CN102247386A - Soluble powder used for treating poultry coccidiosis - Google Patents
Soluble powder used for treating poultry coccidiosis Download PDFInfo
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- CN102247386A CN102247386A CN 201110137526 CN201110137526A CN102247386A CN 102247386 A CN102247386 A CN 102247386A CN 201110137526 CN201110137526 CN 201110137526 CN 201110137526 A CN201110137526 A CN 201110137526A CN 102247386 A CN102247386 A CN 102247386A
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- soluble powder
- coccidiosis
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- sulfaclozine sodium
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Abstract
The invention relates to a soluble powder used for treating poultry coccidiosis, which is characterized in that the soluble powder used for treating poultry coccidiosis is composed of the following raw materials in percentage by weight: 1-8% of Diaveridine, 10-30% of Sulfachloropyrazine sodium and 64-82% of auxiliary materials, wherein the auxiliary material is anhydrous dextrose, oral glucose or beauty powder. In the soluble powder, the Sulfachloropyrazine sodium and the Diaveridine are subjected to compatibility to generate synergistic action to kill adults and eggs, thereby achieving the purposes of effectively treating coccidiosis. The soluble powder has higher safety and can be widely used for treating poultry coccidiosis, and the effective curing rate is above 90%.
Description
Technical field
The invention belongs to field of veterinary, be specifically related to a kind of soluble powder that is used for the treatment of coccidiosis of domestic fowls
Background technology
Coccidiosis is a kind of more common and endanger serious parasitic disease in poultry, also is more common acute epidemic disease, and be example with the coccidiosis of chicken: sick feather is just erect, necking down, slow-witted upright; Along with the considerable damage and the body of enterocyte are poisoned, it is heavy that the state of an illness is changeed, and ataxia occurs, symptoms such as diarrhoea band blood, and mortality rate is higher.This sick the distribution extensively, generation is general and do not have seasonality, grows conditions needed as long as possess coccidiosis in the external world, at any time coccidiosis may take place, especially the chicken of 21～50 ages in days, very easily morbidity, as untimely treatment, can bring great economic loss to the raiser.
Current treatment to coccidiosis mainly relies on medicine, generally uses antibiotic and chemical synthetic drug two classes, yet a kind of antibiotics of life-time service can produce a large amount of drug resistance antibacterials, thereby has a strong impact on medicine therapeutic effect in vivo.
Summary of the invention
The object of the invention is to provide a kind of soluble powder that can effectively treat coccidiosis of domestic fowls.
For achieving the above object, the present invention adopts following technical scheme:
A kind of soluble powder that is used for the treatment of coccidiosis of domestic fowls, it is made up of following raw materials by weight percent:
NSC 408735 1%～8%
Sulfaclozine sodium 10%～30%
Adjuvant 64%～82%
Described adjuvant is anhydrous glucose, oral glucose or auxilliary U.S. powder etc., preferred anhydrous glucose.
Described sulfaclozine sodium and NSC 408735 mass ratio are preferably 5:1.
Described soluble powder, it preferably is made up of following raw materials by weight percent: NSC 408735 6%, sulfaclozine sodium 30%, adjuvant 64%.
Above-mentioned soluble powder adopts the general process of industry to be prepared, as: earlier sulfaclozine sodium, NSC 408735 and adjuvant are pulverized, pulverized the back and cross 80 mesh sieves; Get sulfaclozine sodium, NSC 408735 and carry out premix and get mixture, then promptly getting product behind mixture and the remaining adjuvant mix homogeneously with the adjuvant of the above two quality sum equivalent.
Treatment when medicine of the present invention is mainly used in the coccidiosis of domestic fowls outburst, usage and dosage: initial dose: add medicine 1.0g of the present invention in per 1 premium on currency, freely drank water 1 day; Maintenance dose: add medicine 1.0g of the present invention in per 2 premium on currency, continuous use 3～5 days was a course of treatment.
Sulfaclozine sodium is a sulfa drugs, and structure is similar to aminobenzoic acid (PABA), can compete dihydrofolate synthetase with PABA, has influenced the synthetic of dihydrofoilic acid, thereby bacterial growth and breeding are suppressed.NSC 408735 is a kind of synergist of sulfonamides anticoccidial drug, can suppress the activity of another enzyme (dihydrofolate reductase).The two coupling has synergism, can strengthen drug effect.
Compare beneficial effect of the present invention with prior art:
Adopt two kinds of compatibility of drugss of sulfaclozine sodium and NSC 408735 to use, can produce synergism, can kill adult and worm's ovum, thereby reach the purpose of effective treatment coccidiosis, have higher safety, can be widely used in the treatment coccidiosis of domestic fowls, the treatment effective percentage reaches more than 90%.
The specific embodiment
Embodiment 1:
A kind of soluble powder that is used for the treatment of coccidiosis of domestic fowls, its raw material weight percentage ratio consists of: NSC 408735 7.5%, sulfaclozine sodium 30%, anhydrous glucose 62.5%, when total amount was taken as 1000g, it consisted of NSC 408735 75g, sulfaclozine sodium 300g, anhydrous glucose 625g.
The preparation method of above-mentioned soluble powder is: earlier sulfaclozine sodium 300g, NSC 408735 75g and anhydrous glucose 625g are pulverized respectively, pulverize the back and cross 80 mesh sieves; The anhydrous glucose of getting above-mentioned sulfaclozine sodium, NSC 408735 and 375g carries out premix and gets mixture, promptly gets product with behind itself and the remaining 250g anhydrous glucose mix homogeneously then.
Embodiment 2:
A kind of soluble powder that is used for the treatment of coccidiosis of domestic fowls, its raw material weight percentage ratio consists of: NSC 408735 6%, sulfaclozine sodium 30%, anhydrous glucose 64%, when total amount was taken as 1000g, it consisted of NSC 408735 60g, sulfaclozine sodium 300g, anhydrous glucose 640g.
The preparation method of above-mentioned soluble powder is: earlier sulfaclozine sodium 300g, NSC 408735 60g and anhydrous glucose 640g are pulverized respectively, pulverize the back and cross 80 mesh sieves; The anhydrous glucose of getting above-mentioned sulfaclozine sodium, NSC 408735 and 360g carries out premix and gets mixture, promptly gets product with behind itself and the remaining 280g anhydrous glucose mix homogeneously then.
Embodiment 3:
A kind of soluble powder that is used for the treatment of coccidiosis of domestic fowls, its raw material weight percentage ratio consists of: NSC 408735 5%, sulfaclozine sodium 30%, oral glucose 65%, when total amount was taken as 1000g, it consisted of NSC 408735 50g, sulfaclozine sodium 300g, oral glucose 650g.
The preparation method of above-mentioned soluble powder is: earlier sulfaclozine sodium 300g, NSC 408735 50g and oral glucose 650g are pulverized respectively, pulverize the back and cross 80 mesh sieves, get above-mentioned sulfaclozine sodium, NSC 408735 and 350g oral glucose and carry out premix and get mixture, promptly get product with behind itself and the remaining 300g oral glucose mix homogeneously then.
Embodiment 4:
A kind of soluble powder that is used for the treatment of coccidiosis of domestic fowls, its raw material weight percentage ratio consists of: NSC 408735 3%, sulfaclozine sodium 25%, auxilliary U.S. powder 72%, when total amount was taken as 1000g, it consisted of NSC 408735 30g, sulfaclozine sodium 250g, auxilliary U.S. powder 720g.
The preparation method of above-mentioned soluble powder is: earlier sulfaclozine sodium 250g, NSC 408735 30g and auxilliary U.S. powder 720g are pulverized respectively, pulverize the back and cross 80 mesh sieves, get the auxilliary U.S. powder of above-mentioned sulfaclozine sodium, NSC 408735 and 280g and carry out premix and get mixture, promptly get product after then it being assisted U.S. powder mix homogeneously with remaining 440g.
Embodiment 5:
A kind of soluble powder that is used for the treatment of coccidiosis of domestic fowls, its raw material weight percentage ratio consists of: NSC 408735 8%, sulfaclozine sodium 12%, oral glucose 80%, when total amount was taken as 1000g, it consisted of NSC 408735 80g, sulfaclozine sodium 120g, oral glucose 800g.
The preparation method of above-mentioned soluble powder is: earlier sulfaclozine sodium 120g, NSC 408735 80g and oral glucose 800g are pulverized respectively, pulverize the back and cross 80 mesh sieves, get above-mentioned sulfaclozine sodium, NSC 408735 and 200g oral glucose and carry out premix and get mixture, promptly get product with behind itself and the remaining 600g oral glucose mix homogeneously then.
The test of pesticide effectiveness:Be the curative effect of checking medicine of the present invention, get medicine of the present invention and do clinical trial in Henan breed factory.
(1) experiment material
200 of the chickens (about body weight 1.5kg) that body condition is close, suffer from coccidiosis are chosen in large-scale chicken farm from Henan, are divided into two groups at random, i.e. test group (using embodiment 2 medicines) and blank group (without medicine), 100 every group.
(2) test method and dosage: the chicken initial dose of test group: every premium on currency adds medicine 1.0g of the present invention, freely drinks water maintenance dose one day: every premium on currency adds medicine 0.5g of the present invention,, logotype 5 days was a course of treatment.Result of the test sees Table 1.
(3) clinical symptoms and curative effect determinate standard:
Clinical symptoms: lethargy, feather pine are disorderly, and be slow-witted upright, is off one's feed cockscomb and visual mucosal pallor, row's cerise hemafecia.After medication, taking a turn for the better shows as the mental status, appetite recovery normally; Cure to show as and do not have above-mentioned clinical symptoms; Invalidly show as above-mentioned each clinical symptoms and do not alleviate or aggravate.Effective percentage is improvement rate and cure rate sum.
As can be seen from Table 1, use the present invention to carry out Drug therapy, after the course of treatment, most of ill chicken is cured, and effective percentage reaches 92%.Prove that thus soluble powder of the present invention can be used for the treatment of the coccidiosis of poultry, and evident in efficacy.
Claims (3)
1. a soluble powder that is used for the treatment of coccidiosis of domestic fowls is characterized in that, is made up of following raw materials by weight percent:
NSC 408735 1%～8%
Sulfaclozine sodium 10%～30%
Adjuvant 64%～82%
Described adjuvant is anhydrous glucose, oral glucose or auxilliary U.S. powder.
2. soluble powder according to claim 1 is characterized in that, described sulfaclozine sodium and NSC 408735 mass ratio are 5:1.
3. soluble powder according to claim 1 and 2 is characterized in that, is made up of following raw materials by weight percent: NSC 408735 6%, sulfaclozine sodium 30%, adjuvant 64%.
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| CN 201110137526 CN102247386A (en) | 2011-05-26 | 2011-05-26 | Soluble powder used for treating poultry coccidiosis |
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| CN 201110137526 CN102247386A (en) | 2011-05-26 | 2011-05-26 | Soluble powder used for treating poultry coccidiosis |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920716A (en) * | 2012-11-02 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Method for preparing sulfachloropyrazine sodium solution serving as compound anti-coccidium medicine |
| CN105267148A (en) * | 2015-11-11 | 2016-01-27 | 郑州后羿制药有限公司 | Dissolvable sulfachloropyrazine sodium powder and preparation method thereof |
| CN105853369A (en) * | 2016-06-03 | 2016-08-17 | 卫国刚 | Polyhexamethylene guanidine drug for treating livestock, poultry and fish digestive system infection and preparing method thereof |
| CN106137973A (en) * | 2016-08-10 | 2016-11-23 | 河南牧翔动物药业有限公司 | A kind of compound sulfonamide chloropyrazine soluble powder of sodium and preparation method thereof |
| CN106265527A (en) * | 2016-11-08 | 2017-01-04 | 江西派尼生物药业有限公司 | A kind of water soluble trimethoprim compositions and complex composition thereof |
| CN108578417A (en) * | 2018-01-03 | 2018-09-28 | 浙江万方生物科技有限公司 | A kind of compound sulfonamide chlorine pyridazine sodium dry suspensoid agent and preparation method thereof |
| CN110269853A (en) * | 2019-06-21 | 2019-09-24 | 河南益华动物药业有限公司 | Gallopamil is preparing the application in anti-Eimeria species damage medicine |
| CN113318078A (en) * | 2021-06-09 | 2021-08-31 | 四川恒通动保生物科技有限公司 | Preparation method of sulfachloropyrazine sodium and trimethoprim soluble powder |
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| CN101416973A (en) * | 2007-10-22 | 2009-04-29 | 洛阳普莱柯生物工程有限公司 | Preparation method of novel composite anti-coccidium, antibiotic preparation |
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| CN101416973A (en) * | 2007-10-22 | 2009-04-29 | 洛阳普莱柯生物工程有限公司 | Preparation method of novel composite anti-coccidium, antibiotic preparation |
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| 《中国家禽》 20081231 王国永等 甲氧苄啶、二甲氧苄啶与磺胺氯吡嗪钠联用的抗球虫效果比较 第30卷, 第8期 * |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920716A (en) * | 2012-11-02 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Method for preparing sulfachloropyrazine sodium solution serving as compound anti-coccidium medicine |
| CN102920716B (en) * | 2012-11-02 | 2015-02-25 | 青岛蔚蓝生物股份有限公司 | Method for preparing sulfachloropyrazine sodium solution serving as compound anti-coccidium medicine |
| CN105267148A (en) * | 2015-11-11 | 2016-01-27 | 郑州后羿制药有限公司 | Dissolvable sulfachloropyrazine sodium powder and preparation method thereof |
| CN105267148B (en) * | 2015-11-11 | 2018-06-22 | 河南后羿实业集团有限公司 | A kind of sulfaclozine soluble powder and preparation method thereof |
| CN105853369A (en) * | 2016-06-03 | 2016-08-17 | 卫国刚 | Polyhexamethylene guanidine drug for treating livestock, poultry and fish digestive system infection and preparing method thereof |
| CN106137973A (en) * | 2016-08-10 | 2016-11-23 | 河南牧翔动物药业有限公司 | A kind of compound sulfonamide chloropyrazine soluble powder of sodium and preparation method thereof |
| CN106265527A (en) * | 2016-11-08 | 2017-01-04 | 江西派尼生物药业有限公司 | A kind of water soluble trimethoprim compositions and complex composition thereof |
| CN108578417A (en) * | 2018-01-03 | 2018-09-28 | 浙江万方生物科技有限公司 | A kind of compound sulfonamide chlorine pyridazine sodium dry suspensoid agent and preparation method thereof |
| CN108578417B (en) * | 2018-01-03 | 2020-05-15 | 浙江万方生物科技有限公司 | Compound sulfachlorpyridazine sodium dry suspension and preparation method thereof |
| CN110269853A (en) * | 2019-06-21 | 2019-09-24 | 河南益华动物药业有限公司 | Gallopamil is preparing the application in anti-Eimeria species damage medicine |
| CN110269853B (en) * | 2019-06-21 | 2022-09-23 | 河南益华动物药业有限公司 | Application of galopam in preparation of medicine for resisting coccidiosis |
| CN113318078A (en) * | 2021-06-09 | 2021-08-31 | 四川恒通动保生物科技有限公司 | Preparation method of sulfachloropyrazine sodium and trimethoprim soluble powder |
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Application publication date: 20111123 |