CN115137920B - Vaccine atomizer, assembling method thereof and mask - Google Patents
Vaccine atomizer, assembling method thereof and mask Download PDFInfo
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- CN115137920B CN115137920B CN202210126165.8A CN202210126165A CN115137920B CN 115137920 B CN115137920 B CN 115137920B CN 202210126165 A CN202210126165 A CN 202210126165A CN 115137920 B CN115137920 B CN 115137920B
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- 229960005486 vaccine Drugs 0.000 title claims abstract description 219
- 238000000034 method Methods 0.000 title claims abstract description 21
- 239000000919 ceramic Substances 0.000 claims abstract description 51
- 238000002255 vaccination Methods 0.000 claims abstract description 18
- 238000005553 drilling Methods 0.000 claims abstract description 15
- 239000011148 porous material Substances 0.000 claims description 40
- 238000007789 sealing Methods 0.000 claims description 39
- 239000003292 glue Substances 0.000 claims description 10
- 239000006199 nebulizer Substances 0.000 claims description 7
- 238000003860 storage Methods 0.000 claims description 7
- 238000000889 atomisation Methods 0.000 claims description 5
- 239000010935 stainless steel Substances 0.000 claims description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 229920000742 Cotton Polymers 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000013618 particulate matter Substances 0.000 claims description 2
- 239000002861 polymer material Substances 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims 2
- 239000004745 nonwoven fabric Substances 0.000 claims 1
- 238000005538 encapsulation Methods 0.000 abstract description 6
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 description 7
- 230000007969 cellular immunity Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 230000004727 humoral immunity Effects 0.000 description 5
- 230000029058 respiratory gaseous exchange Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229910001252 Pd alloy Inorganic materials 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
- A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
- A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D27/00—Details of garments or of their making
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D2400/00—Functions or special features of garments
- A41D2400/32—Therapeutic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/088—Supports for equipment on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0606—Face
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Textile Engineering (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Special Spraying Apparatus (AREA)
Abstract
The invention provides a vaccine atomizer, an assembling method thereof and a mask, wherein the vaccine atomizer comprises an atomizer body provided with a containing cavity, and the containing cavity can contain vaccine; a piezoelectric ceramic layer disposed on the atomizer body and in contact with the vaccine; and the sieve mesh layer is arranged at the opening of the accommodating cavity and is contacted with the vaccine. The sieve mesh layer with the cooperation of atomizer body will the vaccine encapsulation is in hold the intracavity, just by laser drilling formation sieve mesh on the sieve mesh layer to realize that the vaccine that does not atomize is stored hold the intracavity, the vaccine after atomizing is followed in the sieve mesh is precipitated. With the above structure, a disposable vaccine atomizer can be obtained, thereby realizing large-scale vaccination at low cost.
Description
Technical Field
The application relates to the technical field of vaccine atomization inoculation, in particular to a vaccine atomizer, an assembly method thereof and a mask.
Background
In the new crown epidemic background, the vaccinations are upgraded into a part of epidemic prevention and control, compared with the traditional intramuscular injection vaccinations, the novel administration mode of the aerosol inhalation vaccine is realized in the prior art, and thus the effects of no needle and no pain, simple use and small dosage are realized.
In the existing aerosol inhalation vaccine technology, a vaccine is generally atomized into tiny liquid drops through an atomizer developed by Aerogen company, then the vaccine liquid drops enter the respiratory tract and the lung through a respiratory inhalation mode by a person to be vaccinated, so that mucosal immunity is stimulated, and the immunity is painless through the aerosol inhalation mode, and has higher accessibility. The core technology of the Aerogen atomizer is palladium alloy vibration grid technology, 1000 precisely-formed micropores are distributed on a central pore plate with the diameter of 5mm, vibration is carried out 128000 times per second, and liquid drops with the size most favorable for deep lung deposition are formed. However, such a nebulizer delivery system is complex, costly, and because it is not a disposable product, repeated use requires cleaning and sterilization, resulting in complex use.
Accordingly, the prior art is in need of improvement.
Disclosure of Invention
The invention aims to solve the technical problem of providing a vaccine atomizer, an assembling method thereof and a mask so as to realize large-scale vaccination with low cost through the disposable vaccine atomizer.
The invention provides a vaccine atomizer, comprising:
The atomizer body is provided with a containing cavity for containing vaccine;
the piezoelectric ceramic layer is arranged on the atomizer body and is in contact with the vaccine;
The sieve mesh layer is arranged at the opening of the accommodating cavity and is in contact with the vaccine, the sieve mesh layer is matched with the atomizer body to encapsulate the vaccine in the accommodating cavity, and sieve holes are formed in the sieve mesh layer by laser drilling so as to realize that the vaccine which is not atomized is stored in the accommodating cavity, and the atomized vaccine is separated out from the sieve holes.
The vaccine atomizer, wherein the diameter of the sieve holes on the sieve hole layer is 0.5-5 μm.
The vaccine atomizer, wherein, piezoceramics layer sets up hold the opening part in chamber and sieve mesh layer sets up piezoceramics layer's central point puts, piezoceramics layer with sieve mesh layer will the vaccine encapsulation is in hold the intracavity.
The vaccine atomizer, wherein, piezoceramics layer sets up the bottom of holding the chamber, piezoceramics layer with the sieve mesh layer sets up the both sides of vaccine, in order to with the vaccine encapsulation is in hold the intracavity.
The vaccine atomizer, wherein the sieve mesh layer is a stainless steel plate subjected to laser drilling treatment.
The vaccine atomizer, wherein, the vaccine atomizer further includes:
The sealing layer is arranged on the sieve pore layer, one side of the sieve pore layer is in contact with the vaccine, the other side of the sieve pore layer is in contact with the sealing layer, and the sealing layer is used for assisting in sealing the sieve pore layer so as to prevent the vaccine from being lost in the storage process.
The vaccine atomizer, wherein, the vaccine atomizer further includes:
And one end of the power interface is connected with the piezoelectric ceramic layer, and the other end of the power interface is connected with an external power supply to provide electric energy for the piezoelectric ceramic layer so as to realize atomization of the vaccine.
The vaccine atomizer, wherein, the sieve mesh layer through medical glue with atomizer body fixed connection, in order to realize the integrated structure of vaccine atomizer.
A method of assembling a vaccine nebuliser as claimed in any one of the preceding claims, comprising the steps of:
forming a receiving cavity on the nebulizer body to receive a vaccine;
forming sieve pores on the sieve pore layer through laser drilling, arranging the sieve pore layer at the opening of the accommodating cavity, and sealing the accommodating cavity by matching the sieve pore layer with the atomizer body;
Injecting the vaccine into the accommodating cavity, packaging the vaccine into the accommodating cavity, and contacting the vaccine with the sieve pore layer and the piezoelectric ceramic layer on the atomizer body so as to realize that the vaccine which is not atomized is stored in the accommodating cavity, and the atomized vaccine is separated out from the sieve pores.
The mask comprises a mask body, the vaccine atomizer and an external power supply, wherein the vaccine atomizer is arranged on the mask body and is electrically connected with the external power supply, and atomized vaccine is separated out after the vaccine atomizer is electrified, so that vaccination of the vaccine is realized.
The invention provides a vaccine atomizer, an assembling method thereof and a mask, wherein the vaccine atomizer comprises an atomizer body provided with a containing cavity, and the containing cavity can contain vaccine; a piezoelectric ceramic layer disposed on the atomizer body and in contact with the vaccine; and the sieve mesh layer is arranged at the opening of the accommodating cavity and is contacted with the vaccine. The sieve mesh layer with the cooperation of atomizer body will the vaccine encapsulation is in hold the intracavity, just by laser drilling formation sieve mesh on the sieve mesh layer to realize that the vaccine that does not atomize is stored hold the intracavity, the vaccine after atomizing is followed in the sieve mesh is precipitated. With the above structure, a disposable vaccine atomizer can be obtained, thereby realizing large-scale vaccination at low cost. .
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required to be used in the embodiments or the description of the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments described in the present invention, and other drawings may be obtained according to the drawings without inventive effort to those skilled in the art.
FIG. 1 is a schematic diagram of a vaccine atomizer according to an embodiment of the present invention in an atomized vaccine state;
FIG. 2 is a schematic view of a vaccine atomizer in a sealed condition according to an embodiment of the present invention;
FIG. 3 is a schematic view of a vaccine atomizer according to another embodiment of the present invention in an atomized vaccine state;
FIG. 4 is a schematic view of a vaccine atomizer according to another embodiment of the present invention in a sealed condition;
FIG. 5 is a schematic front view of a sifting layer of the present invention;
fig. 6 is a flow chart of an assembly method of the vaccine atomizer according to the present invention.
Detailed Description
In order to make the present invention better understood by those skilled in the art, the following description will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that, the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "inner", "outer", "vertical", "horizontal", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the structures referred to must have a specific direction or must be constructed in a specific direction, and are not to be construed as limiting the present invention.
The invention provides a vaccine atomizer and an assembling method thereof. As shown in fig. 1 and 3, the vaccine atomizer includes an atomizer body 100, a piezoceramic layer 200 and a mesh layer 300. Specifically, a housing cavity 110 is provided on the atomizer body 100, and the housing cavity 110 is used for housing vaccine; the piezoelectric ceramic layer 200 is fixed on the atomizer body 100, and the piezoelectric ceramic layer 200 contacts with the vaccine contained in the containing cavity 110, so that when the piezoelectric ceramic layer 200 is electrified and works, electric energy is converted into mechanical energy, and atomization of the vaccine in the containing cavity 110 is realized; the sieve mesh layer 300 is disposed at the opening of the accommodating cavity 110 and contacts with the vaccine accommodated in the accommodating cavity 110, so that the sieve mesh layer 300 and the atomizer body 100 cooperate to seal the accommodating cavity 110, and the vaccine is encapsulated in the vaccine atomizer.
Further, micropores formed by laser drilling are formed on the sieve mesh layer 300 to serve as sieve meshes, so that vaccine is packaged in the accommodating cavity 110 in an unatomized state and cannot flow out through the sieve meshes, the vaccine is separated out from the accommodating cavity 110 through the sieve meshes after being atomized, and a user realizes vaccination by inhaling atomized vaccine droplets. Alternatively, the mesh layer 300 is a stainless steel plate on which mesh holes having diameters of 0.5 μm to 5 μm are formed by a laser drilling technique, the mesh holes being arranged at uniform intervals. Optionally, the mesh formed by laser drilling on the mesh layer 300 is 0.9 μm, so as to ensure that the vaccine is packaged in the accommodating cavity 110 in an unatomized state and cannot flow out through the mesh, the vaccine is separated out from the accommodating cavity 110 through the mesh after being atomized, a user realizes vaccination by inhaling atomized vaccine droplets, and meanwhile, by setting the size of the mesh, micron-scale atomized droplets can be generated, deeper respiratory tract can be achieved, the dosage of the medicament is less, and mucosal immunity, cellular immunity and humoral immunity can be realized simultaneously.
Alternatively, as shown in fig. 5, the mesh layer 300 has a button shape, and uniformly aligned meshes are formed at a central position of the mesh layer 300 by a laser drilling technique. Alternatively, the mesh layer 300 may have any shape, as long as the shape and size of the mesh layer 300 are adapted to the opening of the receiving cavity 110, so as to achieve the encapsulation of the vaccine in the receiving cavity 110, which is not limited herein. Optionally, the mesh layer 300 is fixedly connected with the atomizer body 100 through medical glue to form an integrated structure, so that the cost of manufacturing the vaccine atomizer is reduced, the vaccine atomizer is convenient to use as a disposable vaccination device, and the vaccine atomizer can be applied to vaccination in a large scale. Alternatively, the medical adhesive is a hot-melt pressure-sensitive adhesive.
Further, as shown in fig. 1 and 3, the piezoelectric ceramic layer 200 is provided with a power interface 210. One end of the power interface 210 is connected to the piezoelectric ceramic layer 200, and the other end of the power interface 210 extends out of the vaccine atomizer, thereby being connected to an external power source. The piezoelectric ceramic layer 200 is connected to an external power source through the power interface 210, and works by providing electric energy through the external power source. The piezoelectric ceramic layer 200 converts electric energy into mechanical energy after being electrified, and the piezoelectric ceramic layer 200 achieves atomization of the vaccine after starting to work by contacting with the vaccine inside the accommodating cavity 110.
Further, as shown in fig. 2 and 4, the vaccine atomizer further comprises a sealing layer 400. The sealing layer 400 is disposed on the sieve mesh layer 300, the sealing layer 400 and the vaccine are respectively disposed on two opposite sides of the sieve mesh layer 300, namely, one side of the sieve mesh layer 300 is in contact with the vaccine, the other side of the sieve mesh layer 300 is in contact with the sealing layer 400, and the sealing layer 400 is used for assisting in sealing the sieve mesh layer 300 so as to prevent the vaccine from being lost in the storage process. After injection of the vaccine into the receiving cavity 110, the vaccine atomizer is in a sealed state by the sealing layer 400, and the sealing layer 400 assists in sealing the vaccine into the receiving cavity 110 of the vaccine atomizer, thereby preventing loss of the vaccine during storage and transportation. Optionally, the sealing layer 400 is made of silica gel, after the vaccine atomizer is packaged, the sealing layer 400 assists in sealing the mesh layer 300, so that the vaccine in the accommodating cavity 110 is sealed, when the vaccine atomizer is used, the sealing layer 400 is torn off, the sealing layer 400 is released from sealing the mesh layer 300, and the vaccine atomizer enters into a working state of atomizing the vaccine. The vaccine is atomized and then separated out through the sieve holes on the sieve mesh layer 300, so that a user can realize vaccination through respiration. The sealing layer 400 realizes the single use of the vaccine atomizer, so that the vaccine atomizer is simple to use and can be applied to vaccination in a large scale.
Further, as shown in fig. 1 and 3, the piezoelectric ceramic layer 200 and the mesh layer 300 are provided with different relative positional relationships for different structures.
In one embodiment of the present invention, as shown in fig. 1 and 2, the atomizer body 100 is recessed to form a holding cavity 110 with an open top, the piezoceramic layer 200 is disposed at the opening of the holding cavity 110, the mesh layer 300 is also disposed at the opening of the holding cavity 110, the piezoceramic layer 200 and the mesh layer 300 are coplanar, and the piezoceramic layer 200 and the mesh layer 300 cooperate with the atomizer body 100 to seal the holding cavity 110, thereby encapsulating the vaccine in the holding cavity 110. Alternatively, the mesh layer 300 is disposed at a central position of the piezoelectric ceramic layer 200, and the mesh layer 300 and the piezoelectric ceramic layer 200 are simultaneously in contact with the vaccine received in the receiving chamber 110, the vaccine being interposed between the atomizer body 100 and the piezoelectric ceramic layer 200 and the mesh layer 300. When the vaccine atomizer is in a sealed state, as shown in fig. 2, the sealing layer 400 assists in closing the mesh layer 300, thereby sealing the vaccine within the receiving cavity 110 of the vaccine atomizer; when the vaccine atomizer enters a vaccine atomizing state, as shown in fig. 1, the piezoelectric ceramic layer 200 starts to work, the piezoelectric ceramic layer 200 atomizes the vaccine to form vaccine droplets 500, and the vaccine droplets 500 are separated out from the sieve pores of the sieve pore layer 300, so that a user can inhale the atomized vaccine droplets through respiration and finally reach alveolar tissues, and meanwhile, mucosal immunity, cellular immunity and humoral immunity are realized.
Optionally, the atomizer body 100 is made of medical plastic, the atomizer body 100 and the piezoelectric ceramic layer 200 are fixedly adhered to form an integrated structure through medical glue, and the sieve mesh layer 300 is adhered to form an integrated structure through medical glue and the piezoelectric ceramic layer 200. Alternatively, the nebulizer body 100 is recessed inwardly to form a holding chamber 110 having a volume of one vaccine dose, thereby forming a single-use vaccine nebulizer, and large-scale vaccination can be achieved at low cost. Alternatively, the volume of the receiving chamber 110 is 0.5mL.
In another embodiment of the present invention, as shown in fig. 3 and 4, the piezoceramic layer 200 is disposed at the bottom of the receiving chamber 110 and contacts the vaccine encapsulated in the receiving chamber 110, and the piezoceramic layer 200 cooperates with the atomizer body 100 to form the receiving chamber 110. Optionally, the atomizer body 100 is disposed in a ring shape, and the accommodating cavity 110 is formed on the piezoceramic layer 200 in a surrounding manner. The sieve mesh layer 300 is disposed at an opening at the top of the accommodating cavity 110 and contacts the vaccine encapsulated in the accommodating cavity 110. The atomizer body 100 forms a supporting structure between the mesh layer 300 and the piezoelectric ceramic layer 200, the atomizer body 100, the piezoelectric ceramic layer 200 and the mesh layer 300 cooperate to seal the accommodating cavity 110, and the vaccine is encapsulated inside the accommodating cavity 110. The vaccine is sandwiched between the mesh layer 300 and the piezoelectric ceramic layer 200, and when the vaccine atomizer is in a sealed state, as shown in fig. 4, the sealing layer 400 assists in closing the mesh layer 300, thereby sealing the vaccine in the housing cavity 110 of the vaccine atomizer; when the vaccine atomizer enters a vaccine atomizing state, as shown in fig. 3, when the piezoelectric ceramic layer 200 starts to work, the piezoelectric ceramic layer 200 atomizes the vaccine to form vaccine droplets 500, and the vaccine droplets 500 are separated out from the sieve pores of the sieve pore layer 300, so that a user can inhale the atomized vaccine droplets through respiration and finally reach alveolar tissues, and meanwhile, mucosal immunity, cellular immunity and humoral immunity are realized.
Optionally, the atomizer body 100 is made of medical plastic, and the atomizer body 100, the mesh layer 300 and the piezoelectric ceramic layer 200 are fixed and adhered by medical glue to form an integrated structure. Alternatively, the atomizer body 100, the mesh layer 300 and the piezoelectric ceramic layer 200 cooperate to form the accommodating chamber 110 having a volume of one vaccine dose, thereby forming a vaccine atomizer for single use, and large-scale vaccination can be achieved at low cost. Alternatively, the volume of the receiving chamber 110 is 0.5mL.
The invention also provides an assembling method of the vaccine atomizer, as shown in fig. 6, the assembling method comprises the following steps:
s100, forming a containing cavity on the atomizer body to contain vaccine;
S200, forming sieve holes on the sieve hole layers through laser drilling, arranging the sieve hole layers at the opening of the accommodating cavity, and sealing the accommodating cavity by matching the sieve hole layers with the atomizer body;
S300, injecting the vaccine into the accommodating cavity, packaging the vaccine into the accommodating cavity, and enabling the vaccine to be in contact with the sieve pore layer and the piezoelectric ceramic layer on the atomizer body so as to achieve that the vaccine which is not atomized is stored in the accommodating cavity, and the atomized vaccine is separated out from the sieve pores.
Optionally, after the step S300, the assembling method further includes the steps of:
S400, a sealing layer is arranged on the other side of the sieve pore layer relative to the vaccine so as to assist in sealing the accommodating cavity and prevent the vaccine from being lost in the transportation and storage processes.
Further, the invention also provides a mask, which comprises a mask body, the vaccine atomizer as described in any one of the above, and an external power supply, wherein the vaccine atomizer is arranged on the mask body and is electrically connected with the external power supply, and atomized vaccine is separated out after the vaccine atomizer is electrified, so that vaccination of the vaccine is realized.
Alternatively, the mask may be any mask, such as a cotton mask, a non-woven mask, a high polymer material mask, or a disposable medical mask, a medical surgical mask, a particulate matter protection mask, a medical protection mask, or the like, so long as the vaccine atomizer can be fixed, and atomized liquid drops in the vaccination process can be ensured to enter the respiratory tract.
The following is a brief description of the structure of the vaccine atomizer according to the present invention, with reference to the specific examples and the accompanying drawings:
In an embodiment of the present invention, as shown in fig. 1 and 2, a housing cavity 110 with an open top is formed on a medical plastic atomizer body 100 in a recessed manner, a piezoelectric ceramic layer 200 is disposed at an opening of the housing cavity 110, and the piezoelectric ceramic layer 200 is fixedly integrated with the atomizer body 100 through medical glue. Micropores with diameters of 0.5-5 mu m are formed on a stainless steel plate by utilizing a laser drilling technology, so that a sieve mesh layer 300 is obtained, the sieve mesh layer 300 and the piezoelectric ceramic layer 200 are fixedly and integrally arranged through medical glue, the sieve mesh layer 300 is embedded into the center position of the piezoelectric ceramic layer 200, the sieve mesh layer 300 and the piezoelectric ceramic layer 200 are in direct contact with the inner space of the accommodating cavity 110, and the piezoelectric ceramic layer 200 and the sieve mesh layer 300 are matched with the atomizer body 100 together to seal the accommodating cavity 110.
After the accommodating cavity 110 is closed, injecting a vaccine into the accommodating cavity 110, and setting the diameter of the sieve pores on the sieve pore layer 300 to realize that the vaccine is closed in the accommodating cavity 110 and cannot be separated out when the piezoelectric ceramic layer 200 does not work, i.e. the vaccine is not atomized; when the piezoelectric ceramic layer 200 starts to work, that is, the vaccine is atomized to form vaccine droplets 500, the vaccine droplets 500 are separated out from the mesh holes of the mesh hole layer 300, so that a user can inhale the atomized vaccine droplets through respiration and finally reach alveolar tissues, and mucosal immunity, cellular immunity and humoral immunity are realized.
Further, a sealing layer 400 is disposed on the other side of the mesh layer 300 opposite to the vaccine to assist in sealing the accommodating cavity 110 to achieve a sealed state of the vaccine atomizer, so as to avoid the loss of the vaccine during transportation or storage.
In another embodiment of the present invention, as shown in fig. 3 and 4, an atomizer body 100 is disposed on a piezoelectric ceramic layer 200, the atomizer body surrounds to form a containing cavity 110, the piezoelectric ceramic layer 200 is fixedly integrated with the atomizer body 100 through medical glue, the bottom of the containing cavity 110 is disposed on the piezoelectric ceramic layer 200, and the top of the containing cavity 110 is open. Micropores with diameters of 0.5-5 μm are formed on the stainless steel plate by using a laser drilling technology, so that a sieve mesh layer 300 is obtained, the sieve mesh layer 300 is fixedly connected with the atomizer body 100 through medical glue, and the sieve mesh layer 300 is arranged at the top opening of the accommodating cavity 110, so that the sieve mesh layer 300 and the piezoelectric ceramic layer 200 are directly contacted with the inner space of the accommodating cavity 110. The sieve mesh layer 300, the atomizer body 100 and the piezoelectric ceramic layer 200 cooperate to seal the accommodating cavity 110.
After the accommodating cavity 110 is closed, injecting a vaccine into the accommodating cavity 110, and setting the diameter of the sieve pores on the sieve pore layer 300 to realize that the vaccine is closed in the accommodating cavity 110 and cannot be separated out when the piezoelectric ceramic layer 200 does not work, i.e. the vaccine is not atomized; when the piezoelectric ceramic layer 200 starts to work, that is, the vaccine is atomized to form vaccine droplets 500, the vaccine droplets 500 are separated out from the mesh holes of the mesh hole layer 300, so that a user can inhale the atomized vaccine droplets through respiration and finally reach alveolar tissues, and mucosal immunity, cellular immunity and humoral immunity are realized.
Further, a sealing layer 400 is disposed on the other side of the mesh layer 300 opposite to the vaccine to assist in sealing the accommodating cavity 110 to achieve a sealed state of the vaccine atomizer, so as to avoid the loss of the vaccine during transportation or storage.
In summary, the invention provides a vaccine atomizer, an assembling method thereof and a mask, wherein the vaccine atomizer comprises an atomizer body provided with a containing cavity, and the containing cavity can contain vaccine; a piezoelectric ceramic layer disposed on the atomizer body and in contact with the vaccine; and the sieve mesh layer is arranged at the opening of the accommodating cavity and is contacted with the vaccine. The sieve mesh layer with the cooperation of atomizer body will the vaccine encapsulation is in hold the intracavity, just by laser drilling formation sieve mesh on the sieve mesh layer to realize that the vaccine that does not atomize is stored hold the intracavity, the vaccine after atomizing is followed in the sieve mesh is precipitated. With the above structure, a disposable vaccine atomizer can be obtained, thereby realizing large-scale vaccination at low cost.
The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
Claims (8)
1. A vaccine nebulizer, characterized in that the vaccine nebulizer comprises:
The atomizer body is provided with a containing cavity for containing vaccine;
the piezoelectric ceramic layer is arranged on the atomizer body and is in contact with the vaccine;
The sieve pore layer is arranged at the opening of the accommodating cavity and is in contact with the vaccine, the sieve pore layer is matched with the atomizer body to encapsulate the vaccine in the accommodating cavity, and sieve pores are formed on the sieve pore layer by laser drilling so as to realize that the vaccine which is not atomized is stored in the accommodating cavity, and the atomized vaccine is separated out from the sieve pores;
The vaccine atomizer further comprises a sealing layer, wherein the sealing layer is arranged on the sieve pore layer, one side of the sieve pore layer is in contact with the vaccine, the other side of the sieve pore layer is in contact with the sealing layer, the diameter of the sieve pore on the sieve pore layer is 0.5-5 mu m, and the sealing layer is used for assisting in sealing the sieve pore layer so as to prevent the vaccine from being lost in the storage process;
the atomizer body is recessed on the atomizer body to form the accommodating cavity with the top opening, and the atomizer body, the piezoelectric ceramic layer and the sieve pore layer are of an integrated structure;
The vaccine atomizer is arranged on the mask body, and the mask is any mask capable of fixing the vaccine atomizer;
the sealing layer is made of silica gel;
The mask is any one of a cotton mask, a non-woven fabric mask, a high polymer material mask, a disposable medical mask, a medical surgical mask, a particulate matter protective mask and a medical protective mask.
2. The vaccine atomizer according to claim 1, wherein said piezoceramic layer is disposed at an opening of said housing cavity and said mesh layer is disposed at a central location of said piezoceramic layer, said piezoceramic layer and said mesh layer encapsulating said vaccine within said housing cavity.
3. The vaccine atomizer according to claim 1, wherein said piezoceramic layer is disposed at the bottom of said housing cavity, said piezoceramic layer and said mesh layer being disposed on both sides of said vaccine to encapsulate said vaccine within said housing cavity.
4. A vaccine atomizer according to claim 2 or 3, wherein said mesh layer is a laser perforated stainless steel plate.
5. The vaccine atomizer of claim 4, characterized in that the vaccine atomizer further comprises:
And one end of the power interface is connected with the piezoelectric ceramic layer, and the other end of the power interface is connected with an external power supply to provide electric energy for the piezoelectric ceramic layer so as to realize atomization of the vaccine.
6. The vaccine atomizer of claim 4, wherein said mesh layer is fixedly connected to said atomizer body by a medical glue to provide an integrated structure of said vaccine atomizer.
7. A method of assembling a vaccine nebuliser according to any one of claims 1 to 6, characterised by the steps of:
forming a receiving cavity on the nebulizer body to receive a vaccine;
forming sieve pores on the sieve pore layer through laser drilling, arranging the sieve pore layer at the opening of the accommodating cavity, and sealing the accommodating cavity by matching the sieve pore layer with the atomizer body;
Injecting the vaccine into the accommodating cavity, packaging the vaccine into the accommodating cavity, and contacting the vaccine with the sieve pore layer and the piezoelectric ceramic layer on the atomizer body so as to realize that the vaccine which is not atomized is stored in the accommodating cavity, and the atomized vaccine is separated out from the sieve pores.
8. A mask, characterized in that the mask comprises a mask body, a vaccine atomizer as claimed in any one of claims 1-6, and an external power supply, wherein the vaccine atomizer is arranged on the mask body and is electrically connected with the external power supply, and atomized vaccine is separated out after the vaccine atomizer is electrified, so that vaccination of the vaccine is realized; the mask is any mask capable of fixing the vaccine atomizer.
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