CN102334493B - Novel fluopicolide-containing antibacterial composition - Google Patents
Novel fluopicolide-containing antibacterial composition Download PDFInfo
- Publication number
- CN102334493B CN102334493B CN201110328260.8A CN201110328260A CN102334493B CN 102334493 B CN102334493 B CN 102334493B CN 201110328260 A CN201110328260 A CN 201110328260A CN 102334493 B CN102334493 B CN 102334493B
- Authority
- CN
- China
- Prior art keywords
- fluopicolide
- methyl
- thiophanate
- carbendazim
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a novel fluopicolide-containing antibacterial composition. The novel fluopicolide-containing antibacterial composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is fluopicolide; the active ingredient B is one of thiophanatemethyl and carbendazim; the weight ratio of the active ingredient A to the active ingredient B is 1:80-60:1; and wettable powder, water dispersible granules, suspending agents, suspending emulsion, water emulsion and microemulsion can be prepared by adding aids into the active ingredients. The novel fluopicolide-containing antibacterial composition is used for preventing and controlling downy mildew, epidemic disease, late blight, dampingoff, powdery mildew, botrytis, early blight, fusarium wilt, sclerotiniose, anthracnose, ring spot, penicilliosis and green mould of crops, can resist rain wash and has obvious synergism.
Description
Technical field
The invention belongs to technical field of pesticide, the application of the bactericidal composition that relates to a kind of containing fluopicolide in crop pest.
technical background
Fluopicolide, English name: fluopicolide, molecular formula: C
14h
8c
13f
3n
2o, chemical name: 2,6-dichloro, one N mono-[(the chloro-5-trifluoromethyl-2-of 3-pyridine radicals) methyl] benzamide.Fluopicolide protectiveness is good, permeability is strong, and the true guiding principle fungus diseases of oomycetes is had to higher biologically active, has good control efficiency.Can conduct from leaves of plants basal orientation blade tip direction.
No matter be fluopicolide, effective active composition B or other efficient germicides, long-term use separately, easily makes disease develop immunity to drugs, and causes the problems such as dosage increasing, preventive effect reduction, lasting period shortening, is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease conventional method that develops immunity to drugs, and according to the effect in production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can expand fungicidal spectrum, improves germicidal efficiency, alleviates the pollution to environment.Fluopicolide is different from the effective active composition B mechanism of action, and mutually composite have good synergistic effect within the specific limits, and relevant composite about fluopicolide and thiophanate-methyl, carbendazim, there is not yet at present relevant report at home and abroad.
summary of the invention
The object of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains fluopicolide and effective active composition B.
The present invention is achieved through the following technical solutions:
A bactericidal composition for containing fluopicolide, is characterized in that: the weight ratio of A, two kinds of active components of B is 1:80～60:1, and described active components A is fluopicolide, and active component B is selected from the one in thiophanate-methyl, carbendazim.
Described bactericidal composition, is characterized in that: wherein the weight ratio of fluopicolide and effective active composition B is 40:1～1:60.
Described bactericidal composition, is characterized in that: wherein the weight ratio of fluopicolide and thiophanate-methyl is 10:1～1:40, is preferably 1:1～1:20.
Described bactericidal composition, is characterized in that: wherein the weight ratio of fluopicolide and carbendazim is 10:1～1:40, is preferably 1:1～1:20.
Described bactericidal composition, is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion.
Described bactericidal composition is for preventing and treating the application of disease on gramineous crop, peanut, paddy rice, fruit tree and vegetables.
Described application, is characterized in that: described disease comprises: downy mildew, epidemic disease, late blight, damping off, powdery mildew, gray mold, early blight, fusarium wilt, stalk break, anthracnose, ring spot, mould, green mould.
Described bactericidal composition, wherein effective active component content accounts for 1%～95% of gross weight, is preferably 10%～80%.
Described bactericidal composition is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion.
When making wetting powder, composition comprises following constituent content: fluopicolide 0.1%～60%, effective active composition B 0.1%～80%, dispersant 3%～10%, wetting agent 2%～10%, filler surplus.
Fluopicolide, effective active composition B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into the wetting powder product of the present composition.
When making water dispersible granules, composition comprises following constituent content: fluopicolide 0.1%～60%, effective active composition B 0.1%～80%, dispersant 3%～12%, wetting agent 1%～8%, disintegrant 1%～10%, filler surplus.
Fluopicolide, effective active composition B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, make present composition water dispersible granules product.
When making suspending agent, composition comprises following constituent content: fluopicolide 0.1%～40%, active ingredient B 0.1%～50%, dispersant 2%～10%, wetting agent 2%～10%, defoamer 0.1%～1%, thickener 0.1%～2%, antifreeze 0%～8%, stabilizing agent 0%～3%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formulation material are mixed through high speed shear, fluopicolide, add active ingredient B, ball milling 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes present composition suspending agent product.
When making suspension emulsion, composition comprises following constituent content: fluopicolide 0.1%～40%, effective active composition B 0.1%～50%, emulsifier 2%～12%, dispersant 2%～10%, defoamer 0.1%～2%, thickener 0.1%～2%, antifreeze 0.1%～8%, stabilizing agent 0.05%～3%, water add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in above-mentioned formulation material are mixed through high speed shear, add the former medicine of fluopicolide, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make fluopicolide suspending agent, then by the former medicine of effective active composition B, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make present composition suspension emulsion product.
When making aqueous emulsion, composition comprises following constituent content: fluopicolide 0.1%～40%, active component B 0.1%～50%, solvent 2%～10%, emulsifier 2%～12%, dispersant 2%～10%, co-emulsifier 0.2%～5%, antifreeze 0.1%～8%, defoamer 0.1%～2%, thickener 0.1%～2%, deionized water adds to 100%.
By having former medicine, solvent, emulsifier, co-emulsifier to be added together in above-mentioned formula, make to be dissolved into even oil phase.Deionized water, dispersant, antifreeze, defoamer, thickener are mixed, become homogeneous water, under high-speed stirred, water is slowly splashed into oil phase, make the finely disseminated aqueous emulsion product of the present composition.
When making microemulsion, composition comprises following constituent content: fluopicolide 0.1%～40%, active component B 0.1%～50%, emulsifier 5%～15%, solvent 2%～10%, antifreeze 5%～10%, stabilizing agent 0.5%～3%, deionized water adds to 100%.
Above-mentioned formula Central Plains medicine, solvent, emulsifier are added in mother liquor modulation kettle, make even oil phase, deionized water, antifreeze etc. are mixed and inject product modulation kettle, through high-speed stirred, mix and make the transparent or semitransparent microemulsion product of the present composition.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, alkylaryl APEO, aliphatic alcohol polyethenoxy base ether, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, one or more during ester polyoxyethylene is phonetic.
Described wetting agent is selected from: lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, tea are withered, one or more in silkworm excrement, soapberry powder.
Described disintegrant is selected from: one or more in sodium bicarbonate, sodium carbonate, bentonite, urea, ammonium sulfate, aluminium chloride.
Described binding agent is selected from: one or more in gelatin, melon glue, gum Arabic, xanthans, sodium phosphate trimer, phenolic resins, sodium alginate, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, diethylene glycol (DEG), triethylene glycol, polyethylene glycol.
Described solvent is selected from: DMF, 3-methyl cyclohexanol ketenes, NOP, N-pyrrolidones, toluene, propyl alcohol, cyclohexanone, acetone, methyl alcohol, ethanol, butanols, ethylene glycol monomethyl ether, butyl ether, ethyl acetate, vegetable oil, acetonitrile one or more.
Described defoamer is selected from: silicone, C
8～10aliphatic alcohols, C
10～20one or more in saturated fat acids (as capric acid) and acid amides, silicone oil, silicone compound.
Described emulsifier is selected from: agriculture breast 500# (alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600# phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, agriculture breast 400# (benzyl dimethyl phenol polyoxy ethyl ether), agriculture breast 600# (phenyl phenol polyoxy ethyl ether), Nongru-700 # (alkylphenol-formaldehyde resin polyoxy ethyl ether), agriculture breast 36# (phenethyl fluosite polyoxy ethyl ether), agriculture breast 1600# (phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), agriculture breast 33# (alkylaryl polyoxyethylene polyoxypropylene ether), agriculture breast 34# (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), one or more in AEO series (fat alcohol alcohol APEO).
Described stabilizing agent is selected from: one or more in BHT, triphenyl phosphite, epoxychloropropane, organic acid, organic base, ester class, alcohols, antioxidant, surface-active substance, tributyl phosphate, triethanolamine, diethanol amine, monoethanolamine.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Beneficial effect of the present invention: (1) present composition effective active composition fluopicolide and effective active composition B belong to the bactericide of two kinds of different mechanisms of action, and both mutual mixtures can not produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) organic solvent usage amount of the present invention is little, is difficult for producing poisoning, is convenient to transportation and storage, handling safety; (4) present composition has expanded fungicidal spectrum, and the diseases such as crop downy mildew, epidemic disease, late blight, damping off, powdery mildew, gray mold, early blight, fusarium wilt, stalk break, anthracnose, ring spot, mould, green mould are all had to special efficacy.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.
Application Example one
Example 1 41% fluopicolide thiophanate-methyl wetting powder
Fluopicolide 40%, thiophanate-methyl 1%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, Nekal BX 5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 41% fluopicolide thiophanate-methyl wetting powder.
Example 2 81% fluopicolide thiophanate-methyl wetting powders
Fluopicolide 1%, thiophanate-methyl 80%, alkyl benzene sulfonate calcium salt 5%, lauryl sodium sulfate 3%, diatomite add to 100%, and mixture carries out air-flow crushing, make 81% fluopicolide thiophanate-methyl wetting powder.
Example 3 35% fluopicolide thiophanate-methyl wetting powders
Fluopicolide 5%, thiophanate-methyl 30%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, soapberry powder 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 35% fluopicolide thiophanate-methyl wetting powder.
Example 4 80% fluopicolide thiophanate-methyl wetting powders
Fluopicolide 8%, thiophanate-methyl 72%, polycarboxylate 8%, wetting and penetrating agent F 6%, kaolin add to 100%, and mixture carries out air-flow crushing, make 80% fluopicolide thiophanate-methyl wetting powder.
Example 5 42% fluopicolide thiophanate-methyl wetting powders
Fluopicolide 6%, thiophanate-methyl 36%, ester polyoxyethylene are phonetic 6%, Nekal BX 4%, white carbon add to 100%, and mixture carries out air-flow crushing, makes 42% fluopicolide thiophanate-methyl wetting powder.
Example 6 45% fluopicolide thiophanate-methyl wetting powders
Fluopicolide 5%, thiophanate-methyl 40%, alkyl benzene sulfonate calcium salt 7%, lauryl sodium sulfate 4%, bentonite add to 100%, and mixture carries out air-flow crushing, make 45% fluopicolide thiophanate-methyl wetting powder.
Example 7 40% fluopicolide thiophanate-methyl wetting powders
Fluopicolide 10%, thiophanate-methyl 30%, alkylphenol-polyethenoxy are phonetic 8%, Nekal BX 6%, attapulgite add to 100%, and mixture carries out air-flow crushing, makes 40% fluopicolide thiophanate-methyl wetting powder.
Example 8 65% fluopicolide thiophanate-methyl wetting powders
Fluopicolide 5%, thiophanate-methyl 60%, lignosulfonates 6%, wetting and penetrating agent F 4%, kaolin add to 100%, and mixture carries out air-flow crushing, make 65% fluopicolide thiophanate-methyl wetting powder.
Example 9 50% fluopicolide thiophanate-methyl water dispersible granules
Fluopicolide 5%, thiophanate-methyl 45%, lignosulfonates 8%, silkworm excrement 6%, ammonium sulfate 2.8%, attapulgite add to 100%, mix and make 50% fluopicolide thiophanate-methyl water dispersible granules.
Example 10 70% fluopicolide thiophanate-methyl water dispersible granules
Fluopicolide 10%, thiophanate-methyl 60%, polyoxyethylene carboxylate 5%, sldium lauryl sulfate 4%, sodium bicarbonate 1%, bentonite add to 100%, mix and make 70% fluopicolide thiophanate-methyl water dispersible granules.
Example 11 20% fluopicolide thiophanate-methyl suspending agents
Fluopicolide 4%, thiophanate-methyl 16%, lignosulfonates 7%, soapberry powder 3%, silicone oil 0.1%, Magnesiumaluminumsilicate 0.7%, polyethylene glycol 2.4%, deionized water add to 100%, mix and make 20% fluopicolide thiophanate-methyl suspending agent.
Example 12 40% fluopicolide thiophanate-methyl suspending agents
Fluopicolide 10%, thiophanate-methyl 30%, polycarboxylate 8%, wetting and penetrating agent F 4%, C
8～10aliphatic alcohols 0.3%, hydroxyethylcellulose 0.8%, propane diols 2.5%, deionized water add to 100%, mix and make 40% fluopicolide thiophanate-methyl suspending agent.
Example 13 10% fluopicolide thiophanate-methyl suspension emulsions
Fluopicolide 5%, thiophanate-methyl 5%, alkylnaphthalene sulfonate 6%, lauryl sodium sulfate 2%, silicone compound 0.2%, triethanolamine 1.2%, xanthans 1.1%, castor oil polyoxyethylene ether 8%, ethylene glycol 2%, water add to 100%, aforementioned formula material is mixed, make 10% fluopicolide thiophanate-methyl suspension emulsion.
Example 14 21% fluopicolide thiophanate-methyl suspension emulsions
Fluopicolide 20%, thiophanate-methyl 1%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 7%, tea are withered 5%, silicone 0.4%, triphenyl phosphite 1%, polyvinyl alcohol 0.9%, alkyl benzene calcium sulfonate 7%, triethylene glycol 2.5%, water add to 100%, aforementioned formula material is mixed, make 21% fluopicolide thiophanate-methyl suspension emulsion.
Example 15 30% fluopicolide thiophanate-methyl microemulsions
Fluopicolide 3%, thiophanate-methyl 27%, ethyl acetate 5%, toluene 4%, ethylene oxide-propylene oxide block copolymer 7%, sodium alginate 0.8%, glycerine 2.5%, C
8～10aliphatic alcohols 0.3%, deionized water supplies 100%, mixes and makes 30% fluopicolide thiophanate-methyl microemulsion.
Example 16 33% fluopicolide thiophanate-methyl microemulsions
Fluopicolide 30%, thiophanate-methyl 3%, acetone 5%, vegetable oil 7%, xanthans 0.7%, phenethyl phenol polyoxy ethyl polypropylene-base ether 8%, ethylene glycol 3%, silicone compound 0.4%, deionized water supplies 100%, makes 33% fluopicolide thiophanate-methyl microemulsion.
Example 17 13% fluopicolide thiophanate-methyl aqueous emulsions
Fluopicolide 1%, thiophanate-methyl 12%, 3-methyl cyclohexanol ketenes 4%, acetonitrile 3%, polyoxyethylene nonylphenol ether phosphate 7%, triethylene glycol 2%, hydroxyethylcellulose 0.6%, silicone 0.2%, deionized water supplies 100%, makes 13% fluopicolide thiophanate-methyl aqueous emulsion.
Example 18 48% fluopicolide thiophanate-methyl aqueous emulsions
Fluopicolide 3%, thiophanate-methyl 45%, cyclohexanone 6%, acetone 3%, Magnesiumaluminumsilicate 1.2%, polyethylene glycol 2.5%, sorbitan fatty acid ester APEO 6%, silicone oil 0.3%, deionized water supplies 100%, makes 48% fluopicolide thiophanate-methyl aqueous emulsion.
Example 19 40.5% fluopicolide carbendazol wettable powders
Fluopicolide 0.5%, carbendazim 40%, naphthalene sulfonic acid-formaldehyde condensation product 8%, neopelex 5%, white carbon 10%, diatomite add to 100%, and mixture carries out air-flow crushing, make 40.5% fluopicolide carbendazol wettable powder.
Example 20 61% fluopicolide carbendazol wettable powders
Fluopicolide 60%, carbendazim 1%, octylphenol polyethylene oxyethylene group ether sulfate 6%, Nekal BX 5%, bentonite add to 100%, and mixture carries out air-flow crushing, make 61% fluopicolide carbendazol wettable powder.
Example 21 40% fluopicolide carbendazim water dispersing granules
Fluopicolide 4%, carbendazim 36%, alkyl benzene sulfonate calcium salt 5%, wetting and penetrating agent F4%, urea 3%, kaolin add to 100%, mix and make 40% fluopicolide carbendazim water dispersing granule.
Example 22 80% fluopicolide carbendazim water dispersing granules
Fluopicolide 10%, carbendazim 70%, lignosulfonates 6%, spaonin powder 5%, white carbon add to 100%, mix and make 80% fluopicolide carbendazim water dispersing granule.
Example 23 20% fluopicolide carbendazim suspending agents
Fluopicolide 5%, carbendazim 15%, polycarboxylate 7%, neopelex 3%, silicone oil 0.1%, Magnesiumaluminumsilicate 0.8%, diethylene glycol (DEG) 3%, deionized water add to 100%, mix and make 20% fluopicolide carbendazim suspending agent.
Example 24 35% fluopicolide carbendazim suspending agents
Fluopicolide 10%, carbendazim 25%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, soapberry powder 4%, silicone 0.2%, methylcellulose 1%, propane diols 2.2%, deionized water add to 100%, mix and make 35% fluopicolide carbendazim suspending agent.
Example 25 11% fluopicolide carbendazim suspension emulsions
Fluopicolide 10%, carbendazim 1%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, spaonin powder 5%, silicone 0.3%, Magnesiumaluminumsilicate 0.6%, Nongru-700 #5%, polyethylene glycol 3%, water add to 100%, mix and make 11% fluopicolide carbendazim suspension emulsion.
Example 26 20% fluopicolide carbendazim suspension emulsions
Fluopicolide 2%, carbendazim 18%, alkylnaphthalene sulfonate 6%, lauryl sodium sulfate 5%, silicone oil 0.4%, sodium phosphate trimer 1.2%, agriculture breast 34#6%, diethylene glycol (DEG) 2.5%, water add to 100%, mix and make 20% fluopicolide carbendazim suspension emulsion.
Example 27 26% fluopicolide Bavistin microemulsions
Fluopicolide 2%, carbendazim 24%, DMF 6%, methyl alcohol 4%, agriculture breast 1600#8%, ethylene glycol 2.5%, silicone oil 0.2%, deionized water adds to 100%, makes 26% fluopicolide Bavistin microemulsion through mixing.
Example 28 35% fluopicolide Bavistin microemulsions
Fluopicolide 5%, carbendazim 30%, acetone 8%, ethyl acetate 4%, AEO series 6%, diethylene glycol (DEG) 2.4%, silicone compound 0.3%, deionized water adds to 100%, makes 35% fluopicolide Bavistin microemulsion through mixing.
Example 29 30% fluopicolide carbendazim aqueous emulsions
Fluopicolide 5%, carbendazim 25%, 3-methyl cyclohexanol ketenes 6%, ethyl acetate 3%, agriculture breast 600#8%, polyethylene glycol 3%, silicone 0.2%, deionized water adds to 100%, makes 30% fluopicolide carbendazim aqueous emulsion through mixing.
Example 30 42% fluopicolide carbendazim aqueous emulsions
Fluopicolide 6%, carbendazim 36%, N-pyrrolidones 5%, acetone 4%, propane diols 2.5%, agriculture breast 1600#7%, silicone oil 0.4%, deionized water adds to 100%, makes 42% fluopicolide carbendazim aqueous emulsion through mixing.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First pass through Toxicity Determination, synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carry out field trial.
Fluopicolide and active component B (active component B is selected from the one of thiophanate-methyl, carbendazim) are composite to crop pest Toxicity Determination.
After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 dosage processing by active constituent content, establishes clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure the virulence of medicament to crop germ.After 72h, measure colony diameter by right-angled intersection method, calculate each processing net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) converts logarithm value (x) to, try to achieve virulence regression equation (y=a+bx) with method of least squares, and calculate thus the EC of every kind of medicament
50value.Calculate the different proportioning synergy ratios of two medicaments (SR) according to Wadley method, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component fluopicolide and active component B (thiophanate-methyl, carbendazim) shared ratio in combination;
A is fluopicolide;
B is the one in thiophanate-methyl, carbendazim.
Implementation of an application example two:
Fluopicolide and thiophanate-methyl are composite to cucumber downy mildew Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining fluopicolide, thiophanate methyl raw pesticide and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 1 fluopicolide, thiophanate-methyl and the composite toxicity test analysis of results table to cucumber downy mildew thereof
As shown in Table 2, fluopicolide, the EC of thiophanate-methyl to cucumber downy mildew
50be respectively 1.95mg/L and 16.78mg/L.Fluopicolide and thiophanate-methyl proportioning were at 60: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that fluopicolide and thiophanate-methyl mixture in 60: 1 to 1: 80 scopes all shows synergistic effect, especially when the two proportioning is during at 1: 1 to 1: 15, synergistic effect is more obviously outstanding, wherein synergy ratio SR maximum in the time that fluopicolide and thiophanate-methyl proportioning are 1: 9, synergistic effect is the most obvious, test discovery, fluopicolide and thiophanate-methyl are composite to late blight in 60: 1 to 1: 80 scopes, damping off, powdery mildew, gray mold, early blight, fusarium wilt, stalk break, anthracnose, ring spot, mould, the diseases such as green mould also have good synergistic effect, especially work as fluopicolide and carbendazim at 8: 1, 7: 1, 6: 1, 5: 1, 4: 1, 3: 1, 2: 1, 1: 1, 1: 2, 1: 3, 1: 4, 1: 5, 1: 6, 1: 7, 1: 8, 1: 9, 1: 10, 1: 11, 1: 12, 1: 13, 1: 14, 1: 15, 1: 16, 1: 17, 1: 18, 1: 19, 1: 20 o'clock, synergy ratio SR was all greater than 1.5, and synergistic effect is obvious.
Implementation of an application example three
Fluopicolide and carbendazim are composite to potato late blight Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining fluopicolide, carbendazim active compound and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 2 fluopicolide, carbendazim and the composite toxicity test analysis of results table to potato late blight thereof
As shown in Table 2, fluopicolide, the EC of carbendazim to potato late blight
50be respectively 2.04mg/L and 15.81mg/L.Fluopicolide and carbendazim proportioning were at 60: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that fluopicolide and carbendazim mixture in 60: 1 to 1: 80 scopes all shows synergistic effect, especially when the two proportioning is during at 1: 1 to 1: 15, synergistic effect is more obviously outstanding, wherein synergy ratio SR maximum in the time that fluopicolide and carbendazim proportioning are 1: 9, synergistic effect is the most obvious, test discovery, fluopicolide and carbendazim are composite to downy mildew in 60: 1 to 1: 80 scopes, epidemic disease, anthracnose, powdery mildew, gray mold, the diseases such as fusarium wilt also have good synergistic effect, especially work as fluopicolide and carbendazim at 8: 1, 7: 1, 6: 1, 5: 1, 4: 1, 3: 1, 2: 1, 1: 1, 1: 2, 1: 3, 1: 4, 1: 5, 1: 6, 1: 7, 1: 8, 1: 9, 1: 10, 1: 11, 1: 12, 1: 13, 1: 14, 1: 15, 1: 16, 1: 17, 1: 18, 1: 19, 1: 20 o'clock, synergy ratio SR was all greater than 1.5, and synergistic effect is obvious.
Application Example eight fluopicolides and thiophanate-methyl and composite control cucumber downy mildew medicine thereof
Effect test
This experimental establishment is in Weinan city Linwei district, Shaanxi Province, test medicine is provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 687.5 grams per liter fluopicolide propamocarb suspending agents (commercial), 70% thiophanate-methyl wetting powder (commercial).
The investigation cucumber downy mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 4 fluopicolide, thiophanate-methyl and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 4, after fluopicolide and thiophanate-methyl are composite, can effectively prevent and treat cucumber downy mildew, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects, simultaneously to the preventive effect of the Common Diseases such as late blight, damping off, powdery mildew, gray mold, early blight, fusarium wilt, stalk break, anthracnose, ring spot, mould, green mould all more than 95%, be better than contrasting medicament, have good synergistic effect.
Application Example nine fluopicolides and carbendazim and the composite potato late blight test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Changan District, Xi'an City, Shanxi Province, test medicine is researched and developed, is provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 687.5 grams per liter fluopicolide propamocarb suspending agents (commercial), 50% carbendazol wettable powder (commercial).
Investigation potato late blight disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser 2 times altogether, investigates disease indexs and calculates preventive effect for after dispenser 7 days, 14 days, 30 days for the second time.Experimental result is as follows:
Table 5 fluopicolide, carbendazim and the composite potato late blight test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 5, after fluopicolide and carbendazim are composite, can effectively prevent and treat potato late blight, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects, test is found, the preventive effect of downy mildew, epidemic disease, anthracnose, powdery mildew, gray mold, fusarium wilt is all reached more than 95%, is better than contrasting medicament, has good synergistic effect.
Claims (7)
1. the bactericidal composition of a containing fluopicolide, it is characterized in that: its active component is: active components A and active component B, the weight ratio of A, two kinds of active components of B is 1:80～60:1, described active components A is fluopicolide, and active component B is selected from the one in thiophanate-methyl, carbendazim.
2. according to the bactericidal composition of the containing fluopicolide described in claim l, it is characterized in that: wherein the weight ratio of fluopicolide and effective active composition B is 40:1～1:60.
3. the bactericidal composition of containing fluopicolide according to claim 2, is characterized in that: wherein the weight ratio of fluopicolide and thiophanate-methyl is 10:1～1:40.
4. the bactericidal composition of containing fluopicolide according to claim 2, is characterized in that: wherein the weight ratio of fluopicolide and carbendazim is 10:1～1:40.
5. according to the bactericidal composition of the containing fluopicolide described in claim l, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion.
6. be used for preventing and treating the application of disease on gramineous crop, peanut, fruit tree and vegetables according to the bactericidal composition of the containing fluopicolide described in claim l.
7. application according to claim 6, is characterized in that: described disease comprises downy mildew, epidemic disease, late blight, damping off, powdery mildew, gray mold, early blight, fusarium wilt, stalk break, anthracnose, ring spot, mould, green mould.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110328260.8A CN102334493B (en) | 2011-10-26 | 2011-10-26 | Novel fluopicolide-containing antibacterial composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110328260.8A CN102334493B (en) | 2011-10-26 | 2011-10-26 | Novel fluopicolide-containing antibacterial composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102334493A CN102334493A (en) | 2012-02-01 |
| CN102334493B true CN102334493B (en) | 2014-06-18 |
Family
ID=45510635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110328260.8A Expired - Fee Related CN102334493B (en) | 2011-10-26 | 2011-10-26 | Novel fluopicolide-containing antibacterial composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102334493B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103380777B (en) * | 2012-05-04 | 2016-06-08 | 陕西韦尔奇作物保护有限公司 | A kind of fungicidal composition containing tiadinil |
| CN104381266A (en) * | 2014-09-25 | 2015-03-04 | 北京燕化永乐生物科技股份有限公司 | Sterilization composition |
| CN105724384A (en) * | 2016-05-04 | 2016-07-06 | 东莞市瑞德丰生物科技有限公司 | Sterilization composition containing fluopicolide and application thereof |
| CN106689164A (en) * | 2016-12-30 | 2017-05-24 | 陕西省蒲城美尔果农化有限责任公司 | Fungicidal composition containing oxine-copper |
| CN106879634A (en) * | 2016-12-30 | 2017-06-23 | 新昌县赛因斯生物科技有限公司 | A kind of control of plant disease composition containing fluopicolide |
| CN106719698B (en) * | 2017-02-26 | 2021-11-30 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Bactericidal composition containing thiabendazole and fluopicolide |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647446A (en) * | 2009-06-22 | 2010-02-17 | 陕西标正作物科学有限公司 | Bactericidal composite with fluopicolide and dimethomorph |
| CN101999356A (en) * | 2010-11-26 | 2011-04-06 | 惠州市中迅化工有限公司 | Sterilization composition containing fluopicolide and metalaxyl and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2258177A3 (en) * | 2006-12-15 | 2011-11-09 | Rohm and Haas Company | Mixtures comprising 1-methylcyclopropene |
-
2011
- 2011-10-26 CN CN201110328260.8A patent/CN102334493B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647446A (en) * | 2009-06-22 | 2010-02-17 | 陕西标正作物科学有限公司 | Bactericidal composite with fluopicolide and dimethomorph |
| CN101999356A (en) * | 2010-11-26 | 2011-04-06 | 惠州市中迅化工有限公司 | Sterilization composition containing fluopicolide and metalaxyl and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102334493A (en) | 2012-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102334493B (en) | Novel fluopicolide-containing antibacterial composition | |
| CN102258039A (en) | Bactericidal composition containing prothioconazole and thiocarbamates | |
| CN102210309A (en) | Sterilizing composition containing picoxystrobin and triazole | |
| CN104488870A (en) | Pesticide composition containing bromothalonil | |
| CN102273461A (en) | Synergistic pesticide composition containing prothioconazole and triazoles | |
| CN102369939A (en) | Bactericidal combination containing fluopicolide and thiocarbamate compound | |
| CN102428934B (en) | Novel germicide composition containing probenazole | |
| CN102365956A (en) | Sterilization composition containing fluopicolide and methoxyl acrylic acid ester compounds | |
| CN102204536A (en) | Antibacterial composition containing picoxystrobin and antibiotic compound | |
| CN102239863B (en) | Bactericidal composition containing picoxystrobin and thiocarbamates | |
| CN103238608A (en) | Sterilization composition containing fluoxastrobin and antibiotics | |
| CN102396484A (en) | Bactericidal composition containing iprodione and methoxy acrylate | |
| CN102428953A (en) | Bactericidal composition containing silthiopham and methoxy acrylate compound | |
| CN104719304A (en) | Sedaxane-containing bactericidal composition | |
| CN102197820A (en) | Bactericidal composition containing picoxystrobin and benzimidazoles | |
| CN102845442B (en) | Bactericidal composition containing polyoxins and iprovalicarb | |
| CN102007914A (en) | Triflumizole-containing synergistic sterilization composition | |
| CN102150683B (en) | Fenbuconazole-containing synergic sterilization composition | |
| CN102057927A (en) | Bactericidal composition containing captan and triazole compounds | |
| CN101584324A (en) | 2-cyano-3-amino-3-phenylancryic acetate and epoxiconazole-containing antiseptic composition | |
| CN104719328A (en) | Sedaxane-containing pesticide composition | |
| CN102204544A (en) | Picoxystrobin-containing synergic bactericidal composition | |
| CN103371188A (en) | Synergistic bactericidal composition containing agricultural antibiotic | |
| CN103300016B (en) | A kind of bactericidal composition containing Acibenzolar and dithianon | |
| CN102057935B (en) | Bactericidal composition containing imidazole |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140618 Termination date: 20171026 |