CN115475112A - A facial mask containing low molecular sodium hyaluronate and silk fibroin and its preparation method - Google Patents
A facial mask containing low molecular sodium hyaluronate and silk fibroin and its preparation method Download PDFInfo
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- CN115475112A CN115475112A CN202211162064.2A CN202211162064A CN115475112A CN 115475112 A CN115475112 A CN 115475112A CN 202211162064 A CN202211162064 A CN 202211162064A CN 115475112 A CN115475112 A CN 115475112A
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- China
- Prior art keywords
- percent
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- sodium hyaluronate
- silk fibroin
- low molecular
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Links
- 108010022355 Fibroins Proteins 0.000 title claims abstract description 46
- 229920002385 Sodium hyaluronate Polymers 0.000 title claims abstract description 46
- 229940010747 sodium hyaluronate Drugs 0.000 title claims abstract description 46
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 title claims abstract description 46
- 230000001815 facial effect Effects 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 230000003796 beauty Effects 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000012907 honey Nutrition 0.000 claims abstract description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
- 238000003756 stirring Methods 0.000 claims description 24
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 22
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 20
- 239000002994 raw material Substances 0.000 claims description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- 238000001816 cooling Methods 0.000 claims description 12
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 11
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 10
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 10
- 229920002498 Beta-glucan Polymers 0.000 claims description 10
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 10
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 10
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 10
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 10
- 229920002125 Sokalan® Polymers 0.000 claims description 10
- 229960000458 allantoin Drugs 0.000 claims description 10
- 229960003237 betaine Drugs 0.000 claims description 10
- 229960001631 carbomer Drugs 0.000 claims description 10
- 239000008367 deionised water Substances 0.000 claims description 10
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 10
- 239000003755 preservative agent Substances 0.000 claims description 10
- 230000002335 preservative effect Effects 0.000 claims description 10
- 229920001285 xanthan gum Polymers 0.000 claims description 10
- 239000000230 xanthan gum Substances 0.000 claims description 10
- 229940082509 xanthan gum Drugs 0.000 claims description 10
- 235000010493 xanthan gum Nutrition 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 239000003513 alkali Substances 0.000 claims description 7
- 239000002537 cosmetic Substances 0.000 claims description 7
- 239000011703 D-panthenol Substances 0.000 claims description 6
- 235000004866 D-panthenol Nutrition 0.000 claims description 6
- 150000001735 carboxylic acids Chemical class 0.000 claims description 6
- 229960003949 dexpanthenol Drugs 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 2
- -1 pyrollidone carboxylic acid Chemical class 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 8
- 230000003020 moisturizing effect Effects 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 230000006750 UV protection Effects 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 230000002087 whitening effect Effects 0.000 abstract description 3
- 210000004207 dermis Anatomy 0.000 abstract description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 2
- 239000011707 mineral Substances 0.000 abstract description 2
- 229920001542 oligosaccharide Polymers 0.000 abstract description 2
- 150000002482 oligosaccharides Chemical class 0.000 abstract description 2
- 150000007524 organic acids Chemical class 0.000 abstract description 2
- 239000012466 permeate Substances 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000000049 pigment Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229920005615 natural polymer Polymers 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- GGLZPLKKBSSKCX-YFKPBYRVSA-N L-ethionine Chemical compound CCSCC[C@H](N)C(O)=O GGLZPLKKBSSKCX-YFKPBYRVSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a beauty mask containing low molecular sodium hyaluronate and silk fibroin and a preparation method thereof, the beauty mask is divided into four components A, B, C and D, the mask can permeate into a dermis layer, increase the absorption of nutrient substances, inhibit the formation of free radicals and keep the skin smooth by compounding the low molecular sodium hyaluronate with different proportions; the natural silk fibroin has good comfort, good water absorption and water resistance, good glossiness and good ultraviolet resistance effect, can promote the synthesis of collagen, enhance the tension and elasticity of skin, promote the decomposition of pigment and homogenize the skin color; the honey extract mainly plays a long-acting moisturizing role in the horny layer of the skin, is rich in oligosaccharide, organic acid and various mineral substances, can rapidly soften the dry and hardened horny layer, recovers softness and elasticity, has a good beautifying effect, and has the function of superposing various effective components, so that the mask has the functions of diminishing inflammation, inhibiting bacteria, resisting oxidation and replenishing water. Multiple effects of whitening skin, etc.
Description
Technical Field
The invention relates to the field of cosmetics, and in particular relates to a beauty mask containing low-molecular sodium hyaluronate and silk fibroin and a preparation method thereof.
Background
The facial mask can be used as a carrier of a beauty product, can be divided into various types according to different forms, and has the functions of moisturizing, whitening, resisting aging, balancing grease and the like when being applied to the face. And has the advantages of quick effect, high cost performance and the like when being applied to the face, and the cosmetic becomes a more and more sought-after cosmetic in recent years. The principle is that the skin is wrapped by the mask for a short time to temporarily isolate external air and pollution, so that the stratum corneum of the skin is supplemented with moisture, humectant, nutritional agents and the like contained in the mask. Generally, moisturizers such as polyhydric alcohols including glycerin, propylene glycol, sorbitol, 1, 3-butylene glycol, and the like are added to cosmetics, and a natural moisturizing factor sodium hyaluronate having a unique water-retaining and lubricating function is also added to high-grade cosmetics. However, the commonly used sodium hyaluronate is sodium hyaluronate with relatively high molecular weight, and the molecular weight of the commonly used sodium hyaluronate is more than 100-300 ten thousand Da. Although a layer of breathable film is formed on the surface layer of the skin, the breathable film helps to lock moisture and prevent moisture from evaporating and preserving moisture for a long time. But have poor penetration and are not absorbed by the skin. The effect of lasting moisture retention desired by consumers is difficult to achieve by adding common sodium hyaluronate. And the low-molecular sodium hyaluronate within 100 ten thousand Da can easily permeate into the dermis layer of the skin, can nourish cells, lock water for a long time and delay the evaporation of water on the surface of the skin.
The silk fibroin is natural polymer fibrin extracted from silk, the content of the natural polymer fibrin accounts for about 70-80% of the silk, the silk fibroin contains 18 amino acids, and glycine (Gly), alanine (Ala) and serine (Ser) account for more than 80% of the total composition and are most similar to the protein contained in a human body. The silk fibroin used as the raw material of the skin care product has the unique characteristics that: such as good comfort, good water absorption, good water resistance, good glossiness and good ultraviolet resistance. The silk fibroin is slowly degraded, and is very beneficial to cell repair. And the degradation of the silk fibroin has controllability, so that the loss of materials is reduced while the cell growth space is ensured. The silk fibroin can also be partially degraded, and the degradation product can obviously promote the healing of skin tissues, so that the silk fibroin is commonly used in the fields of medical science, beauty and biological tissue repair.
Disclosure of Invention
The invention aims to provide a beauty mask containing low-molecular sodium hyaluronate and silk fibroin.
Yet another object of the present invention is to: provides a preparation method of a beauty mask containing low molecular sodium hyaluronate and silk fibroin.
The purpose of the invention is realized by the following scheme: a beauty mask containing low molecular sodium hyaluronate and silk fibroin is characterized by being prepared from the following four components A, B, C and D, wherein the components are as follows by weight percent:
component A
(1) Deionized water: 50% -80%;
(2) Glycerol: 1% -10%;
(3) Allantoin: 0.01% -1%;
(4) D-panthenol: 0.05% -2%;
(5) Betaine: 0.1% -5%;
(6) Beta-glucan: 0.05% -2%;
(7) Dipotassium glycyrrhizinate: 0.005% -0.5%;
(8) Carbomer: 0.005% -2%;
(9) Low molecular sodium hyaluronate: 0.001% -2%;
(10) Pyrollidinone carboxylic acids: 0.001% -2%;
and the component B comprises:
(11) Xanthan gum: 1% -20%;
(12) And (3) honey extract: 1% -20%;
(13) Silk fibroin: 0.01% -1%;
and C, component C:
(14) Alkali liquor: 0.05 to 15 percent;
and (D) component:
(15) 1, 3-butanediol: 1% -10%;
(16) Essence: 0.00% -0.50%;
(17) Preservative: 0.00% -0.50%.
The invention provides a beauty mask containing low-molecular sodium hyaluronate and silk fibroin, which is prepared from the following four components A, B, C and D, wherein the component contents are as follows by weight percent:
component A
(1) Deionized water: 60% -75%;
(2) Glycerol: 2% -8%;
(3) Allantoin: 0.05% -0.5%;
(4) D-panthenol: 0.1% -1%;
(5) Betaine: 0.5% -2%;
(6) Beta-glucan: 0.1% -1%;
(7) Dipotassium glycyrrhizinate: 0.01 to 0.1 percent
(8) Carbomer: 0.01% -1%
(9) Low molecular sodium hyaluronate: 0.01 to 1 percent
(10) Pyrollidinone carboxylic acid: 0.01 to 1 percent
And the component B comprises:
(11) Xanthan gum: 5% -15%;
(12) And (3) honey extract: 5% -15%;
(13) Silk fibroin: 0.5 to 5 percent
And C, component C:
(14) Alkali liquor: 0.1% -10%;
and (D) component:
(15) 1, 3-butanediol: 2% -8%;
(16) Essence: 0.00% -0.3%;
(17) Preservative: 0.00% -0.3%.
The invention provides a beauty mask containing low-molecular sodium hyaluronate and silk fibroin, which is characterized by being prepared from the following four components A, B, C and D in percentage by weight:
component A
(1) Deionized water: 63.5 percent;
(2) Glycerol: 5 percent;
(3) Allantoin: 0.1 percent;
(4) D-panthenol: 0.6 percent;
(5) Betaine: 1 percent;
(6) Beta-glucan: 0.5 percent;
(7) Dipotassium glycyrrhizinate: 0.1 percent of
(8) Carbomer: 0.5 percent
(9) Low molecular sodium hyaluronate: 0.5 percent
(10) Pyrollidinone carboxylic acids: 0.5 percent
And B component:
(11) Xanthan gum: 10 percent;
(12) And (3) honey extract: 10 percent;
(13) Silk fibroin: 0.5 percent
And (C) component:
(14) Alkali liquor: 2 percent
And (D) component:
(15) 1, 3-butanediol: 5 percent
(16) Essence: 0.1 percent of
(17) Preservative: 0.1 percent.
The low molecular sodium hyaluronate is sodium hyaluronate with molecular weight below 100 ten thousand Da.
The alkali solution is one of 4.5% KOH solution or 5% NaOH solution.
The silk fibroin is one or a mixture of silk powder 144, silk powder 400, silk peptide 500, silk peptide 1000 and silk amino acid 90.
The invention provides a preparation method of a beauty mask containing low-molecular sodium hyaluronate and silk fibroin, which comprises the following steps:
(1) Respectively adding the raw materials in the component A into a reaction kettle, introducing sterile nitrogen, mixing and stirring at 50 r/min-80 r/min, slowly heating to 70 ℃, controlling heating, continuously stirring until the raw materials are completely dissolved, and cooling to 50 ℃ for later use;
(2) Adding the raw material of the component B in the step (1), introducing sterile nitrogen, continuously stirring uniformly, and cooling to below 45 ℃ for later use;
(3) Adding the raw material of the component C in the step (2), and uniformly stirring;
(4) And (4) uniformly stirring the material of the component D, adding the material into the reaction kettle obtained in the step (3), stirring for 5min, cooling to 30 ℃, detecting to be qualified, and discharging.
Has the advantages that:
1. the low molecular sodium hyaluronate with the permeability of less than 100 ten thousand Da is added, and the low molecular sodium hyaluronate with the good permeability is deeply penetrated into a corium layer, so that the low molecular sodium hyaluronate can slightly expand capillary vessels, increase blood circulation, enhance nutrient absorption, inhibit the formation of free radicals, reduce the evaporation of skin moisture and keep the skin smooth.
2. The added silk fibroin, also called fibroin, is a structural protein extracted from natural high molecular material silk. The main components of the skin-care cream comprise various amino acids such as the ethionine, the alanine, the serine, the proline, the tyrosine and the like, and the skin-care cream has obvious efficacy, is safe and has no side effect, and also has strong advantages and development space in the fields of beauty treatment and skin care. The silk fibroin used as the raw material of the skin care product has the unique characteristics that: good comfort, good water absorption and water resistance, good glossiness and good ultraviolet resistance. The composite gel of silk fibroin and sodium hyaluronate can promote the gelation of hyaluronic acid macromolecules, slow down the degradation rate of hyaluronic acid macromolecules, optimize the filling effect and prolong the effective time. Compared with the traditional gel with hyaluronic acid simply crosslinked, the silk fibroin particles effectively slow down the degradation speed of the composite gel, prolong the action time of the composite gel in tissue repair and filling, and improve the effectiveness of the material.
3. The added honey extract mainly plays a long-acting moisturizing role in the skin cuticle, is rich in oligosaccharide, organic acid and various mineral substances, can rapidly soften the dry and hardened cuticle and recover softness and elasticity, and has a good beautifying effect.
Detailed Description
The present invention is described in detail by the following specific examples, but the scope of the present invention is not limited to these examples.
The first embodiment is as follows:
a beauty mask containing low molecular sodium hyaluronate and silk fibroin is prepared by the following four groups of components A, B, C and D, and is prepared by the following steps:
the component A comprises: deionized water: 63.5 percent; glycerin: 5 percent; allantoin: 0.1 percent; d-panthenol: 0.6 percent;
betaine: 1 percent; beta-glucan: 0.5 percent; dipotassium glycyrrhizinate: 0.1 percent; carbomer: 0.5 percent; low molecular sodium hyaluronate: 0.5 percent; pyrollidinone carboxylic acid: 0.5 percent;
and the component B comprises: xanthan gum: 10 percent; and (3) honey extract: 10 percent; silk fibroin: 0.5 percent;
and C, component C: 4.5% KOH solution: 2 percent;
and (D) component: 1, 3-butanediol: 5 percent; essence: 0.1 percent; preservative: 0.1 percent;
the preparation method of the facial mask comprises the following steps:
(1) Respectively adding the raw materials in the component A into a reaction kettle, introducing sterile nitrogen, mixing and stirring at 50r/min, slowly heating to 70 ℃, controlling heating, continuously stirring until the raw materials are completely dissolved, and cooling to 50 ℃ for later use;
(2) Adding the raw material of the component B in the step (1), introducing sterile nitrogen, continuously stirring uniformly, and cooling to below 45 ℃ for later use;
(3) Adding the raw material of the component C in the step (2), and uniformly stirring;
(4) And (4) uniformly stirring the material of the component D, adding the material into the reaction kettle obtained in the step (3), stirring for 5min, cooling to 30 ℃, and discharging after the detection is qualified.
Example two:
a beauty mask containing low molecular sodium hyaluronate and silk fibroin is prepared by four groups of components A, B, C and D, wherein the component contents are as follows by weight percent:
the component A comprises: deionized water: 66.48 percent; glycerol: 5 percent; allantoin: 0.05 percent; d-panthenol: 0.1 percent;
betaine: 0.5 percent; beta-glucan: 0.05 percent; dipotassium glycyrrhizinate: 0.01 percent; carbomer: 1 percent; low molecular sodium hyaluronate: 0.5 percent; pyrollidinone carboxylic acids: 0.01 percent;
and B component: xanthan gum: 7 percent; and (3) honey extract: 2.5 percent; silk fibroin: 1.5 percent;
and (C) component: 5% NaOH solution: 7 percent;
and (D) component: 1, 3-butanediol: 8 percent; essence: 0.2 percent; preservative: 0.1 percent;
the preparation method of the facial mask comprises the following steps:
(1) Respectively adding the raw materials in the component A into a reaction kettle, introducing sterile nitrogen, mixing and stirring at the speed of 80r/min, slowly heating to 70 ℃, controlling heating, continuously stirring until the raw materials are completely dissolved, and cooling to 50 ℃ for later use;
(2) Adding the raw material of the component B in the step (1), introducing sterile nitrogen, continuously stirring uniformly, and cooling to below 45 ℃ for later use;
(3) Adding the raw material of the component C in the step (2), and uniformly stirring;
(4) And (4) uniformly stirring the material of the component D, adding the material into the reaction kettle obtained in the step (3), stirring for 5min, cooling to 30 ℃, and discharging after the detection is qualified.
Example three:
a beauty mask containing low molecular sodium hyaluronate and silk fibroin is prepared by four groups of components A, B, C and D, wherein the contents of the components are as follows by weight percent:
and (2) component A: deionized water: 79.26 percent; glycerol: 3 percent; allantoin: 0.01 percent; d-panthenol: 0.1 percent;
betaine: 0.1 percent; beta-glucan: 0.05 percent; dipotassium glycyrrhizinate: 0.01 percent; carbomer: 0.2 percent; low molecular sodium hyaluronate: 2 percent; pyrollidinone carboxylic acids: 0.01 percent;
and the component B comprises: xanthan gum: 3 percent; and (3) honey extract: 2 percent; silk fibroin: 0.2 percent;
and C, component C: 5% NaOH solution: 5 percent;
and (D) component: 1, 3-butanediol: 5 percent; essence: 0.05 percent; preservative: 0, 01%;
the preparation method of the mask is the same as the first embodiment.
Example four:
a beauty mask containing low molecular sodium hyaluronate and silk fibroin is prepared by four groups of components A, B, C and D, wherein the component contents are as follows by weight percent:
the component A comprises: deionized water: 55.89 percent; glycerol: 5 percent; allantoin: 0.5 percent; d-panthenol: 2 percent;
betaine: 2 percent; beta-glucan: 0.5 percent; dipotassium glycyrrhizinate: 0.1 percent; carbomer: 0.8 percent; low molecular sodium hyaluronate: 0.1 percent; pyrollidinone carboxylic acid: 1 percent;
and B component: xanthan gum: 5 percent; and (3) honey extract: 10 percent; silk fibroin: 5 percent;
and C, component C: 4.5% KOH solution: 10 percent;
and (D) component: 1, 3-butanediol: 2 percent; essence: 0.1 percent; preservative: 0.01 percent;
the preparation method of the mask is the same as the second embodiment.
Example five:
and (3) testing the using effect: randomly selecting 30 healthy adults (average age of 35 years) as objects, wiping the products prepared in the first embodiment and the third embodiment on the face for 30min each time and 14 days continuously, and having good moisturizing and whitening effects, wherein the feedback of the testers is shown in tables 1 and 2:
Claims (7)
1. a beauty mask containing low molecular sodium hyaluronate and silk fibroin is characterized by being prepared from the following four components A, B, C and D, wherein the components are as follows by weight percent:
the component A comprises: 50% to 80% deionized water, 1% to 10% glycerin, 0.01% to 1% allantoin, 0.05% to 2% of D-panthenol, 0.1% to 5% betaine, 0.05% to 2% beta-glucan, 0.005% to 0.5% dipotassium glycyrrhizinate: 0.005% -2% of carbomer, 0.001% -2% of low molecular weight sodium hyaluronate and 0.001% -2% of pyrollidone carboxylic acid;
the component B comprises: 1% -20% of xanthan gum, 1% -20% of honey extract and 0.01% -1% of silk fibroin;
a component C comprising: alkali liquor: 0.05 to 15 percent;
a component D comprising: 1 to 10 percent of 1, 3-butanediol, 0.00 to 0.50 percent of essence and 0.00 to 0.50 percent of preservative.
2. The beauty mask containing the low-molecular-weight sodium hyaluronate and the silk fibroin according to claim 1 is characterized by being prepared from the following four components A, B, C and D, wherein the components are as follows in percentage by weight:
component A
(1) Deionized water: 60% -75%;
(2) Glycerol: 2% -8%;
(3) Allantoin: 0.05% -0.5%;
(4) D-panthenol: 0.1% -1%;
(5) Betaine: 0.5% -2%;
(6) Beta-glucan: 0.1% -1%;
(7) Dipotassium glycyrrhizinate: 0.01 to 0.1 percent
(8) Carbomer: 0.01 to 1 percent
(9) Low molecular sodium hyaluronate: 0.01 to 1 percent
(10) Pyrollidinone carboxylic acids: 0.01 to 1 percent
And B component:
(11) Xanthan gum: 5% -15%;
(12) And (3) honey extract: 5% -15%;
(13) Silk fibroin: 0.5% -5%;
and C, component C:
(14) Alkali liquor: 0.1% -10%;
and (D) component:
(15) 1, 3-butanediol: 2% -8%;
(16) Essence: 0.00% -0.3%;
(17) Preservative: 0.00% -0.3%.
3. The beauty mask containing the low-molecular sodium hyaluronate and the silk fibroin as claimed in claim 1 is characterized by being prepared from the following four components A, B, C and D, wherein the component contents are as follows by weight percent:
component A
(1) Deionized water: 63.5 percent;
(2) Glycerol: 5 percent;
(3) Allantoin: 0.1 percent;
(4) D-panthenol: 0.6 percent;
(5) Betaine: 1 percent;
(6) Beta-glucan: 0.5 percent;
(7) Dipotassium glycyrrhizinate: 0.1 percent of
(8) Carbomer: 0.5 percent
(9) Low molecular sodium hyaluronate: 0.5 percent
(10) Pyrollidinone carboxylic acids: 0.5 percent
And the component B comprises:
(11) Xanthan gum: 10 percent;
(12) And (3) honey extract: 10 percent;
(13) Silk fibroin: 0.5 percent
And C, component C:
(14) Alkali liquor: 2 percent of
And (D) component:
(15) 1, 3-butanediol: 5 percent of
(16) Essence: 0.1 percent of
(17) Preservative: 0.1 percent.
4. A cosmetic mask as claimed in any one of claims 1 to 3 comprising low molecular weight sodium hyaluronate and silk fibroin, wherein the low molecular weight sodium hyaluronate is sodium hyaluronate with a molecular weight of less than 100 kiloda.
5. A cosmetic mask as claimed in any one of claims 1-3 containing low molecular sodium hyaluronate and silk fibroin, wherein said lye is one of 4.5% koh solution or 5% naoh solution.
6. The facial mask according to any one of claims 1 to 3, comprising low molecular sodium hyaluronate and silk fibroin, wherein the silk fibroin is one or more selected from silk powder 144, silk powder 400, silk peptide 500, silk peptide 1000 and silk amino acid 90.
7. A method for preparing a facial mask containing low molecular sodium hyaluronate and silk fibroin according to any one of claims 1-6. The method is characterized by comprising the following steps:
(1) Respectively adding the raw materials in the component A into a reaction kettle, introducing sterile nitrogen at the speed of 50-80 r/min, mixing and stirring, slowly heating to 70 ℃, controlling heating, continuously stirring until the raw materials are completely dissolved, and cooling to 50 ℃ for later use;
(2) Adding the raw material of the component B in the step (1), introducing sterile nitrogen, continuously stirring uniformly, and cooling to below 45 ℃ for later use;
(3) Adding the raw material of the component C in the step (2), and uniformly stirring;
(4) And (4) uniformly stirring the material of the component D, adding the material into the reaction kettle obtained in the step (3), stirring for 5min, cooling to 30 ℃, and discharging after the detection is qualified.
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Citations (3)
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|---|---|---|---|---|
| CN104784094A (en) * | 2015-04-03 | 2015-07-22 | 姚晓谊 | Silk whitening mask |
| CN106511227A (en) * | 2016-11-25 | 2017-03-22 | 江苏爱西施科技服务咨询股份有限公司 | Skincare facial mask containing silk peptide and preparation method of skincare facial mask |
| CN107714559A (en) * | 2017-11-27 | 2018-02-23 | 曾万祥 | One kind is without anti-corrosion deep water supplement skin care item |
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2022
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104784094A (en) * | 2015-04-03 | 2015-07-22 | 姚晓谊 | Silk whitening mask |
| CN106511227A (en) * | 2016-11-25 | 2017-03-22 | 江苏爱西施科技服务咨询股份有限公司 | Skincare facial mask containing silk peptide and preparation method of skincare facial mask |
| CN107714559A (en) * | 2017-11-27 | 2018-02-23 | 曾万祥 | One kind is without anti-corrosion deep water supplement skin care item |
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