CN101966200A - Composition for treating poultry digestive tract bacterial infection and preparation method thereof - Google Patents
Composition for treating poultry digestive tract bacterial infection and preparation method thereof Download PDFInfo
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- CN101966200A CN101966200A CN2010102364273A CN201010236427A CN101966200A CN 101966200 A CN101966200 A CN 101966200A CN 2010102364273 A CN2010102364273 A CN 2010102364273A CN 201010236427 A CN201010236427 A CN 201010236427A CN 101966200 A CN101966200 A CN 101966200A
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- digestive tract
- florfenicol
- sodium
- bacterial infection
- taurine
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Abstract
The invention discloses a composition for treating poultry digestive tract bacterial infection and a preparation method thereof, and aims to provide a composition for treating poultry digestive tract infection, treating the root cause and symptoms of disease and reducing medicament-resistant probability and a preparation method thereof. The composition consists of the following raw materials in percentage by weight: 5 to 15 percent of florfenicol, 5 to 15 percent of sulfamonomethoxine sodium, 5 to 15 percent of taurine, 1 to 3 percent of trimethoprim lactate, 5 percent of sodium chloride, 5 percent of potassium chloride and the balance of anhydrous dextrose. The florfenicol and the sulfamonomethoxine sodium serving as antibacterial components have double effects and can effectively avoid the medicament resistance of bacteria; and the composition can be absorbed and avoid destroying beneficial bacteria in the intestinal tract. The lactate TMP (trimethoprim lactate) has synergistic effect on the florfenicol and the sulfamonomethoxine sodium; the taurine with anti-inflammatory effect is acted on the digestive tract, does not injure the function of the gastrointestinal tract and is favorable for treating intestinal inflammation; and the combination of the sodium chloride and the potassium chloride has complementing effect on electrolyte loss caused by great defecation of sick poultry.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that is used for the treatment of fowl digestive tract bacterial infection.
Background technology
Fowl digestive tract bacterial infection is the normal disease that occurs of fowl, sick fowl shows as situations such as diarrhoea dysentery, and is main single or mixed infection causes by gram negative bacterias such as escherichia coli, Salmonellas.Sick fowl undergrowth, morbidity are rapidly.Show as diarrhoea, dysentery, row's white, Lycoperdon polymorphum Vitt, yellow or yellow green loose stool, what have is water sample, and sick fowl dehydration is serious, and inflammatory reaction is serious, and may cause the too much phenomenon of electrolyte loss, weak phenomenon occurs, causes mortality rate very high.
At present, the trend of the oriented mixed type of disease, complicated development, pathogen is a resident bacterium in the body, and drug resistance is serious, single drug such as florfenicol, sulfamonomethoxine sodium etc. often because of its drug resistance makes therapeutic effect not good, bring very big loss to the raiser now.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat fowl digestive tract bacterial infection instant effect, treating both the principal and secondary aspects of a disease, minimizing pathogen drug resistance probability, the compositions of reinforcement curative effect.
It is simple that another object of the present invention provides a kind of technology, easily the preparation of compositions method that is used for the treatment of fowl digestive tract bacterial infection that realizes.
The present invention is achieved through the following technical solutions:
A kind of compositions that is used for the treatment of fowl digestive tract bacterial infection; it is characterized in that; form by following raw material by mass percentage: florfenicol 5～15%; sulfamonomethoxine sodium 5～15%; taurine 5～15%, lactic acid trimethoprim (lactic acid TMP) 1～3%, sodium chloride 5%; potassium chloride 5%, surplus are anhydrous glucose.
A kind of preparation of compositions method that is used for the treatment of fowl digestive tract bacterial infection is characterized in that, comprises the steps:
With florfenicol; sulfamonomethoxine sodium; taurine; lactic acid TMP, sodium chloride, potassium chloride promptly got the compositions that is used to treat fowl digestive tract bacterial infection after pulverizing and sieving the back and anhydrous glucose fully mixes for No. 5; the mass percent in the compositions wherein: florfenicol 5～15%, sulfamonomethoxine sodium 5～15%, taurine 5～15%; lactic acid trimethoprim 1～3%, sodium chloride 5%, potassium chloride 5%, surplus are anhydrous glucose.
Preferable consisting of by weight percentage wherein: florfenicol 8～12%, sulfamonomethoxine sodium 8～12%, taurine 9～12%, lactic acid trimethoprim 1.6～2.4%, sodium chloride 5%, potassium chloride 5%, surplus is an anhydrous glucose
Best group by weight percentage becomes: florfenicol 10%, sulfamonomethoxine sodium 10%, taurine 10%, lactic acid trimethoprim 2%, sodium chloride 5%, potassium chloride 5%, anhydrous glucose 58%.
The present invention has following technique effect:
Compositions of the present invention is a compound preparation, adopts florfenicol and sulfamonomethoxine sodium as antimicrobial component, has double effects, can effectively avoid the problem of bacterial drug resistance, and this product can absorb, and avoids the destruction to intestinal beneficial bacterium.Simultaneously; lactic acid TMP has potentiation to florfenicol and sulfamonomethoxine sodium; the antiinflammatory action of taurine is in digestive tract; do not damage the gastrointestinal function; help the treatment of enteritis, the electrolyte loss that the combination of sodium chloride and potassium chloride causes a large amount of defecations of sick fowl has supplementary function.All medicines share and by rational proportion, have the effect that fowl digestive tract bacterial infection is had treating both the principal and secondary aspects of a disease, minimizing pathogenic bacterium drug resistance probability.
Fowl of the present invention is simple with the preparation method of composition technology of treatment fowl digestive tract bacterial infection, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
With florfenicol, sulfamonomethoxine sodium, taurine, it is standby to cross No. 5 sieve backs behind lactic acid TMP, sodium chloride, the potassium chloride pulverize separately.
Embodiment 1
Accurately take by weighing florfenicol 5kg, sulfamonomethoxine sodium 15kg, taurine 5kg, lactic acid TMP3kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl digestive tract bacterial infection after anhydrous glucose 62kg fully mixes.
Embodiment 2
Accurately take by weighing florfenicol 15kg, sulfamonomethoxine sodium 5kg, taurine 15kg, lactic acid TMP1kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl digestive tract bacterial infection after anhydrous glucose 54kg fully mixes.
Embodiment 3
Accurately take by weighing florfenicol 8kg, sulfamonomethoxine sodium 12kg, taurine 9kg, lactic acid TMP2.4kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl digestive tract bacterial infection after anhydrous glucose 58.6kg fully mixes.
Embodiment 4
Accurately take by weighing florfenicol 12kg, sulfamonomethoxine sodium 8kg, taurine 12kg, lactic acid TMP1.6kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl digestive tract bacterial infection after anhydrous glucose 56.4kg fully mixes.
Embodiment 5
Accurately take by weighing florfenicol 9kg, sulfamonomethoxine sodium 11kg, taurine 11kg, lactic acid TMP 2.2kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl digestive tract bacterial infection after anhydrous glucose 56.8kg fully mixes.
Embodiment 6
Accurately take by weighing florfenicol 10kg, sulfamonomethoxine sodium 10kg, taurine 10kg, lactic acid TMP2kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl digestive tract bacterial infection after anhydrous glucose 58kg fully mixes.
Clinical trial:
Compositions of the present invention both can be used for the chicken class, also can be used for duck, goose etc.Be laboratory animal below with the chicken, the effect that is used for the treatment of the compositions of fowl digestive tract bacterial infection of the present invention is experimentized.
1. laboratory animal:
1000 of the ill one-tenth of picked at random chickens, body weight is about about 1kg.
2. experiment medicine
The compositions our unit development that is used for the treatment of fowl digestive tract bacterial infection of the embodiment of the invention 6 preparations;
10% florfenicol powder our unit prepared in laboratory;
10% sulfamonomethoxine sodium powder our unit prepared in laboratory.
3. experimental technique:
Suffer from chicken with 1000 and be divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 10% florfenicol powder: with drinking water every 1L water 1g, 1 time on the one, logotype 5 days behind the hot water dissolving more than 80 ℃.
The C group is treated usage with 10% sulfamonomethoxine sodium powder: drinking-water, every 1L water 0.5g, 1 time on the one, logotype 5 days.
The D group is treated usage with the compositions that is used for the treatment of fowl digestive tract bacterial infection of the embodiment of the invention 6 preparations: with drinking water every 1L water 0.5g, 1 time on the one, logotype 4 days behind the hot water dissolving more than 80 ℃.
After the treatment beginning, every day, chicken health situation of change and dead animal distribution suffered from record, and treat and add up therapeutic effect after 7 days, wherein:
Invalid: as after referring to 7 days, to suffer from the chicken symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the chicken symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from chicken and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from chicken and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from chicken and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 is used for the treatment of combination treatment group, 10% florfenicol treated powder group and the 10% sulfamonomethoxine sodium powder group of digestive tract bacterial infection and matched group difference extremely significantly (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | The symptom number of elements is arranged during end | Dead number of elements |
| A | Matched group | 250 | 0 | 0 | 132 | 118 |
| B | 10% florfenicol treated powder | 114 | 136 | 98 | 90 | 62 |
| C | 10% sulfamonomethoxine sodium treated powder | 98 | 152 | 85 | 112 | 53 |
| D | The combination treatment of the embodiment of the invention 6 | 26 | 224 | 206 | 29 | 15 |
Claims (6)
1. compositions that is used for the treatment of fowl digestive tract bacterial infection; it is characterized in that; form by following raw material by weight percentage: florfenicol 5～15%; sulfamonomethoxine sodium 5～15%; taurine 5～15%, lactic acid trimethoprim 1～3%, sodium chloride 5%; potassium chloride 5%, surplus are anhydrous glucose.
2. the compositions that is used for the treatment of fowl digestive tract bacterial infection according to claim 1; it is characterized in that; form by following raw material by weight percentage: florfenicol 8～12%; sulfamonomethoxine sodium 8～12%; taurine 9～12%, lactic acid trimethoprim 1.6～2.4%, sodium chloride 5%; potassium chloride 5%, surplus are anhydrous glucose.
3. the compositions that is used for the treatment of fowl digestive tract bacterial infection according to claim 1; it is characterized in that; form by following raw material by weight percentage: florfenicol 10%; sulfamonomethoxine sodium 10%; taurine 10%, lactic acid trimethoprim 2%, sodium chloride 5%; potassium chloride 5%, anhydrous glucose 58%.
4. the described preparation of compositions method that is used for the treatment of fowl digestive tract bacterial infection of claim 1 is characterized in that, comprises the steps:
Florfenicol, sulfamonomethoxine sodium, taurine, lactic acid trimethoprim, sodium chloride, potassium chloride are pulverized No. 5 sieves afterwards and after anhydrous glucose fully mixes promptly got the compositions that is used to treat fowl digestive tract bacterial infection; wherein by weight percentage: florfenicol 5～15%; sulfamonomethoxine sodium 5～15%; taurine 5～15%; lactic acid trimethoprim 1～3%, sodium chloride 5%, potassium chloride 5%, surplus are anhydrous glucose.
5. the preparation of compositions method that is used for the treatment of fowl digestive tract bacterial infection according to claim 4; it is characterized in that; by weight percentage: florfenicol 8～12%; sulfamonomethoxine sodium 8～12%; taurine 9～12%, lactic acid trimethoprim 1.6～2.4%, sodium chloride 5%; potassium chloride 5%, surplus are anhydrous glucose.
6. the preparation of compositions method that is used for the treatment of fowl digestive tract bacterial infection according to claim 4; it is characterized in that; by weight percentage: florfenicol 10%; sulfamonomethoxine sodium 10%; taurine 10%, lactic acid trimethoprim 2%, sodium chloride 5%; potassium chloride 5%, anhydrous glucose 58%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102364273A CN101966200A (en) | 2010-07-26 | 2010-07-26 | Composition for treating poultry digestive tract bacterial infection and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102364273A CN101966200A (en) | 2010-07-26 | 2010-07-26 | Composition for treating poultry digestive tract bacterial infection and preparation method thereof |
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| CN101966200A true CN101966200A (en) | 2011-02-09 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705528A (en) * | 2013-12-26 | 2014-04-09 | 南阳新先锋制药有限公司 | Compound colinflosaxin soluble powder for preventing and treating poultry colibacillosis |
| CN104645311A (en) * | 2015-03-06 | 2015-05-27 | 邳州正康生物技术有限公司 | Drinking agent for treating intestinal infection of livestock and poultry and preparation method of drinking agent |
| CN108157596A (en) * | 2017-12-28 | 2018-06-15 | 广州和仕康生物技术有限公司 | A kind of composition for preventing livestock and poultry diarrhea and preparation method thereof |
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| WO2008085310A2 (en) * | 2006-12-19 | 2008-07-17 | Schering-Plough Ltd. | Effervescent formulations of florfenicol for addition in drinking water systems |
| CN101406449A (en) * | 2007-10-12 | 2009-04-15 | 河南农业大学 | Compound dichlofluanid injection and technique for preparing the same |
| WO2009061780A1 (en) * | 2007-11-09 | 2009-05-14 | Schering-Plough Limited | Fast release solid formulation, preparation and use thereof |
| CN101653596A (en) * | 2008-08-22 | 2010-02-24 | 天津生机集团股份有限公司 | Soluble powder for treating canine colibacillosis and preparation method thereof |
-
2010
- 2010-07-26 CN CN2010102364273A patent/CN101966200A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008085310A2 (en) * | 2006-12-19 | 2008-07-17 | Schering-Plough Ltd. | Effervescent formulations of florfenicol for addition in drinking water systems |
| CN101406449A (en) * | 2007-10-12 | 2009-04-15 | 河南农业大学 | Compound dichlofluanid injection and technique for preparing the same |
| WO2009061780A1 (en) * | 2007-11-09 | 2009-05-14 | Schering-Plough Limited | Fast release solid formulation, preparation and use thereof |
| CN101653596A (en) * | 2008-08-22 | 2010-02-24 | 天津生机集团股份有限公司 | Soluble powder for treating canine colibacillosis and preparation method thereof |
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| 胡发硕等，: "鸭传染性浆膜炎和大肠杆菌病混合感染的诊治", 《中国畜牧兽医》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705528A (en) * | 2013-12-26 | 2014-04-09 | 南阳新先锋制药有限公司 | Compound colinflosaxin soluble powder for preventing and treating poultry colibacillosis |
| CN104645311A (en) * | 2015-03-06 | 2015-05-27 | 邳州正康生物技术有限公司 | Drinking agent for treating intestinal infection of livestock and poultry and preparation method of drinking agent |
| CN108157596A (en) * | 2017-12-28 | 2018-06-15 | 广州和仕康生物技术有限公司 | A kind of composition for preventing livestock and poultry diarrhea and preparation method thereof |
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Application publication date: 20110209 |