CN117388039A - Peripheral blood mixing mechanism, mixing mechanism and sample analyzer - Google Patents

Abstract

The invention provides a peripheral blood mixing mechanism, a mixing mechanism and a sample analyzer, wherein the peripheral blood mixing mechanism comprises a bearing seat and a mixing driving assembly; the bearing seat is used for bearing the sample container; the mixing driving assembly is connected with the bearing seat and used for driving the bearing seat to transversely move so as to drive the sample container to transversely move to uniformly mix the peripheral blood sample in the sample container. The peripheral blood mixing mechanism, the peripheral blood mixing mechanism and the sample analyzer can well meet the mixing requirement of peripheral blood and improve the measurement accuracy.

Description

Peripheral blood mixing mechanism, mixing mechanism and sample analyzer

Technical Field

The invention relates to the technical field of blood sample analysis, in particular to a peripheral blood mixing mechanism, a peripheral blood mixing mechanism and a sample analyzer.

Background

Blood sample testing requires the collection of a certain amount of sample from a patient, including venous blood collection and peripheral blood collection. Peripheral blood is usually collected from patients who are not suitable for intravenous blood collection, such as neonates, infants, intensive care patients, and the like. Layering phenomenon can occur after the collected peripheral blood is placed for a period of time, and if the peripheral blood is directly sampled and measured, larger deviation can occur in the measurement result. Because the blood collection amount of the peripheral blood is small, the fluidity is poor, and the mixing effect of the traditional peripheral blood mixing mode is poor, so that the measurement accuracy can be influenced.

Disclosure of Invention

The invention provides a peripheral blood mixing mechanism, a mixing mechanism and a sample analyzer, which are used for well meeting the mixing requirement of peripheral blood and improving the measurement accuracy.

The present invention provides a peripheral blood mixing mechanism for mixing peripheral blood in a sample container, the peripheral blood mixing mechanism comprising:

a carrying seat for carrying the sample container;

the mixing driving assembly is connected with the bearing seat and is used for driving the bearing seat to transversely move so as to drive the sample container to transversely move to uniformly mix the peripheral blood sample in the sample container.

In the peripheral blood mixing mechanism, the mixing driving assembly is used for driving the bearing seat to transversely reciprocate.

In the peripheral blood mixing mechanism, the mixing driving assembly is used for driving the bearing seat to do curve or linear reciprocating movement.

In the peripheral blood mixing mechanism, the mixing driving assembly is used for driving the bearing seat to do arc reciprocating movement.

In the peripheral blood mixing mechanism, the bearing seat is used for bearing an emergency sample container and/or a conventional sample container.

In the peripheral blood mixing mechanism, the mixing driving assembly is used for driving the bearing seat to reciprocate for 300 times/min-800 times/min.

In the peripheral blood mixing mechanism, the mixing driving assembly is used for driving the bearing seat to reciprocate for 800 times/min.

In the peripheral blood mixing mechanism of the present invention, the mixing drive assembly includes:

uniformly mixing the driving piece;

the mixing driving piece is connected with the mixing driving piece and the bearing seat, and the mixing driving piece can drive the mixing driving piece to do rotary motion so as to drive the bearing seat to transversely move.

In the peripheral blood mixing mechanism of the present invention, the mixing transmission member includes:

and the cam is fixedly connected with the mixing driving piece and is in transmission connection with the bearing seat.

In the peripheral blood mixing mechanism, the bearing seat is provided with a bearing, and the bearing is in transmission connection with the cam.

In the peripheral blood mixing mechanism of the present invention, the mixing transmission member includes:

the crank is connected with the uniform mixing driving piece;

and one end of the crank connecting rod is connected with the crank, and the other end of the crank connecting rod is connected with the bearing seat.

In the peripheral blood mixing mechanism, the peripheral blood mixing mechanism further comprises a mixing bracket, and the mixing driving assembly is arranged on the mixing bracket; the mixing driving assembly further comprises:

and one end of the mixing reset piece is abutted with the mixing support, and the other end of the mixing reset piece is abutted with the bearing seat and used for resetting the bearing seat.

In the peripheral blood mixing mechanism, the mixing reset piece comprises an elastic piece, one end of the elastic piece is abutted with the mixing bracket, and the other end of the elastic piece is abutted with the bearing seat.

In the peripheral blood blending mechanism of the present invention, the peripheral blood blending mechanism further includes:

the guide rod is arranged on the mixing bracket and is in sliding fit with the bearing seat.

In the peripheral blood mixing mechanism, the mixing support is provided with the mixing slide rail which is in sliding fit with the bearing seat, and the mixing driving assembly is used for driving the bearing seat to slide along the mixing slide rail.

In the peripheral blood mixing mechanism of the present invention, the carrying seat is provided with a receiving groove for receiving the sample container, and the diameter of the receiving groove is larger than that of the sample container.

In the peripheral blood mixing mechanism of the present invention, the diameter of the accommodation groove is 0.5mm to 3mm larger than the diameter of the sample container.

In the peripheral blood mixing mechanism, the bearing seat is provided with the containing groove for containing the sample container, the containing groove is arranged in a variable diameter mode, one end of the containing groove is in limit fit with the sample container, and the diameter of the other end of the containing groove is 0.5-3 mm larger than that of the sample container.

In the peripheral blood mixing mechanism, two accommodating grooves are formed in the bearing seat, and each accommodating groove is used for accommodating one sample container.

In the peripheral blood mixing mechanism of the present invention, one of the two accommodation grooves is used for intermediately buffering the sample container.

In the peripheral blood mixing mechanism, the bearing seat is provided with a containing groove for containing the sample container, and a damping piece arranged between the groove wall of the containing groove and the sample container is arranged in the containing groove.

The invention also provides a mixing mechanism for mixing samples in a sample container, the mixing mechanism comprising:

a receptacle for carrying the sample container;

the bearing seat is connected with the container seat;

the mixing driving assembly is connected with the bearing seat and is used for driving the bearing seat to transversely move;

a locking assembly, when the sample container is of the peripheral blood container type, the locking assembly being in a locked state, the locking assembly locking the receptacle to limit lateral oscillation of the receptacle relative to the carrier; when the sample container is of the venous blood container type, the locking assembly is in an unlocked state, and the locking assembly unlocks the container mount to enable the container mount to swing laterally relative to the carrier mount.

In the mixing mechanism, the bearing seat is provided with two limiting rods for limiting the swinging angle of the container seat to be not more than 180 degrees.

In the mixing mechanism of the present invention, the mixing mechanism further includes:

and the container type detection device is arranged on the bearing seat and is used for detecting the type of the sample container, wherein the type of the sample container comprises a peripheral blood container and a venous blood container.

In the mixing mechanism of the invention, the container type detection device comprises at least one of a capacitance sensor, an optical coupler sensor, an inductance sensor and a pressure sensor.

In the mixing mechanism of the present invention, the locking assembly comprises: the device comprises an electromagnet and an iron sheet matched with the electromagnet, wherein one of the electromagnet and the iron sheet is arranged on the bearing seat, the other one of the electromagnet and the iron sheet is arranged on the container seat, and the position of the electromagnet corresponds to the position of the iron sheet.

The present invention also provides a sample analyzer comprising:

the peripheral blood mixing mechanism of any one of the above or the mixing mechanism of any one of the above;

the sampling mechanism is used for collecting the uniformly mixed sample in the sample container; and

and the sampling mechanism is used for injecting the acquired sample into the reaction measuring mechanism.

According to the peripheral blood mixing mechanism, the mixing mechanism and the sample analyzer provided by the invention, the mixing driving assembly drives the bearing seat to transversely move, so that the sample container is driven to transversely move to mix peripheral blood samples in the sample container. The mixing mode can keep the sample at the bottom of the sample container as much as possible in the mixing process, well meet the mixing requirement of the sample, especially well meet the mixing requirement of trace peripheral blood, and improve the measuring accuracy; and the sample container is reciprocally and horizontally moved so as to realize a uniform mixing mode, so that the hanging liquid residual quantity of the sample on the inner wall of the sample container can be reduced, the effect of sample loss is reduced, and the problem that the sample overflows the sample container due to climbing of the liquid level can be reduced or avoided.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure of embodiments of the invention.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 (A) is a schematic diagram of a sample analyzer according to an embodiment of the present invention;

FIG. 1 (B) is a schematic view of a portion of a sample analyzer according to an embodiment of the present invention;

FIG. 2 (A) is a schematic structural view of a tip blending mechanism according to an embodiment of the present invention;

FIG. 2 (B) is a cross-sectional view of a tip blending mechanism according to an embodiment of the present invention;

fig. 2 (C) is a schematic structural diagram of a tip blending mechanism according to an embodiment of the present invention;

fig. 2 (D) is a schematic structural diagram of a blending mechanism according to an embodiment of the present invention;

fig. 2 (E) is a schematic structural diagram of a carrier according to an embodiment of the present invention.

Reference numerals illustrate:

10. a sample injection mechanism; 20. a moving and taking mechanism;

30. a mixing mechanism; 31. a bearing seat; 311. mixing the sliding blocks; 312. a receiving groove; 32. uniformly mixing and driving the components; 321. uniformly mixing the driving piece; 322. uniformly mixing the transmission parts; 3221. a crank; 3222. a crank connecting rod; 323. a bearing; 324. mixing evenly and resetting the piece; 33. mixing the support; 331. uniformly mixing the sliding rails; 34. a guide rod; 35. a container base; 36. a locking assembly; 361. an electromagnet; 362. iron sheet;

40. a sampling mechanism; 50. a reaction measurement mechanism.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more of the described features. In the description of the present invention, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.

It is also to be understood that the terminology used in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

It should be further understood that the term "and/or" as used in the present specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations.

The present invention provides a sample analyzer for analyzing a sample. The sample analyzer may include at least one of a blood analyzer, a specific protein analyzer, a hemoglobin analyzer, and the like. The sample may include blood, urine, gynecological secretions, ascites, cerebral spinal cord, or hydrothorax, and the like.

Referring to fig. 1 (a) and 1 (B), the sample analyzer includes a mixing mechanism 30, a sampling mechanism 40, and a reaction measurement mechanism 50. The mixing mechanism 30 is used for performing a mixing operation on the sample in the sample container. The sampling mechanism 40 is used to collect a sample in a sample container. The sampling mechanism 40 injects the collected sample into the reaction measurement mechanism 50. The sampling mechanism 40 is used to collect a sample in a sample container and inject the collected sample into the reaction measurement mechanism 50. The reaction measurement mechanism 50 is used to perform a measurement operation on a sample.

It will be appreciated that certain components of the present embodiment may be omitted or not used for testing of certain samples. For example, for samples such as urine, which are not typically homogenized prior to measurement, and thus, the homogenizing mechanism 30 is not required, the sample may be collected by the sampling mechanism 40 and injected into the reaction measurement mechanism 50 for measurement, such as five-class detection of white blood cells. For samples that do not require homogenization using the homogenization mechanism 30, the sample container may be sampled without a container cap.

For samples such as peripheral blood and venous blood, the samples are usually mixed before measurement, and the sampling mechanism 40 can collect the mixed samples and inject the samples into the reaction measurement mechanism 50 for measurement operation. For samples that need to be homogenized using the homogenization mechanism 30, the sample container is typically capped to prevent the sample from spilling out of the sample container during homogenization.

Referring to fig. 1 (a), in some embodiments, the sample analyzer further includes a sample introduction mechanism 10 and a removal mechanism 20. The sample introduction mechanism 10 is used for storing sample containers. The transfer mechanism 20 is used to transfer the sample containers to the mixing mechanism 30 or the sampling mechanism 40, etc.

An embodiment of the present invention provides a mixing mechanism 30 including a peripheral blood mixing mechanism for mixing peripheral blood in a sample container S. Referring to fig. 2 (a), the peripheral blood mixing mechanism includes a carrier 31 and a mixing driving assembly 32. The carrying seat 31 is used for carrying the sample container S. The mixing driving assembly 32 is connected with the bearing seat 31. The mixing driving assembly 32 is used for driving the carrying seat 31 to move transversely, so as to drive the sample container S to move transversely to mix the peripheral blood sample in the sample container S.

The peripheral blood mixing mechanism of the above embodiment has smart structural design and strong practicability, and drives the bearing seat 31 to move transversely through the mixing driving assembly 32, so as to drive the sample container S to move transversely to mix the peripheral blood sample in the sample container S. The mixing mode can keep the sample at the bottom of the sample container S as much as possible in the mixing process, well meet the mixing requirement of the sample, especially well meet the mixing requirement of trace peripheral blood, and improve the measuring accuracy; and the sample container S is reciprocally and horizontally moved so as to realize a uniform mixing mode, so that the residual quantity of hanging liquid of a sample on the inner wall of the sample container S can be reduced, the effect of sample loss is reduced, and the problem that the liquid level climbs to cause the sample to overflow the sample container S can be reduced or avoided.

Of course, the peripheral blood mixing mechanism may be used to mix a sample container S containing a large sample amount. Accordingly, the sample container S that the carrier 31 can carry may be a peripheral blood container containing a small amount of peripheral blood (for example, a trace amount of blood collection tube containing peripheral blood), a venous blood container containing a large amount of venous blood (for example, a vacuum blood collection tube containing venous blood), or a sample container containing urine, ascites, or the like. However, the peripheral blood homogenization mechanism of the present embodiment has significant advantages for sample containers containing small amounts of sample (e.g., micropipettes of peripheral blood).

Referring to fig. 2 (a), in some embodiments, the blending driving assembly 32 is configured to drive the carrier 31 to reciprocate laterally (hereinafter referred to as "reciprocate"). By the reciprocating traversing of the carrying seat 31, the sample container S also follows the reciprocating traversing, thereby achieving a better mixing effect.

Referring to fig. 2 (a), the mixing driving assembly 32 is for driving the carrier 31 to linearly reciprocate. Therefore, not only can the requirement of sample mixing be well met, but also the samples in the sample container S do not need to rotate circumferentially, so that the residual quantity of hanging liquid of the samples on the inner wall of the sample container S is reduced, the effect of sample loss is reduced, and the problem that the samples overflow the sample container S due to liquid level climbing caused by the circumferential rotation of the samples is prevented.

In some embodiments, the blending driving assembly 32 is configured to drive the carrier 31 to reciprocate in a curved or linear manner.

In some embodiments, the blending driving assembly 32 is configured to drive the carrier 31 to reciprocate in an arc shape. The reciprocating track of the bearing seat 31 is simple and convenient to process.

In some embodiments, the sample containers S include emergency sample containers and conventional sample containers. The carrying seat 31 is used for carrying an emergency sample container and/or a conventional sample container, so as to achieve both emergency sample mixing and conventional sample mixing. The conventional sample container contains a conventional sample therein. The emergency sample container contains an emergency sample. Illustratively, the carrying seat 31 is used for carrying an emergency sample container when testing the emergency sample, so that the peripheral blood mixing mechanism can mix the emergency sample in the emergency sample container; the carrying seat 31 is used for carrying a conventional sample container when testing the conventional sample, so that the peripheral blood mixing mechanism can mix the conventional sample in the conventional sample container. Under certain application scenarios, the bearing seat 31 can bear the emergency sample container and the conventional sample container at the same time, so that the peripheral blood mixing mechanism can mix the emergency sample in the emergency sample container and the conventional sample in the conventional sample container at the same time, and the testing efficiency is improved.

In some embodiments, the blending driving assembly 32 is configured to drive the carrier 31 to reciprocate for 300 times/min-800 times/min, for example, 300 times/min, 600 times/min, 800 times/min, and any other suitable value between 300 times/min-800 times/min, so as to achieve better blending effect and realizability. It can be appreciated that if the frequency of the reciprocating movement of the carrier 31 is too small, the sample mixing effect is not ideal; if the reciprocating frequency of the carrier 31 is too high, the mixing driving assembly 32 needs to work at a relatively high working frequency, which results in a difficult design and difficult implementation.

Illustratively, the blending driving assembly 32 is configured to drive the carrier 31 to reciprocate 500 times/min-800 times/min. For example, the mixing driving assembly 32 is configured to drive the carrier 31 to reciprocate for 800 times/min.

In some embodiments, blending drive assembly 32 includes blending drive 321 and blending transmission 322. The mixing transmission member 322 is connected to the mixing driving member 321. The mixing driving member 322 is connected with the bearing seat 31, and the mixing driving member 321 can drive the mixing driving member 322 to perform rotary motion to drive the bearing seat 31 to move transversely. By designing the mixing transmission member 322, the rotational movement of the mixing driving assembly 32 can be converted into the lateral movement of the carrier 31.

In some embodiments, blending driver 321 includes a blending motor or cylinder, or the like. The mixing motor may include a stepper motor, a DC motor, a servo motor, or the like. Illustratively, the blending motor is a stepper motor.

It will be appreciated that the mixing driver 321 may be communicatively coupled to a control element (not shown) of the sample analyzer for controlling the activation, deactivation, rotational speed, etc. of the mixing driver 321.

Illustratively, the blending driver 321 includes a blending motor that drives the blending driver 322 to rotate clockwise and/or counterclockwise, thereby driving the carrier 31 to move laterally.

Referring to fig. 2 (B), in some embodiments, the blending driver 322 includes a cam. The cam is fixedly connected with the mixing driving member 321. The cam is in driving connection with the bearing seat 31. When the mixing driving member 321 drives the cam to perform a rotation motion, the bearing seat 31 moves reciprocally and laterally along with the shape change of the outer periphery of the cam. The mixing driving assembly 32 with the structure is compact and simple in structure and high in stability.

Referring to fig. 2 (B), in some embodiments, a bearing 323 is disposed on the carrier 31. The bearing 323 is in driving connection with the cam to reduce friction between the carrier 31 and the cam, so that the carrier 31 moves laterally more smoothly and efficiently.

Referring to fig. 2 (C), in some embodiments, the mixing drive 322 includes a crank 3221 and a crank connecting rod 3222. The crank 3221 is connected to the kneading driver 321. One end of the crank link 3222 is connected to the crank 3221, and the other end of the crank link 3222 is connected to the carrier 31. It is understood that the movement direction of the crank link 3222 is the same as the reciprocating traversing direction of the carrier 31. The crank 3221 rotates under the drive of the mixing driving member 321; the crank rod 3222 moves linearly, and thus realizes the reciprocating lateral movement of the bearing seat 31.

Referring to fig. 2 (a) and 2 (B), in some embodiments, the peripheral blood blending mechanism further includes a blending bracket 33. The mixing drive assembly 32 is provided on a mixing support 33. Illustratively, blending driver 321 is secured to blending bracket 33.

Referring to fig. 2 (a) and 2 (B), in some embodiments, blending drive assembly 32 further includes a blending reset element 324. One end of the mixing reset piece 324 is abutted with the mixing bracket 33, and the other end of the mixing reset piece 324 is abutted with the bearing seat 31 for resetting the bearing seat 31. The blending restoring piece 324 can restore the bearing seat 31 and enable the bearing seat 31 to abut against the blending transmission piece 322 so that the bearing seat 31 and the blending transmission piece 322 keep reliable transmission fit.

In some embodiments, the blending restoring member 324 includes an elastic member, one end of the elastic member abuts against the blending bracket 33, and the other end of the elastic member abuts against the bearing seat 31. Illustratively, the resilient member comprises a spring.

Referring to fig. 2 (a) and 2 (B), in some embodiments, the peripheral blood blending mechanism further includes a guide bar 34. The guide rod 34 is provided on the mixing bracket 33. The guide rod 34 is in sliding fit with the bearing seat 31. The guide rod 34 can guide the movement of the bearing seat 31, so that the bearing seat 31 can move transversely stably and reliably, and the structure is simple and easy to realize. Referring to fig. 2 (a), an exemplary embodiment of the present invention is shown in which the carrier 31 is provided with a mixing slider 311, and the mixing slider 311 is slidably engaged with the guide rod 34.

Referring to fig. 2 (C) and fig. 2 (D), in some embodiments, the mixing rack 33 is provided with a mixing rail 331 slidably engaged with the carrier 31, and the mixing driving assembly 32 is configured to drive the carrier 31 to slide along the mixing rail 331. So, the setting of mixing slide rail 331 can guarantee to bear the weight of seat 31 steady reliable lateral shifting, simple structure easily realizes.

Referring to fig. 2 (C), an exemplary embodiment of the present invention is shown in which the mixing slider 311 is disposed on the carrying base 31, and the mixing slider 311 is slidably engaged with the mixing rail 331.

Referring to fig. 2 (a) and 2 (C), it can be understood that the carrier 31 is provided with a receiving slot 312 for receiving the sample container S.

In some embodiments, the diameter of the receiving slot 312 is greater than the diameter of the sample container S. So, when bearing seat 31 reciprocal sideslip, sample container S follows and bears seat 31 reciprocal sideslip, and sample container S can collide repeatedly with the cell wall of holding tank 312 and form the action of beating repeatedly, simulate medical personnel and point to the mixing mode that bullet test tube, and the mixing effect is better with the mixing mode that the medical personnel pointed to the bullet test tube fairly, need not medical personnel manual operation simultaneously.

The diameter of the receiving groove 312 is too large as compared with the diameter of the sample container S, which may cause the sample container S to be easily detached from the receiving groove 312, and it is difficult to stably and reliably be carried in the receiving groove 312 to achieve uniform mixing. The diameter of the accommodating groove 312 is too close to the diameter of the sample container S, so that the sample container S and the groove wall of the accommodating groove 312 are difficult to form a reciprocating knocking action when the carrying seat 31 reciprocally moves, and thus the mixing effect is poor. Illustratively, the diameter of the receiving slot 312 is 0.5mm-3mm, such as any other suitable value of 0.5mm, 1mm, 2mm, 3mm, and 0.5mm-3mm, greater than the diameter of the sample container S.

In some embodiments, the receiving slot 312 is provided in a variable diameter configuration, one end of the receiving slot 312 is in a positive fit with the sample container S, and the other end of the receiving slot 312 has a diameter 0.5mm-3mm greater than the diameter of the sample container S. So, when carrying the reciprocal sideslip of seat 31, the one end of holding tank 312 can carry out spacingly to the corresponding position of sample container S, and sample container S 'S the other end follows and carries the reciprocal sideslip of seat 31, and sample container S' S the other end can collide repeatedly with the cell wall of holding tank 312 and form the action of beating repeatedly, simulate medical personnel and point to the mixing mode that bullet test tube, and the mixing effect is better with the mixing mode that medical personnel point to bullet test tube relatively, need not medical personnel manual operation simultaneously.

Illustratively, the upper end of the receiving slot 312 is in positive engagement with the sample container S, and the lower end of the receiving slot 312 has a diameter that is 0.5mm-3mm greater than the diameter of the sample container S. In the embodiment, a small amount of blood sample can be fully and uniformly mixed, and the uniform mixing effect is good.

Illustratively, the lower end of the receiving slot 312 is in positive engagement with the sample container S, and the upper end of the receiving slot 312 has a diameter that is 0.5mm-3mm greater than the diameter of the sample container S.

Referring to fig. 2 (E), in some embodiments, two receiving slots 312 are provided on the carrier 31. Each receiving slot 312 is for receiving one sample container S. In this way, the samples in the two sample containers S can be mixed uniformly at the same time, and the mixing efficiency can be improved.

In some embodiments, one of the two receiving slots 312 is used to relay the buffered sample container S. Because the path between the peripheral blood mixing mechanism and the subsequently operated mechanism (e.g., the second mixing mechanism 302 or the sampling mechanism 40) is smaller than the path between the sample introduction site and the subsequently operated mechanism, one of the two accommodating grooves 312 is used for transferring the buffer sample container S, so that the test efficiency of the sample analyzer can be improved.

In some embodiments, a shock absorbing member (not shown) is provided in the receiving groove 312 for being disposed between the groove wall of the receiving groove 312 and the sample container S, so as to reduce the sound generated by the receiving groove 312 striking the sample container S when the carriage 31 reciprocally moves.

Referring to fig. 2 (D), an embodiment of the present invention further provides a mixing mechanism 30 for mixing samples in the sample container S. The kneading mechanism 30 includes a receptacle 35, a carrier 31, a kneading drive unit 32 (see fig. 2 (a)), and a lock unit 36. The receptacle 35 is for carrying a sample container S. The carrier 31 is connected to the receptacle 35. The mixing driving assembly 32 is connected with the bearing seat 31. The mixing driving assembly 32 is used for driving the bearing seat 31 to move transversely. When the sample container S is of the peripheral blood container type, the locking assembly 36 is in a locked state, and the locking assembly 36 locks the receptacle 35 to restrict the receptacle 35 from swinging laterally relative to the carrier 31. When the sample container S is of the venous blood container type, the locking assembly 36 is in an unlocked state, and the locking assembly 36 unlocks the receptacle 35 so that the receptacle 35 can swing laterally with respect to the carrier 31.

In the mixing mechanism 30 in the above embodiment, the locking assembly 36 can be switched between the locked state and the unlocked state according to the type of the sample container S, so that the mixing mechanism 30 can perform the mixing operation on the sample in the sample container S in the mixing manner corresponding to the type of the sample container S, and the optimal mixing effect is achieved. Specifically, when the sample container S is a peripheral blood container, the locking assembly 36 locks the container holder 35 to limit the container holder 35 to swing laterally relative to the carrier holder 31, and during the sample mixing process, the container holder 35 is fixed relative to the carrier holder 31, and the mixing driving assembly 32 drives the carrier holder 31 to move laterally, so that the container holder 35 and the sample container S move laterally along with the carrier holder 31, thereby realizing the mixing operation of the sample. Therefore, the sample can be kept at the bottom of the sample container S as much as possible in the mixing process, and the mixing requirement of the sample can be well met, and especially the mixing requirement of trace peripheral blood can be well met; and the sample container S is reciprocally moved so as to realize the uniform mixing operation, so that the residual quantity of hanging liquid of the sample on the inner wall of the sample container S is reduced, and the effect of sample loss is reduced, and the method has obvious advantages for the sample container S with a small quantity of sample (such as a trace blood collection tube with peripheral blood).

When the sample container S is of the venous blood container type, the locking assembly 36 unlocks the receptacle 35 to enable the receptacle 35 to swing laterally relative to the carrier 31. In the sample mixing process, the mixing driving assembly 32 drives the bearing seat 31 to transversely move, the container seat 35 transversely moves along with the bearing seat 31, and the container seat 35 transversely swings relative to the bearing seat 31, so that the sample container S on the container seat 35 transversely swings while transversely moving, and the sample mixing operation is realized. This way of mixing has a distinct advantage for sample containers S with a larger sample volume, such as venous blood containers with venous blood.

Illustratively, the carrier 31 comprises the carrier 31 of any of the embodiments described above. The blending drive assembly 32 includes the blending drive assembly 32 of any of the embodiments described above.

In some embodiments, two limiting rods (not shown) are provided on the bearing seat 31 for limiting the swinging angle of the container seat 35 to not more than 180 degrees. Therefore, on the premise of realizing the mixing requirement, the residual quantity of hanging liquid of the sample on the inner wall of the sample container S can be reduced as much as possible, so that the effect of sample loss is reduced, and the problem that the liquid level climbs and the sample overflows the sample container S is solved as much as possible.

In some embodiments, the mixing mechanism 30 further comprises a container type detection device (not shown) for detecting the type of sample container S. The container type detecting means is provided on the carrier 31, and the types of the sample container S include a peripheral blood container and a venous blood container. Illustratively, the container type detecting means includes the container type detecting means of any one of the embodiments described above.

It will be appreciated that the peripheral blood vessel will typically have a sample in the middle and no sample in the bottom. The venous blood vessel is typically free of sample in the middle and sample in the bottom. The container type detecting device is used for detecting the middle or bottom of the sample container to determine the container type of the normal sample container.

In some embodiments, the container type detection device includes at least one of a capacitive sensor, an opto-coupler sensor, an inductive sensor, a pressure sensor, and the like.

Referring to fig. 2 (D), in some embodiments, the locking assembly 36 includes an electromagnet 361 and a blade 362 that mates with the electromagnet 361. One of the electromagnet 361 and the iron piece 362 is provided on the carrier 31, and the other is provided on the container holder 35. The position of the electromagnet 361 corresponds to the position of the iron piece 362. Illustratively, the electromagnet 361 is disposed on the carrier 31, and the iron piece 362 is disposed on the receptacle 35. When the electromagnet 361 is powered off, the locking assembly 36 is in an unlocked state, and the container holder 35 can be driven to swing transversely relative to the carrier holder 31 by a swing driving member (such as a swing motor). When the electromagnet 361 is powered on, the locking assembly 36 is in a locked state, and the container holder 35 cannot swing laterally relative to the carrier holder 31.

In other embodiments, the locking assembly 36 may also include locking protrusions (not shown) and locking grooves (not shown). One of the locking protrusion and the locking groove is provided on the receptacle 35, and the other is provided on the carrier 31. The locking protrusion is driven to move by a locking motor (not shown) to be inserted into the locking groove in a locked state, and is moved out of the locking groove in an unlocked state.

In the description of the present invention, it should be noted that the terms "mounted," "connected," and "coupled" are to be construed broadly, as well as, for example, fixedly coupled, detachably coupled, or integrally coupled, unless otherwise specifically indicated and defined. Either mechanically or electrically. Can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.

In the present invention, unless expressly stated or limited otherwise, a first feature "above" or "below" a second feature may include both the first and second features being in direct contact, as well as the first and second features not being in direct contact but being in contact with each other through additional features therebetween. Moreover, a first feature being "above," "over" and "on" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicating that the first feature is higher in level than the second feature. The first feature being "under", "below" and "beneath" the second feature includes the first feature being directly under and obliquely below the second feature, or simply means that the first feature is less level than the second feature.

The above disclosure provides many different embodiments, or examples, for implementing different structures of the invention. The foregoing description of specific example components and arrangements has been presented to simplify the present disclosure. They are, of course, merely examples and are not intended to limit the invention. Furthermore, the present invention may repeat reference numerals and/or letters in the various examples, which are for the purpose of brevity and clarity, and which do not themselves indicate the relationship between the various embodiments and/or arrangements discussed. In addition, the present invention provides examples of various specific processes and materials, but one of ordinary skill in the art will recognize the application of other processes and/or the use of other materials.

In the description of the present specification, reference to the terms "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples," etc., means that a particular method step, feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular method steps, features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

While the invention has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the invention. Therefore, the protection scope of the invention is subject to the protection scope of the claims.

Claims (27)

1. A peripheral blood blending mechanism for blending peripheral blood in a sample container, the peripheral blood blending mechanism comprising:

a carrying seat for carrying the sample container;

the mixing driving assembly is connected with the bearing seat and is used for driving the bearing seat to transversely move so as to drive the sample container to transversely move to uniformly mix the peripheral blood sample in the sample container.

2. The peripheral blood mixing mechanism of claim 1, wherein the mixing drive assembly is configured to drive the carrier to reciprocate laterally.

3. The peripheral blood mixing mechanism of claim 1, wherein the mixing drive assembly is configured to drive the carrier to reciprocate in a curved or linear manner.

4. A peripheral blood mixing mechanism as claimed in claim 3 wherein the mixing drive assembly is adapted to drive the carrier to reciprocate in an arcuate motion.

5. The peripheral blood mixing mechanism of claim 1, wherein the carrier is configured to carry emergency sample containers and/or conventional sample containers.

6. The peripheral blood mixing mechanism of claim 1, wherein the mixing drive assembly is configured to drive the carrier to traverse 300-800 times/min.

7. The peripheral blood mixing mechanism of claim 6, wherein the mixing drive assembly is configured to drive the carrier to traverse the carrier for 800 times/min.

8. The peripheral blood blending mechanism of claim 1, wherein the blending drive assembly comprises:

uniformly mixing the driving piece;

the mixing driving piece is connected with the mixing driving piece and the bearing seat, and the mixing driving piece can drive the mixing driving piece to do rotary motion so as to drive the bearing seat to transversely move.

9. The peripheral blood blending mechanism of claim 8, wherein the blending driver comprises:

and the cam is fixedly connected with the mixing driving piece and is in transmission connection with the bearing seat.

10. The peripheral blood mixing mechanism of claim 9, wherein the bearing is provided with a bearing, and wherein the bearing is in driving connection with the cam.

11. The peripheral blood blending mechanism of claim 8, wherein the blending driver comprises:

the crank is connected with the uniform mixing driving piece;

and one end of the crank connecting rod is connected with the crank, and the other end of the crank connecting rod is connected with the bearing seat.

12. The peripheral blood blending mechanism of claim 1, further comprising a blending bracket, wherein the blending drive assembly is disposed on the blending bracket; the mixing driving assembly further comprises:

and one end of the mixing reset piece is abutted with the mixing support, and the other end of the mixing reset piece is abutted with the bearing seat and used for resetting the bearing seat.

13. The peripheral blood mixing mechanism of claim 12, wherein the mixing reset member comprises an elastic member, one end of the elastic member abuts against the mixing bracket, and the other end of the elastic member abuts against the bearing seat.

14. The peripheral blood blending mechanism of claim 12, further comprising:

the guide rod is arranged on the mixing bracket and is in sliding fit with the bearing seat.

15. The peripheral blood mixing mechanism of claim 12, wherein the mixing bracket is provided with a mixing slide rail slidably engaged with the bearing seat, and the mixing drive assembly is configured to drive the bearing seat to slide along the mixing slide rail.

16. The peripheral blood mixing mechanism of any one of claims 1-15, wherein the carrier is provided with a receiving slot for receiving the sample container, the receiving slot having a diameter greater than the diameter of the sample container.

17. The peripheral blood blending mechanism of claim 16, wherein the diameter of the receiving groove is 0.5mm-3mm greater than the diameter of the sample container.

18. The peripheral blood mixing mechanism according to any one of claims 1 to 15, wherein the carrying seat is provided with a containing groove for containing the sample container, the containing groove is arranged in a variable diameter mode, one end of the containing groove is in limit fit with the sample container, and the diameter of the other end of the containing groove is 0.5mm to 3mm larger than the diameter of the sample container.

19. The peripheral blood mixing mechanism of any one of claims 1-15, wherein the carrier is provided with two receiving slots, each for receiving one of the sample containers.

20. The peripheral blood blending mechanism of claim 19, wherein one of the two receiving slots is configured to intermediately cache the sample container.

21. The peripheral blood mixing mechanism of any one of claims 1-15, wherein the carrier is provided with a receiving slot for receiving the sample container, and a shock absorbing member is disposed in the receiving slot and is disposed between a wall of the receiving slot and the sample container.

22. A mixing mechanism for mixing samples in a sample container, the mixing mechanism comprising:

a receptacle for carrying the sample container;

the bearing seat is connected with the container seat;

the mixing driving assembly is connected with the bearing seat and is used for driving the bearing seat to transversely move;

a locking assembly, when the sample container is of the peripheral blood container type, the locking assembly being in a locked state, the locking assembly locking the receptacle to limit lateral oscillation of the receptacle relative to the carrier; when the sample container is of the venous blood container type, the locking assembly is in an unlocked state, and the locking assembly unlocks the container mount to enable the container mount to swing laterally relative to the carrier mount.

23. The blending mechanism of claim 22, wherein the carrier is provided with two stop bars for limiting the angle of oscillation of the receptacle to no more than 180 degrees.

24. The blending mechanism of claim 22, wherein the blending mechanism further comprises:

and the container type detection device is arranged on the bearing seat and is used for detecting the type of the sample container, wherein the type of the sample container comprises a peripheral blood container and a venous blood container.

25. The blending mechanism of claim 24, wherein the container type detection device comprises at least one of a capacitive sensor, an opto-coupler sensor, an inductive sensor, and a pressure sensor.

26. The blending mechanism of claim 22, wherein the locking assembly comprises: the device comprises an electromagnet and an iron sheet matched with the electromagnet, wherein one of the electromagnet and the iron sheet is arranged on the bearing seat, the other one of the electromagnet and the iron sheet is arranged on the container seat, and the position of the electromagnet corresponds to the position of the iron sheet.

27. A sample analyzer, comprising:

the peripheral blood blending mechanism of any one of claims 1-21 or the blending mechanism of any one of claims 22-26;

the sampling mechanism is used for collecting the uniformly mixed sample in the sample container; and

and the sampling mechanism is used for injecting the acquired sample into the reaction measuring mechanism.