patient is divided into two groups at random.Treatment group 40 examples, male's 23 examples wherein, women's 17 examples, 22～55 years old age, 42.6 years old mean age, the shortest person of the course of disease 6 months, elder 9 years, average 6.8 years.Matched group 40 examples, male's 24 examples wherein, women's 16 examples, 19～57 years old age, 41.4 years old mean age, the shortest person of the course of disease 7 months, elder 12 years, average 7.4 years.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.
2, the treatment group patient takes medicine of the present invention, adult every day 3 times, and each oral 0.6g, patient with severe symptoms every day 4 times, each oral 1.0g, 9 days is a course for the treatment of.Matched group gives respectively gastric acid secretion medicine (such as cimetidine, ranitidine, famotidine etc.), mucosa protective agent (such as sucralfate, bismuth potassium citrate, misoprostol etc.) and digestive tract power reinforcing medicine.
3, efficacy determination:
(1) recovery from illness: the transference cure such as burn feeling behind pain, Yuan gas, acid regurgitation, big belly, the breastbone.
(2) take a turn for the better: above-mentioned symptom is clearly better, or seizure frequency obviously descends.
(3) invalid: symptom is controlled front no significant difference with executing.
4, result
Cure 27 examples, 9 examples that take a turn for the better, invalid 4 examples, cure rate 67.5%, total effective rate 90.0% in the treatment group.
Cure 8 examples, 11 examples that take a turn for the better, invalid 21 examples, cure rate 20.0%, total effective rate 47.5% in the matched group.
Above result's demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Above-mentioned data shows, medicine of the present invention has obvious therapeutic effect to duodenal ulcer, the Cardiochalasia indication that is particularly useful for burn feeling symptom behind Yuan gas, acid regurgitation, big belly, the breastbone, art method nursing to operative therapys such as hemorrhage, perforation also has splendid effect, is suitable for clinical application.
Claims (5)
1. one kind is used for the medicine that duodenal ulcer is nursed, and it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
60～80 parts of 65～85 parts of Pericarpium Citris of 70～90 portions of Radix Aucklandiae (Radix Vladimiriae) of 75～100 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Radix Glycyrrhizae
45～60 parts of 50～65 parts of Radix et Rhizoma Thalictri of 55～70 parts of Fructus Toosendans of 60～75 parts of Caulis Perillaes of Pericarpium Citri Reticulatae
25～40 parts of 30～45 parts of Os Sepiae of 35～50 parts of Rhizoma Corydalis of 40～55 portions of Fructus Citri Sarcodactylis of Rhizoma Cyperi
10～25 parts of 15～30 parts of Herba Taraxacis of 20～35 parts of Radix Bupleuri of Fructus Aurantii Immaturus are forged 5～20 parts of Concha Arcaes.
2. a kind of medicine for duodenal ulcer nursing according to claim 1 is characterized in that: the raw material of making described effective ingredient forms and parts by weight are:
63～78 parts of 68～82 parts of Pericarpium Citris of 72～88 portions of Radix Aucklandiae (Radix Vladimiriae) of 78～95 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Radix Glycyrrhizae
48～58 parts of 52～62 parts of Radix et Rhizoma Thalictri of 58～68 parts of Fructus Toosendans of 63～73 parts of Caulis Perillaes of Pericarpium Citri Reticulatae
28～38 parts of 32～43 parts of Os Sepiae of 38～48 parts of Rhizoma Corydalis of 43～52 portions of Fructus Citri Sarcodactylis of Rhizoma Cyperi
12～22 parts of 18～28 parts of Herba Taraxacis of 23～32 parts of Radix Bupleuri of Fructus Aurantii Immaturus are forged 6～18 parts of Concha Arcaes.
3. a kind of medicine for duodenal ulcer nursing according to claim 1 is characterized in that: the raw material of making described effective ingredient forms and parts by weight are:
65～75 parts of 70～80 parts of Pericarpium Citris of 75～85 portions of Radix Aucklandiae (Radix Vladimiriae) of 82～90 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Radix Glycyrrhizae
50～56 parts of 55～60 parts of Radix et Rhizoma Thalictri of 60～65 parts of Fructus Toosendans of 65～70 parts of Caulis Perillaes of Pericarpium Citri Reticulatae
30～36 parts of 34～40 parts of Os Sepiae of 42～46 parts of Rhizoma Corydalis of 45～50 portions of Fructus Citri Sarcodactylis of Rhizoma Cyperi
14～20 parts of 20～25 parts of Herba Taraxacis of 25～30 parts of Radix Bupleuri of Fructus Aurantii Immaturus are forged 8～15 parts of Concha Arcaes.
4. a kind of medicine for duodenal ulcer nursing according to claim 1 is characterized in that: the raw material of making described effective ingredient forms and parts by weight are:
68 parts of 73 parts of Pericarpium Citris of 78 portions of Radix Aucklandiae (Radix Vladimiriae) of 84 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Radix Glycyrrhizae
52 parts of 57 parts of Radix et Rhizoma Thalictri of 62 parts of Fructus Toosendans of 67 parts of Caulis Perillaes of Pericarpium Citri Reticulatae
32 parts of 36 parts of Os Sepiae of 44 parts of Rhizoma Corydalis of 47 portions of Fructus Citri Sarcodactylis of Rhizoma Cyperi
16 parts of 22 parts of Herba Taraxacis of 27 parts of Radix Bupleuri of Fructus Aurantii Immaturus are forged 10 parts of Concha Arcaes.
5. preparation method that is used for the medicine of duodenal ulcer nursing is characterized in that: comprise following processing step:
(1) with Radix et Rhizoma Thalictri, Os Sepiae, pulverize after forging Concha Arcae and mixing and grind into powder, cross 120 order fine powders, for subsequent use.
(2) Rhizoma Cyperi, Rhizoma Corydalis are mixed thoroughly with vinegar, infiltrated, after being exhausted fully to vinegar, fry to little dried with slow fire, grind into powder after the pulverizing, cross 120 order fine powders, for subsequent use.
(3) Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Aucklandiae (Radix Vladimiriae), Pericarpium Citri, Pericarpium Citri Reticulatae, Caulis Perillae, Fructus Toosendan, Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus, Radix Bupleuri, Herba Taraxaci are put into container, add the water of octuple amount, boil rear continuation and soaked 9～12 hours, get immersion; The water that adds again six times of amounts in remaining medicinal residues boils rear continuation and soaked 6～8 hours, gets immersion; Merge twice gained immersion, evaporation and concentration is the thick paste of relative density 1.15～1.20 under 60 ℃ of environment, and is for subsequent use.
(4) with the fine powder of step (1), step (2) gained, the thick paste that makes with step (3) mixes, and adds vaseline, and after Sucus Zingberis mediation evenly, quick-freezing becomes powder, is prepared as the tablet product with modern science technique.
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| CN106110164A (en) * | 2016-08-10 | 2016-11-16 | 北京科诺德医药科技有限公司 | A kind of oral Chinese medicine powder formale treating taste-blindness rate |
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Application publication date: 20130403 |