CN102488105B - Health care feed additive for farrowing sows and preparation method thereof - Google Patents

Abstract

The invention discloses a health-care feed additive for farrowing sows and a preparation method thereof, which is mainly prepared by mixing vitamin A, vitamin E, buliuxing, chuanxiong, saponin, and potassium diformate in a certain weight ratio Therefore, the present invention selects vitamin A and vitamin E which have beneficial effects on sow fecundity, potassium diformate and Chinese herbal medicine powder which can replace antibiotics. The prescription is scientific and well-prepared, which can not only prevent diseases, improve immune function, improve The fertility of sows can also provide various nutrition, improve the quality and quantity of milk of sows, enhance the physique of piglets, and reduce the feeding cycle.

Description

Health-care feed additive for farrowing sows and preparation method thereof

technical field

The invention relates to a pig feed, in particular to a health-care feed additive for farrowing sows.

Background technique

With the development of intensive and large-scale pig production and the improvement of management level, in order to achieve high production efficiency of sow herds, producers have higher and higher requirements on the quality, variety, health status and litter rate of pig herds. By improving the management means, the pigs can be produced at full capacity under the control of a strict production plan, which will increase the proportion of abnormal elimination of the pigs. In these culled herds, a significant proportion of individuals were culled due to reproductive and lactation problems. Excessive sow culling rate will bring pressure to normal production, increase the production cost of gilts, and also have a negative impact on the stability of the production of the entire herd. People add a large amount of chemical drugs and antibiotics to the feed, which has achieved certain results in improving the fecundity of sows and preventing diseases, but the effect is not satisfactory. The problem of drug residues in the application of chemicals and antibiotics has an impact on human health. And its harm has increasingly attracted the attention of scholars at home and abroad.

Contents of the invention

Therefore people can improve immunity, enhance disease resistance, improve sow's fecundity and milk quality health-care sow feed additive for farrowing sows and there is a great demand. So far, have not found any relevant report about the present invention. After repeated studies and repeated clinical verifications, the inventor finally successfully researched a health-care feed additive for farrowing sows, thereby completing the present invention.

The purpose of the present invention is to provide a health-care feed additive for farrowing sows that can improve immunity, enhance disease resistance, and improve sow fecundity and milk quality.

Another object of the present invention is to provide a preparation method of the health-care feed additive for farrowing sows.

The solution of the present invention is to select vitamin A, vitamin E, blancia, astragalus, Codonopsis pilosula, Angelica sinensis, Chuanxiong, Passepartout, licorice, saponin thorn, leaking reed, Atractylodes macrocephala and potassium diformate to combine. The drug combination makes each drug produce a synergistic effect, thereby effectively improving the immunity of the sow, improving the fecundity of the sow and the quality of milk. Among them, vitamin A is selected, English name: vitamin A, other names: retinol (retinol), definition: the general name of all β ionone derivatives. A fat-soluble vitamin structurally related to carotene. There are two types of vitamin A ₁ and vitamin A ₂ . Different from carotenoids, it has a variety of biological activities of all-trans retinol. Necessary for certain metabolic processes, especially the biochemical processes of vision. Vitamin A, chemically called retinol, was the first vitamin to be discovered. There are two types of vitamin A. One is vitamin A alcohol (retionl), which is the original form of vitamin A (only found in animal foods); the other is carotene, which is converted into a preformed substance of vitamin A in the body (provitaminA, which can Intake from plant and animal foods); the measurement units of vitamin A are USP unit (United States Pharmacopea), IU unit (International Units), RE unit (Retinol Equivalents) and so on. Vitamin A (vitaminA), also known as retinol (its aldehyde derivative retinal), is an unsaturated monohydric alcohol with an alicyclic ring, including vitamin A ₁ and vitamin A ₂ . Vitamins A ₁ and A ₂ are structurally similar). Retinol can be synthesized from plant-derived β-carotene. Under the catalysis of β-carotene-15,15′-dioxygenase (dioxygenase) in the body, β-carotene can be converted into two molecules of retinol Aldehyde (ratinal), retinal is reduced to retinol under the action of retinal reductase. But β-carotene can also synthesize astaxanthin (a strong antioxidant), vitamin A ₁ molecular formula: C ₂ 0H ₃ 0O, vitamin A ₂ molecular formula: C20H28O, molecular weight 286.452, the role of vitamin A on the human body[1] utility : 1. Prevent night blindness and vision loss, help to treat various eye diseases (vitamin A can promote the formation of photosensitive pigment in the eye); 2. Have anti-respiratory system infection; 3. Help the immune system function normally; 4. Can recover quickly when sick; 5. Can maintain the health of the surface of tissues or organs; 6. Helps get rid of brown spots; 7. Promotes development, strengthens bones, and maintains the health of skin, hair, teeth, and gums; 8. External use Helpful in the treatment of acne, pustules, boils, and skin surface ulcers; 9. Helpful in the treatment of emphysema and hyperthyroidism. Choose vitamin E, English name: vitamin E, other names: tocopherol (tocopherol), definition: a group of fat-soluble vitamins, including tocopherols and tocotrienols. All have anti-oxidant functions, which are necessary for the normal growth and reproduction of animals. Vitamin E (Vitamin E) is a fat-soluble vitamin, also known as tocopherol, is one of the most important antioxidants. Soluble in organic solvents such as fat and ethanol, insoluble in water, stable to heat and acid, unstable to alkali, sensitive to oxygen, not sensitive to heat, but the activity of vitamin E is significantly reduced when fried. Tocopherol can promote the secretion of sex hormones, increase the vitality and quantity of male sperm; increase the concentration of estrogen, improve fertility, prevent abortion, and can also be used to prevent and treat male infertility, burns, frostbite, and capillary bleeding. Recently, it has also been found that vitamin E can inhibit the lipid peroxide reaction in the lens of the eye, dilate peripheral blood vessels, improve blood circulation, and prevent the occurrence and development of myopia. Function: 1. Promote the secretion of pituitary gonadotropin, promote the production and activity of sperm, increase ovarian function, increase follicles, increase corpus luteum cells and enhance the effect of progesterone. When it is lacking, the reproductive organs are damaged and it is not easy to fertilize or cause habitual abortion. 2. Improve lipid metabolism, when lacking, it will lead to the increase of plasma cholesterol (TC) and triglyceride (TG), forming atherosclerosis. 3. Sensitive to oxygen and easily oxidized, it can protect other easily oxidized substances, such as unsaturated fatty acids, vitamin A and ATP. Reduce the generation of lipid peroxide, protect the body cells from free radicals, and give full play to the specific physiological functions of the protected substances. 4. Stabilize the cell membrane and intracellular lipids, reduce the fragility of red blood cells, and prevent hemolysis. Hemolytic anemia occurs in deficiency. 5. Large doses can promote the proliferation of capillaries and small blood vessels, and improve peripheral circulation. Select wangbuliuxing to be because its nature and flavor are bitter, flat, returns to liver, stomach meridian, has the effect of promoting blood circulation and stimulating menstruation, promoting breastfeeding, reducing swelling and suppressing sores, and can cure galactostasis, dystocia and bloody stranguria. Select Radix Astragali to be because its nature and flavor are sweet, lukewarm, enter lung, spleen meridian, raw use is beneficial to defend and solidify exterior, diuresis detumescence, detoxification, the function of muscle regeneration, controls spontaneous perspiration, night sweat, arthralgia due to blood, edema, carbuncle ulcer does not ulcerate Or collapse for a long time; Sunburn has the function of nourishing the middle and benefiting, treating internal injury and fatigue, spleen deficiency and diarrhea, prolapse of the anus, qi deficiency and blood loss, collapse and all symptoms of qi deficiency and blood deficiency. Codonopsis Codonopsis is selected because its nature and flavor are sweet and flat, and it divides Qi into the hands and foot Taiyin meridians. , prolapse of the anus. Angelica sinensis is selected because its nature and flavor are sweet and pungent, warm, enter the heart, liver, and spleen meridians, have the functions of nourishing blood and blood, regulating menstruation and relieving pain, moistening dryness and smoothing the intestines, and can treat irregular menstruation, amenorrhea, abdominal pain, lumps in the abdomen, metrorrhagia and metrorrhagia , blood deficiency, headache, dizziness, impotence, dryness of the intestines and difficulty in defecation, heavy dysentery after redness, carbuncle sores, golden sores, injury from falls. Select Rhizoma Chuanxiong to be because its nature and flavor are pungent, warm, enter liver, gallbladder meridian, have promoting the circulation of qi and promoting depression, dispelling wind and dampness, the function of promoting blood circulation and relieving pain, controls wind-cold headache, dizziness, hypochondriac pain, abdominal pain, arthralgia due to cold, Amenorrhea, dystocia, postpartum stasis block pain, carbuncle sores. Honeysuckle is selected to be because its nature and flavor are bitter and flat, belongs to the twelve meridians, has the functions of dispelling wind and dredging collaterals, diuresis and dehumidification, and controls limb pain, edema, fullness, amenorrhea, and less milk. Select Radix Glycyrrhizae to be because its nature and flavor sweet flat, return spleen, stomach, lung meridian, have lung moistening, detoxification, the effect of reconciling various medicines, controls peptic ulcer, carbuncle sore, detoxifies drug poison and food poisoning because its nature and flavor are sweet and flat. Select Radix Fructus Radix Sinensis for use to be because its nature and flavor are pungent, warm, has search wind, draws out toxin, detumescence, the function of evacuating pus, controls carbuncle, sore, febrile wind, tinea sore, retained placenta. Select for use Loulu to be because its nature and flavor are bitter-cold, return Stomach Channel, have heat-clearing and toxic substances removing, the function of eliminating carbuncle and lowering milk, is used for mastitis swells and ache, and galactostasis. Atractylodes macrocephala is selected because its nature and flavor are bitter and sweet, warm, enters the spleen and stomach meridians, has the functions of invigorating the spleen, benefiting the stomach, drying dampness, neutralizing the middle, and controls spleen and stomach qi weakness, lack of appetite, fatigue and lack of qi, bloating, and diarrhea. Diarrhea, phlegm retention, edema, jaundice, arthralgia from dampness, dysuria, dizziness, spontaneous perspiration, restless fetal gas. Potassium diformate is a new type of antibiotic growth promoter substitute product launched by BASF in 2001, which has a good effect on Escherichia coli and Salmonella. Domestic application research has also received attention. Beijing Challenge Agricultural Technology Co., Ltd. took the lead in obtaining the production license of new feed additives. Due to the large amount of potassium diformate added in the feed, there will be a lot of feed cost input in the feed. In a general sense, when antibiotics are allowed to be used in China, too high adding costs will be difficult for feed production. Accepted by enterprises and farmers, there are few public reports on the synthesis technology of potassium diformate at home and abroad, but if the reference process (Liang Ping, 2004) is produced, the cost is quite high under the condition of satisfying the yield. How to find cheaper raw materials, obtain more ideal yields, reduce production costs, and accelerate the promotion of this new, green, and efficient product are the primary issues worthy of discussion in the industry. The research and development of potassium diformate for feed originated in Europe in the mid-1990s. Among the options currently being discussed and studied, potassium diformate is of widespread interest to the nutrition community and the swine industry. Potassium diformate has been reported to have anti-bacterial effects and improve feed digestibility. It has obvious growth-promoting effect on growing and finishing pigs and lactating sows, and can significantly improve production performance. Pig growth performance tests and large-scale application in Europe have shown that compared with antibiotic growth-promoting agents, it is not only safe and has no side effects, but also has considerable and stable improvements in daily weight gain and feed remuneration of pigs. Secondly, the safety determined by the simple chemical structure and the ease of use determined by the physical properties of pure crystalline salts have become another reason for their popularity. Preparation and properties and characteristics: 1. Materials and methods. 1.1 Raw materials: formic acid, Tianjin Huadong Chemical Reagent Factory, potassium hydroxide with an analytically pure content of 88%, and Laiyang Shuangshuang Chemical Co., Ltd., with an analytically pure content of 82% deionized water. 1.2 Instrument raw materials: four-necked round bottom reaction flask, powerful electric stirrer, thermometer, temperature-controllable oil bath, Buchner funnel, suction filter, oven and other glass instruments. 1.3 Principle: The molar ratio of formic acid and potassium hydroxide is 1-1.5:1 to obtain potassium formate in the form of acid-base reaction at a certain temperature, and then supplement the formic acid required to form potassium diformate. 1.4 Test: Method: Weigh 65.5g, 88% formic acid and add it into a 25Oml four-necked round bottom reaction bottle, slowly add 68.2g potassium hydroxide under stirring, react for 2 hours at a temperature lower than 80°C, then add 43g formic acid, and continue the reaction 2h, lowered to 25°C, filtered, and dried in a vacuum oven at 60°C for 7-10 hours to obtain white crystals of potassium diformate with a yield of 65.5-67g and a one-way yield of 50.19%. After treating the mother liquor, the product can be obtained About 35-48g, the total yield can reach 88%. 1.5 Product analysis: determination of product indicators (1) main content and requirements, 97-105% (2) volatile formic acid content, 33-37%.

The consumption of the raw materials of the present invention is also obtained by the inventor through a large amount of exploration, and the consumption of each raw material has a better effect within the following weight ranges.

Vitamin A 1.5～2.5g Vitamin E 6～10g Wangbuliuxing 70～75g

Astragalus 40～45g Dangshen 40～45g Angelica 70～75g

Chuanxiong 70～75g Passepartout 25～30g Licorice 40～45g

Saponaria thorn 40～45g Leaky reed 25～30g Atractylodes macrocephala 40～45g

Potassium diformate 450～500g

preferably

Vitamin A 2g Vitamin E 8g Wangbuliuxing 73g

Astragalus 43g Dangshen 43g Angelica 73g

Chuanxiong 73g Passepartout 28g Licorice 43g

Saponaria thorn 43g Leaky reed 28g Atractylodes rhizome 43g

Potassium diformate 500g

The preparation method of the present invention comprises the following steps

1. Preparation

1. Wang buliuxing: dust off impurities, put it in a pot, stir-fry over low heat until 60% to 70% of the white flowers burst, take it out, and let it cool;

2. Radix Astragali: Clean the impurities, remove the remaining roots and those with larger hollows, soak them in water, remove them, slice them in time after moistening, and dry them in the sun;

3. Codonopsis pilosula: wash the sediment and moisten thoroughly to remove the reeds, slice or cut into sections, and dry in the sun;

4. Angelica sinensis: pick and remove miscellaneous ingredients, wash, moisten, dry for a while until the internal and external humidity is suitable, then slice and dry;

5. Ligusticum chuanxiong: remove impurities, separate the large and small ones, soak them in water, dry them in the sun, moisten them, slice them, and dry them;

6. Passepartout: Picked in winter, remove impurities, wash and dry;

7. Licorice: pick out impurities, wash, soak in water until 80% transparent, remove, moisten, slice, and dry;

8. Saponaria thorn: remove impurities, soak in water, moisten thoroughly, slice into slices, and dry in the sun;

9. Leaking reed: remove impurities, bristles, wash, moisten thoroughly, cut into thick slices, dry, and sieve to remove debris;

10. Atractylodes macrocephala: pick out impurities, soak in water, remove after soaking, moisten thoroughly, slice into pieces, and dry in the sun.

2. Preparation

1. Put vitamin A and vitamin E into the mixing tank according to the weight of the above raw materials and mix them for 5-10 minutes, as vitamin masterbatch;

2. According to the weight of the above raw materials, pulverize all the vaccum, astragalus, codonopsis, angelica, chuanxiong, Passepartout, hay, saponins, leaking reeds, and Atractylodes macrocephala, pass through a No. 2 sieve, and then put them into the mixing tank for mixing and stirring for 5 ~10 minutes, as a masterbatch of Chinese herbal medicine;

3. Mix the above-mentioned vitamin masterbatch, Chinese herbal medicine masterbatch and potassium diformate together for 10-15 minutes;

4. After testing and weighing, pack them in airtight containers or plastic bags to obtain health-care feed additives for farrowing sows;

5. When in use, add health-care feed additive for farrowing sows to the full-price feed for sows according to the addition amount of 1% by weight, mix evenly, and then feed.

The beneficial effects of the present invention are: the present invention selects vitamin A and vitamin E which have beneficial effects on the fecundity of sows, potassium diformate and crushed Chinese herbal medicines which can replace antibiotics, and has scientific prescriptions, which can not only prevent diseases and improve immune function 1. Improve the fecundity of sows and increase the quality and quantity of sow milk. It can also provide various nutrients, thereby increasing the birth weight and weaning weight of piglets, and reducing the feeding cycle. At the same time, due to the scientific use of Chinese herbal medicines in the formula, antibiotics are greatly reduced The application of animal products can achieve no drug residues.

Detailed ways

[Test example 1]

Feed the sows with 1% health-care feed additive for farrowing sows by weight, and then observe and record the sows' disease resistance, farrowing and weaning every day, so as to evaluate the feeding effect of the product.

1. Test date: July 2, 2011 to October 2, 2011.

2. Experimenters: Wang Yong, Liu Huimin, Du Heng.

3. Test site: Fuyang West Lake Ecological Pig Farm.

4. Test method:

(1) Control group: special full-price feed for feeding lactating sows, manufacturer: Weifang Xincheng Animal Nutrition Technology Co., Ltd., batch number: 110620

(2) Test group: on the basis of the full-price feed specially used for feeding lactating sows, add the health care feed additive for farrowing sows of the present invention with a weight ratio of 1%.

(3) Experimental animals

In this experiment, sows with adjacent due dates were randomly selected in the gestation house, and randomly divided into two groups, with 36 sows in each group as test animals. In this experiment, an automatic feeding system was adopted, and the full-price feed for lactating sows was changed from the 90th day of pregnancy. Pregnant sows were transferred to the farrowing room 3 days before delivery, and from 3 days before delivery to 3 days after delivery, the amount of feed was restricted according to the actual situation, and then the amount of feed was increased day by day to ad libitum. Piglets were supplemented with iron at the age of 1 day, and began to induce food and feed at the age of 7. According to the actual situation, they were weaned between 24 and 30 days of age.

The control group was fed with the special full-price feed for lactating sows produced by Weifang Xincheng Animal Nutrition Technology Co., Ltd., and the experimental group was fed a ration based on the special full-price feed for lactating sows and its weight ratio was 1% according to the present invention. Sow health feed additive. Record the number of qualified piglets produced by sows, newborn litter weight, weaning weight, survival rate and other indicators.

(5) Observation of feeding situation:

The 90-day test results (from July 2, 2011 to October 2, 2011) showed that the average birth weight of piglets in the test group was 1.64kg/head, which was 160g/head higher than that in the control group (see Table 1 for details).

Table 1 Statistical table of primary data of each group

The weaning weight of the 25-day-old piglets in the test group was 8.575kg/head, which was 1.1kg higher than that of the control group; the average daily gain was 283g/day, which was 44g/day higher than that of the control group; the survival rate increased by 7.15%. (See Table 2 for details)

Table 2 Statistical table of weaning data in each group

5. Result analysis:

After the test group was added with the health-care feed additive for farrowing sows of the present invention, the ability of the sow body to resist diseases was significantly enhanced. The coat color is ruddy and shiny, the health is high, and the sows are in estrus in time after weaning.

6 Conclusion:

Adding the piglet health-care feed additive of the present invention to the feed can not only prevent sow diseases, improve immune function, improve sow fecundity, improve sow milk quality and quantity, but also provide various nutrition, thereby improving piglet health. Birth weight and weaning weight. Therefore, the health-care feed additive for farrowing sows of the present invention is worthy of vigorous promotion and use.

Claims (3)

1. A health-care feed additive for farrowing sows, characterized in that: it is made from raw materials in the following weight ranges: Vitamin A 1.5～2.5g Vitamin E 6～10g Wang Buliuxing 70～75g Astragalus 40～45g Codonopsis Ginseng 40～45g Angelica 70～75g Chuanxiong 70～75g Passepartout 25～30g Licorice 40～45g Saponaria thorn 40～45g Leaky reed 25～30g Atractylodes macrocephala 40～45g Potassium diformate 450-500g. 2. The health-care feed additive for farrowing sows according to claim 1, wherein the consumption of each raw material is: Vitamin A 2g Vitamin E 8g Wangbuliuxing 73g Astragalus 43g Codonopsis ginseng 43g Angelica 73g Chuanxiong 73g Passepartout 28g Licorice 43g Saponaria thorn 43g Leaky reed 28g Atractylodes macrocephala 43g Potassium diformate 500g. 3. The preparation method of the health-care feed additive for farrowing sows according to claim 1 or 2, characterized in that: it comprises the following steps: (1) Material preparation (1) Wang Buliuxing: Whisk away impurities, put it in a pot, stir-fry over low heat until 60% to 70% of the white flowers burst, take it out, and let it cool; (2) Radix Astragali: Clean the impurities, remove the remaining roots and those with larger hollows, soak them in water, remove them, slice them in time after moistening, and dry them in the sun; (3) Codonopsis pilosula: wash the sediment and moisten thoroughly to remove the reeds, slice or cut into sections, and dry in the sun; (4) Angelica: remove impurities, wash, moisten, let dry for a while until the internal and external humidity is suitable, then slice and dry; (5) Ligusticum chuanxiong: remove impurities, separate the large and small ones, soak them in water, dry them in the sun, moisten them, slice them, and dry them; (6) Passepartout: Picked in winter, remove impurities, wash and dry; (7) Licorice: pick out impurities, wash, soak in water until 80% transparent, remove, moisten, slice, and dry; (8) Saponaria thorn: remove impurities, soak in water, moisten thoroughly, slice into slices, and dry in the sun; (9) Leaking reed: remove impurities and bristles, wash, moisten thoroughly, cut into thick slices, dry, and sieve to remove debris; (10) Atractylodes macrocephala: pick out impurities, soak in water, remove after soaking, moisten thoroughly, slice, and dry in the sun; (2) Preparation (1) Put vitamin A and vitamin E into the mixing tank according to the weight of the above raw materials and mix for 5 to 10 minutes, as vitamin masterbatch; (2) According to the weight of the above raw materials, grind all the blancia, astragalus, codonopsis, angelica, chuanxiong, Passepartout, licorice, saponins, leaking reeds, and Atractylodes macrocephala, pass through a No. 2 sieve, and then put them into a mixing tank for mixing 5-10 minutes, as a masterbatch of Chinese herbal medicine; (3) Mix and stir the above-mentioned vitamin masterbatch, Chinese herbal medicine masterbatch and potassium diformate for 10-15 minutes; (4) After testing and weighing, pack them in airtight containers or plastic bags to obtain health-care feed additives for farrowing sows.