CN102579731B - Chinese herbal preparation for treating chronic respiratory diseases - Google Patents
Chinese herbal preparation for treating chronic respiratory diseases Download PDFInfo
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- CN102579731B CN102579731B CN2012100830060A CN201210083006A CN102579731B CN 102579731 B CN102579731 B CN 102579731B CN 2012100830060 A CN2012100830060 A CN 2012100830060A CN 201210083006 A CN201210083006 A CN 201210083006A CN 102579731 B CN102579731 B CN 102579731B
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese medicinal herbal preparation for treating chronic respiratory diseases. The Chinese herbal preparation is prepared from wild buckwheat rhizome, angelica dahurica, Siberian cocklour fruit, spreading hedyotis herb, ephedra, cassia twig, almond, prepared pinellia tuber, platycodon root, phellodendron, rhynohophylla, philippine violet herb and liquoric root. The Chinese herbal preparation has an obvious inhibitory effect on avian escherichia coli CVCC-245 pathogenic strains and mycoplasma gallisepticum 352-PG31 strains; experiments of the artificial infection and prevention and control of the mycoplasma gallisepticum 352-PG31 strains prove that the effective rate is between 84.6 and 86.7 percent, and experiments of the application and popularization of fields prove that the effective rate is 86.06 percent; and the Chinese herbal preparation has a good prevention and control effect and high using safety, and has the effects of relieving exterior syndromes with pungent-warm medicines, relieving cough and asthma, dispelling phlegm, opening inhibited lung-energy, promoting defecation and urination and relieving diarrhea with astringents.
Description
Technical field
The present invention relates to a kind of Chinese herbal and crude drugs preparations for animals, particularly a kind of chronic respiratory disease Chinese herbal and crude drugs preparations for the treatment of belongs to the veterinary drug technical field.
Background technology
Chronic respiratory disease is comparatively often to send out during poultry is produced, a kind of chronic, expendable, opportunistic illnesses that influence surface is wider, and it mainly causes a disease was chicken virus mycoplasma originally.It is to inspire this sick main inducing that cold flu stress or be met by force in multiple autumn and winter season and the bigger high altitude localities of difference variation be born in, productivity, mainly shows as ataxia, chicken growth retardation, is the gradual death of becoming thin; Pathogenic entero becterias such as morbidity later stage many secondary escherichia coli, Salmonella infect, and pathological phenomenons such as the heart, bag liver appear wrapping in ill chicken group.For a long time, doxycycline, tylosin, to examine chemical medicine such as star, azithromycin for miaow be this sick common drug of control, life-time service have stronger drug resistance and chemical medicine residual, safety in production brings potential harm to food.In recent years, we use the Chinese herbal medicine screening technique that corresponding study on prevention has been carried out in the control of chronic respiratory disease, intend seeking that toxic and side effects is little, residual hazard is low, be difficult for the Chinese herbal and crude drugs preparations for animals that produces drug resistance, have better curative effect.
Summary of the invention
The object of the present invention is to provide a kind ofly all has the obvious suppression effect to chicken colibacillosis CVCC-245 bacterial strain and chicken virus mycoplasma 352-PG31 strain; It is 84.6～86.7% that chicken virus mycoplasma 352-PG31 strain artificial challenge prevents and treats the experiment effective percentage, field application test effective percentage is 86.06%, and its application has a kind of chronic respiratory disease Chinese herbal and crude drugs preparations for the treatment of of better prevention effect and safety in utilization.
The present invention is achieved in that a kind of chronic respiratory disease Chinese herbal and crude drugs preparations for the treatment of is to be got by following crude drug preparation: golden Semen Fagopyri Esculenti 25-65g, Radix Angelicae Dahuricae 25-65g, storehouse ears or side handles of a utensil 25-65g, Herba Hedyotidis Diffusae 20-60g, Herba Ephedrae 25-45g, Ramulus Cinnamomi 20-60g, Semen Armeniacae Amarum 20-60g, Rhizoma Pinelliae Preparata 25-45g, Radix Platycodonis 20-60g, Cortex Phellodendri 20-60g, Ramulus Uncariae Cum Uncis 20-60g, Herba Violae 25-45g, Radix Glycyrrhizae 10-30g.
Preferably, the treatment chronic respiratory disease Chinese herbal and crude drugs preparations after preferred is by following crude drug preparation and get: golden Semen Fagopyri Esculenti 45g, Radix Angelicae Dahuricae 45g, storehouse ears or side handles of a utensil 45g, Herba Hedyotidis Diffusae 40g, Herba Ephedrae 35g, Ramulus Cinnamomi 40g, Semen Armeniacae Amarum 40g, Rhizoma Pinelliae Preparata 35g, Radix Platycodonis 40g, Cortex Phellodendri 40g, Ramulus Uncariae Cum Uncis 40g, Herba Violae 35g, Radix Glycyrrhizae 20g.
Above medical material is shattered, and 80 orders sieve, and mix homogeneously encapsulates airtight.Usage and consumption: usage: spice is freely adopted and is raised; Therapeutic dose: 500g spice 250kg; The preventive dose use that reduces by half.
The present invention is mainly used in chicken and brings out mycoplasma gallisepticam infection because of anemofrigid cold, be the disease of the chronic respiratory of main clinical characteristics with ataxia, upper respiratory tract adnormal respiration, coli-infection to the while secondary also has the better prevention effect, through mycoplasma gallisepticam infection morbidity treatment, external antibacterial, series of experiment research such as the acute and chronic toxicity of laboratory animal medicine, physical and chemical determination, field application control test show: chicken colibacillosis CVCC-245 bacterial strain and chicken virus mycoplasma 352-PG31 strain are all had the obvious suppression effect; It is 84.6～86.7 % that chicken virus mycoplasma 352-PG31 strain artificial challenge prevents and treats the experiment effective percentage, field application test effective percentage is 86.06%, the control theory of Chinese veterinarian's medical science " treating both the principal and secondary aspects of a disease " is followed in its prescription medicine screening strictness, fully taken into account the clinical pathology characteristic of chronic respiratory disease during poultry is produced, its application has better prevention effect and safety in utilization.Effect with relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, relieving cough and asthma, expectorant, the sharp key of lung qi dispersing, relieving diarrhea with astringents.
, test material
Preparation trade name of the present invention is " chronic respiratory diseases is logical ".
1.1 experiment medicine and prescription:
" chronic respiratory diseases is logical " main ingredient of prescription: golden Semen Fagopyri Esculenti, the Radix Angelicae Dahuricae, the storehouse ears or side handles of a utensil, Herba Ephedrae, Ramulus Cinnamomi, Cortex Phellodendri, Herba Violae etc.
1.2 experimental strain: chicken colibacillosis CVCC-245 pathogenic strain, chicken virus mycoplasma 352-PG31 strain are available from China Veterinery Drug Inspection Office.
1.3 artificial challenge's laboratory animal: 400 of 35 ages in days hybridization broiler, body weight 400g ± 25g
1.4 acute, sub-acute toxicity test animal: 40 of Kunming white mice (each 20 of male and females), 32 of SD rats (each 16 of male and females), laboratory animal room provides by Guiyang Medical College.
1.5 experiment culture medium: meat soup, Yihong methylene blue, Mai Kangkai, mycoplasma selective medium.
, experiment content and method
2.1 antibacterial culturing and counting: through 37 ℃ of 24h the CVCC245 bacterial strain is cultivated rejuvenation with Yihong methylene blue, Mai Kangkai selective medium, be inoculated in amplification culture in the broth bouillon; Through 37 ℃ of 24h chicken virus mycoplasma strain 352-PG31 is cultivated rejuvenation and amplification culture 36h counting with the mycoplasma selective medium, press 4X10
10/ ml bottling is standby.
2.2 external bacteriostatic experiment:
Preparation is decocted the drug level preparation that is condensed into 1g crude drug/ml make the annular antibacterial scraps of paper (diameter 3mm), carry out antibacterial cultivation 24h in ordinary flat, observe the growing state of chicken colibacillosis CVCC-245 bacterial strain, chicken virus mycoplasma 352-PG31 strain, be judged to significantly greater than 5～6mm as antibacterial circle diameter.
2.3 artificial challenge and control experiment
2.3.1 laboratory animal grouping: establish 4 of bacteria artificial infection experiment groups, wherein be used for 1 of prescription Prevention Processing postoperative infection group, 1 of direct infection prescription treatment group, 1 of direct infection chemical medicine treatment group, 1 of direct infection observation matched group; 1 of experiment blank group; Every group of experimental chicken quantity is 80.
2.3.2 artificial challenge's experiment: to 4 infection experiment group chicken collunarium 1ml mycoplasma bacterium liquid (4 * 10 that arrange
10/ ml viable bacteria).
2.3.3 medicine for treatment dosage and method: treat experimental infection chicken mass-sending after being ill, to first, second experimental group with " chronic respiratory diseases leads to " Chinese herbal medicine powder (80 orders sieve) of preparation by every day per kilogram of body weight 0.3g spice freely adopt and raise, use 7d continuously; The 3rd experimental group is converted water 150 ㎏ by 100g and freely drunk with 5% tylosin (Henan stablize the country animal pharmaceutcal corporation, Ltd produce) every day, be used in conjunction 7d; The 4th not medication of experimental group is the treatment matched group; The 5th group is the blank group.
2.4 acute, subacute toxicity pharmacological testing: according to country " Chinese medicine natural drug long term toxicity research guideline ", formulate acute toxicity test (MTD) and repetitively administered toxicity test with II level laboratory animal Kunming white mice, rat (SD strain), at utmost to expose its drug toxicity, to inspections such as its blood coagulation system index, blood parameters and each main device disease of ZANG-organs reason histology variations.
2.5 physical and chemical determination experiment: will " chronic respiratory diseases is logical " Chinese herbal and crude drugs preparations entrust Institute of Analysis of Guizhou Normal University according to 5337-2008 JY/T023-1996 carry out main determination of heavy metal elements such as lead, cadmium, hydrargyrum, arsenic, copper.
2.6 field application test: in Kweiyang, Guizhou Province, prevention and the clinical treatment application of carrying out chronic respiratory disease of the part chicken farm in areas such as Zun Yi, the south of Guizhou Province, the southeast of Guizhou Province, Anshun, six Pan Shui test.
, experimental result:
3.1 bacteriostatic experiment: to chicken colibacillosis CVCC-245 bacterial strain antibacterial circle diameter all between 4.6～6.5mm; To chicken virus mycoplasma 352-PG31 strain antibacterial circle diameter all between 3.5～4.5mm.
3.2 medical treatment experiment: the results are shown in Table 1.
Subordinate list 1:
Annotate: prescription prophylactic treatment group is earlier with the laggard pedestrian worker's infection experiment of experiment prescription Prevention Processing 7d.
3.3 acute, subacute toxicity pharmacological testing:
3.4 physical and chemical determination analysis: see Table 2.
Subordinate list 2:
3.5 application test: the results are shown in Table 3.
Subordinate list 3:
4, experimentation analysis:
4.1 the Chinese medicine formula that this experimentation filters out " chronic respiratory diseases is logical " has the effect of relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, relieving cough and asthma, expectorant, the sharp key of lung qi dispersing, relieving diarrhea with astringents.The effect of the sharp key of lung qi dispersing.Bacteriostatic experiment shows that " chronic respiratory diseases is logical " all has the obvious suppression effect to chicken colibacillosis CVCC-245 bacterial strain and chicken virus mycoplasma 352-PG31 strain; The artificial challenge prevents and treats experiment and the clinical prevention application test shows, the experiment prescription has tangible prevention effect to the chicken chronic respiratory tract infection, it is 84.6～86.7% that its artificial challenge prevents and treats the experiment effective percentage, 22.25 ten thousand of field application test chicken groups, average effectiveness level 86.06%.Wherein, test 1 group of sickness rate and cure rate and all be better than other experimental group, show that " chronic respiratory diseases is logical " has the early prevention and treatment effect to chronic respiratory disease.
4.2 acute and sub-acute toxicity experimentation shows that " chronic respiratory diseases is logical " no obvious toxicology meaning does not have obvious toxic and side effects in production application, have good safety in utilization and reliability.
4.3 the treatment use amount of " spirit of intestinal bar is loose " is per kilogram of body weight 0.3g every day, using method is spice, be 1000g spice 250kg, the every 1000g feedstuff of content that increases behind the main heavy metal ion batch mixing in the physical and chemical determination is: arsenic 0.0006mg, plumbous 0.0876mg, hydrargyrum 0.0001mg, diaphragm 0.0019mg.The content of relevant heavy metal ion in China's feed safety production standard, that is: 0mg, lead≤13.0mg, hydrargyrum≤0.10mg, the diaphragm≤0.50mg of arsenic in every 1000g feedstuff≤2..Simultaneously, be 5～7d the service time of preventing and treating in the process, is difficult for causing the long-term cumulative action of heavy metal ion.
4.4 in the poultry production practices, in the chronic respiratory disease generating process often secondary have pathogenic entero becterias such as escherichia coli, Salmonella to infect, drug screening in " chronic respiratory diseases is logical " prescription has fully taken into account the inhibitory action to pathogenic entero becteria, can significantly reduce morbidity chicken group's mortality rate and strengthen its therapeutic effect.
The specific embodiment
The embodiment of the invention 1: golden Semen Fagopyri Esculenti 45g, Radix Angelicae Dahuricae 45g, storehouse ears or side handles of a utensil 45g, Herba Hedyotidis Diffusae 40g, Herba Ephedrae 35g, Ramulus Cinnamomi 40g, Semen Armeniacae Amarum 40g, Rhizoma Pinelliae Preparata 35g, Radix Platycodonis 40g, Cortex Phellodendri 40g, Ramulus Uncariae Cum Uncis 40g, Herba Violae 35g, Radix Glycyrrhizae 20g.
Above medical material is shattered, and 80 orders sieve, and mix homogeneously encapsulates airtight.Usage and consumption: usage: spice is freely adopted and is raised; Therapeutic dose: 500g spice 250kg; The preventive dose use that reduces by half.
The embodiment of the invention 2: golden Semen Fagopyri Esculenti 25g, Radix Angelicae Dahuricae 25g, storehouse ears or side handles of a utensil 25g, Herba Hedyotidis Diffusae 20g, Herba Ephedrae 25g, Ramulus Cinnamomi 20g, Semen Armeniacae Amarum 20g, Rhizoma Pinelliae Preparata 25g, Radix Platycodonis 20g, Cortex Phellodendri 20g, Ramulus Uncariae Cum Uncis 20g, Herba Violae 25g, Radix Glycyrrhizae 10g.
Above medical material is shattered, and 80 orders sieve, and mix homogeneously encapsulates airtight.Usage and consumption: usage: spice is freely adopted and is raised; Therapeutic dose: 500g spice 250kg; The preventive dose use that reduces by half.
The embodiment of the invention 3: golden Semen Fagopyri Esculenti 65g, Radix Angelicae Dahuricae 65g, storehouse ears or side handles of a utensil 65g, Herba Hedyotidis Diffusae 60g, Herba Ephedrae 45g, Ramulus Cinnamomi 60g, Semen Armeniacae Amarum 60g, Rhizoma Pinelliae Preparata 45g, Radix Platycodonis 60g, Cortex Phellodendri 60g, Ramulus Uncariae Cum Uncis 60g, Herba Violae 45g, Radix Glycyrrhizae 30g.
Above medical material is shattered, and 80 orders sieve, and mix homogeneously encapsulates airtight.Usage and consumption: usage: spice is freely adopted and is raised; Therapeutic dose: 500g spice 250kg; The preventive dose use that reduces by half.
Claims (2)
1. treat the chronic respiratory disease Chinese herbal and crude drugs preparations for one kind, it is characterized in that: it is made up of following crude drug: golden Semen Fagopyri Esculenti 25-65g, Radix Angelicae Dahuricae 25-65g, Fructus Xanthii 25-65g, Herba Hedyotidis Diffusae 20-60g, Herba Ephedrae 25-45g, Ramulus Cinnamomi 20-60g, Semen Armeniacae Amarum 20-60g, Rhizoma Pinelliae Preparata 25-45g, Radix Platycodonis 20-60g, Cortex Phellodendri 20-60g, Ramulus Uncariae Cum Uncis 20-60g, Herba Violae 25-45g, Radix Glycyrrhizae 10-30g.
2. a kind of chronic respiratory disease Chinese herbal and crude drugs preparations for the treatment of according to claim 1, it is characterized in that: it is made up of following crude drug: golden Semen Fagopyri Esculenti 45g, Radix Angelicae Dahuricae 45g,, Fructus Xanthii 45g, Herba Hedyotidis Diffusae 40g, Herba Ephedrae 35g, Ramulus Cinnamomi 40g, Semen Armeniacae Amarum 40g, Rhizoma Pinelliae Preparata 35g, Radix Platycodonis 40g, Cortex Phellodendri 40g, Ramulus Uncariae Cum Uncis 40g, Herba Violae 35g, Radix Glycyrrhizae 20g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100830060A CN102579731B (en) | 2012-03-27 | 2012-03-27 | Chinese herbal preparation for treating chronic respiratory diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100830060A CN102579731B (en) | 2012-03-27 | 2012-03-27 | Chinese herbal preparation for treating chronic respiratory diseases |
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| Publication Number | Publication Date |
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| CN102579731A CN102579731A (en) | 2012-07-18 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1562151A (en) * | 2004-03-30 | 2005-01-12 | 沈惠明 | Medicinal formulation for treating upper respiratory track infection and its design method |
| CN101612226A (en) * | 2009-07-22 | 2009-12-30 | 朱正君 | A kind of Chinese medicine preparation for the treatment of flu |
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| CN1562151A (en) * | 2004-03-30 | 2005-01-12 | 沈惠明 | Medicinal formulation for treating upper respiratory track infection and its design method |
| CN101612226A (en) * | 2009-07-22 | 2009-12-30 | 朱正君 | A kind of Chinese medicine preparation for the treatment of flu |
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