Nothing Special   »   [go: up one dir, main page]

CN103328040B - 具有径向固定机构的无导线起搏器 - Google Patents

具有径向固定机构的无导线起搏器 Download PDF

Info

Publication number
CN103328040B
CN103328040B CN201180061312.8A CN201180061312A CN103328040B CN 103328040 B CN103328040 B CN 103328040B CN 201180061312 A CN201180061312 A CN 201180061312A CN 103328040 B CN103328040 B CN 103328040B
Authority
CN
China
Prior art keywords
fixed mechanism
pacemaker
housing
electrode
heart
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201180061312.8A
Other languages
English (en)
Other versions
CN103328040A (zh
Inventor
A.凯尔卡汉
A.奥斯特罗夫
E.瓦拉迪
P.帕斯帕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanostim Inc
Original Assignee
Nanostim Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanostim Inc filed Critical Nanostim Inc
Publication of CN103328040A publication Critical patent/CN103328040A/zh
Application granted granted Critical
Publication of CN103328040B publication Critical patent/CN103328040B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37205—Microstimulators, e.g. implantable through a cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/37512—Pacemakers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/37518—Anchoring of the implants, e.g. fixation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/057—Anchoring means; Means for fixing the head inside the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/057—Anchoring means; Means for fixing the head inside the heart
    • A61N1/0573—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/3756—Casings with electrodes thereon, e.g. leadless stimulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Electrotherapy Devices (AREA)

Abstract

本发明提供一种具有径向固定机构的无导线心脏起搏器。该心脏起搏器可包括与起搏电极分开的并且直径等于或小于起搏器外直径的固定机构。固定机构可允许起搏器被通过起搏器的小于2次旋转插入组织中，以与组织接触放置起搏电极。在一些实施例中，固定机构可包括靠近起搏器远侧部分设置的多个钩或突出部。一个或多个固定机构可配置为刺入患者的心脏内膜，并且大部分位于心肌内。本发明还提供将无导线心脏起搏器传递到心脏中的方法。

Description

具有径向固定机构的无导线起搏器
交叉引用
本申请要求2010年12月20日提交的名称为“LEADLESS PACEMAKERWITH RADIAL FIXATION MECHANISM”的美国临时专利申请No.61/425,064的权益，该申请在此以其全部内容通过引用并入本文中。
通过引用并入
本说明书中提到的所有公开文件和专利申请都以引用的方式并入本文中，如同每一个单独的出版物或专利申请被具体并且单独说明以通过引用并入本文中一样。
技术领域
本发明涉及无导线心脏起搏器，更特别地，涉及其被附接到心脏组织所借助的结构和方法。具体来说，本发明涉及用于将无导线心脏起搏器通过径向固定机构附接到组织的结构和方法。
背景技术
在心脏自身的天然起搏点和/或传导系统不能提供其速率和间隔足以满足患者健康的心房和心室的同步收缩时，通过人工心脏起搏器进行的心脏起搏提供心脏的电刺激。该抗心动过缓的起搏为成千上万的患者提供症状缓解，甚至生命维持。心脏起搏还可提供电过速刺激，以抑制或改变快速性心律失常，同样提供症状缓解，并且防止或终止可能导致心脏性猝死的心律失常。
由目前可得的或传统的起搏器提供的心脏起搏通常通过皮下或肌肉中植入患者胸肌区中或附近的脉冲发生器进行。脉冲发生器参数通常由体外的编程装置通过具有体内的一个感应器和体外的另一个感应器的松耦合互感器，或通过具有体内的一个天线和体外的一个天线的电磁发射器询问和改变。发生器通常连接到一根或多根被植入的导线的近端，其远端容纳一个或多个电极，所述一个或多个电极用于邻近心腔的内壁或外壁定位。导线具有一个或多个绝缘电导体，用于将脉冲发生器连接到心脏中的电极。该电极导线通常具有50到70厘米的长度。
虽然每年不止植入十万个传统的心脏起搏器，但是仍存在很多已知的问题，仅说明所述问题中的一些。例如，脉冲发生器在设置在皮下时，在皮肤中存在鼓胀部分，患者可能感觉不好看、不舒服或恼怒，并且患者可能潜意识地或强迫地推拿或“捻弄”。甚至在没有持续推拿的情况下，皮下脉冲发生器仍可能发生腐蚀、挤出、感染和断开、绝缘损坏或在导线处导体断裂。虽然肌肉或腹部放置可能解决一些烦恼，但是这样的放置涉及更困难的用于植入和调整的手术过程，这可能延长患者的恢复期。
传统的脉冲发生器，无论是胸部或腹部，具有用于连接到电极导线和从电极导线断开的接合部，其将信号输送至心脏或将信号从心脏输送。通常，至少一个凸接头模制件在电极导线近端处具有至少一个接线端子。凸接头与脉冲发生器处接头模制件内的相应的凹接头模制件和接线板结合。通常固定螺钉被拧入每一根导线的至少一个接线板中，以确保电和机械连接。还提供一个或多个O形环，以辅助保持接头模制件之间的电绝缘。通常包括固定螺钉帽或开槽盖，以提供螺钉的电绝缘。接头和导线之间的该简要描述的复杂连接使得出现故障的可能更大。
传统起搏器的其他有问题方面涉及分开植入的脉冲发生器和起搏导线。举另一个示例来说，特别地，起搏导线可能变为感染和发病位置。通过开发独立和自支撑起搏器，或所谓的无导线起搏器可解决与传统的起搏器相关的多个问题，如在上面引用的相关申请中所述。
独立或无导线起搏器或其他生物刺激器通常通过主动接合机构，例如旋入心肌中的螺钉或螺旋构件固定到心脏内植入位置。
发明内容
提供一种无导线心脏起搏器，包括密封壳体；布置在壳体远侧部分上的起搏电极；布置在壳体中的电子封装部，该电子封装部配置为产生起搏信号和将起搏信号传递到起搏电极；和固定机构，其与起搏电极分开，并且布置在壳体的远侧部分上，该固定机构具有小于或等于密封壳体的外直径的直径，并且从固定机构的远端到固定机构的近端包括小于两个旋转圈。
在一些实施例中，固定机构从固定机构的远端到固定机构的近端包括小于一个半旋转圈。在其他实施例中，固定机构从固定机构的远端到固定机构的近端包括小于一又四分之一旋转圈。
在一些实施例中，起搏电极包括圆顶形状。在另外的实施例中，起搏电极被通过柔质弹簧附接到壳体，以减小抵靠心脏组织的压缩力。在另一个实施例中，起搏电极被通过硅酮胶附接到壳体，以减小抵靠心脏组织的压缩力。
在一个实施例中，固定机构包括螺旋件。在一些实施例中，螺旋件旋转小于或等于450度。在其他实施例中，螺旋件至少部分地围绕起搏电极。
在一些实施例中，固定机构包括恒定的直径。在另一个实施例中，固定机构具有2.5mm至5mm的直径。
在一些实施例中，固定机构包括小于1.8mm的纵向长度。在其他实施例中，壳体的远侧部分具有小于密封壳体外直径的外直径。在一些实施例中，固定机构尺寸制成并且配置为得，其在完全旋入心脏组织中时不将患者的心肌穿孔。
在一些实施例中，固定机构包括径向部分和连接部分，该径向部分基本上与壳体的圆周对准，该连接部分将固定机构附接到壳体。在一个实施例中，径向部分基本上垂直于连接部分。在另一个实施例中，连接部分具有小于患者心脏的心肌层厚度的长度。在又一个实施例中，连接部分具有小于或等于1.8mm的长度。在另外的实施例中，固定机构的径向部分配置为位于患者的心脏心肌层内，并且基本上与患者的心脏心脏内膜层接触。在各实施例中，固定机构可进一步包括倒钩，所述倒钩布置在固定机构的径向部分的内表面上。
在另一个实施例中，起搏器配置为在收回过程中接收保护套管，该保护套管具有与密封壳体的外直径类似的内直径。
还提供一种将起搏器固定到心脏中的组织的方法，包括将起搏器的固定机构邻近心脏的心脏内膜定位，所述固定机构具有小于或等于起搏器外直径的直径；用固定机构穿入心脏内膜，和使固定机构旋转小于一又四分之一圈，以基本上将固定机构全部插入心脏的心肌中，并且将起搏器的起搏电极放置为与心脏组织接触。
在一些实施例中，固定机构包括螺旋件。在一些实施例中，起搏器包括无导线心脏起搏器。
在另一个实施例中，该方法进一步包括使用保护套管覆盖起搏器和该固定机构，和将起搏器从患者移除。
附图说明
图1A-1C示出无导线心脏起搏器。
图2A-2D为具有径向固定机构的无导线心脏起搏器的各个视图。
具体实施方式
提供具有至少一个径向固定机构的无导线心脏起搏器的各个实施例。无导线心脏起搏器可通过引导通讯(conducted communication)来通信，代表着从传统起搏系统的实质突破。例如，示例性心脏起搏系统可进行心脏起搏，所述心脏起搏具有很多传统心脏起搏器的优点，同时通过若干改进中的一个或多个扩展了性能、功能和操作特性。
在心脏起搏系统的一些实施例中，心脏起搏在没有设置在胸部区域或腹部中的脉冲发射器、没有与脉冲发生器分开的电极导线、没有通讯线圈或天线、和没有对用于传输通讯的电池功率的进一步要求的情况下被提供。
配置为获得这些特性的心脏起搏系统的一个实施例包括无导线心脏起搏器，其基本上封闭在适用于放置在心腔内部或外部上或附接到心腔内部或外部的密封壳体中。心脏起搏器可具有两个或多个设置在壳体内、上或附近的电极，用于将起搏脉冲传递到心腔肌肉，和可选地，用于从肌肉感测电活动，和用于与体内或体外的至少一个其他装置双向通讯。该壳体可容纳主电池，以给起搏、感测和通讯提供功率，所述通讯例如为双向通讯。壳体可以可选地容纳用于从电极感测心脏活动的电路。该壳体容纳用于从至少一个其他装置通过电极接收信息的电路，并且容纳用于产生通过电极输送的起搏脉冲的电路。该壳体可选地容纳用于将信息通过电极传递到至少一个其他装置的电路，并且可选地容纳用于监测装置健康状况的电路。壳体容纳用于以预定方式控制这些操作的电路。
在一些实施例中，心脏起搏器可适用于传递和植入人体中的组织内。在特定实施例中，无导线心脏起搏器可适用于使用两个或多个电极邻近心腔内壁或外壁上的心脏组织植入，所述电极设置在起搏器壳体上或内，用于在从体内的至少一个其他装置接收促发信号时起搏心腔。
独立或无导线起搏器或其他生物刺激器通常通过主动接合机构，例如旋入心肌中的螺钉或螺旋构件固定到心脏内植入位置。这样的无导线生物刺激器的示例在下面的出版物中有所描述，所述出版物的公开内容以引用的方式并入本文中：(1)US申请No.11/549,599，提交日为10/13/2006，标题为“Leadless Cardiac Pacemaker System for Usage in Combination with anImplantable Cardioverter-Defibrillator”，于4/19/2007公开US2007/0088394A1；(2)美国专利申请No.11/549,581，提交日为10/13/2006,标题为“LeadlessCardiac Pacemaker”,于4/19/2007公开为US2007/0088396A1；(3)美国专利申请No.11/549,591，提交日为10/13/2006，标题为“Leadless Cardiac PacemakerSystem with Conductive Communication”，于4/19/2007公开为US2007/0088397A1；(4)美国专利申请No.11/549,596，提交日为10/13/2006,标题为“Leadless Cardiac Pacemaker Triggered by ConductiveCommunication”，于4/19/2007公开为US2007/0088398A1；(5)美国专利申请No.11/549,603，提交日为10/13/2006，标题为“Rate Responsive LeadlessCardiac Pacemaker”，于4/19/2007公开为US2007/0088400A1；(6)美国专利申请No.11/549,605，提交日为10/13/2006，标题为“Programmer forBiostimulator System”，于4/19/2007公开为US2007/0088405A1；(7)美国专利申请No.11/549,574，提交日为10/13/2006,标题为“Delivery System forImplantable Biostimulator”，于4/19/2007公开为US2007/0088418A1；以及(8)国际申请No.PCT/US2006/040564，提交日为10/13/2006,标题为“LeadlessCardiac Pacemaker and System”，于4/26/2007公开为WO07047681A2。
除了主固定机构，例如螺旋件，一些起搏器可进一步包括第二固定机构，以提供用于将生物刺激器在体内保持在位的另一个结构。第二固定机构可以是主动型的(例如第二固定机构可主动接合心脏内或心脏外的组织)，或可以是被动型的(例如第二固定机构没有附接到组织，而是在意外脱开的情况下防止生物刺激器在体内到处移动)。关于第二固定机构的进一步的详细内容可见于美国申请No.12/698,969。
独立或无导线起搏器或其他生物刺激器通常通过主动接合机构，例如旋入心肌中的螺钉或螺旋构件，固定到心脏内植入位置。在出现故障的情况下，非常期望能够急性地(在植入手术过程中)或慢性地(在微创植入后一段时间之后)收回生物刺激器的无导线起搏器。
图1A显示了无导线心脏起搏器100。生物刺激器可包括密封壳体102，其上布置有电极104和106。如图所示，电极106可与固定机构105分离，但是部分地由固定机构105围绕，并且电极104可布置在壳体102上。固定机构105可以是固定螺旋件、多个钩、倒钩或配置为将起搏器附接到组织(例如心脏组织)的其他附接结构。
壳体也可包括在壳体内的电子隔室110，其容纳起搏器运行所需的电子部件，包括例如脉冲发生器、通讯电子装置、电池和用于运算的处理器。密封壳体102可适用于植入在人类心脏上或中，并且可以例如是圆柱状形状、矩形、球形或任何其他适当形状。
壳体可包括导电、生物相容、惰性和阳极安全材料，例如钛、316L不锈钢或其他类似材料。壳体可进一步包括布置在导电材料上的绝缘体，以分隔电极104和106。绝缘体可以是壳体的一部分上的位于电极之间的绝缘涂层，并且可包含例如硅树脂、聚氨酯、二甲苯塑胶或通常用于可植入医疗装置的其他生物相容电绝缘体等材料。在图1A的实施例中，单个绝缘体108沿壳体的一部分布置在电极104和106之间。在一些实施例中，壳体自身可包括绝缘体而不是导体，例如氧化铝陶瓷或其他材料，并且电极可布置在壳体上。
如图1A中所示，起搏器可进一步包括头组件112，用于将电极104与106绝缘。头组件112可由PEEK、Techothane或其他生物相容塑料制造，并且可包括陶瓷-金属引线、玻璃-金属引线或本领域中已知的其他适当引线绝缘体。
电极104和106可包括起搏/感测电极或返回电极。低极化涂层可被涂敷到电极，例如烧结的铂、铂-铱、铱、铱氧化物、氮化钛、碳或通常用于降低极化效应的其他材料。图1A中，电极106可以是起搏/感测电极，并且电极104可以是返回电极。电极104可以是导电壳体102的不包括绝缘体108的部分。
若干技术和结构可用于将壳体102附接到心脏的内壁或外壁。螺旋固定机构105能够使得该装置通过引导导管经心脏内膜或心外膜插入。可扭转导管可被用于旋转壳体，并且将固定装置推入心脏组织中，因而将固定装置(以及图1A中的电极106)固定，以与可刺激的组织接触。电极104可用作用于感测和起搏的中性电极。固定机构可被部分或全部涂覆，用于电绝缘，并且在装置上或附近可包括类固醇洗脱基质，以最小化纤维变性的反应，如传统起搏电极导线中所知的。
图1B-1C示出起搏器100的远端部分的另外的放大视图，包括固定机构105和电极106。如图1B-1C中所示，固定机构可包括螺旋件，其部分包围电极106或围绕电极106旋转。在一些实施例中，固定装置包括等于或小于起搏器自身壳体外直径的直径。在螺旋件实施例中，螺旋件可包括恒定直径，其小于或等于起搏器壳体的外直径。在一个实施例中，固定装置包括小于5mm的直径。在另一个实施例中，固定装置包括大于2.5mm并且小于5mm的直径。在一些实施例中，螺旋固定装置可具有0.005”-0.03”的线直径，和0.5mm到1.5mm的螺距。利用其直径达到壳体直径的固定机构，可增大将固定装置从组织去除所需的拉力，由此减小装置从心脏移开的可能性。而且，固定机构的增大的直径可增大与心脏的心脏内膜层接触的表面积，进一步提高起搏器保持植入在患者中的能力。
图1A-1C的螺旋固定机构可包括从机构的前远侧边缘到机构的附接到起搏器壳体的近侧部分具有小于两个完整圈的线圈。例如，在图1B中，固定机构105的远侧前边缘114距离固定机构的近端116约为一又四分之一圈(约450度)。如图1B中所示，壳体的附接到固定机构的远侧部分可具有小于壳体的主外直径的外直径，以便于固定机构的附接，同时允许固定机构具有小于壳体主外直径的直径。
固定机构105可还包括小于1.8mm的纵向长度L，其被认为是防止植入过程中心肌穿孔的安全长度。因而，在小于2圈(且优选地为小于或等于一又四分之一圈)的情况下，固定机构由此配置为完全旋入心脏组织中，而没有使患者的心肌穿孔。当固定机构完全旋入心脏组织中时，起搏器的电极106与该组织可靠接触。图1C显示了固定机构的远侧前边缘114和近端116的跨越一又四分之一圈或更少圈的、起始和终止点上下倒置的视图。在一些其他实施例中，从固定机构的远端到近端，固定机构可跨越小于2个完整圈。
也如图1A-1C中所示，固定机构可包括抗旋转结构，例如倒钩或缝线，以在该装置已经旋入组织中时，防止该装置反转。
参照图1C中的上下倒置视图，电极106可包括“按钮”或圆顶形状，其略微从起搏器的远端头向远侧地伸出。圆顶状电极可包括1.5-2.5mm的直径，并且可从起搏器的端部向远侧伸出约0.05”到0.3”。电极106优选为防止损伤表面，并且可从起搏器的端头伸出，以在固定机构105旋入组织中时接触组织。
电极106可通过柔质弹簧(compliant spring)和/或硅酮胶(未示出)电力地和机械地附接到起搏器，以减小施加到待刺激组织的张力或压缩力和摩擦运动。电极相对于待刺激组织的力和/或摩擦运动的减小将导致电极/组织交界处的组织炎症反应的减小，引起纤维化组织形成的减少。该纤维化的减少导致刺激活组织所需的起搏电压/电流更低。
在传统的起搏器中，通常将起搏电极并入到固定装置自身中。但是，由于起搏电极接触在插入过程中由固定装置损坏的组织，因此该组合可能造成对组织的另外的刺激。通过将电极106与固定装置105分离，如图1B-1C中所示，由电极106执行的起搏功能不接触由固定装置105另外刺激的组织。由起搏器的重量和运动产生的力旨在分布到与固定机构直接接触的组织，并且不分布到与电极106接触的、设置在较短距离处的组织。通过将固定位置与刺激位置分离，在远侧端头处的作为结果的纤维化可降低，导致刺激活组织所需的电压和电流降低。而且，由于待刺激的区域不经受由于固定创伤造成的刺激，因此可在即时的电极接触时降低损伤电流，并且可实现低刺激阈值。
图2A-2C示出具有至少一个径向固定机构205的无导线起搏器100的各个视图，该径向固定机构205配置为将起搏器附接到心脏组织。径向固定机构(即钩、突出部、刺等)可径向向外延伸小于或等于无导线心脏起搏器200的壳体最大外直径(OD)的距离，并且可设置在起搏器远侧部分附近。在一些实施例中，在通过起搏器旋转接合到心脏组织中时，径向固定机构可被作为安全的心脏固定机构依靠。
在图2A-2C的系统中，固定机构包括多个围绕电极206布置或布置在电极206附近的L状钩。图2A显示了起搏器的一个实施例，包括三个L状钩或固定机构。图2B显示了图2A的起搏器的上下倒置视图，图2C示出图2A的起搏器的侧视图，显示了固定机构关于电极206的位置。如图所示，钩可包括组织刺入远端头，用于穿刺心脏组织，特别地用于刺入心脏的心脏内膜。
图2A-2C的固定机构205配置为通过缩短的径向圈或螺圈固定到组织。参照图2A，每一个固定机构可包括径向部分209和连接部分211，所述径向部分209基本上平行于起搏器壳体的圆周延伸，并且连接部分211基本上垂直于径向部分并将径向部分连接到起搏器。连接部分可例如具有与心脏的心肌平均厚度大约相同的长度。在使用中，固定机构的径向部分为穿刺并且固定到组织的部分。将所述机构转动或旋转进入组织中，这将使径向部分接合组织，直到达到固定机构的连接部分。通过该装置在连接部分接触组织时的“止动”旋转，这还可提供触觉响应。
在图2A-2C中所示的实施例中，起搏器200包括三个L状径向钩或倒钩。每一个钩可包括起搏器的一圈的例如约60-90度或四分之一到六分之一，以将钩放置在组织内。所用的钩的数量越大，并且因此钩的长度越小，则需要越少的旋转来将组织与钩接合。
图2D示出起搏器200的另一个实施例，该起搏器200具有向远侧弯曲的径向钩205。如图2D中所示，该钩可朝向电极206以从水平位置达到并且包括45度的角度向远侧弯曲。使钩向远侧朝向电极弯曲，这可辅助电极在插入组织过程中与钩接触。在一些实施例中，沿远侧方向的弯曲角度可为30至60度。
固定机构可被封闭在传递和取回导管的可折叠套管(未示出)中，以允许容易地将无导线起搏器传递、重新定位到右心室或心房和从右心室或心房取回。由于固定机构总是具有小于起搏器外直径的直径，因此通过套管取回是可行的。作为对照，具有大于起搏器外直径的倒钩或钩的起搏器很难或不能从患者取回，因为不能使用保护套管覆盖较大的钩或倒钩。适当的取回导管和套管的示例可见于共同待审的申请No.13/324,802。
这些固定机构可还包括防止起搏器旋开的结构，例如倒钩207(所述固定机构上的面向后方的尖头或结构，旨在抓握组织，并且增大移除机构所需的力或扭矩)和/或孔和凹部，其允许组织粘附和内生长。固定机构可与起搏器的中性返回电极电绝缘(浮动的)。由于不止一个固定机构可被结合到起搏器上，因此该想法提供冗余的固定装置。
作为心腔衬里的组织最内层是薄但强韧的心脏内膜。柔软的心肌位于其下面，心脏的肌肉组织包括心脏壁的厚度的大部分。当上面所述的一个或多个固定机构接合在急性心脏组织中时，尖锐的端头刺入心脏内膜并且进入心肌，直到其长度的大部分位于心肌中。正是薄但是结实的心脏内膜提供组织中固定机构的保持力的大部分。图2A-2C中所示的固定机构的钩设计由于心脏内膜和下面的钩之间的大的接触表面，可提供优于替代设计(例如小螺旋件)的超高保持力。更具体地，钩的径向部分209可倾斜并且对准，以最大化钩和心脏内膜之间的接触表面，如图2D中所示。
而且，每一个钩上实施的小的倒钩结构(例如倒钩207)配置为当起搏器被旋开，钩向后从刺入位置滑出时，从里抓住心脏内膜。倒钩结构可设计得非常小(在0.1”数量级)，以在去除时充分抓住心脏内膜，但是将必须设计得不可接受地大，以单独地在心肌中具有相同的保持力。
由于小的倒钩207设计用于保持心脏内膜，因此倒钩在每一个机构上的数量和位置为设计灵活性的另一方面。每一个钩205可具有一个或多个倒钩，所述倒钩可设置在远侧、近侧和中间。在一些实施例中，每一个固定机构具有两个倒钩是足够的，一个在近侧设置在每一个钩基部附近，并且一个在远侧设置在每一个固定机构的尖锐尖头附近。当钩适当接合在心肌组织中时，钩的大部分(例如钩的径向部分)已经刺入心脏内膜，并且布置在心脏组织内。在该情况下，近侧倒钩将于是直接设置在心脏内膜后方；在仅角度旋开几度之后，这些近侧倒钩将立即抓住心脏内膜，并且防止进一步旋开。在钩没有100％接合在组织中的情况下，设置靠近固定机构端部的远侧倒钩；只要已经进行几度接合，则这些远侧倒钩将在组织中，并且可被依赖来阻止取出。
具有倒钩的固定机构通过本领域中技术人员已知的多种方法形成。例如，具有倒钩的轴对称多固定机构可通过激光、线EDM或化学蚀刻从金属薄片切割。金属部件还可使用金属注射成型技术制造。一些边缘可通过电抛光或或翻滚技术圆角化或锐化。塑料部件也可从薄片切割或注射成型。
倒钩207可形成在每一个单独的钩的任何表面上或表面组合上，但是最容易的两个面应是面向里朝向起搏器的表面，和面向外朝向组织的表面。将倒钩仅设置在面向里表面上具有实现抗旋开设计目的，同时保持面向外表面光滑，降低传递、再定位或取回过程中挂破或撕裂组织或倒钩保护套管的优点。
钩或倒钩的机械特性可通过选择钩材料和横截面外形改变。其可设计成通过增大其轴向厚度(增大切割其的薄片的厚度)具有轴向硬度，同时设计成通过降低其切割外形的柱宽度具有径向柔软性。钩可由塑料或金属制出。其可通过使用玻璃填充聚合物或硬金属，例如MP35N、不锈钢或钛，变得刚硬。其还可通过由柔性聚合物或超弹性nitinol制造钩来设计具有弹性。而且，其可部分或全部由生物可吸收聚合物制出，以使其提供可靠的急性固定，但是允许更容易地慢性取回。固定钩可制成多孔的，或使用高微观表面积涂层涂覆来促进慢性组织内生长和/或附着。钩还可使用类似于用于电极的类固醇涂覆，以降低最终的纤维化响应。
钩的角度也可调节来适应固定性能。当起搏器被设置在心室顶点处，并且旋转来接合组织时，钩的角度可确定当钩沿着其轨迹进入心脏组织中时，起搏器是否被沿远侧或近侧方向拉动或推动。如果钩向下倾斜(以使钩的尖锐的端头比钩的基部更远时)，则起搏器将在起搏器旋转时沿远侧方向移动。该起搏器的附加的远侧运动可确保其远侧电极被拉动更靠近远侧心脏内可刺激组织，并且将保持与该组织接触。
该配置允许传统的固醇类心脏内起搏电极沿中心轴设置在远端头处。该电极可用作主起搏/感测端头电极，设置在距离本发明的固定机构几毫米处。
对于本发明的相关的另外的详细内容，可采用相关技术领域内的技术人员水平所知的材料和制造技术。关于本发明的基于方法的方面，也可根据通常或逻辑上采用的另外的行动也是可行的。而且，可预期的，可提出并且独立地要求保护所述的本发明的变形形式的任何可任选的特征或本文所述的特征中的任一个或多个的组合。同样，提到单数物件包括可能存在多个相同的物件。更具体地，如本文及所附权利要求中所用，单数形式“一个”和“所述”以及“该”包括复数形式，除非文中清楚另外说明。还应注意，权利要求可撰写以排除任何可任选元件。这样，该说明旨在用作与权利要求元件的引用一起使用这样的排除性术语，例如“唯一”、“仅”等，或使用“否定”限定的前提基础。除非本文中另外限定，本文中使用的全部技术和科技术语都具有与本发明所述领域的普通技术人员通常理解的相同的意思。本发明的范围不由本说明书限定，而是仅由采用的权利要求术语的普通意思限定。

Claims (22)

1.一种无导线心脏起搏器，包括：
密封壳体；
起搏电极，布置在壳体的远侧部分上；
电子封装部，布置在壳体中，该电子封装部配置为产生起搏信号并将该起搏信号传递到起搏电极；和
固定机构，与起搏电极分开，并且布置在壳体的远侧部分上，该固定机构包括单个盘圈且具有小于或等于密封壳体外直径的直径，并且包括从固定机构的远端到固定机构的近端小于两个旋转圈，其中起搏电极包括圆顶形状，使得电极是防止损伤表面。
2.根据权利要求1所述的起搏器，其中，固定机构包括从固定机构的远端到固定机构的近端小于一个半旋转圈。
3.根据权利要求1所述的起搏器，其中，固定机构包括从固定机构的远端到固定机构的近端小于一又四分之一个旋转圈。
4.根据权利要求1所述的起搏器，其中，起搏电极被通过柔质弹簧附接到壳体，以减小抵靠心脏组织的压缩力。
5.根据权利要求1所述的起搏器，其中，起搏电极被通过硅酮胶附接到壳体，以减小抵靠心脏组织的压缩力。
6.根据权利要求1所述的起搏器，其中，固定机构包括螺旋件。
7.根据权利要求6所述的起搏器，其中，螺旋件旋转小于或等于450度。
8.根据权利要求6所述的起搏器，其中，螺旋件至少部分地围绕起搏电极。
9.根据权利要求1所述的起搏器，其中固定机构包括恒定的直径。
10.根据权利要求1所述的起搏器，其中固定机构具有2.5mm至5mm的直径。
11.根据权利要求1所述的起搏器，其中固定机构包括小于1.8mm的纵向长度。
12.根据权利要求1所述的起搏器，其中壳体的远侧部分具有小于密封壳体外直径的外直径。
13.根据权利要求1所述的起搏器，其中固定机构尺寸确定和配置为使得，该固定机构在完全旋入心脏组织中时不引起患者的心肌穿孔。
14.根据权利要求1所述的起搏器，其中，固定机构包括径向部分和连接部分，该径向部分基本上与壳体的圆周对准，该连接部分将固定机构附接到壳体。
15.根据权利要求14所述的起搏器，其中，径向部分基本上垂直于连接部分。
16.根据权利要求14所述的起搏器，其中，连接部分具有小于患者心脏的心肌层厚度的长度。
17.根据权利要求14所述的起搏器，其中连接部分具有小于或等于1.8mm的长度。
18.根据权利要求14所述的起搏器，其中，固定机构的径向部分配置为位于患者的心脏的心肌层内，并且基本上与患者心脏的心脏内膜层接触。
19.根据权利要求14所述的起搏器，进一步包括倒钩，所述倒钩布置在固定机构的径向部分的内表面上。
20.根据权利要求1所述的起搏器，进一步配置为在收回过程中接收保护套管，所述保护套管具有与密封壳体的外直径基本相同的内直径。
21.根据权利要求1所述的起搏器，其中，所述盘圈具有0.5mm至1.5mm的螺距。
22.根据权利要求1所述的起搏器，其中圆顶形状包括1.5至2.5mm的直径，且从壳体的远侧部分向远侧伸出0.05英寸至0.3英寸。
CN201180061312.8A 2010-12-20 2011-12-20 具有径向固定机构的无导线起搏器 Active CN103328040B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061425064P 2010-12-20 2010-12-20
US61/425,064 2010-12-20
PCT/US2011/066168 WO2012088118A1 (en) 2010-12-20 2011-12-20 Leadless pacemaker with radial fixation mechanism

Publications (2)

Publication Number Publication Date
CN103328040A CN103328040A (zh) 2013-09-25
CN103328040B true CN103328040B (zh) 2016-09-14

Family

ID=46235393

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180061312.8A Active CN103328040B (zh) 2010-12-20 2011-12-20 具有径向固定机构的无导线起搏器

Country Status (5)

Country Link
US (1) US9242102B2 (zh)
EP (1) EP2654889B1 (zh)
JP (1) JP2014501584A (zh)
CN (1) CN103328040B (zh)
WO (1) WO2012088118A1 (zh)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7128073B1 (en) 1998-11-06 2006-10-31 Ev3 Endovascular, Inc. Method and device for left atrial appendage occlusion
US7532933B2 (en) 2004-10-20 2009-05-12 Boston Scientific Scimed, Inc. Leadless cardiac stimulation systems
US7937148B2 (en) 2005-10-14 2011-05-03 Nanostim, Inc. Rate responsive leadless cardiac pacemaker
US7848823B2 (en) 2005-12-09 2010-12-07 Boston Scientific Scimed, Inc. Cardiac stimulation system
US7840281B2 (en) 2006-07-21 2010-11-23 Boston Scientific Scimed, Inc. Delivery of cardiac stimulation devices
US8644934B2 (en) 2006-09-13 2014-02-04 Boston Scientific Scimed Inc. Cardiac stimulation using leadless electrode assemblies
WO2009099550A1 (en) 2008-02-07 2009-08-13 Cardiac Pacemakers, Inc. Wireless tissue electrostimulation
WO2010088687A1 (en) 2009-02-02 2010-08-05 Nanostim, Inc. Leadless cardiac pacemaker with secondary fixation capability
US9060692B2 (en) 2010-10-12 2015-06-23 Pacesetter, Inc. Temperature sensor for a leadless cardiac pacemaker
US10112045B2 (en) 2010-12-29 2018-10-30 Medtronic, Inc. Implantable medical device fixation
US9775982B2 (en) 2010-12-29 2017-10-03 Medtronic, Inc. Implantable medical device fixation
EP2773416B1 (en) 2011-11-04 2019-04-24 Pacesetter, Inc. Leadless cardiac pacemaker with integral battery and redundant welds
US10485435B2 (en) 2012-03-26 2019-11-26 Medtronic, Inc. Pass-through implantable medical device delivery catheter with removeable distal tip
WO2014022661A1 (en) 2012-08-01 2014-02-06 Nanostim, Inc. Biostimulator circuit with flying cell
WO2014031752A1 (en) 2012-08-21 2014-02-27 Nanostim, Inc. X-ray identification for active implantable medical device
US9358387B2 (en) * 2013-04-09 2016-06-07 Biotronik Se & Co Kg Leadless pacemaker
US9333342B2 (en) 2013-07-22 2016-05-10 Cardiac Pacemakers, Inc. System and methods for chronic fixation of medical devices
US10071243B2 (en) 2013-07-31 2018-09-11 Medtronic, Inc. Fixation for implantable medical devices
US10842993B2 (en) 2013-08-16 2020-11-24 Cardiac Pacemakers, Inc. Leadless cardiac pacing devices
US9480850B2 (en) 2013-08-16 2016-11-01 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker and retrieval device
US9492674B2 (en) 2013-08-16 2016-11-15 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker with delivery and/or retrieval features
BR112016003148B1 (pt) 2013-08-16 2021-01-12 Cardiac Pacemakers, Inc. dispositivos de estimulação cardíaca sem derivação
US10265503B2 (en) 2013-08-16 2019-04-23 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
US10722723B2 (en) 2013-08-16 2020-07-28 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
US9393427B2 (en) 2013-08-16 2016-07-19 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker with delivery and/or retrieval features
WO2015023474A1 (en) 2013-08-16 2015-02-19 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker and retrieval device
CN105473178B (zh) 2013-08-20 2017-08-29 心脏起搏器股份公司 用于可植入装置的固定机构组件和方法
JP6295327B2 (ja) * 2013-08-23 2018-03-14 カーディアック ペースメイカーズ， インコーポレイテッド リードレス植込み型医療装置及び方法
US9433368B2 (en) 2013-08-23 2016-09-06 Cardiac Pacemakers, Inc. Leadless pacemaker with tripolar electrode
AU2015204693B2 (en) 2014-01-10 2017-03-23 Cardiac Pacemakers, Inc. Methods and systems for improved communication between medical devices
CN106068141B (zh) 2014-01-10 2019-05-14 心脏起搏器股份公司 用于检测心脏心律失常的系统和方法
US9795781B2 (en) 2014-04-29 2017-10-24 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker with retrieval features
WO2015168153A1 (en) 2014-04-29 2015-11-05 Cardiac Pacemakers, Inc. Leadless cardiac pacing devices including tissue engagement verification
FR3022790A1 (fr) * 2014-06-25 2016-01-01 Sorin Crm Sas Capsule implantable a fixation par vissage, notamment capsule autonome de stimulation cardiaque
US10390720B2 (en) 2014-07-17 2019-08-27 Medtronic, Inc. Leadless pacing system including sensing extension
US9399140B2 (en) 2014-07-25 2016-07-26 Medtronic, Inc. Atrial contraction detection by a ventricular leadless pacing device for atrio-synchronous ventricular pacing
US9526909B2 (en) 2014-08-28 2016-12-27 Cardiac Pacemakers, Inc. Medical device with triggered blanking period
WO2016065058A1 (en) 2014-10-22 2016-04-28 Cardiac Pacemakers, Inc. Delivery devices for leadless cardiac devices
US11278720B2 (en) 2014-10-22 2022-03-22 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
US9724519B2 (en) 2014-11-11 2017-08-08 Medtronic, Inc. Ventricular leadless pacing device mode switching
US9492668B2 (en) 2014-11-11 2016-11-15 Medtronic, Inc. Mode switching by a ventricular leadless pacing device
US9492669B2 (en) 2014-11-11 2016-11-15 Medtronic, Inc. Mode switching by a ventricular leadless pacing device
US9623234B2 (en) 2014-11-11 2017-04-18 Medtronic, Inc. Leadless pacing device implantation
US9289612B1 (en) 2014-12-11 2016-03-22 Medtronic Inc. Coordination of ventricular pacing in a leadless pacing system
CN107206242B (zh) 2015-02-06 2020-10-30 心脏起搏器股份公司 用于电刺激治疗的安全递送的系统和方法
US9669230B2 (en) 2015-02-06 2017-06-06 Cardiac Pacemakers, Inc. Systems and methods for treating cardiac arrhythmias
WO2016130477A2 (en) 2015-02-09 2016-08-18 Cardiac Pacemakers, Inc. Implantable medical device with radiopaque id tag
US11285326B2 (en) 2015-03-04 2022-03-29 Cardiac Pacemakers, Inc. Systems and methods for treating cardiac arrhythmias
US10050700B2 (en) 2015-03-18 2018-08-14 Cardiac Pacemakers, Inc. Communications in a medical device system with temporal optimization
US10213610B2 (en) 2015-03-18 2019-02-26 Cardiac Pacemakers, Inc. Communications in a medical device system with link quality assessment
WO2017031347A1 (en) 2015-08-20 2017-02-23 Cardiac Pacemakers, Inc. Systems and methods for communication between medical devices
CN107921268B (zh) * 2015-08-20 2021-01-22 心脏起搏器股份公司 具有改进表面纹理的可植入医疗装置
WO2017031221A1 (en) 2015-08-20 2017-02-23 Cardiac Pacemakers, Inc. Systems and methods for communication between medical devices
US9956414B2 (en) 2015-08-27 2018-05-01 Cardiac Pacemakers, Inc. Temporal configuration of a motion sensor in an implantable medical device
US9968787B2 (en) 2015-08-27 2018-05-15 Cardiac Pacemakers, Inc. Spatial configuration of a motion sensor in an implantable medical device
US10226631B2 (en) 2015-08-28 2019-03-12 Cardiac Pacemakers, Inc. Systems and methods for infarct detection
EP3341076B1 (en) 2015-08-28 2022-05-11 Cardiac Pacemakers, Inc. Systems and methods for behaviorally responsive signal detection and therapy delivery
US10159842B2 (en) 2015-08-28 2018-12-25 Cardiac Pacemakers, Inc. System and method for detecting tamponade
US10092760B2 (en) 2015-09-11 2018-10-09 Cardiac Pacemakers, Inc. Arrhythmia detection and confirmation
WO2017062806A1 (en) 2015-10-08 2017-04-13 Cardiac Pacemakers, Inc. Devices and methods for adjusting pacing rates in an implantable medical device
EP3173126B1 (fr) * 2015-11-27 2020-03-25 Sorin CRM SAS Capsule implantable, notamment capsule autonome de stimulation cardiaque, et son procede d'assemblage
WO2017106693A1 (en) 2015-12-17 2017-06-22 Cardiac Pacemakers, Inc. Conducted communication in a medical device system
US10905886B2 (en) 2015-12-28 2021-02-02 Cardiac Pacemakers, Inc. Implantable medical device for deployment across the atrioventricular septum
WO2017127548A1 (en) 2016-01-19 2017-07-27 Cardiac Pacemakers, Inc. Devices for wirelessly recharging a rechargeable battery of an implantable medical device
US10099050B2 (en) 2016-01-21 2018-10-16 Medtronic, Inc. Interventional medical devices, device systems, and fixation components thereof
US10463853B2 (en) 2016-01-21 2019-11-05 Medtronic, Inc. Interventional medical systems
WO2017136548A1 (en) * 2016-02-04 2017-08-10 Cardiac Pacemakers, Inc. Delivery system with force sensor for leadless cardiac device
EP3436142A1 (en) 2016-03-31 2019-02-06 Cardiac Pacemakers, Inc. Implantable medical device with rechargeable battery
US10668294B2 (en) 2016-05-10 2020-06-02 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker configured for over the wire delivery
US10328272B2 (en) 2016-05-10 2019-06-25 Cardiac Pacemakers, Inc. Retrievability for implantable medical devices
DE102016110697A1 (de) * 2016-06-10 2017-12-14 Biotronik Se & Co. Kg Einführkatheter und Implantatsystem
WO2018005373A1 (en) 2016-06-27 2018-01-04 Cardiac Pacemakers, Inc. Cardiac therapy system using subcutaneously sensed p-waves for resynchronization pacing management
US11207527B2 (en) 2016-07-06 2021-12-28 Cardiac Pacemakers, Inc. Method and system for determining an atrial contraction timing fiducial in a leadless cardiac pacemaker system
WO2018009392A1 (en) 2016-07-07 2018-01-11 Cardiac Pacemakers, Inc. Leadless pacemaker using pressure measurements for pacing capture verification
CN109475743B (zh) 2016-07-20 2022-09-02 心脏起搏器股份公司 在无引线心脏起搏器系统中利用心房收缩定时基准的系统
EP3500342B1 (en) 2016-08-19 2020-05-13 Cardiac Pacemakers, Inc. Trans-septal implantable medical device
US10870008B2 (en) 2016-08-24 2020-12-22 Cardiac Pacemakers, Inc. Cardiac resynchronization using fusion promotion for timing management
CN109640809B (zh) 2016-08-24 2021-08-17 心脏起搏器股份公司 使用p波到起搏定时的集成式多装置心脏再同步治疗
EP3292884B1 (en) 2016-09-12 2019-09-04 BIOTRONIK SE & Co. KG Modified implantation tool tip configuration for the improved installation of leadless pacemakers with short tine-based anchors
US10518095B2 (en) 2016-09-12 2019-12-31 Pacesetter, Inc. System for repeated delivery of implantable devices
WO2018057626A1 (en) 2016-09-21 2018-03-29 Cardiac Pacemakers, Inc. Implantable cardiac monitor
US10758737B2 (en) 2016-09-21 2020-09-01 Cardiac Pacemakers, Inc. Using sensor data from an intracardially implanted medical device to influence operation of an extracardially implantable cardioverter
WO2018057318A1 (en) 2016-09-21 2018-03-29 Cardiac Pacemakers, Inc. Leadless stimulation device with a housing that houses internal components of the leadless stimulation device and functions as the battery case and a terminal of an internal battery
US10413733B2 (en) 2016-10-27 2019-09-17 Cardiac Pacemakers, Inc. Implantable medical device with gyroscope
AU2017350759B2 (en) 2016-10-27 2019-10-17 Cardiac Pacemakers, Inc. Implantable medical device with pressure sensor
WO2018081225A1 (en) 2016-10-27 2018-05-03 Cardiac Pacemakers, Inc. Implantable medical device delivery system with integrated sensor
WO2018081133A1 (en) 2016-10-27 2018-05-03 Cardiac Pacemakers, Inc. Implantable medical device having a sense channel with performance adjustment
CN109890457B (zh) 2016-10-27 2023-07-04 心脏起搏器股份公司 单独的设备在管理心脏起搏器的起搏脉冲能量时的使用
US10463305B2 (en) 2016-10-27 2019-11-05 Cardiac Pacemakers, Inc. Multi-device cardiac resynchronization therapy with timing enhancements
US10617874B2 (en) 2016-10-31 2020-04-14 Cardiac Pacemakers, Inc. Systems and methods for activity level pacing
US10434317B2 (en) 2016-10-31 2019-10-08 Cardiac Pacemakers, Inc. Systems and methods for activity level pacing
WO2018089311A1 (en) 2016-11-08 2018-05-17 Cardiac Pacemakers, Inc Implantable medical device for atrial deployment
EP3538213B1 (en) 2016-11-09 2023-04-12 Cardiac Pacemakers, Inc. Systems and devices for setting cardiac pacing pulse parameters for a cardiac pacing device
WO2018094193A1 (en) 2016-11-21 2018-05-24 Cardiac Pacemakers, Inc. Delivery devices and wall apposition sensing
US10881869B2 (en) 2016-11-21 2021-01-05 Cardiac Pacemakers, Inc. Wireless re-charge of an implantable medical device
US10639486B2 (en) 2016-11-21 2020-05-05 Cardiac Pacemakers, Inc. Implantable medical device with recharge coil
WO2018094344A2 (en) 2016-11-21 2018-05-24 Cardiac Pacemakers, Inc Leadless cardiac pacemaker with multimode communication
EP3541472B1 (en) 2016-11-21 2023-06-07 Cardiac Pacemakers, Inc. Implantable medical device with a magnetically permeable housing and an inductive coil disposed about the housing
US11198013B2 (en) 2016-11-21 2021-12-14 Cardiac Pacemakers, Inc. Catheter and leadless cardiac devices including electrical pathway barrier
CN109982746B (zh) 2016-11-21 2023-04-04 心脏起搏器股份公司 提供心脏再同步治疗的无引线心脏起搏器
US10806931B2 (en) 2016-12-27 2020-10-20 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
US10485981B2 (en) 2016-12-27 2019-11-26 Cardiac Pacemakers, Inc. Fixation methods for leadless cardiac devices
WO2018125791A1 (en) 2016-12-27 2018-07-05 Cardiac Pacemakers, Inc. Leadless delivery catheter with conductive pathway
WO2018136203A1 (en) 2016-12-27 2018-07-26 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
US11207532B2 (en) 2017-01-04 2021-12-28 Cardiac Pacemakers, Inc. Dynamic sensing updates using postural input in a multiple device cardiac rhythm management system
AU2018213326B2 (en) 2017-01-26 2020-09-10 Cardiac Pacemakers, Inc. Intra-body device communication with redundant message transmission
CN110198759B (zh) 2017-01-26 2023-08-11 心脏起搏器股份公司 具有可拆卸固定件的无引线可植入装置
AU2018211925B2 (en) 2017-01-26 2020-02-27 Cardiac Pacemakers, Inc. Delivery devices for leadless cardiac devices
CN110234392B (zh) 2017-01-26 2023-08-11 心脏起搏器股份公司 具有被包覆模制的组件的无引线装置
EP3592418B1 (en) 2017-03-10 2023-08-23 Cardiac Pacemakers, Inc. Fixation for leadless cardiac devices
US10737092B2 (en) 2017-03-30 2020-08-11 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
CN110740779B (zh) 2017-04-03 2024-03-08 心脏起搏器股份公司 具有基于感测到的心率的起搏脉冲能量调节的心脏起搏器
US10905872B2 (en) 2017-04-03 2021-02-02 Cardiac Pacemakers, Inc. Implantable medical device with a movable electrode biased toward an extended position
CN107233665B (zh) * 2017-08-01 2024-08-06 郭成军 心腔内植入物
US11577085B2 (en) 2017-08-03 2023-02-14 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
CN111032148B (zh) 2017-08-18 2024-04-02 心脏起搏器股份公司 具有压力传感器的可植入医疗设备
WO2019036568A1 (en) 2017-08-18 2019-02-21 Cardiac Pacemakers, Inc. IMPLANTABLE MEDICAL DEVICE COMPRISING A FLOW CONCENTRATOR AND A RECEPTION COIL PROVIDED AROUND THE FLOW CONCENTRATOR
EP3456377B1 (en) * 2017-09-14 2023-04-26 Sorin CRM SAS Attachment means for implantable cardiac device
US11426578B2 (en) * 2017-09-15 2022-08-30 Medtronic, Inc. Electrodes for intra-cardiac pacemaker
CN111107899B (zh) 2017-09-20 2024-04-02 心脏起搏器股份公司 具有多种操作模式的可植入医疗装置
CN107583187B (zh) 2017-09-25 2020-04-10 创领心律管理医疗器械（上海）有限公司 无导线起搏器系统及其使用方法
EP3950053B1 (en) 2017-11-06 2023-06-21 Pacesetter, Inc. Biostimulator having fixation element
US11185703B2 (en) 2017-11-07 2021-11-30 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker for bundle of his pacing
US11813463B2 (en) 2017-12-01 2023-11-14 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker with reversionary behavior
WO2019108482A1 (en) 2017-12-01 2019-06-06 Cardiac Pacemakers, Inc. Methods and systems for detecting atrial contraction timing fiducials and determining a cardiac interval from a ventricularly implanted leadless cardiac pacemaker
US11052258B2 (en) 2017-12-01 2021-07-06 Cardiac Pacemakers, Inc. Methods and systems for detecting atrial contraction timing fiducials within a search window from a ventricularly implanted leadless cardiac pacemaker
WO2019108545A1 (en) 2017-12-01 2019-06-06 Cardiac Pacemakers, Inc. Methods and systems for detecting atrial contraction timing fiducials during ventricular filling from a ventricularly implanted leadless cardiac pacemaker
US11529523B2 (en) 2018-01-04 2022-12-20 Cardiac Pacemakers, Inc. Handheld bridge device for providing a communication bridge between an implanted medical device and a smartphone
WO2019136148A1 (en) 2018-01-04 2019-07-11 Cardiac Pacemakers, Inc. Dual chamber pacing without beat-to-beat communication
CN111902187A (zh) 2018-03-23 2020-11-06 美敦力公司 Vfa心脏再同步治疗
JP2021518208A (ja) 2018-03-23 2021-08-02 メドトロニック，インコーポレイテッド ＡＶ同期ＶｆＡ心臓治療
EP3768160B1 (en) 2018-03-23 2023-06-07 Medtronic, Inc. Vfa cardiac therapy for tachycardia
EP3549620A1 (en) * 2018-04-04 2019-10-09 BIOTRONIK SE & Co. KG Coated implantable medical device and coating method
CN108310652B (zh) 2018-04-10 2021-09-28 创领心律管理医疗器械（上海）有限公司 心脏植入装置及起搏系统
US11577086B2 (en) 2018-08-20 2023-02-14 Pacesetter, Inc. Fixation mechanisms for a leadless cardiac biostimulator
CN110870948B (zh) * 2018-08-31 2021-11-05 创领心律管理医疗器械（上海）有限公司 输送装置、心脏起搏装置及其固定结构
US11235161B2 (en) 2018-09-26 2022-02-01 Medtronic, Inc. Capture in ventricle-from-atrium cardiac therapy
US11648397B1 (en) 2018-10-12 2023-05-16 Vincent Gaudiani Transcoronary sinus pacing of posteroseptal left ventricular base
US11951313B2 (en) 2018-11-17 2024-04-09 Medtronic, Inc. VFA delivery systems and methods
CN109568793B (zh) * 2018-12-25 2023-08-04 创领心律管理医疗器械（上海）有限公司 无导线起搏器及无导线起搏系统
CN109498983B (zh) * 2018-12-29 2024-01-23 创领心律管理医疗器械（上海）有限公司 无导线起搏器
US11679265B2 (en) 2019-02-14 2023-06-20 Medtronic, Inc. Lead-in-lead systems and methods for cardiac therapy
USD894396S1 (en) 2019-03-08 2020-08-25 Pacesetter, Inc. Leadless biostimulator attachment feature
US11541243B2 (en) * 2019-03-15 2023-01-03 Pacesetter, Inc. Biostimulator having coaxial fixation elements
CN113631220A (zh) 2019-03-22 2021-11-09 先导者股份有限公司 利用温度传感器的速率调节心脏治疗系统
US11759632B2 (en) 2019-03-28 2023-09-19 Medtronic, Inc. Fixation components for implantable medical devices
WO2020205401A1 (en) 2019-03-29 2020-10-08 Cardiac Pacemakers, Inc. Systems and methods for treating cardiac arrhythmias
US11697025B2 (en) 2019-03-29 2023-07-11 Medtronic, Inc. Cardiac conduction system capture
US11446510B2 (en) 2019-03-29 2022-09-20 Cardiac Pacemakers, Inc. Systems and methods for treating cardiac arrhythmias
US11213676B2 (en) 2019-04-01 2022-01-04 Medtronic, Inc. Delivery systems for VfA cardiac therapy
EP3730186B1 (en) * 2019-04-24 2023-11-29 BIOTRONIK SE & Co. KG Leadless cardiac pacemaker device configured to provide his bundle pacing
US11504528B2 (en) * 2019-05-03 2022-11-22 Pacesetter, Inc. Biostimulator transport system having weldless bearing retainer
US11712188B2 (en) 2019-05-07 2023-08-01 Medtronic, Inc. Posterior left bundle branch engagement
US11541232B2 (en) 2019-06-18 2023-01-03 Medtronic, Inc. Electrode configuration for a medical device
US11305127B2 (en) 2019-08-26 2022-04-19 Medtronic Inc. VfA delivery and implant region detection
US11571582B2 (en) 2019-09-11 2023-02-07 Cardiac Pacemakers, Inc. Tools and systems for implanting and/or retrieving a leadless cardiac pacing device with helix fixation
JP7478811B2 (ja) 2019-09-11 2024-05-07 カーディアック ペースメイカーズ， インコーポレイテッド 螺旋固定を用いてリードレス心臓ペーシング装置の植込みおよび／または回収を行う器具およびシステム
US11813466B2 (en) 2020-01-27 2023-11-14 Medtronic, Inc. Atrioventricular nodal stimulation
CN115151965B (zh) * 2020-03-11 2024-04-30 国立大学法人大阪大学 导管-模拟器以及导管-模拟器用的心脏模型
US11911168B2 (en) 2020-04-03 2024-02-27 Medtronic, Inc. Cardiac conduction system therapy benefit determination
CN111420274A (zh) * 2020-04-03 2020-07-17 复旦大学附属中山医院 一种固定装置及其起搏电极导线
US11813464B2 (en) 2020-07-31 2023-11-14 Medtronic, Inc. Cardiac conduction system evaluation
CN112675431B (zh) * 2020-12-25 2023-08-25 创领心律管理医疗器械（上海）有限公司 无导线起搏器、头端部件及尾端部件
WO2022152585A1 (en) 2021-01-15 2022-07-21 Biotronik Se & Co. Kg Implantable medical device
WO2022152586A1 (en) 2021-01-15 2022-07-21 Biotronik Se & Co. Kg Implantable medical device
WO2022152587A1 (en) 2021-01-15 2022-07-21 Biotronik Se & Co. Kg Medical implant, particularly in form of an implantable intracardiac pacemaker, comprising a rotatable anchoring device to allow extraction of the encapsulated medical implant
CN115591121A (zh) * 2021-06-28 2023-01-13 创领心律管理医疗器械（上海）有限公司（Cn） 起搏系统及其固定装置
CN216456543U (zh) * 2021-10-08 2022-05-10 中国医学科学院阜外医院 一种无导线左束支起搏器
US20240335667A1 (en) * 2023-04-05 2024-10-10 Cardiac Pacemakers, Inc. Edm manufacture of medical lead fixation helix
CN117504137B (zh) * 2024-01-05 2024-03-12 山东瑞安泰医疗技术有限公司 一种心脏起搏器固定装置及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3300050A1 (de) * 1983-01-03 1984-07-05 Siemens AG, 1000 Berlin und 8000 München Intravenoese herzschrittmacherelektrode
US4649938A (en) * 1985-04-29 1987-03-17 Mcarthur William A Tissue-stimulating electrode having sealed, low-friction extendable/retractable active fixation means

Family Cites Families (515)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3199508A (en) 1962-04-25 1965-08-10 W R Medical Electronies Co Coding of physiological signals
BE632412A (zh) 1962-05-17
US3218638A (en) 1962-05-29 1965-11-16 William M Honig Wireless passive biological telemetry system
US3212496A (en) 1962-08-21 1965-10-19 United Aircraft Corp Molecular physiological monitoring system
US3478746A (en) 1965-05-12 1969-11-18 Medtronic Inc Cardiac implantable demand pacemaker
US3603881A (en) 1968-03-01 1971-09-07 Del Mar Eng Lab Frequency shift telemetry system with both radio and wire transmission paths
US3836798A (en) 1970-05-11 1974-09-17 Greatbatch W Ltd Device for converting nuclear energy into electrical energy
US3835864A (en) 1970-09-21 1974-09-17 Rasor Ass Inc Intra-cardiac stimulator
USRE30366E (en) 1970-09-21 1980-08-12 Rasor Associates, Inc. Organ stimulator
US3757778A (en) 1971-01-13 1973-09-11 Comprehensive Health Testing L Electrocardiograph lead distribution and contact testing apparatus
US3727616A (en) 1971-06-15 1973-04-17 Gen Dynamics Corp Electronic system for the stimulation of biological systems
GB1434524A (en) 1972-04-27 1976-05-05 Nat Res Dev Urinary control apparatus
US3946744A (en) 1972-05-30 1976-03-30 Medalert Corporation Electrocardiography signal transmission-reception method including method of measuring pacemaker signal frequency
US3823708A (en) 1972-06-08 1974-07-16 Cardiodynamics Tachycardia detector
US3830228A (en) 1972-06-12 1974-08-20 M Foner Biophysiological information processing device
GB1443705A (en) 1972-12-15 1976-07-21 Int Research & Dev Co Ltd Rock drills
US3872251A (en) 1973-02-20 1975-03-18 Medalert Corp Electrocardiography transmitter and transmission method
US3943926A (en) 1974-04-10 1976-03-16 Oscar Arvizu Barragan Wholly disposable dental type syringe
US3905364A (en) 1974-04-17 1975-09-16 Marquette Electronics Inc Artifact detector
US4146029A (en) 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US3952750A (en) 1974-04-25 1976-04-27 Mieczyslaw Mirowski Command atrial cardioverting device
US4318412A (en) 1974-08-05 1982-03-09 Gilbert P. Hyatt Arrangement for cardiac electrode implementation
IL45786A (en) 1974-10-04 1977-08-31 Yeda Res & Dev Heart beat detector
US4151513A (en) 1975-03-06 1979-04-24 Medtronic, Inc. Apparatus for sensing and transmitting a pacemaker's stimulating pulse
US4072154A (en) 1976-05-28 1978-02-07 Cardiac Pacemakers, Inc. Sealing arrangement for heart pacer electrode leads
US4083366A (en) 1976-06-16 1978-04-11 Peter P. Gombrich Heart beat rate monitor
US4102344A (en) 1976-11-15 1978-07-25 Mentor Corporation Stimulator apparatus for internal body organ
US4256115A (en) 1976-12-20 1981-03-17 American Technology, Inc. Leadless cardiac pacer
US4173221A (en) 1977-04-15 1979-11-06 Wallace Rogozinski EKG cable monitoring system
US4152540A (en) 1977-05-03 1979-05-01 American Pacemaker Corporation Feedthrough connector for implantable cardiac pacer
US4187854A (en) 1977-10-17 1980-02-12 Medtronic, Inc. Implantable demand pacemaker and monitor
US4151540A (en) 1977-12-08 1979-04-24 Fairchild Camera And Instrument Corporation High beta, high frequency transistor structure
DE2755643A1 (de) 1977-12-14 1979-06-21 Zeiss Carl Fa Verfahren und anordnung zur elektronischen langzeit-herzueberwachung
FR2419720A1 (fr) 1978-03-14 1979-10-12 Cardiofrance Co Stimulateur cardiaque implantable a fonctions therapeutique et diagnostique
US4210149A (en) 1978-04-17 1980-07-01 Mieczyslaw Mirowski Implantable cardioverter with patient communication
US4223678A (en) 1978-05-03 1980-09-23 Mieczyslaw Mirowski Arrhythmia recorder for use with an implantable defibrillator
US4350169A (en) 1979-01-05 1982-09-21 Medtronic, Inc. Flexible tip stiffening stylet for use with body implantable lead
US4481950A (en) 1979-04-27 1984-11-13 Medtronic, Inc. Acoustic signalling apparatus for implantable devices
US4296756A (en) 1979-07-26 1981-10-27 Cyber Diagnostics, Inc. Remote pulmonary function tester
US4440173A (en) 1979-11-08 1984-04-03 Medtronic Programmable body stimulation system
US4310000A (en) 1980-01-23 1982-01-12 Medtronic, Inc. Implantable pulse generator having separate passive sensing reference electrode
US4336810A (en) 1980-09-30 1982-06-29 Del Mar Avionics Method and apparatus for arrhythmia analysis of ECG recordings
US4374382A (en) 1981-01-16 1983-02-15 Medtronic, Inc. Marker channel telemetry system for a medical device
US4406288A (en) 1981-04-06 1983-09-27 Hugh P. Cash Bladder control device and method
US4522208A (en) 1981-04-16 1985-06-11 Cardiofrance Compagnie Francaise D'electrocardiologie Method for determining parameter values of an implanted programmable pacemaker
US4612934A (en) 1981-06-30 1986-09-23 Borkan William N Non-invasive multiprogrammable tissue stimulator
US4793353A (en) 1981-06-30 1988-12-27 Borkan William N Non-invasive multiprogrammable tissue stimulator and method
DE3130104A1 (de) 1981-07-30 1983-02-17 Messerschmitt-Bölkow-Blohm GmbH, 8000 München Anordnung zur stimulation eines menschlichen muskels
US4428378A (en) 1981-11-19 1984-01-31 Medtronic, Inc. Rate adaptive pacer
US4424551B1 (en) 1982-01-25 1991-06-11 Highly-reliable feed through/filter capacitor and method for making same
US4411271A (en) 1982-02-10 1983-10-25 Medtronic, Inc. Body tissue depolarization evaluation system
US4458692A (en) 1982-02-11 1984-07-10 Arrhythmia Research Technology, Inc. System and method for predicting ventricular tachycardia with a gain controlled high pass filter
EP0108052A4 (en) 1982-04-23 1985-09-26 Survival Technology PORTABLE CONTROL UNIT WITH REAL-TIME ANALYSIS AND TRANSMISSION VIA TELEPHONE.
US4453162A (en) 1982-05-10 1984-06-05 Telectronics Pty. Ltd. Efficient and fast-switching telemetry transmitter
US4995390A (en) 1982-05-19 1991-02-26 Purdue Research Foundation Exercise responsive cardiac pacemaker
US4442840A (en) 1982-06-07 1984-04-17 Wojciechowicz Jr Alexander Electrical connector apparatus and method for a temporary cardiac pacing wire
DE3232478C1 (de) 1982-09-01 1984-03-01 Werner Prof. Dr.-Ing. 6301 Wettenberg Irnich Synchronisierbarer Herzschrittmacher
US4550370A (en) 1982-10-29 1985-10-29 Medtronic, Inc. Pacemaker programmer with telemetric functions
US4513743A (en) 1982-11-12 1985-04-30 Vitatron Medical B.V. Physiological devices such as pacemakers and method for providing histogram data
US4681117A (en) 1983-02-15 1987-07-21 Brodman Richard F Intracardiac catheter and a method for detecting myocardial ischemia
US4552127A (en) 1983-04-01 1985-11-12 Peter Schiff Percutaneous intra-aortic balloon having an EKG electrode and a twisting stylet for coupling the EKG electrode to monitoring and/or pacing instrumentation external to the body
US4543955A (en) 1983-08-01 1985-10-01 Cordis Corporation System for controlling body implantable action device
US4562846A (en) 1983-09-15 1986-01-07 Duke University System and process for monitoring myocardial integrity
US4875483A (en) 1983-10-17 1989-10-24 Telectronics, N.V. Implantable cardiac pacer with programmable antitachycardia mechanisms
JPS60134543A (ja) 1983-12-22 1985-07-17 Sharp Corp 非接触型デ−タ転送方式
US4552154A (en) 1984-03-12 1985-11-12 Medtronic, Inc. Waveform morphology discriminator and method
US4586508A (en) 1984-03-23 1986-05-06 Cordis Corporation Implant communication system with patient coil
US4607639A (en) 1984-05-18 1986-08-26 Regents Of The University Of California Method and system for controlling bladder evacuation
US4606352A (en) 1984-07-13 1986-08-19 Purdue Research Foundation Personal electrocardiogram monitor
US4802481A (en) 1984-07-19 1989-02-07 Cordis Leads, Inc. Apparatus for controlling pacing of a heart in response to changes in stroke volume
US4679144A (en) 1984-08-21 1987-07-07 Q-Med, Inc. Cardiac signal real time monitor and method of analysis
US4681111A (en) 1985-04-05 1987-07-21 Siemens-Pacesetter, Inc. Analog and digital telemetry system for an implantable device
US4625730A (en) 1985-04-09 1986-12-02 The Johns Hopkins University Patient ECG recording control for an automatic implantable defibrillator
US4706682A (en) * 1985-08-21 1987-11-17 Minnesota Mining And Manufacturing Company External ear canal electrode to be placed proximate the tympanic membrane
US4702253A (en) 1985-10-15 1987-10-27 Telectronics N.V. Metabolic-demand pacemaker and method of using the same to determine minute volume
US4905708A (en) 1985-10-31 1990-03-06 Davies David W Apparatus for recognizing cardiac rhythms
DE3541598A1 (de) 1985-11-25 1987-11-19 Alt Eckhard Belastungsabhaengig frequenzvariabler herzschrittmacher
EP0236562B2 (en) 1985-12-11 2006-06-07 Telectronics N.V. Apparatus for cardiac pacing with detection of cardiac evoked potentials
US4860750A (en) 1986-04-17 1989-08-29 Intermedics Inc. Sidelock pacer lead connector
US4722342A (en) 1986-06-16 1988-02-02 Siemens Aktiengesellschaft Cardiac pacer for pacing a human heart and pacing method
EP0249822B1 (de) 1986-06-16 1991-10-16 Siemens Aktiengesellschaft Frequenzgesteuerter Herzschrittmacher
US4830006B1 (en) 1986-06-17 1997-10-28 Intermedics Inc Implantable cardiac stimulator for detection and treatment of ventricular arrhythmias
DE3631155A1 (de) 1986-09-12 1988-03-24 Alt Eckhard Frequenzvariabler herzschrittmacher mit belastungsadaequatem frequenzverhalten
DE3783854D1 (de) 1986-09-30 1993-03-11 Siemens Ag Aktivitaetssensor fuer einen herzschrittmacher.
US4794532A (en) 1986-11-10 1988-12-27 Hewlett-Packard Company Virtual arrhythmia system
IT1214738B (it) 1986-11-11 1990-01-18 Sbm Soc Brevetti Medicina Perfezionamento negli impianti di stimolazione cardiaca mediante pacemaker
DE3887134T2 (de) 1987-01-29 1997-07-10 P A & M Spa Zur zeitweiligen herzreizung von aussen mit einem radiofrequenzherzempfänger versehene und für dauernde reizung vorbereitete epikardische elektrode.
DE3709073A1 (de) 1987-03-19 1988-09-29 Alt Eckhard Implantierbares medizinisches geraet
US4827940A (en) 1987-04-13 1989-05-09 Cardiac Pacemakers, Inc. Soluble covering for cardiac pacing electrode
US4750495A (en) 1987-06-05 1988-06-14 Medtronic, Inc. Oxygen sensing pacemaker
US4903701A (en) 1987-06-05 1990-02-27 Medtronic, Inc. Oxygen sensing pacemaker
US4787389A (en) 1987-07-16 1988-11-29 Tnc Medical Devices Pte. Ltd. Using an implantable antitachycardia defibrillator circuit
US4791931A (en) 1987-08-13 1988-12-20 Pacesetter Infusion, Ltd. Demand pacemaker using an artificial baroreceptor reflex
US4809697A (en) 1987-10-14 1989-03-07 Siemens-Pacesetter, Inc. Interactive programming and diagnostic system for use with implantable pacemaker
US4883064A (en) 1987-11-19 1989-11-28 Equimed Corporation Method and system for gathering electrocardiographic data
US4886064A (en) 1987-11-25 1989-12-12 Siemens Aktiengesellschaft Body activity controlled heart pacer
US4880004A (en) 1988-06-07 1989-11-14 Intermedics, Inc. Implantable cardiac stimulator with automatic gain control and bandpass filtering in feedback loop
US4844076A (en) 1988-08-26 1989-07-04 The Johns Hopkins University Ingestible size continuously transmitting temperature monitoring pill
DE3831809A1 (de) 1988-09-19 1990-03-22 Funke Hermann Zur mindestens teilweisen implantation im lebenden koerper bestimmtes geraet
US5040534A (en) 1989-01-25 1991-08-20 Siemens-Pacesetter, Inc. Microprocessor controlled rate-responsive pacemaker having automatic rate response threshold adjustment
US5014701A (en) 1989-05-19 1991-05-14 Ventritex, Inc. Implantable cardiac defibrillator employing a digital waveform analyzer system
US5111816A (en) 1989-05-23 1992-05-12 Ventritex System configuration for combined defibrillator/pacemaker
US4987897A (en) 1989-09-18 1991-01-29 Medtronic, Inc. Body bus medical device communication system
US5876425A (en) 1989-09-22 1999-03-02 Advanced Bionics Corporation Power control loop for implantable tissue stimulator
US4974589A (en) 1989-10-17 1990-12-04 Siemens-Pacesetter, Inc. Automatically adjustable blanking period for implantable pacemaker
JPH0659319B2 (ja) 1989-11-17 1994-08-10 三洋電機株式会社 ワイヤレス低周波治療器
US5010887A (en) 1989-11-17 1991-04-30 Siemens-Pacesetter, Inc. Noise discrimination in implantable pacemakers
US5235742A (en) 1989-11-20 1993-08-17 Siemens Pacesetter, Inc. Method of making an implantable device
US5088488A (en) 1989-12-22 1992-02-18 Medtronic, Inc. Method and apparatus for implementing histogram storage and trend analysis in a medical stimulator
US5040533A (en) 1989-12-29 1991-08-20 Medical Engineering And Development Institute Incorporated Implantable cardiovascular treatment device container for sensing a physiological parameter
US5042497A (en) 1990-01-30 1991-08-27 Cardiac Pacemakers, Inc. Arrhythmia prediction and prevention for implanted devices
US5040536A (en) 1990-01-31 1991-08-20 Medtronic, Inc. Intravascular pressure posture detector
US5058581A (en) 1990-02-20 1991-10-22 Siemens-Pacesetter, Inc. Telemetry apparatus and method for implantable tissue stimulator
US5284136A (en) 1990-04-04 1994-02-08 Cardiac Pacemakers, Inc. Dual indifferent electrode pacemaker
US5076270A (en) 1990-05-03 1991-12-31 Siemens-Pacesetter, Inc. Apparatus and method for making electrical connections in an implantable pacemaker
US5085224A (en) 1990-05-25 1992-02-04 Hewlett-Packard Company Portable signalling unit for an ekg
DE4019002A1 (de) 1990-06-13 1992-01-02 Siemens Ag Elektrodenanordnung fuer einen defibrillator
JPH0649078B2 (ja) 1990-06-13 1994-06-29 シーメンス アクチエンゲゼルシヤフト プログラマブルで自動式の植え込み可能なカージオバータ／デフィブリレータおよびペースメーカシステム
US5076272A (en) 1990-06-15 1991-12-31 Telectronics Pacing Systems, Inc. Autocontrollable pacemaker with alarm
US5086772A (en) 1990-07-30 1992-02-11 Telectronics Pacing Systems, Inc. Arrhythmia control system employing arrhythmia recognition algorithm
US5252962A (en) 1990-08-03 1993-10-12 Bio Medic Data Systems System monitoring programmable implantable transponder
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
US5065759A (en) 1990-08-30 1991-11-19 Vitatron Medical B.V. Pacemaker with optimized rate responsiveness and method of rate control
US5052399A (en) 1990-09-20 1991-10-01 Cardiac Pacemakers, Inc. Holter function data encoder for implantable device
US5170784A (en) 1990-11-27 1992-12-15 Ceon Ramon Leadless magnetic cardiac pacemaker
US5193550A (en) 1990-11-30 1993-03-16 Medtronic, Inc. Method and apparatus for discriminating among normal and pathological tachyarrhythmias
FR2671010B1 (fr) 1990-12-27 1993-07-09 Ela Medical Sa Sonde endocardiaque munie d'un organe de fixation active.
US5170802A (en) 1991-01-07 1992-12-15 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5179947A (en) 1991-01-15 1993-01-19 Cardiac Pacemakers, Inc. Acceleration-sensitive cardiac pacemaker and method of operation
US5133350A (en) 1991-01-31 1992-07-28 Medtronic, Inc. Mode switching pacemaker
US5135004A (en) 1991-03-12 1992-08-04 Incontrol, Inc. Implantable myocardial ischemia monitor and related method
EP0578748B1 (en) 1991-04-05 1996-05-01 Medtronic, Inc. Subcutaneous multi-electrode sensing system
US5383915A (en) 1991-04-10 1995-01-24 Angeion Corporation Wireless programmer/repeater system for an implanted medical device
US5197978B1 (en) 1991-04-26 1996-05-28 Advanced Coronary Tech Removable heat-recoverable tissue supporting device
US5674259A (en) 1992-10-20 1997-10-07 Gray; Noel Desmond Multi-focal leadless apical cardiac pacemaker
US5217010A (en) 1991-05-28 1993-06-08 The Johns Hopkins University Ecg amplifier and cardiac pacemaker for use during magnetic resonance imaging
US5267150A (en) 1991-08-07 1993-11-30 Medtronic, Inc. Input isolation circuit for computer-controlled medical device
US5304209A (en) 1991-09-24 1994-04-19 Angeion Corporation Remote-control temporary pacemaker
US5184616A (en) 1991-10-21 1993-02-09 Telectronics Pacing Systems, Inc. Apparatus and method for generation of varying waveforms in arrhythmia control system
US5318596A (en) 1991-11-13 1994-06-07 Exonic Corporation Activity sensing pacemaker
US5304206A (en) 1991-11-18 1994-04-19 Cyberonics, Inc. Activation techniques for implantable medical device
US5193540A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5358514A (en) 1991-12-18 1994-10-25 Alfred E. Mann Foundation For Scientific Research Implantable microdevice with self-attaching electrodes
US5193539A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
US5217019A (en) 1991-12-27 1993-06-08 Abbott Laboratories Apparatus and method for continuously monitoring cardiac output
US5313953A (en) 1992-01-14 1994-05-24 Incontrol, Inc. Implantable cardiac patient monitor
GB2264176B (en) 1992-02-14 1995-12-20 George John Dempsey A non-invasive multi-electrocardiographic apparatus and method of assessing acute ischaemic damage
US5565005A (en) 1992-02-20 1996-10-15 Amei Technologies Inc. Implantable growth tissue stimulator and method operation
JPH05245215A (ja) 1992-03-03 1993-09-24 Terumo Corp 心臓ペースメーカ
US5354317A (en) 1992-04-03 1994-10-11 Intermedics, Inc. Apparatus and method for cardiac pacing responsive to patient position
GB9211085D0 (en) 1992-05-23 1992-07-08 Tippey Keith E Electrical stimulation
US5342401A (en) 1992-08-19 1994-08-30 The Regents Of The University Of California Real time cardiac arrhythmia stabilizing system
US5300093A (en) 1992-09-14 1994-04-05 Telectronics Pacing Systems, Inc. Apparatus and method for measuring, formatting and transmitting combined intracardiac impedance data and electrograms
WO1994007564A2 (en) 1992-10-01 1994-04-14 Cardiac Pacemakers, Inc. Stent-type defibrillation electrode structures
US5336244A (en) 1992-10-07 1994-08-09 Medtronic, Inc. Temperature sensor based capture detection for a pacer
SE9203284D0 (sv) 1992-11-04 1992-11-04 Siemens Elema Ab Hjaertstimulator
US5291902A (en) 1993-01-11 1994-03-08 Brent Carman Incontinence treatment
SE9300825D0 (sv) 1993-03-12 1993-03-12 Siemens Elema Ab Anordning foer maetning av elektrisk aktivitet i hjaertat
US5539775A (en) 1993-03-17 1996-07-23 Micron Technology, Inc. Modulated spread spectrum in RF identification systems method
US5406444A (en) 1993-03-29 1995-04-11 Medtronic, Inc. Coated tantalum feedthrough pin
DK0617914T3 (da) 1993-03-31 1999-06-21 Siemens Medical Systems Inc Indretning og fremgangsmåde til afgivelse af dobbelte udgangssignaler i en telemetri-sender
US5333095A (en) 1993-05-03 1994-07-26 Maxwell Laboratories, Inc., Sierra Capacitor Filter Division Feedthrough filter capacitor assembly for human implant
US5383912A (en) 1993-05-05 1995-01-24 Intermedics, Inc. Apparatus for high speed data communication between an external medical device and an implantable medical device
US5404877A (en) 1993-06-04 1995-04-11 Telectronics Pacing Systems, Inc. Leadless implantable sensor assembly and a cardiac emergency warning alarm
US5411532A (en) 1993-06-04 1995-05-02 Pacesetter, Inc. Cardiac pacemaker having integrated pacing lead and oxygen sensor
US5373852A (en) 1993-06-25 1994-12-20 The Regents Of The University Of California Monitoring uterine contractions by radiotelemetric transmission
US5431171A (en) 1993-06-25 1995-07-11 The Regents Of The University Of California Monitoring fetal characteristics by radiotelemetric transmission
DE69432148T2 (de) 1993-07-01 2003-10-16 Boston Scientific Ltd., St. Michael Katheter zur bilddarstellung, zur anzeige elektrischer signale und zur ablation
US5411537A (en) 1993-10-29 1995-05-02 Intermedics, Inc. Rechargeable biomedical battery powered devices with recharging and control system therefor
US5531781A (en) 1993-11-02 1996-07-02 Alferness; Clifton A. Implantable lead having a steering distal guide tip
US5654984A (en) 1993-12-03 1997-08-05 Silicon Systems, Inc. Signal modulation across capacitors
US5413594A (en) 1993-12-09 1995-05-09 Ventritex, Inc. Method and apparatus for interrogating an implanted cardiac device
US5456261A (en) 1993-12-16 1995-10-10 Marquette Electronics, Inc. Cardiac monitoring and diagnostic system
JP2703510B2 (ja) 1993-12-28 1998-01-26 アドヴァンスド カーディオヴァスキュラー システムズ インコーポレーテッド 拡大可能なステント及びその製造方法
US5417222A (en) 1994-01-21 1995-05-23 Hewlett-Packard Company Patient monitoring system
US5446447A (en) 1994-02-16 1995-08-29 Motorola, Inc. RF tagging system including RF tags with variable frequency resonant circuits
US5738102A (en) 1994-03-31 1998-04-14 Lemelson; Jerome H. Patient monitoring system
US5598848A (en) 1994-03-31 1997-02-04 Ep Technologies, Inc. Systems and methods for positioning multiple electrode structures in electrical contact with the myocardium
US5549654A (en) 1994-04-15 1996-08-27 Medtronic, Inc. Interactive interpretation of event markers in body-implantable medical device
US6139510A (en) 1994-05-11 2000-10-31 Target Therapeutics Inc. Super elastic alloy guidewire
US5466246A (en) 1994-07-29 1995-11-14 Pacesetter, Inc. Telemetry receiver for implantable device, incorporating digital signal processing
US5571148A (en) 1994-08-10 1996-11-05 Loeb; Gerald E. Implantable multichannel stimulator
US5579775A (en) 1994-10-20 1996-12-03 Hewlett-Packard Company Dynamic control of a patient monitoring system
US5522876A (en) 1994-10-26 1996-06-04 Vitatron Medical, B.V. Screw-in pacing lead
US5549659A (en) 1994-11-04 1996-08-27 Physio-Control Corporation Communication interface for transmitting and receiving serial data between medical instruments
US5628778A (en) 1994-11-21 1997-05-13 Medtronic Inc. Single pass medical electrical lead
SE9404374D0 (sv) 1994-12-15 1994-12-15 Pacesetter Ab Magnetfältsdetektor
US5591217A (en) 1995-01-04 1997-01-07 Plexus, Inc. Implantable stimulator with replenishable, high value capacitive power source and method therefor
US5531783A (en) 1995-01-17 1996-07-02 Vitatron Medical, B.V. Pacing lead with x-ray visible soluble covering and method of inserting same into a patient's heart
US5551427A (en) 1995-02-13 1996-09-03 Altman; Peter A. Implantable device for the effective elimination of cardiac arrhythmogenic sites
US5556421A (en) 1995-02-22 1996-09-17 Intermedics, Inc. Implantable medical device with enclosed physiological parameter sensors or telemetry link
AU4760196A (en) 1995-02-27 1996-09-18 Medtronic, Inc. External patient reference sensor
EP0988838B1 (en) 1995-03-23 2003-05-21 Advanced Animal Technology Limited Substance delivery device
US5586556A (en) 1995-05-11 1996-12-24 T Z Medical, Inc. Pacemaker and heart monitoring and data transmitting device and method
US5697958A (en) 1995-06-07 1997-12-16 Intermedics, Inc. Electromagnetic noise detector for implantable medical devices
US5662689A (en) 1995-09-08 1997-09-02 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain
CA2235216C (en) 1995-10-19 2006-05-30 The University Of Melbourne Embedded data link and protocol
US6076016A (en) 1995-10-19 2000-06-13 Feierbach; Gary F. Galvanic transdermal conduction communication system and method
US5650759A (en) 1995-11-09 1997-07-22 Hittman Materials & Medical Components, Inc. Filtered feedthrough assembly having a mounted chip capacitor for medical implantable devices and method of manufacture therefor
WO1997018857A1 (en) 1995-11-24 1997-05-29 Advanced Bionics Corporation System and method for conditioning pelvic musculature using an implanted microstimulator
SE9504258D0 (sv) 1995-11-28 1995-11-28 Pacesetter Ab Device and method for generating a synthesized ECG
US5693076A (en) 1996-01-16 1997-12-02 Medtronic, Inc. Compressed patient narrative storage in and full text reconstruction from implantable medical devices
SE9600389D0 (sv) 1996-02-02 1996-02-02 Pacesetter Ab Medical device used to stimulate tissue
US5814076A (en) 1996-02-09 1998-09-29 Cardiac Control Systems, Inc. Apparatus for improved cardiac pacing and sensing using extracardiac indifferent electrode configurations
US5605159A (en) 1996-02-16 1997-02-25 Smith; Joseph M. System and method for determining spatial organization of atrial activation
US6132390A (en) 1996-02-28 2000-10-17 Eupalamus Llc Handle for manipulation of a stylet used for deflecting a tip of a lead or catheter
US5728154A (en) 1996-02-29 1998-03-17 Minnesota Mining And Manfacturing Company Communication method for implantable medical device
US5702427A (en) 1996-03-28 1997-12-30 Medtronic, Inc. Verification of capture using pressure waves transmitted through a pacing lead
US6223081B1 (en) 1996-03-28 2001-04-24 Medtronic, Inc. Implantable stimulus system having stimulus generator with pressure sensor and common lead for transmitting stimulus pulses to a body location and pressure signals from the body location to the stimulus generator
US6208900B1 (en) 1996-03-28 2001-03-27 Medtronic, Inc. Method and apparatus for rate-responsive cardiac pacing using header mounted pressure wave transducer
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US5730143A (en) 1996-05-03 1998-03-24 Ralin Medical, Inc. Electrocardiographic monitoring and recording device
US5891178A (en) 1996-05-14 1999-04-06 Pacesetter, Inc. Programmer system and associated methods for rapidly evaluating and programming an implanted cardiac device
US5899928A (en) 1996-05-14 1999-05-04 Pacesetter, Inc. Descriptive transtelephonic pacing intervals for use by an emplantable pacemaker
US6594523B1 (en) 1996-05-14 2003-07-15 Pacesetter, Inc. Implantable stimulation device, programmer, and method for automatically evaluating interaction of the device with a patient's heart
US5725559A (en) 1996-05-16 1998-03-10 Intermedics Inc. Programmably upgradable implantable medical device
US6496715B1 (en) 1996-07-11 2002-12-17 Medtronic, Inc. System and method for non-invasive determination of optimal orientation of an implantable sensing device
JP2000514682A (ja) 1996-07-11 2000-11-07 メドトロニック・インコーポレーテッド 生理的事象を監視するための最小限の侵入用植込み可能装置
US5735880A (en) 1996-09-16 1998-04-07 Sulzer Intermedics Inc. Method and apparatus for reliably producing pacing pulse trains
US5792205A (en) 1996-10-21 1998-08-11 Intermedics, Inc. Cardiac pacemaker with bidirectional communication
SE9604143D0 (sv) 1996-11-13 1996-11-13 Pacesetter Ab Implanterbar elektrodkabel
US6119031A (en) 1996-11-21 2000-09-12 Boston Scientific Corporation Miniature spectrometer
US5814089A (en) 1996-12-18 1998-09-29 Medtronic, Inc. Leadless multisite implantable stimulus and diagnostic system
US5814087A (en) 1996-12-18 1998-09-29 Medtronic, Inc. Rate responsive pacemaker adapted to adjust lower rate limit according to monitored patient blood temperature
US5999857A (en) 1996-12-18 1999-12-07 Medtronic, Inc. Implantable device telemetry system and method
US5957861A (en) 1997-01-31 1999-09-28 Medtronic, Inc. Impedance monitor for discerning edema through evaluation of respiratory rate
US5876353A (en) 1997-01-31 1999-03-02 Medtronic, Inc. Impedance monitor for discerning edema through evaluation of respiratory rate
EP1647300A3 (en) 1997-02-26 2009-04-29 The Alfred E Mann Foundation for Scientific Research Battery-powered patient implantable device
US6695885B2 (en) 1997-02-26 2004-02-24 Alfred E. Mann Foundation For Scientific Research Method and apparatus for coupling an implantable stimulator/sensor to a prosthetic device
US6164284A (en) 1997-02-26 2000-12-26 Schulman; Joseph H. System of implantable devices for monitoring and/or affecting body parameters
US6208894B1 (en) 1997-02-26 2001-03-27 Alfred E. Mann Foundation For Scientific Research And Advanced Bionics System of implantable devices for monitoring and/or affecting body parameters
US20050075682A1 (en) 1997-02-26 2005-04-07 Schulman Joseph H. Neural device for sensing temperature
US6558321B1 (en) 1997-03-04 2003-05-06 Dexcom, Inc. Systems and methods for remote monitoring and modulation of medical devices
US6741877B1 (en) 1997-03-04 2004-05-25 Dexcom, Inc. Device and method for determining analyte levels
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
US6785576B2 (en) 1997-04-21 2004-08-31 Medtronic, Inc. Medical electrical lead
US5931861A (en) 1997-04-25 1999-08-03 Medtronic, Inc. Medical lead adaptor having rotatable locking clip mechanism
US5984861A (en) 1997-09-29 1999-11-16 Boston Scientific Corporation Endofluorescence imaging module for an endoscope
US6238348B1 (en) 1997-07-22 2001-05-29 Scimed Life Systems, Inc. Miniature spectrometer system and method
US6324418B1 (en) 1997-09-29 2001-11-27 Boston Scientific Corporation Portable tissue spectroscopy apparatus and method
US6096065A (en) 1997-09-29 2000-08-01 Boston Scientific Corporation Sheath for tissue spectroscopy
US6185443B1 (en) 1997-09-29 2001-02-06 Boston Scientific Corporation Visible display for an interventional device
US6248080B1 (en) 1997-09-03 2001-06-19 Medtronic, Inc. Intracranial monitoring and therapy delivery control device, system and method
US6198952B1 (en) 1998-10-30 2001-03-06 Medtronic, Inc. Multiple lens oxygen sensor for medical electrical lead
US6134459A (en) 1998-10-30 2000-10-17 Medtronic, Inc. Light focusing apparatus for medical electrical lead oxygen sensor
US6125291A (en) 1998-10-30 2000-09-26 Medtronic, Inc. Light barrier for medical electrical lead oxygen sensor
US6731976B2 (en) 1997-09-03 2004-05-04 Medtronic, Inc. Device and method to measure and communicate body parameters
US6125290A (en) 1998-10-30 2000-09-26 Medtronic, Inc. Tissue overgrowth detector for implantable medical device
US6144866A (en) 1998-10-30 2000-11-07 Medtronic, Inc. Multiple sensor assembly for medical electric lead
US6409674B1 (en) 1998-09-24 2002-06-25 Data Sciences International, Inc. Implantable sensor with wireless communication
US6296615B1 (en) 1999-03-05 2001-10-02 Data Sciences International, Inc. Catheter with physiological sensor
US6212434B1 (en) 1998-07-22 2001-04-03 Cardiac Pacemakers, Inc. Single pass lead system
SE9800126D0 (sv) 1998-01-20 1998-01-20 Pacesetter Ab Implantable medical device
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6148230A (en) 1998-01-30 2000-11-14 Uab Research Foundation Method for the monitoring and treatment of spontaneous cardiac arrhythmias
US5931864A (en) 1998-02-20 1999-08-03 Cardiac Pacemakers, Inc. Coronary venous lead having fixation mechanism
US6265100B1 (en) 1998-02-23 2001-07-24 Research International, Inc. Rechargeable battery
US6141592A (en) 1998-03-06 2000-10-31 Intermedics Inc. Data transmission using a varying electric field
US5902331A (en) 1998-03-10 1999-05-11 Medtronic, Inc. Arrangement for implanting an endocardial cardiac lead
US6132456A (en) 1998-03-10 2000-10-17 Medtronic, Inc. Arrangement for implanting an endocardial cardiac lead
US6045513A (en) 1998-05-13 2000-04-04 Medtronic, Inc. Implantable medical device for tracking patient functional status
US6093146A (en) 1998-06-05 2000-07-25 Matsushita Electric Works, Ltd. Physiological monitoring
US6243608B1 (en) 1998-06-12 2001-06-05 Intermedics Inc. Implantable device with optical telemetry
EP1378262A3 (en) 1998-06-12 2004-03-17 Cardiac Pacemakers, Inc. Modified guidewire for left ventricular access lead
US6477424B1 (en) 1998-06-19 2002-11-05 Medtronic, Inc. Medical management system integrated programming apparatus for communication with an implantable medical device
US6444970B1 (en) 1998-06-26 2002-09-03 Scimed Life Systems, Inc. Miniature low-noise photodiode system
US6704602B2 (en) 1998-07-02 2004-03-09 Medtronic, Inc. Implanted medical device/external medical instrument communication utilizing surface electrodes
US6735474B1 (en) 1998-07-06 2004-05-11 Advanced Bionics Corporation Implantable stimulator system and method for treatment of incontinence and pain
US6141588A (en) 1998-07-24 2000-10-31 Intermedics Inc. Cardiac simulation system having multiple stimulators for anti-arrhythmia therapy
US6129751A (en) 1998-07-28 2000-10-10 Intermedics Inc. Cardiac lead with active fixation and biocompatible lubricant
US6002969A (en) 1998-08-05 1999-12-14 Intermedics Inc. Cardiac lead with shape-memory structure
EP1102560A4 (en) 1998-08-07 2003-03-12 Infinite Biomedical Technologi MYOCARDIAL ISCHEMIA: IMPLANTABLE DETECTION, COMMUNICATION AND INTERVENTION SYSTEM
US6240321B1 (en) 1998-08-12 2001-05-29 Cardiac Pacemakers, Inc. Expandable seal for use with medical device and system
US6402689B1 (en) 1998-09-30 2002-06-11 Sicel Technologies, Inc. Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors
US6141584A (en) 1998-09-30 2000-10-31 Agilent Technologies, Inc. Defibrillator with wireless communications
US6306088B1 (en) 1998-10-03 2001-10-23 Individual Monitoring Systems, Inc. Ambulatory distributed recorders system for diagnosing medical disorders
IL127481A (en) 1998-10-06 2004-05-12 Bio Control Medical Ltd Urine excretion prevention device
US6163723A (en) 1998-10-22 2000-12-19 Medtronic, Inc. Circuit and method for implantable dual sensor medical electrical lead
US20020041987A1 (en) 1998-10-23 2002-04-11 Joseph H. Schulman Prismatic zincair battery for use with biological stimulator
US8244370B2 (en) 2001-04-13 2012-08-14 Greatbatch Ltd. Band stop filter employing a capacitor and an inductor tank circuit to enhance MRI compatibility of active medical devices
US6134470A (en) 1998-11-09 2000-10-17 Medtronic, Inc. Method and apparatus for treating a tachyarrhythmic patient
US6201993B1 (en) 1998-12-09 2001-03-13 Medtronic, Inc. Medical device telemetry receiver having improved noise discrimination
US6115636A (en) 1998-12-22 2000-09-05 Medtronic, Inc. Telemetry for implantable devices using the body as an antenna
US6466820B1 (en) 1998-12-29 2002-10-15 Medtronic, Inc. Multi-site cardiac pacing system having trigger pace window
WO2000038783A1 (en) 1998-12-31 2000-07-06 Ball Semiconductor, Inc. Injectable thermal balls for tumor ablation
US6358202B1 (en) 1999-01-25 2002-03-19 Sun Microsystems, Inc. Network for implanted computer devices
US6152882A (en) 1999-01-26 2000-11-28 Impulse Dynamics N.V. Apparatus and method for chronic measurement of monophasic action potentials
US6266554B1 (en) 1999-02-12 2001-07-24 Cardiac Pacemakers, Inc. System and method for classifying cardiac complexes
US6112116A (en) 1999-02-22 2000-08-29 Cathco, Inc. Implantable responsive system for sensing and treating acute myocardial infarction
US6223078B1 (en) 1999-03-12 2001-04-24 Cardiac Pacemakers, Inc. Discrimination of supraventricular tachycardia and ventricular tachycardia events
US6230059B1 (en) 1999-03-17 2001-05-08 Medtronic, Inc. Implantable monitor
US6272379B1 (en) 1999-03-17 2001-08-07 Cathco, Inc. Implantable electronic system with acute myocardial infarction detection and patient warning capabilities
US6263242B1 (en) 1999-03-25 2001-07-17 Impulse Dynamics N.V. Apparatus and method for timing the delivery of non-excitatory ETC signals to a heart
US6115630A (en) 1999-03-29 2000-09-05 Medtronic, Inc. Determination of orientation of electrocardiogram signal in implantable medical devices
US6324421B1 (en) 1999-03-29 2001-11-27 Medtronic, Inc. Axis shift analysis of electrocardiogram signal parameters especially applicable for multivector analysis by implantable medical devices, and use of same
US6128526A (en) 1999-03-29 2000-10-03 Medtronic, Inc. Method for ischemia detection and apparatus for using same
US6115628A (en) 1999-03-29 2000-09-05 Medtronic, Inc. Method and apparatus for filtering electrocardiogram (ECG) signals to remove bad cycle information and for use of physiologic signals determined from said filtered ECG signals
US6167310A (en) 1999-03-31 2000-12-26 Medtronic, Inc. Downlink telemetry system and method for implantable medical device
US6178349B1 (en) 1999-04-15 2001-01-23 Medtronic, Inc. Drug delivery neural stimulation device for treatment of cardiovascular disorders
US6190324B1 (en) 1999-04-28 2001-02-20 Medtronic, Inc. Implantable medical device for tracking patient cardiac status
US6233487B1 (en) 1999-06-08 2001-05-15 Impulse Dynamics N.V. Apparatus and method for setting the parameters of an alert window used for timing the delivery of ETC signals to a heart under varying cardiac conditions
US6223072B1 (en) 1999-06-08 2001-04-24 Impulse Dynamics N.V. Apparatus and method for collecting data useful for determining the parameters of an alert window for timing delivery of ETC signals to a heart under varying cardiac conditions
DE19930256A1 (de) 1999-06-25 2000-12-28 Biotronik Mess & Therapieg Implantat mit Nah- und Fernfeldtelemetrie
DE19930241A1 (de) 1999-06-25 2000-12-28 Biotronik Mess & Therapieg Verfahren zur Datenübertragung bei der Implantatsüberwachung
DE19930245A1 (de) 1999-06-25 2000-12-28 Biotronik Mess & Therapieg Elektromedizinisches Implantat
DE19930250A1 (de) 1999-06-25 2001-02-15 Biotronik Mess & Therapieg Vorrichtung zur Überwachung von Daten insbesondere aus einem elektromedizinischen Implantat
DE19930263A1 (de) 1999-06-25 2000-12-28 Biotronik Mess & Therapieg Verfahren und Vorrichtung zur Datenübertragung zwischen einem elektromedizinischen Implantat und einem externen Gerät
DE19930262A1 (de) 1999-06-25 2000-12-28 Biotronik Mess & Therapieg Sender für die Telemetrieeinrichtung eines Implantats
DE19930240A1 (de) 1999-06-25 2000-12-28 Biotronik Mess & Therapieg Verfahren zur Datenabfrage bei der Implantatsnachsorge
US7181505B2 (en) 1999-07-07 2007-02-20 Medtronic, Inc. System and method for remote programming of an implantable medical device
US6512949B1 (en) 1999-07-12 2003-01-28 Medtronic, Inc. Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto
US6347245B1 (en) 1999-07-14 2002-02-12 Medtronic, Inc. Medical device ECG marker for use in compressed data system
US6236882B1 (en) 1999-07-14 2001-05-22 Medtronic, Inc. Noise rejection for monitoring ECG's
US6449503B1 (en) 1999-07-14 2002-09-10 Cardiac Pacemakers, Inc. Classification of supraventricular and ventricular cardiac rhythms using cross channel timing algorithm
US6334859B1 (en) 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
US6263245B1 (en) 1999-08-12 2001-07-17 Pacesetter, Inc. System and method for portable implantable device interogation
US6381494B1 (en) 1999-08-20 2002-04-30 Cardiac Pacemakers, Inc. Response to ambient noise in implantable pulse generator
US6361522B1 (en) 1999-10-21 2002-03-26 Cardiac Pacemakers, Inc. Drug delivery system for implantable cardiac device
US6442433B1 (en) 1999-10-26 2002-08-27 Medtronic, Inc. Apparatus and method for remote troubleshooting, maintenance and upgrade of implantable device systems
US6363282B1 (en) 1999-10-29 2002-03-26 Medtronic, Inc. Apparatus and method to automatic remote software updates of medical device systems
DE10053118A1 (de) 1999-10-29 2001-05-31 Medtronic Inc Apparat und Verfahren zur Selbstidentifizierung aus der Ferne von Komponenten in medizinischen Vorrichtungssystemen
US6385593B2 (en) 1999-10-29 2002-05-07 Medtronic, Inc. Apparatus and method for automated invoicing of medical device systems
US6386882B1 (en) 1999-11-10 2002-05-14 Medtronic, Inc. Remote delivery of software-based training for implantable medical device systems
US6409675B1 (en) 1999-11-10 2002-06-25 Pacesetter, Inc. Extravascular hemodynamic monitor
US6480733B1 (en) 1999-11-10 2002-11-12 Pacesetter, Inc. Method for monitoring heart failure
US6542781B1 (en) 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6418346B1 (en) 1999-12-14 2002-07-09 Medtronic, Inc. Apparatus and method for remote therapy and diagnosis in medical devices via interface systems
DE19963246A1 (de) 1999-12-17 2001-06-21 Biotronik Mess & Therapieg Vorrichtung zur Erkennung der Kreislaufwirkungen von Extrasystolen
US6497655B1 (en) 1999-12-17 2002-12-24 Medtronic, Inc. Virtual remote monitor, alert, diagnostics and programming for implantable medical device systems
US6471645B1 (en) 1999-12-30 2002-10-29 Medtronic, Inc. Communications system for an implantable device and a drug dispenser
FR2803186B1 (fr) 2000-01-05 2002-08-09 Guy Charvin Procede et dispositif de recueil de potentiels evoques auditif
AU776786B2 (en) 2000-01-07 2004-09-23 Biowave Corporation Electro therapy method and apparatus
US6585644B2 (en) 2000-01-21 2003-07-01 Medtronic Minimed, Inc. Ambulatory medical apparatus and method using a telemetry system with predefined reception listening periods
US6370434B1 (en) 2000-02-28 2002-04-09 Cardiac Pacemakers, Inc. Cardiac lead and method for lead implantation
US6699200B2 (en) 2000-03-01 2004-03-02 Medtronic, Inc. Implantable medical device with multi-vector sensing electrodes
US6556860B1 (en) 2000-03-15 2003-04-29 The Regents Of The University Of California System and method for developing a database of body surface ECG flutter wave data maps for classification of atrial flutter
AU2001247440A1 (en) 2000-03-15 2001-09-24 Cardiac Focus, Inc. Non-invasive localization and treatment of focal atrial fibrillation
US6615075B2 (en) 2000-03-15 2003-09-02 The Regents Of The University Of California QRST subtraction using an adaptive template for analysis of TU wave obscured atrial activity
US6895281B1 (en) 2000-03-31 2005-05-17 Cardiac Pacemakers, Inc. Inductive coil apparatus for bio-medical telemetry
US6654638B1 (en) 2000-04-06 2003-11-25 Cardiac Pacemakers, Inc. Ultrasonically activated electrodes
US6441747B1 (en) 2000-04-18 2002-08-27 Motorola, Inc. Wireless system protocol for telemetry monitoring
US6925328B2 (en) 2000-04-20 2005-08-02 Biophan Technologies, Inc. MRI-compatible implantable device
US6574511B2 (en) 2000-04-21 2003-06-03 Medtronic, Inc. Passive data collection system from a fleet of medical instruments and implantable devices
US6459937B1 (en) 2000-04-25 2002-10-01 Pacesetter, Inc. Endocardial pacing lead with detachable tip electrode assembly
US6580948B2 (en) 2000-04-25 2003-06-17 Medtronic, Inc. Interface devices for instruments in communication with implantable medical devices
US6522928B2 (en) 2000-04-27 2003-02-18 Advanced Bionics Corporation Physiologically based adjustment of stimulation parameters to an implantable electronic stimulator to reduce data transmission rate
EP1284781B1 (en) 2000-05-04 2017-10-11 Impulse Dynamics N.V. Signal delivery through the right ventricular septum
US6712826B2 (en) 2000-05-17 2004-03-30 Cook Vascular Incorporated Apparatus for removing an elongated structure implanted in biological tissue
WO2001097909A2 (en) 2000-06-14 2001-12-27 Medtronic, Inc. Deep computing applications in medical device systems
US6738670B1 (en) 2000-06-19 2004-05-18 Medtronic, Inc. Implantable medical device telemetry processor
US6482154B1 (en) 2000-08-02 2002-11-19 Medtronic, Inc Long range implantable medical device telemetry system with positive patient identification
US6871099B1 (en) 2000-08-18 2005-03-22 Advanced Bionics Corporation Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain
US6690959B2 (en) 2000-09-01 2004-02-10 Medtronic, Inc. Skin-mounted electrodes with nano spikes
DE60144429D1 (de) 2000-09-07 2011-05-26 Apparat zur kontrolle der darmfunktion
ATE490801T1 (de) 2000-09-13 2010-12-15 Mann Medical Res Organization Gerät zur konditionierung von muskeln im schlaf
WO2002032499A1 (en) 2000-09-14 2002-04-25 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Method and apparatus to treat disorders of gastrointestinal peristalsis
US6856835B2 (en) 2000-09-18 2005-02-15 Cameron Health, Inc. Biphasic waveform for anti-tachycardia pacing for a subcutaneous implantable cardioverter-defibrillator
US6721597B1 (en) 2000-09-18 2004-04-13 Cameron Health, Inc. Subcutaneous only implantable cardioverter defibrillator and optional pacer
US6647292B1 (en) 2000-09-18 2003-11-11 Cameron Health Unitary subcutaneous only implantable cardioverter-defibrillator and optional pacer
US6522926B1 (en) 2000-09-27 2003-02-18 Cvrx, Inc. Devices and methods for cardiovascular reflex control
SE0003480D0 (sv) 2000-09-27 2000-09-27 St Jude Medical Implantable heart stimulator
US6850801B2 (en) 2001-09-26 2005-02-01 Cvrx, Inc. Mapping methods for cardiovascular reflex control devices
US6804561B2 (en) 2000-10-11 2004-10-12 Alfred E. Mann Foundation For Scientific Research Antenna for miniature implanted medical device
US6498951B1 (en) 2000-10-13 2002-12-24 Medtronic, Inc. Implantable medical device employing integral housing for a formable flat battery
US6764446B2 (en) 2000-10-16 2004-07-20 Remon Medical Technologies Ltd Implantable pressure sensors and methods for making and using them
US6522915B1 (en) 2000-10-26 2003-02-18 Medtronic, Inc. Surround shroud connector and electrode housings for a subcutaneous electrode array and leadless ECGS
US6681135B1 (en) 2000-10-30 2004-01-20 Medtronic, Inc. System and method for employing temperature measurements to control the operation of an implantable medical device
US6684100B1 (en) 2000-10-31 2004-01-27 Cardiac Pacemakers, Inc. Curvature based method for selecting features from an electrophysiologic signals for purpose of complex identification and classification
US6512959B1 (en) 2000-11-28 2003-01-28 Pacesetter, Inc. Double threaded stylet for extraction of leads with a threaded electrode
US6458145B1 (en) 2000-11-28 2002-10-01 Hatch Medical L.L.C. Intra vascular snare and method of forming the same
US6611710B2 (en) 2000-11-29 2003-08-26 Pacesetter, Inc. Double threaded stylet for extraction of leads with a threaded electrode
US6649078B2 (en) 2000-12-06 2003-11-18 The Regents Of The University Of California Thin film capillary process and apparatus
US6589187B1 (en) 2000-12-08 2003-07-08 Medtronic, Inc. Prioritized dynamic memory allocation of arrhythmia episode detail collection
US6746404B2 (en) 2000-12-18 2004-06-08 Biosense, Inc. Method for anchoring a medical device between tissue
US6689117B2 (en) 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
US6783499B2 (en) 2000-12-18 2004-08-31 Biosense, Inc. Anchoring mechanism for implantable telemetric medical sensor
US7254441B2 (en) 2000-12-21 2007-08-07 Medtronic, Inc. Fully inhibited dual chamber pacing mode
US6484057B2 (en) 2000-12-21 2002-11-19 Uab Research Foundation Pacing methods and devices for treating cardiac arrhythmias and fibrillation
US6584352B2 (en) 2000-12-27 2003-06-24 Medtronic, Inc. Leadless fully automatic pacemaker follow-up
US6697677B2 (en) 2000-12-28 2004-02-24 Medtronic, Inc. System and method for placing a medical electrical lead
US7146225B2 (en) 2002-10-30 2006-12-05 Medtronic, Inc. Methods and apparatus for accessing and stabilizing an area of the heart
US6445953B1 (en) 2001-01-16 2002-09-03 Kenergy, Inc. Wireless cardiac pacing system with vascular electrode-stents
US6735475B1 (en) 2001-01-30 2004-05-11 Advanced Bionics Corporation Fully implantable miniature neurostimulator for stimulation as a therapy for headache and/or facial pain
US6567680B2 (en) 2001-02-02 2003-05-20 Medical Data Electronics Disposable electro-cardiogram transmitter device and electrode node placement facilitator
US20020116028A1 (en) 2001-02-20 2002-08-22 Wilson Greatbatch MRI-compatible pacemaker with pulse carrying photonic catheter providing VOO functionality
US6848052B2 (en) 2001-03-21 2005-01-25 Activcard Ireland Limited High security personalized wireless portable biometric device
WO2002078592A2 (en) 2001-03-30 2002-10-10 Case Western Reserve University Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses
US6766203B2 (en) 2001-04-05 2004-07-20 Pacesetter, Inc. Body implantable lead with improved tip electrode assembly
US6592518B2 (en) 2001-04-05 2003-07-15 Kenergy, Inc. Cardiac monitoring system and method with multiple implanted transponders
US6912420B2 (en) 2001-04-10 2005-06-28 Cardiac Pacemakers, Inc. Cardiac rhythm management system for hypotension
US6580946B2 (en) 2001-04-26 2003-06-17 Medtronic, Inc. Pressure-modulated rate-responsive cardiac pacing
US6901296B1 (en) 2001-05-25 2005-05-31 Advanced Bionics Corporation Methods and systems for direct electrical current stimulation as a therapy for cancer and other neoplastic diseases
US6901294B1 (en) 2001-05-25 2005-05-31 Advanced Bionics Corporation Methods and systems for direct electrical current stimulation as a therapy for prostatic hypertrophy
US7756582B2 (en) 2001-05-01 2010-07-13 Intrapace, Inc. Gastric stimulation anchor and method
US6716238B2 (en) 2001-05-10 2004-04-06 Scimed Life Systems, Inc. Stent with detachable tethers and method of using same
US6468263B1 (en) 2001-05-21 2002-10-22 Angel Medical Systems, Inc. Implantable responsive system for sensing and treating acute myocardial infarction and for treating stroke
US6733485B1 (en) 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
US6472991B1 (en) 2001-06-15 2002-10-29 Alfred E. Mann Foundation For Scientific Research Multichannel communication protocol configured to extend the battery life of an implantable device
US6792314B2 (en) 2001-06-18 2004-09-14 Alfred E. Mann Foundation For Scientific Research Miniature implantable array and stimulation system suitable for eyelid stimulation
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US6648823B2 (en) 2001-07-31 2003-11-18 Medtronic, Inc. Method and system of follow-up support for a medical device
US6823217B2 (en) 2001-08-21 2004-11-23 Medtronic, Inc. Method and apparatus for imparting curves in elongated implantable medical instruments
US6731979B2 (en) 2001-08-30 2004-05-04 Biophan Technologies Inc. Pulse width cardiac pacing apparatus
US6786860B2 (en) 2001-10-03 2004-09-07 Advanced Bionics Corporation Hearing aid design
US6879695B2 (en) 2001-10-03 2005-04-12 Advanced Bionics Corporation Personal sound link module
US7027876B2 (en) * 2001-10-12 2006-04-11 Medtronic, Inc. Lead system for providing electrical stimulation to the Bundle of His
US6829508B2 (en) 2001-10-19 2004-12-07 Alfred E. Mann Foundation For Scientific Research Electrically sensing and stimulating system for placement of a nerve stimulator or sensor
US6728574B2 (en) 2001-10-19 2004-04-27 Medtronic, Inc. System and method for patient-controlled relief of pain associated with electrical therapies
US6809507B2 (en) 2001-10-23 2004-10-26 Medtronic Minimed, Inc. Implantable sensor electrodes and electronic circuitry
US6741886B2 (en) 2001-10-25 2004-05-25 Cardiac Pacemakers, Inc. ECG system with minute ventilation detector
US6728576B2 (en) 2001-10-31 2004-04-27 Medtronic, Inc. Non-contact EKG
US6862480B2 (en) 2001-11-29 2005-03-01 Biocontrol Medical Ltd. Pelvic disorder treatment device
US6961621B2 (en) 2001-12-04 2005-11-01 Cardiac Pacemakers, Inc. Apparatus and method for stabilizing an implantable lead
US6768923B2 (en) 2001-12-05 2004-07-27 Cardiac Pacemakers, Inc. Apparatus and method for ventricular pacing triggered by detection of early ventricular excitation
US6865420B1 (en) 2002-01-14 2005-03-08 Pacesetter, Inc. Cardiac stimulation device for optimizing cardiac output with myocardial ischemia protection
US6999821B2 (en) 2002-01-18 2006-02-14 Pacesetter, Inc. Body implantable lead including one or more conductive polymer electrodes and methods for fabricating same
WO2003063951A1 (en) 2002-01-29 2003-08-07 Advanced Bionics Corporation Lead assembly for implantable microstimulator
TW536871B (en) 2002-01-31 2003-06-11 Elan Microelectronics Corp Wireless communication coding method for representing digital data with variable length signal
US7236821B2 (en) 2002-02-19 2007-06-26 Cardiac Pacemakers, Inc. Chronically-implanted device for sensing and therapy
US6839596B2 (en) 2002-02-21 2005-01-04 Alfred E. Mann Foundation For Scientific Research Magnet control system for battery powered living tissue stimulators
US7023359B2 (en) 2002-03-15 2006-04-04 Medtronic, Inc. Telemetry module with configurable physical layer for use with an implantable medical device
US6711440B2 (en) 2002-04-11 2004-03-23 Biophan Technologies, Inc. MRI-compatible medical device with passive generation of optical sensing signals
US7146222B2 (en) 2002-04-15 2006-12-05 Neurospace, Inc. Reinforced sensing and stimulation leads and use in detection systems
US6922330B2 (en) 2002-04-18 2005-07-26 Medtronic, Inc. Implantable medical device having flat electrolytic capacitor fabricated with laser welded anode sheets
US7177704B2 (en) * 2002-04-29 2007-02-13 Medtronic, Inc. Pacing method and apparatus
US20050038474A1 (en) 2002-04-30 2005-02-17 Wool Thomas J. Implantable automatic defibrillator with subcutaneous electrodes
US20040147973A1 (en) 2002-06-27 2004-07-29 Hauser Robert G. Intra cardiac pacer and method
EP1517725B1 (en) 2002-06-28 2015-09-09 Boston Scientific Neuromodulation Corporation Microstimulator having self-contained power source and bi-directional telemetry system
WO2004012810A1 (ja) 2002-08-05 2004-02-12 Japan As Represented By President Of National Cardiovascular Center 超小型一体化心臓ペースメーカ及び分散心臓ペーシングシステム
GB0220770D0 (en) 2002-09-06 2002-10-16 Ares Trading Sa Proteins
US6609023B1 (en) 2002-09-20 2003-08-19 Angel Medical Systems, Inc. System for the detection of cardiac events
US8303511B2 (en) 2002-09-26 2012-11-06 Pacesetter, Inc. Implantable pressure transducer system optimized for reduced thrombosis effect
US7209790B2 (en) 2002-09-30 2007-04-24 Medtronic, Inc. Multi-mode programmer for medical device communication
US7103418B2 (en) 2002-10-02 2006-09-05 Medtronic, Inc. Active fluid delivery catheter
US7164950B2 (en) 2002-10-30 2007-01-16 Pacesetter, Inc. Implantable stimulation device with isolating system for minimizing magnetic induction
US20040133242A1 (en) 2003-01-02 2004-07-08 Chapman Fred W. Medical device communication
US20040143262A1 (en) 2003-01-21 2004-07-22 Baylis Medical Company Inc. Surgical perforation device and method with pressure monitoring and staining abilities
US9510900B2 (en) * 2003-01-21 2016-12-06 Baylis Medical Company Inc. Electrosurgical device for creating a channel through a region of tissue and methods of use thereof
US7013176B2 (en) 2003-01-28 2006-03-14 Cardiac Pacemakers, Inc. Method and apparatus for setting pacing parameters in cardiac resynchronization therapy
US7158838B2 (en) 2003-01-31 2007-01-02 Medtronic, Inc. Arrangement for implanting a miniaturized cardiac lead having a fixation helix
US6869404B2 (en) 2003-02-26 2005-03-22 Medtronic, Inc. Apparatus and method for chronically monitoring heart sounds for deriving estimated blood pressure
GB0307866D0 (en) 2003-04-04 2003-05-14 Novartis Ag Pharmaceutical composition
US7082336B2 (en) 2003-06-04 2006-07-25 Synecor, Llc Implantable intravascular device for defibrillation and/or pacing
CA2527909A1 (en) 2003-06-04 2005-01-06 Synecor Llc Intravascular electrophysiological system and methods
US7276029B2 (en) 2003-08-01 2007-10-02 Dexcom, Inc. System and methods for processing analyte sensor data
EP2865320A1 (en) 2003-08-04 2015-04-29 Vision-Sciences, Inc. Sheath with channel for endoscope
US20050038491A1 (en) 2003-08-11 2005-02-17 Haack Scott Graham Cardiac pacing lead having dual fixation and method of using the same
US7289853B1 (en) 2003-08-28 2007-10-30 David Campbell High frequency wireless pacemaker
US6917833B2 (en) 2003-09-16 2005-07-12 Kenergy, Inc. Omnidirectional antenna for wireless communication with implanted medical devices
US6821154B1 (en) 2003-10-03 2004-11-23 Alfred E. Mann Foundation For Scientific Research Electrical device connector and method therefor
US7017267B2 (en) 2003-10-15 2006-03-28 James Allen Carroll Method and apparatus for zone cabling
US7003350B2 (en) 2003-11-03 2006-02-21 Kenergy, Inc. Intravenous cardiac pacing system with wireless power supply
US8521284B2 (en) 2003-12-12 2013-08-27 Cardiac Pacemakers, Inc. Cardiac response classification using multisite sensing and pacing
WO2005062823A2 (en) 2003-12-19 2005-07-14 Savacor, Inc. Digital electrode for cardiac rhythm management
US7277754B2 (en) 2003-12-24 2007-10-02 Cardiac Pacemakers, Inc. Method and system for removing pacing artifacts from subcutaneous electrocardiograms
US20050149138A1 (en) 2003-12-24 2005-07-07 Xiaoyi Min System and method for determining optimal pacing sites based on myocardial activation times
WO2005107852A1 (en) 2004-05-04 2005-11-17 University Of Rochester Leadless implantable intravascular electrophysiologic device for neurologic/cardiovascular sensing and stimulation
US20050267555A1 (en) 2004-05-28 2005-12-01 Marnfeldt Goran N Engagement tool for implantable medical devices
US7765001B2 (en) 2005-08-31 2010-07-27 Ebr Systems, Inc. Methods and systems for heart failure prevention and treatments using ultrasound and leadless implantable devices
US7630767B1 (en) 2004-07-14 2009-12-08 Pacesetter, Inc. System and method for communicating information using encoded pacing pulses within an implantable medical system
US7212870B1 (en) 2004-09-16 2007-05-01 Pacesetter, Inc. Dual helix active fixation stimulation lead
US7493174B2 (en) 2004-09-23 2009-02-17 Medtronic, Inc. Implantable medical lead
US7200437B1 (en) 2004-10-13 2007-04-03 Pacesetter, Inc. Tissue contact for satellite cardiac pacemaker
US7532933B2 (en) 2004-10-20 2009-05-12 Boston Scientific Scimed, Inc. Leadless cardiac stimulation systems
US7647109B2 (en) 2004-10-20 2010-01-12 Boston Scientific Scimed, Inc. Leadless cardiac stimulation systems
WO2006050125A1 (en) 2004-10-29 2006-05-11 Medtronic, Inc. Laser penetration weld
US8818504B2 (en) 2004-12-16 2014-08-26 Cardiac Pacemakers Inc Leadless cardiac stimulation device employing distributed logic
JP5111116B2 (ja) 2004-12-21 2012-12-26 イービーアール システムズ， インコーポレイテッド ペーシングおよび不整脈処置のためのリード線のない心臓システム
US7558631B2 (en) 2004-12-21 2009-07-07 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US20060161222A1 (en) 2005-01-15 2006-07-20 Haubrich Gregory J Multiple band communications for an implantable medical device
US7634313B1 (en) 2005-04-11 2009-12-15 Pacesetter, Inc. Failsafe satellite pacemaker system
US7565195B1 (en) 2005-04-11 2009-07-21 Pacesetter, Inc. Failsafe satellite pacemaker system
DE102005020071A1 (de) 2005-04-22 2006-10-26 Biotronik Crm Patent Ag Herzschrittmacher
US20060247750A1 (en) 2005-04-28 2006-11-02 Seifert Kevin R Guide catheters for accessing cardiac sites
US7938851B2 (en) 2005-06-08 2011-05-10 Xtent, Inc. Devices and methods for operating and controlling interventional apparatus
US7711419B2 (en) 2005-07-13 2010-05-04 Cyberonics, Inc. Neurostimulator with reduced size
JP2009504331A (ja) 2005-08-15 2009-02-05 シネコー・エルエルシー リードの固定と摘出
DE102005042369A1 (de) * 2005-09-07 2007-03-15 Biotronik Crm Patent Ag Einschraubelektrodensonde zur kardiologischen Anwendung
US7937148B2 (en) 2005-10-14 2011-05-03 Nanostim, Inc. Rate responsive leadless cardiac pacemaker
WO2007059386A2 (en) 2005-11-10 2007-05-24 Medtronic, Inc. Intravascular medical device
US20070123923A1 (en) 2005-11-30 2007-05-31 Lindstrom Curtis C Implantable medical device minimizing rotation and dislocation
US7848823B2 (en) 2005-12-09 2010-12-07 Boston Scientific Scimed, Inc. Cardiac stimulation system
EP1968698B1 (en) 2005-12-12 2016-11-23 Peters, Tor Intra cardiac device
US7627376B2 (en) 2006-01-30 2009-12-01 Medtronic, Inc. Intravascular medical device
US8403981B2 (en) 2006-02-27 2013-03-26 CardiacMC, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8630710B2 (en) 2006-03-01 2014-01-14 The Board Of Trustees Of The Leland Stanford Junior University Implanted cardiac device for defibrillation
US7809441B2 (en) 2006-05-17 2010-10-05 Cardiac Pacemakers, Inc. Implantable medical device with chemical sensor and related methods
US20070276444A1 (en) 2006-05-24 2007-11-29 Daniel Gelbart Self-powered leadless pacemaker
US20070293904A1 (en) * 2006-06-20 2007-12-20 Daniel Gelbart Self-powered resonant leadless pacemaker
US20080004535A1 (en) 2006-06-29 2008-01-03 Smits Karel F A A Implantable medical device with sensing electrodes
US7840281B2 (en) 2006-07-21 2010-11-23 Boston Scientific Scimed, Inc. Delivery of cardiac stimulation devices
US9439581B2 (en) * 2006-08-11 2016-09-13 Medtronic, Inc. Guided medical element implantation
US8644934B2 (en) 2006-09-13 2014-02-04 Boston Scientific Scimed Inc. Cardiac stimulation using leadless electrode assemblies
US8992545B2 (en) 2006-09-28 2015-03-31 W.L. Gore & Associates, Inc. Implant-catheter attachment mechanism using snare and method of use
US20080091255A1 (en) 2006-10-11 2008-04-17 Cardiac Pacemakers Implantable neurostimulator for modulating cardiovascular function
WO2008058265A2 (en) * 2006-11-08 2008-05-15 Emerge Medsystems Llc Transmuscular left ventricular cardiac stimulation leads and related systems and methods
US7657326B2 (en) * 2006-11-08 2010-02-02 Cardiac Pacemakers, Inc. Cardiac lead with a retractable helix
KR101413679B1 (ko) 2007-03-19 2014-07-01 보스톤 사이언티픽 뉴로모듈레이션 코포레이션 Ｍｒｉ 및 ｒｆ 적합성 리드와 관련 리드 작동 방법 및 제조 방법
WO2009006531A1 (en) 2007-07-03 2009-01-08 Ebr Systems, Inc. Minimization of tissue stimulation energy using a microstimulator
US20090082828A1 (en) * 2007-09-20 2009-03-26 Alan Ostroff Leadless Cardiac Pacemaker with Secondary Fixation Capability
US20090082827A1 (en) 2007-09-26 2009-03-26 Cardiac Pacemakers, Inc. Hinged anchors for wireless pacing electrodes
WO2009099550A1 (en) 2008-02-07 2009-08-13 Cardiac Pacemakers, Inc. Wireless tissue electrostimulation
WO2010028300A1 (en) 2008-09-04 2010-03-11 Curaseal Inc. Inflatable device for enteric fistula treatment
US20130261597A1 (en) 2008-11-20 2013-10-03 Bioactive Surgical, Inc. Therapeutic Material Delivery System for Tissue Voids and Cannulated Implants
US9370654B2 (en) 2009-01-27 2016-06-21 Medtronic, Inc. High frequency stimulation to block laryngeal stimulation during vagal nerve stimulation
WO2010088687A1 (en) * 2009-02-02 2010-08-05 Nanostim, Inc. Leadless cardiac pacemaker with secondary fixation capability
US8170690B2 (en) 2009-02-13 2012-05-01 Pacesetter, Inc. Implantable medical lead having an anchor providing enhanced fixation
US20100274129A1 (en) * 2009-04-24 2010-10-28 Hooven Michael D Apparatus And Methods for Separating Pericardial Tissue From The Epicardium of the Heart
US8834361B2 (en) 2009-05-15 2014-09-16 Cook Medical Technologies Llc Systems, devices and methods for accessing a bodily opening
US8359098B2 (en) 2009-05-29 2013-01-22 Medtronic, Inc. Implantable medical device with exposed generator
WO2011002546A1 (en) 2009-07-01 2011-01-06 Medtronic, Inc. Implantable medical device including mechanical stress sensor
US9072890B2 (en) 2009-09-03 2015-07-07 Mayo Foundation For Medical Education And Research Pacing, sensing or defibrillator leads for implantation into the myocardium
US20110077708A1 (en) 2009-09-28 2011-03-31 Alan Ostroff MRI Compatible Leadless Cardiac Pacemaker
EP2773416B1 (en) 2011-11-04 2019-04-24 Pacesetter, Inc. Leadless cardiac pacemaker with integral battery and redundant welds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3300050A1 (de) * 1983-01-03 1984-07-05 Siemens AG, 1000 Berlin und 8000 München Intravenoese herzschrittmacherelektrode
US4649938A (en) * 1985-04-29 1987-03-17 Mcarthur William A Tissue-stimulating electrode having sealed, low-friction extendable/retractable active fixation means

Also Published As

Publication number Publication date
US9242102B2 (en) 2016-01-26
JP2014501584A (ja) 2014-01-23
EP2654889A1 (en) 2013-10-30
WO2012088118A1 (en) 2012-06-28
EP2654889B1 (en) 2017-03-01
CN103328040A (zh) 2013-09-25
EP2654889A4 (en) 2014-06-18
US20120158111A1 (en) 2012-06-21

Similar Documents

Publication Publication Date Title
CN103328040B (zh) 具有径向固定机构的无导线起搏器
US20230023767A1 (en) Tube-cut helical fixation anchor for electrotherapy device
US10960216B2 (en) Extraction devices configued to extract chronically implanted medical devices
US4858623A (en) Active fixation mechanism for lead assembly of an implantable cardiac stimulator
AU672543B2 (en) Steroid eluting stitch-in chronic cardiac lead
US7617004B2 (en) Electrode lead
CN103249454A (zh) 带有防旋出构造的无引线心脏起搏器
US20080021505A1 (en) Electrical stimulation of body tissue using interconnected electrode assemblies
US20150088155A1 (en) Mechanical configurations for a multi-site leadless pacemaker
EP0788808A2 (en) Single preformed catheter configuration for a dual-chamber pacemaker system
EP2424613B1 (en) Implantable electric lead
WO2013098644A2 (en) Implantable medical device housing and anchoring
WO1995008366A1 (en) Pacing and defibrillating lead with sensing capability
EP2200693A1 (en) Lead assembly servicing distinct myocardial contact areas
US9192317B2 (en) Implantable active fixation lead with biodegradable helical tip
EP1037690A2 (en) Lead system
JP5688469B2 (ja) 植え込み型医療用電気リード
US8972025B2 (en) Active fixation implantable medical lead
WO2024194708A1 (en) Distal end fixation for implantable medical device

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant