Nothing Special   »   [go: up one dir, main page]

CN101304683B - 以渐进增加的分辨率观察和分析一个或多个生物样品的方法和用于该方法的设备 - Google Patents

以渐进增加的分辨率观察和分析一个或多个生物样品的方法和用于该方法的设备 Download PDF

Info

Publication number
CN101304683B
CN101304683B CN200680040695XA CN200680040695A CN101304683B CN 101304683 B CN101304683 B CN 101304683B CN 200680040695X A CN200680040695X A CN 200680040695XA CN 200680040695 A CN200680040695 A CN 200680040695A CN 101304683 B CN101304683 B CN 101304683B
Authority
CN
China
Prior art keywords
information
image
demonstration
zone
anatomical structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200680040695XA
Other languages
English (en)
Other versions
CN101304683A (zh
Inventor
吉列尔莫·J·蒂尔尼
德维尔·叶林
本杰明·J·瓦科奇
梅利莎·苏特
布雷特·尤金·鲍马
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of CN101304683A publication Critical patent/CN101304683A/zh
Application granted granted Critical
Publication of CN101304683B publication Critical patent/CN101304683B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852—Catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02015—Interferometers characterised by the beam path configuration
    • G01B9/02027—Two or more interferometric channels or interferometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02049—Interferometers characterised by particular mechanical design details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02055—Reduction or prevention of errors; Testing; Calibration
    • G01B9/02062—Active error reduction, i.e. varying with time
    • G01B9/02064—Active error reduction, i.e. varying with time by particular adjustment of coherence gate, i.e. adjusting position of zero path difference in low coherence interferometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02083—Interferometers characterised by particular signal processing and presentation
    • G01B9/02087—Combining two or more images of the same region
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/04—Measuring microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
    • G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
    • G01N23/046—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2423—Optical details of the distal end
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2423—Optical details of the distal end
    • G02B23/243—Objectives for endoscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2461—Illumination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2476—Non-optical details, e.g. housings, mountings, supports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1765—Method using an image detector and processing of image signal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/40—Imaging
    • G01N2223/419—Imaging computed tomograph
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Astronomy & Astrophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Signal Processing (AREA)
  • Pulmonology (AREA)
  • Mathematical Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Endoscopes (AREA)
  • Microscoopes, Condenser (AREA)
  • Automatic Focus Adjustment (AREA)
  • Transforming Light Signals Into Electric Signals (AREA)
  • Focusing (AREA)

Abstract

提供了根据本发明的示范性实施例的方法、设备和装置，用于分析和/或图示解剖结构的至少一个部分。例如，将光转送到这样的部分，以便生成与该部分相关的第一信息。例如，将光提供到受检对象上或受检对象之内。接收第一信息，并且可以基于第一信息选择该部分的至少一个截面，以便生成第二信息。可以作为第二信息的函数而渐进修改该部分的显示的放大率。

Description

以渐进增加的分辨率观察和分析一个或多个生物样品的方法和用于该方法的设备
相关申请的交叉引用 
本申请基于并要求2005年9月29日提交的序列号为60/721,802的美国专利申请的权益，其整体内容通过引用结合于此。 
技术领域
本发明涉及用于以渐进增加的分辨率观察和分析一个或多个生物样品和解剖结构的方法和装置。 
背景技术
放射技术如X射线计算机断层扫描(“CT”)、磁共振成像(“MRI”)和超声波能够使得器官水平的人体病变的非侵入可视化成为可能。尽管这些医疗器械可能能够识别大尺度的病变，但是癌症的诊断能够需要微观结构的评估，这超出了传统成像技术的分辨率。因此，诊断可能需要活组织检查和病理组织学检查。因为癌症前期的生长和早期癌症常常以微观尺度出现，所以它们能够为识别和诊断提供显著的挑战。这些病变的传统筛选和监视依赖于苏木精和伊红(“H&E”)染色玻片的无制导的活组织检查和形态分析。尽管这种方法可以被认为是用于微观诊断的当前标准，但是它需要从患者去除组织并且需要显著的处理时间以生成玻片。更重要地，组织病理学固有地为点采样技术；常常只有非常小的一部分的患病组织能够被切除，并且病理学家常常可能检查小于1％的活组织检查样品。 
可以优选的是，从活人患者的整个器官或生物系统中获得微观诊断。然而，合适成像技术的缺乏极大地限制了用于筛选肿瘤前的状况(例如转化)和发育异常的选项。另外，无能力现场识别发育异常和恶性肿瘤的区域已导致诸如像前列腺、结肠、食道和膀胱等等的随机活组织检查的筛选过程，这是高度不希望的和杂乱无章的。当前涉及冷冻切片实验室的许多诊断任务如外科肿瘤边界的描绘可以通过诊断医疗器械来改进，该诊断医 疗器械能够以微观尺度迅速成像大的组织体积。能够填补病理学和放射学之间的这个空白的技术将会对患者管理和卫生保健具有重大利益。 
已进行了技术进步以增加非侵入成像技术诸如像微CT、微PET和磁共振成像(“MRI”)显微的分辨率。通过这些技术已实现了接近20μm的分辨率，但是基本的物理限制仍然阻止它们应用于患者。对于非切除的组织病理学诊断，现场进行的微观光学活组织检查技术近来已取得进展。反射共焦显微(“RCM”)可以特别好地适合于对患者的非侵入显微镜检查，因为它能够测量微观结构而没有组织接触，并且不需要管理外在造影剂。RCM能够抑制离焦光，并且检测选择性地起源于组织内单平面的背散射的光子。例如通过在平行于组织表面的平面内迅速扫描电磁辐射的聚焦束，能够实施RCM，获得组织的横断或表面图像。可以用在RCM中的大数值孔径(NA)能够获得非常高的空间分辨率(1-2μm)，使得亚细胞结构的可视化成为可能。然而，高NA成像对随着光传播通过不均匀的组织而出现的像差特别敏感。而且，使用RCM的高分辨率成像典型地被限制到大约100-400μm的深度。 
RCM已被广泛地展示为用于表皮组织的可行成像技术。内窥镜共焦显微系统的开发已变得更加困难，这至少部分地归因于涉及使扫描显微镜小型化的重要技术挑战。将共焦显微镜检查的概念直接应用于内窥镜检查的一个主要障碍是机构的操纵，该机构用于在小直径软质探针的远端快速扫描聚焦束。已提议了多种方法来应对这个问题，包括远端微机电系统(“MEMS”)束扫描装置的使用和单模光纤束的近端扫描。而且，RCM可以提供仅在离散位置处的微观图像——“点采样”技术。如当前实施的那样，点采样是RCM所固有的，因为它具有有限的视场，其可以与切除活组织检查的视场相当或比它小，并且对于全面的大视场显微镜检查，成像速率太慢。 
使共焦显微镜检查适用于内窥镜应用的另一个挑战包括可以用于光学切片的高NA物镜的小型化。通过提供例如梯度指数透镜系统、双轴物镜或定制设计的小型化物镜，可以实现这样的小型化。例如，使用耦合到小型化物镜的光纤束，可以在体内获得子宫颈上皮的形态的详细图像，并且使用商用仪器如可以从例如Olympus Corp.(奥林巴斯公司)和Pentax/Optiscan获得的商用仪器，可以得到结直肠病变的基于荧光的图像。 
尽管有这些进展，仍然需要提供方法和装置，该方法和装置能够解析(例如从大的表面面积乃至可能整个器官获得的以细胞水平、结构水平或 两者提供的)数据，以便它可以以及时、准确的方式被适当地解释。事实上，这种数据的量很大并且难以同时观察这样的数据，因而这样的方法和装置将会对于其观察和分析有益。 
发明内容
本发明的目的之一是要克服现有技术系统的某些缺陷和缺点(包括上面在此描述的那些)，并且提供用于以渐进增加的分辨率观察和分析一个或多个生物样品和解剖结构的方法和装置的示范性实施例。这样的示范性方法和装置能够和数据的目视检查一起使用，或者通过数据的自动处理过程使用，以引导最有可能包含异常和/或不健康组织的区域的可视化。 
因此，提供了根据本发明的示范性实施例的方法、设备和装置，它们可以分析和/或图示解剖结构的至少一个部分。例如，在这样的示范性实施例中，将光转送到这样的部分，以便生成与该部分相关的第一信息。例如，将光提供到受检对象上或受检对象之内。接收第一信息，并且可以基于第一信息选择该部分的至少一个截面，以便生成第二信息。可以作为第二信息的函数而渐进修改该部分的显示的放大率。 
在本发明的进一步的示范性实施例中，(例如在解剖结构之内)能够修改所述至少一个部分的位置和/或深度的显示。第二信息能够与在这样的部分之内提供的区域相关联，和/或可以通过用户选择该区域来获得。该选择能够通过处理装置自动进行而不用从用户输入。可以确定所述至少一个部分之内的异常性区域，并且处理装置可以进行选择和修改，以便显示异常性的至少一个截面。使用处理装置能够确定该部分之内的异常性区域以便生成第三信息，并且该选择能够作为第三信息的函数而被用户和/或处理装置执行。 
根据本发明的再一个示范性实施例，第一信息能够与该部分的二维、三维、四维或更多维表示相关联。进一步，该部分可以具有大于1mm2 和/或10mm2的面积。该部分的显示的截面可以具有小于1cm2、1mm2和/或100μm2的面积。第一信息能够与共焦显微镜检查过程、谱编码共焦显微镜检查过程、光学相干断层扫描过程和/或光学频域干涉量度过程相关联。装置位于解剖结构之内，以便将光提供给该部分。 
结合所附的权利要求书，当阅读以下对本发明实施例的详细描述时，本发明的其它特征和优点将会变得明显。 
附图说明
结合示出了本发明的示意性实施例的附图，从以下详细描述中，本发明的进一步的目的、特征和优点将会变得明显，其中： 
图1是示范性谱编码共焦显微镜检查(SECM)系统的示意性图示； 
图2A是使用单模源和单模检测(SM-MM)配置离组织表面100μm在体外获得的猪肠上皮的示范性SECM图像； 
图2B是使用单模源和多模检测(SM-MM)配置获得的猪肠上皮的另一个示范性SECM图像； 
图2C是猪肠上皮的SECM图像的放大图； 
图3A是在以50μm的成像深度压缩肠壁之后在体外获得的猪肠上皮的示范性SECM图像； 
图3B是在以100μm的成像深度压缩肠壁之后在体外获得的猪肠上皮的示范性SECM图像； 
图4是示范性SECM设备的示意性图示； 
图5是USAF图表的示范性SECM图像； 
图6A是以1x的放大率显示的基于取自镜头纸样品的数据的示范性SECM图像； 
图6B是以4.5x的放大率显示的基于取自镜头纸样品的数据的示范性SECM图像； 
图6C是以16.7x的放大率显示的基于取自镜头纸样品的数据的示范性SECM图像； 
图6D是以50x的放大率显示的基于取自镜头纸样品的数据的示范性SECM图像； 
图6E是以125x的放大率显示的基于取自镜头纸样品的数据的示范性SECM图像； 
图7是在5个不同焦点位置从镜头纸样品获得的一系列示范性SECM数据以及通过组合5个各自图像中的数据生成的组合图像； 
图8A是以1x的放大率显示的基于取自猪肠组织片段的数据的示范 性SECM图像； 
图8B是以4x的放大率显示的基于取自猪肠组织片段的数据的示范性SECM图像； 
图8C是以20x的放大率显示的基于取自猪肠组织片段的数据的示范性SECM图像； 
图8D是以40x的放大率显示的基于取自猪肠组织片段的数据的示范性SECM图像； 
图9A是在体内的猪食道的微观图像的前视图和侧视图，其使用根据本发明的方法和装置的示范性实施例示出了黏膜下层之内的脉管网络，而没有使用图像增强剂或外在的造影剂； 
图9B是通过图9A中图示的位置处的食道壁的纵向横截面的微观图像的侧视图； 
图9C是A中图示的位置处的打开横断截面的侧视图； 
图9D是图9C中图示的图像的选择截面的展开图的侧视图； 
图9E是从对应于图9D中图示的图像的解剖区域获得的代表性组织截面的示范性图像； 
图10是本发明的用于渐进变焦到解剖结构的微观数据集中的方法的示范性实施例的流程图； 
图11是使用光学相干断层扫描(“OCT”)技术获得的食道黏膜的一系列示范性图像，展示了用于识别与Barrett的食道和腺癌相比较的正常鳞状黏膜的自动处理过程的示范性实施例的实施； 
图12是使用OCT技术获得的动脉粥样硬化斑的一组示范性图像，其已被处理以识别巨噬细胞密度；以及 
图13是根据本发明的方法的另一个示范性实施例的流程图，该方法用于基于经由信号处理技术获得的结果，渐进变焦到解剖结构的微观数据集，以自动识别可以以高放大率观察的所关心区域。 
贯穿附图，除非另外声明，否则相同的标号和字符用于指示图示实施例的相同特征、元件、部件或部分。此外，虽然现在将参考附图详细地描述本发明，但是这将结合示意性实施例进行。能够对描述的实施例进行改变和修改，而不认为脱离了如所附权利要求所限定的本发明的真实范围和 精神。 
具体实施方式
根据本发明的示范性实施例，能够提供根据本发明的示范性实施例的方法和装置，用于以渐进增加的分辨率观察和分析一个或多个生物样品和解剖结构。这样的示范性方法和装置能够和数据的目视检查一起使用，或者通过数据的自动处理过程使用，以引导最有可能包含异常和/或不健康组织的区域的可视化。 
在图1中示出了示范性SECM技术。来自可以位于探针远端的单模光纤100的输出能够被准直透镜110校准，然后照射色散光学元件(诸如像透射衍射光栅120)。物镜130然后能够将每个衍射波长聚焦到样品之内的不同空间位置，导致横断线状焦点140，其中线上的每个点用不同的波长表征。在从可以例如是生物组织的样品反射之后，光信号可以被衍射元件120重新组合并由单模光纤100收集。单模光纤100的核心孔径可以提供空间滤波机制，其能够滤去散焦光。在探针外部(并且任选地在系统控制台之内)，返回的光的光谱可以被测量并被转换成作为样品之内横向位移的函数的共焦反射。能够快速执行谱解码。这样一来，通过相对缓慢和直接的机械动作，就能够完成通过在正交于线状焦点的方向上扫描射束而产生的图像。 
SECM技术可以允许使用内窥镜RCM，并且能够通过使用高速线性CCD摄像机以极高速率提供图像数据。商业上可用的线性CCD阵列能够以大于大约每秒60兆像素的速率获得数据。当结合到SECM分光计中时，这些阵列能够以大约10倍于典型视频速率并且一直到100倍于某些内窥镜RCM技术的速度产生共焦图像。典型SECM系统的快速成像速率和光纤设计允许通过内窥镜探针的全面的大面积显微镜检查。 
使用光学相干断层扫描(“OCT”)的技术及其变体可以用于全面的构造筛选。获取波长域中的而不是时域中的OCT信号，能够提供成像速度的数量级改善，同时维持良好的图像质量。使用谱域OCT(“SD-OCT”)技术，通过检测组织样品和基准之间的谱分辨干涉，能够在生物组织中实施高分辨率测距。因为SD-OCT系统能够使用与SECM系统相同的高速线性CCD，所以它们也能够以每秒60兆像素捕捉图像，这近似于两个数量级的传统时域OCT(“TD-OCT”)系统的速率。使用这种获取速率和 分辨率，SD-OCT系统能够在临床环境中以构造水平提供全面的体积显微镜检查。 
SD-OCT和SECM系统提供的信息可以是互补的，并且使用这两种技术的混合平台能够提供可能对于准确诊断所必需的有关组织的构造和细胞结构的信息。尽管不同技术的结合典型地需要大范围的工程并且可能使性能折衷，但是SECM和SD-OCT系统能够共享关键的部件，并且能够提供高性能多模态的系统，而不会显著增加单个系统的复杂性或成本。 
根据本发明的某些示范性实施例的SECM系统能够使用波长扫描1300nm的源和单元件光检测器来获得作为时间函数的谱编码信息。使用这个系统，能够以在400μm视场(“FOV”)之上具有高横向(1.4μm)和轴向(6μm)分辨率的高达约30帧/秒的速率获取图像。用高速系统在体外成像新近切除的猪十二指肠片段的图像，以展示SECM系统识别亚细胞结构的能力，该亚细胞结构可以在专化肠上皮化生(“SIM”)即BE的化生变化中发现。 
图2A-2C描绘了在体外获得的猪肠上皮的示范性SECM图像，其使用了两种成像模式和相应的光纤配置：具有单模检测的单模照射(“SM-SM”)以及具有多模检测的单模照射(“SM-MM”)。图2A中的SM-SM图像示出了使用单模源和单模检测的距离组织表面100μm的上皮结构。使用具有1∶4的核心-孔径比的单模源和多模检测(SM-MM)获得的示出在图2B中的相同组织区域的图像，因为斑点噪声减少而显得更加平滑并且可以更加容易地解释。图2C是图2B中示出的图像的放大图，其示出了包含不良反射的核心(例如固有层或“lp”)和较高散射的柱状上皮的绒毛的证据。在柱状细胞的底部可见的明亮图像密度，其与核一致(用箭头指示)，在图2C中是明显的。 
使用膨胀气囊，能够将使用OCT技术在体内成像的食道壁的厚度减少例如大约二分之一。图2A-2C中示出的猪肠样品被减少相同的量，并且使用SECM技术观察到的亚细胞特征被很好地保存。图3A和3B分别示出了在50μm和100μm的深度获得的该变薄样品的图像。 
商用800nm激光扫描共焦显微镜的穿透深度被观察到与用1300nmSECM系统获得的穿透深度相比减少了大约20％。减少的穿透可能是较短波长源的散射增加的结果。这样一来，使用840nm源的SECM系统就可以提供足够的穿透，以识别例如肠上皮的亚细胞结构。 
在图4中示意性地图示了被配置成提供全面SECM图像的根据本发明的某些示范性实施例的设备。这个示范性设备被配置成从圆柱形样品获得图像，该圆柱形样品具有2.5cm的长度和2.0cm的直径，这近似为远端食道的尺度。具有以800nm为中心的波长和45nm的带宽的光纤耦合的2.0mW超辐射二极管200(QSSL-790-2，qPhotonics，Chesapeake，VA)，被配置成照射50/50单模光纤分束器405。被传输通过分束器的一个端口的光被准直仪410校准，并且被传输通过光纤412到达聚焦设备415并到达光栅透镜对，该光栅透镜对包括：光栅420(1780lpmm，Holographix，LLC，Hudson，MA)；以及350230-B非球面透镜425(Thor Labs，Inc.，Newton，NJ)，其具有4.5mm的焦距f、5.0mm的通光孔径和0.55的NA。这种布置能够在圆柱形样品的内表面上产生聚焦的谱编码的斑点430的500μm纵向线性阵列或线。光栅透镜对通过壳体440附着到马达435(1516SR，15mm直径，MicroMo Electronics，Inc.，Clearwater，FL)的轴。随着马达435旋转，跨越圆柱形样品的内圆周扫描谱编码线。使用计算机控制的线性级445(Nanomotion II，2.5cm range，Melles Griot，Rochester，NY)，在马达435的旋转期间沿着圆柱形样品的纵轴平移马达435、壳体440和光栅透镜对。这个过程产生了圆柱形样品的整个内表面的螺旋扫描。 
从样品反射的光被传输返回通过光学系统进入单模光纤412，并且被光纤412提供给分光计450和线性CCD 455，该线性CCD 455包括2048个像素并且具有30kHz的线速率(Basler L104K，Basler VisionTechnologies，Exton，PA)。计算机460用于存储、分析和显示分光计450和CCD 455提供的图像数据。每周马达旋转大约有60,000点(以0.5Hz或30rpm)被数字化，以实现1.0μm的圆周采样密度。马达的纵向速度为0.25mm/s，并且圆柱形样品的一个完整扫描所需的时间为100秒。 
光栅透镜对上的准直束的1/e2直径为4.0mm。结果，这个示范性设备的有效NA近似为0.4，这对应于近似1.2μm的理论斑点直径和近似2.5μm的共焦参数。在没有光学像差的系统中，样品上的理论谱分辨率可以为 
Figure S200680040695XD00081
其能够跨越谱编码线430得到高达近似630个可分辨点。检测臂中的分光计450被设计成超过探针的预测谱分辨率。 
在图5中示出了使用这种设备获得的1951 USAF分辨率图表的SECM扫描。被分开2.2μm的这个图中的最小条被分辨。使用扫描通过焦点的镜获得的横断线扩展函数半高宽(“FWHM”)和轴向FWHM函 数分别被测量为2.1μm和5.5μm。观察到视场大约为500μm。这些测量结果略微低于相应的理论值，这可能归因于光路中的像差。这些实际的参数表明，在此描述的示范性设备能够提供足够的分辨率以用于生物组织中的共焦显微镜检查。 
在图6中示出了用于2.5cm体模样品的完全回拉图像的SECM图像数据。在生成这些显示的图像之前，将极坐标转换成直角坐标。使用附着到2.1cm内径的特氟隆(Teflon)管的内表面的镜头纸来制作体模样品。在图6A示出的低放大率图像中，能够观察到纸的包括褶皱和空隙的宏观结构。可见的圆周条纹可能起因于存在于谱编码线的末端处或其附近的较低的谱功率和透镜像差。如图6B-6E所示，在以较高的放大率提供的这个数据集的区域中，能够清楚地分辨各个纤维和纤维微观结构。 
通过调整图4A中的聚焦设备415，在120μm的范围的5个离散聚焦深度处获取仿真样品的圆柱形二维(“2D”)图像。图7中示出的这5个图像710-750然后被求和以产生综合图像760，其展示了体模样品表面的几乎完整的覆盖。 
由于缺少用于光学扫描头的定心设备，使用如在此描述的SECM设备来成像生物样品能够被复杂化。为了提供进一步的改进以便生成宽视场显微图像和数据，在2.0cm直径的透明圆柱之上放置猪肠的样品。在图8A中示出了1秒内获取的这个样品的360°扫描。成像的组织仅在圆柱形扫描的一个区段中出现，因为探针未被置于中心，并且样品没有完全缠绕在圆柱周围。图8B-8D示出了这个组织样品的一系列放大区域。图8B中示出的图像是图8A中的打点矩形框出的1.5cm区段的扩展。类似地，图8C中的图像表示了图8B中框出的矩形的扩展，而图8D中的图像则表示了图8C中框出的矩形的扩展。图8B中的组织的放大图像暗示了腺结构。图8C-8D中的放大图像展示了绒毛和核特征，它们类似于如图2和3所示的使用1300nm SECM系统观察到的绒毛和核特征。图8A中的SECM扫描的其它区域示出了伪像(artifact)，包括来自透明圆柱的镜反射和全信号丢失，这两者都可能起因于聚焦SECM束的不适当定位。 
对患者实施全面共焦显微镜检查提出了多种技术挑战。这样的挑战可能包括例如增加成像速率、使探针光学部件和机械部件小型化、结合定心机构以及实施用于动态改变焦平面的技术。 
与在上文描述的示范性系统相比，能够将SECM系统的图像获取速度改进为该示范性系统的例如大约2-4倍。通过提供某些修改能够实现这 样的改进。例如，更高功率半导体光源(诸如像超辐射二极管T-840HP：25mW，840nm，100nm谱带宽)能够提供1000个谱可分辨点。光功率的增加能够改进灵敏度，并且较大的带宽可以拓宽视场，使得可以以近似两倍的速度扫描SECM束。而且，使用光环行器诸如像OC-3-850(Optics for Research，Caldwell，NJ)能够增加被传递到探针和从探针收集的光的效率。使用更快更灵敏的线性CCD诸如像具有2048个像素和60kHz读出速率的AVIIVA M4-2048(Atmel Corporation)能够提供两倍的数据获取速度和用于生成图像数据的波长范围的改进的谱响应。还可以通过使用例如Camera Link(摄像机链接)接口来改进性能，所述Camera Link接口能够以近似120MB/s的速率从摄像机向用于存储的硬盘驱动器阵列传送数据。 
被理解为指的是最小可检测反射率的灵敏度是影响共焦图像质量和穿透深度的系统参数。当使用近红外RCM技术时，能够从一直到近似300μm的深度处的皮肤反射入射光的一小部分，其可能近似为10-4到10-7 。基于在此描述的根据本发明的某些示范性实施例的示范性系统中使用的物镜的NA以及皮肤比非角质化上皮黏膜更加显著地可以使光衰减的观察，在此描述的示范性SECM探针物镜可以收集近似3×10-4到3×10-7 的从组织之内深处反射的照射光。25mW光源可以被分成例如近似1000个独立的射束。最大双程插入损耗被估计为近似10dB(6dB来自探针，4dB来自光纤和分光计)。基于这些估计的参数，对于每线集成周期，从而可以用近似50到50,000个光子/像素来照射阵列中的每个像素。 
使用多模检测技术，可以实现10倍的信号增益，使得对于这样的配置每次扫描有近似500到500,000光子/像素。如果信号在以近似240个光子发生的暗电流波动之上，则例如Atmel AVIIVA M4摄像机上的单个像素能够可靠地检测光。如果这个装置在这些波长处具有近似50％量子效率，则能够以每次扫描有近似480光子/像素产生最小可检测信号。基于这些近似，Atmel摄像机可以具有足够的灵敏度以允许较深的组织深度处的SECM成像。通过使用多模光纤来收集或者通过增加源功率，能够实现对预测的最小反射率进行的量子噪声限制检测。 
根据本发明的一个示范性实施例，能够提供用于导航、分析和显示来自解剖结构的大的微观数据集的方法和装置。 
图9A-9E图示了使用全面的显微镜检查与本发明的方法和装置的示范性实施例获得的体内猪食道的各种图像。这些示范性图像由图4中示出 的计算机460(例如个人计算机、微型计算机等等)生成，或者由别的处理装置生成，所述计算机460或处理装置可以(例如通过软件)被配置成将这样的图像转发到图4的显示器470或别的输出装置。另外，计算机460控制图4的示范性系统的各种部件(例如马达435、线平移器445、聚焦设备415等等)，以自动地和/或在人工控制之下聚焦在解剖结构的各个区域上，这将使得能够导航、分析和显示与解剖结构相关联的大的微观数据集。 
例如，图9A分别示出了在体内的猪食道的微观图像的前视图和侧视图900、905，其使用根据本发明的方法和装置的示范性实施例提供了黏膜下层之内的脉管网络，而没有使用图像增强剂或外在的造影剂。事实上，可以对图9A的例如14GB容量的数据集进行再现和降采样，以用于在任意的取向和透视图中呈现。在没有使用这样的图像增强剂或外在的造影剂的情况下，示出了黏膜下层之内的脉管网络。使用为(一个或多个)这样的示范性任务配置的计算机460和图4的系统的其它部件，能够在体积图像上定位横截面图像，用于更高分辨率观察。 
图9B示出了通过图9A中图示的位置处的食道壁的纵向横截面的微观图像的侧视图910。例如，这个图像910以上皮在顶部的方式反转；尺度：水平45mm，垂直2.6mm。在原始数据中，能够观察到对应于心跳运动的周期性垂直偏移。表面对准过程的示范性实施例用于减少这种伪像而只剩余垂直条带，该剩余的垂直条带仍然可以以对应于90次/分钟的心率的300微米的周期被观察到。相邻A线之间的示范性纵向间距被示出为32μm。 
图9C示出了图9A中图示的位置处的打开横断截面(例如圆柱坐标r和θ被映射到垂直和水平坐标)的侧视图920。例如，图示的示范性尺度如下：57mm-水平，2.6mm-垂直。图9B和9C都图示了通过整个食道壁的成像，并且能够识别鳞状上皮(e)、固有层(lp)、黏膜肌层(mm)、黏膜下层(s)和固有肌层(mp)。图9D示出了有助于这样的识别的图9C中图示的图像的选择截面的展开图的侧视图930。图9E示出了从对应于图9D中图示的图像的解剖区域获得的代表性组织截面(H&E染色)的示范性图像。 
例如，图10描绘了流程图，其描述了能够使用图4中示出的计算机460来执行的用于以渐进更高的分辨率分析和/或观察数据集的根据本发明的方法或过程的示范性实施例。具体地，在步骤1000中，在组织的大 面积之上，或者从组织或其中的器官的体积中，可以获取具有小于10μm的分辨率的微观数据集。然后能够以如下的表达(在步骤1010中)将数据格式化：可以图示整个数据集或数据集的一部分的低放大率或低倍视图。在步骤1020中，用户可以观察数据集，并且使用计算机接口选择(a)矩形区域、(b)点、(c)任意成形区域和/或(d)深度，以目视更高放大率视图。在步骤1020中观察新的区域，并且用户在数据集之内(a)选择另一个区域、(b)在点处放大、(c)缩小、(d)在三维中平移当前视图和/或(e)改变观察的深度位置。 
重复图10中图示的整个示范性过程，直到所关心的一个或多个区域被可视化地识别为止。用户以任何放大率或视图来选择不同的图像，以存储用于稍后的检查。在示范性导航过程期间还能够对每个单独视图进行标记。不同放大率/位置的各种区域/图像能够被标上书签，以便用户能够在随后的导航会话期间返回到相同的区域/图像。图6A-6E、7和9A-9E图示了观察大面积微观数据集时的渐进放大率的例子。 
在此描述的导航过程的示范性实施例通过计算机460来实施，并且还利用各种处理技术辅助用户确定各种区域以放大和观察样品及其不同的部分和区域。例如，图11描绘了使用光学相干断层扫描(“OCT”)技术获得的食道黏膜的一系列示范性图像，展示了用于经由OCT图像空间频率的分析而识别与Barrett的食道和腺癌相比较的正常或良性鳞状黏膜的自动处理过程的示范性实施例的实施。 
如图11所示，示出了不同病状的OCT图像1100、1110和1120以及空间频率分布1105、1115和1125。鳞状上皮1100(SE)具有垂直空间频率(见面板1105中的箭头1007)，其对应于在SIM中可能不存在的水平层。与SIMND 1110和1115相对照，在腺癌(CA)1120的示范性OCT图像及其相应的空间频率1125中示出了广泛变化的空间频率分布。图12描绘了通过确定归一化的标准偏差参数(NSD)而从动脉粥样硬化斑1200的OCT图像中获得的巨噬细胞含量1210的图示。使用色表1220，可以获得巨噬细胞的密度并将其显示为图像。 
这些以及其它的示范性图像处理分析过程和步骤能够被应用于微观数据集并用于突出潜在疾病的区域，用于随后的定向导航。图13描绘了用于导航和评估微观图像数据集的根据本发明的方法和过程的示范性实施例的流程图。在这个示范性方法/过程中，在步骤1300中获得微观数据集，其优选地具有在组织的大面积之上或者从组织或其中的器官的体积中 获取的小于10μm的分辨率。然后在步骤1310中通过处理装置(例如使用计算机460)自动地处理数据，以识别包含疑似疾病区域或相反地疑似不包含疾病区域(亦即健康部位)的区域/位置。在步骤1320中，不健康区域通过使用颜色或其它标记方法而被表达，然后在步骤1330中以整个微观数据体积的低放大率而被观察。 
用户然后能够由处理数据及其表达引导，在步骤1340中选择区域来观察。然后用户可以观察数据集，并且使用计算机接口来选择(a)矩形区域、(a)点、(c)任意成形区域和/或(d)深度，以目视更高放大率视图。可以观察新的区域，并且用户(或计算机460)可以在数据集之内手动或自动地(a)选择另一个区域、(b)在点处放大/缩小(步骤1350)、(d)在三维中平移当前视图和/或(e)改变观察的深度位置。进一步，在步骤1360中，用户观察新近图示的区域。可以重复示范性的方法/过程，直到所关心的(一个或多个)区域被可视化地识别为止。用户或计算机460可以选择任何放大率或视图的不同图像，以存储用于稍后检查。在示范性导航过程期间还可以对每个单独视图进行标记。不同放大率/位置的各种区域/图像可以被标上书签并存储，以便用户能够在随后的导航会话期间返回到相同的区域/图像。 
前述仅仅表明了本发明的原理。考虑到在此的教导，对所描述的实施例的各种修改和变更对本领域技术人员而言将会是明显的。事实上，根据本发明的示范性实施例的装置、系统和方法，可以与任何OCT系统、OFDI系统、SD-OCT系统或其它成像系统一起使用，并且例如与2004年9月8日提交的国际专利申请PCT/US2004/029148、2005年11月2日提交的美国专利申请No.11/266,779和2004年7月9日提交的美国专利申请No.10/501,276中描述的那些一起使用，这些专利申请的整体内容通过引用结合于此。这样一来，将会意识到的是，本领域技术人员将会设计众多的系统、装置和方法，它们尽管没有在此明确地示出或描述，但却体现了本发明的原理，并从而处在本发明的精神和范围之内。另外，就上面尚未明确地将现有技术知识通过引用结合于此而言，明确地以其整体结合于此。上面引用在此的所有公布都以其整体通过引用结合于此。 

Claims (22)

1.一种用于分析和/或图示解剖结构的至少一个部分的方法，包括：
将光转送到所述至少一个部分以便生成与所述至少一个部分相关的第一信息，其中，位于包含所述解剖结构的受检对象之内的生成装置将所述光提供到所述受检对象上或所述受检对象之内，所述生成装置生成所述第一信息，所述第一信息与图像相关联；
接收所述第一信息，并且基于所述第一信息选择所述至少一个部分的至少一个截面，以便生成第二信息；以及
渐进地修改作为所述第二信息的函数的所述至少一个部分的显示的放大率。
2.根据权利要求1所述的方法，其中，所述修改步骤包括修改所述至少一个部分的位置的显示。
3.根据权利要求1所述的方法，其中，所述修改步骤包括修改所述至少一个部分在所述解剖结构之内的深度的显示。
4.根据权利要求1所述的方法，其中，所述第二信息与所述至少一个部分之内提供的区域相关联。
5.根据权利要求1所述的方法，其中，通过用户选择所述区域来获得所述第二信息。
6.根据权利要求1所述的方法，其中，所述选择步骤通过处理装置自动执行而不用从用户输入。
7.根据权利要求1所述的方法，进一步包括确定所述至少一个部分之内的异常性区域，并且其中处理装置执行所述选择步骤和修改步骤，以便显示所述异常性的至少一个截面。
8.根据权利要求1所述的方法，进一步包括使用处理装置确定所述至少一个部分之内的异常性区域，以便生成第三信息，并且其中所述选择步骤作为所述第三信息的画数而被用户执行。
9.根据权利要求1所述的方法，进一步包括使用处理装置确定所述至少一个部分之内的异常性区域，以便生成第三信息，并且其中所述选择步骤作为所述第三信息的函数而被所述处理装置执行。
10.根据权利要求1所述的方法，其中，所述第一信息与所述至少一个部分的二维表示相关联。
11.根据权利要求1所述的方法，其中，所述第一信息与所述至少一个部分的三维表示相关联。
12.根据权利要求1所述的方法，其中，所述第一信息与具有多于三维的所述至少一个部分的表示相关联。
13.根据权利要求1所述的方法，其中，所述至少一个部分具有大于1mm2的面积。
14.根据权利要求1所述的方法，其中，所述至少一个部分具有大于10mm2的面积。
15.根据权利要求1所述的方法，其中，所述至少一个部分的显示的截面具有小于1cm2的面积。
16.根据权利要求1所述的方法，其中，所述至少一个部分的显示的截面具有小于1mm2的面积。
17.根据权利要求1所述的方法，其中，所述至少一个部分的显示的截面具有小于100μm2的面积。
18.根据权利要求1所述的方法，其中，所述第一信息与以下中的至少一个相关联：
共焦显微镜检查过程；
谱编码共焦显微镜检查过程；
光学相干断层扫描过程；以及
光学频域干涉量度过程。
19.根据权利要求1所述的方法，进一步包括在所述解剖结构之内提供装置，以便将所述光提供给所述至少一个部分。
20.根据权利要求1所述的方法，其中，所述至少一个部分是血管。
21.一种用于分析和/或图示解剖结构的至少一个部分的设备，包括：
至少一个第一装置，其位于包含所述解剖结构的受检对象之内并且配置成将光转送到所述至少一个部分上或所述受检对象之内，以便生成与所述至少一个部分相关的第一信息，所述第一信息与图像相关联；
至少一个第二装置，其配置成接收所述第一信息，并且基于所述第一信息选择所述至少一个部分的至少一个截面，以便生成第二信息；以及
至少一个第三装置，其配置成渐进地修改作为所述第二信息的函数的所述至少一个部分的显示的放大率。
22.根据权利要求21所述的设备，其中，所述至少一个部分是血管。
CN200680040695XA 2005-09-29 2006-09-29 以渐进增加的分辨率观察和分析一个或多个生物样品的方法和用于该方法的设备 Expired - Fee Related CN101304683B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72180205P 2005-09-29 2005-09-29
US60/721,802 2005-09-29
PCT/US2006/038277 WO2007041412A1 (en) 2005-09-29 2006-09-29 Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions

Publications (2)

Publication Number Publication Date
CN101304683A CN101304683A (zh) 2008-11-12
CN101304683B true CN101304683B (zh) 2012-12-12

Family

ID=37533302

Family Applications (5)

Application Number Title Priority Date Filing Date
CN2006800409801A Expired - Fee Related CN101360447B (zh) 2005-09-29 2006-09-29 通过光谱编码进行光学成像的方法和装置
CN201310343981.5A Pending CN103479331A (zh) 2005-09-29 2006-09-29 用于经由谱编码进行光学成像的方法和设备
CN200680040695XA Expired - Fee Related CN101304683B (zh) 2005-09-29 2006-09-29 以渐进增加的分辨率观察和分析一个或多个生物样品的方法和用于该方法的设备
CN2006800405035A Active CN101365375B (zh) 2005-09-29 2006-09-29 用于经由谱编码进行光学成像的方法和设备
CN2006800405482A Active CN101304682B (zh) 2005-09-29 2006-09-29 用于提供一个或多个生物结构的多模态显微成像的装置和方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CN2006800409801A Expired - Fee Related CN101360447B (zh) 2005-09-29 2006-09-29 通过光谱编码进行光学成像的方法和装置
CN201310343981.5A Pending CN103479331A (zh) 2005-09-29 2006-09-29 用于经由谱编码进行光学成像的方法和设备

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2006800405035A Active CN101365375B (zh) 2005-09-29 2006-09-29 用于经由谱编码进行光学成像的方法和设备
CN2006800405482A Active CN101304682B (zh) 2005-09-29 2006-09-29 用于提供一个或多个生物结构的多模态显微成像的装置和方法

Country Status (11)

Country Link
US (11) US7843572B2 (zh)
EP (6) EP1940286A1 (zh)
JP (8) JP5275804B2 (zh)
KR (1) KR20080066705A (zh)
CN (5) CN101360447B (zh)
AU (1) AU2006299659A1 (zh)
CA (1) CA2624109A1 (zh)
DK (1) DK1937137T3 (zh)
ES (1) ES2925725T3 (zh)
PL (1) PL1937137T3 (zh)
WO (4) WO2007041376A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104224117A (zh) * 2014-09-10 2014-12-24 南京航空航天大学 一种光谱编码共焦与光学相干层析协同成像方法与系统

Families Citing this family (466)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1434522B1 (en) 2000-10-30 2010-01-13 The General Hospital Corporation Optical systems for tissue analysis
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
US7865231B2 (en) 2001-05-01 2011-01-04 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
WO2004088361A2 (en) 2003-03-31 2004-10-14 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
US8054468B2 (en) 2003-01-24 2011-11-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
EP1639330B1 (en) 2003-06-06 2008-10-08 The General Hospital Corporation Wavelength tunable light source
US7733497B2 (en) 2003-10-27 2010-06-08 The General Hospital Corporation Method and apparatus for performing optical imaging using frequency-domain interferometry
AU2004320269B2 (en) 2004-05-29 2011-07-21 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (OCT) imaging
JP4995720B2 (ja) 2004-07-02 2012-08-08 ザ ジェネラル ホスピタル コーポレイション ダブルクラッドファイバを有する内視鏡撮像プローブ
WO2006017837A2 (en) 2004-08-06 2006-02-16 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
US8208995B2 (en) 2004-08-24 2012-06-26 The General Hospital Corporation Method and apparatus for imaging of vessel segments
US8965487B2 (en) 2004-08-24 2015-02-24 The General Hospital Corporation Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample
EP1804638B1 (en) 2004-09-29 2012-12-19 The General Hospital Corporation System and method for optical coherence imaging
EP2278267A3 (en) 2004-11-24 2011-06-29 The General Hospital Corporation Common-Path Interferometer for Endoscopic OCT
EP1816949A1 (en) 2004-11-29 2007-08-15 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
US7336366B2 (en) * 2005-01-20 2008-02-26 Duke University Methods and systems for reducing complex conjugate ambiguity in interferometric data
WO2006116769A1 (en) 2005-04-28 2006-11-02 The General Hospital Corporation Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique
US7859679B2 (en) 2005-05-31 2010-12-28 The General Hospital Corporation System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging
EP1889037A2 (en) 2005-06-01 2008-02-20 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
US9441948B2 (en) 2005-08-09 2016-09-13 The General Hospital Corporation Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography
EP1940286A1 (en) 2005-09-29 2008-07-09 General Hospital Corporation Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
US7889348B2 (en) 2005-10-14 2011-02-15 The General Hospital Corporation Arrangements and methods for facilitating photoluminescence imaging
FI20051329A0 (fi) * 2005-12-27 2005-12-27 Wallac Oy Laitteisto ja menetelmä näytteiden optista mittausta varten
EP1971848B1 (en) 2006-01-10 2019-12-04 The General Hospital Corporation Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
DK1973466T3 (da) 2006-01-19 2021-02-01 Massachusetts Gen Hospital Ballonbilleddannelseskateter
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
EP1983921B1 (en) 2006-02-01 2016-05-25 The General Hospital Corporation Systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures
JP5680829B2 (ja) 2006-02-01 2015-03-04 ザ ジェネラル ホスピタル コーポレイション 複数の電磁放射をサンプルに照射する装置
JP5519152B2 (ja) 2006-02-08 2014-06-11 ザ ジェネラル ホスピタル コーポレイション 光学顕微鏡法を用いて解剖学的サンプルに関わる情報を取得するための装置
EP2309221A1 (en) 2006-02-24 2011-04-13 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
CN101466298B (zh) 2006-04-05 2011-08-31 通用医疗公司 用于样本的偏振敏感光频域成像的方法、装置和系统
US7439483B2 (en) * 2006-04-17 2008-10-21 Korea Advanced Institute Of Science And Technology Real-time confocal microscope using the dispersion optics
JP2009536740A (ja) 2006-05-10 2009-10-15 ザ ジェネラル ホスピタル コーポレイション サンプルの周波数領域画像形成を提供するためのプロセス、構成およびシステム
US7782464B2 (en) 2006-05-12 2010-08-24 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
US9867530B2 (en) 2006-08-14 2018-01-16 Volcano Corporation Telescopic side port catheter device with imaging system and method for accessing side branch occlusions
WO2008024948A2 (en) 2006-08-25 2008-02-28 The General Hospital Corporation Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques
DE102006046925A1 (de) * 2006-09-28 2008-04-03 Jenlab Gmbh Verfahren und Anordnung zur Laser-Endoskopie für die Mikrobearbeitung
WO2008049118A2 (en) * 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
EP2081486B1 (en) 2006-11-08 2014-04-09 Lightlab Imaging, Inc. Opto-acoustic imaging device
WO2008089342A1 (en) 2007-01-19 2008-07-24 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadband light
US8190244B2 (en) * 2007-01-23 2012-05-29 Case Western Reserve University Gated optical coherence tomography (OCT) environmental chamber
JP5558839B2 (ja) 2007-03-23 2014-07-23 ザ ジェネラル ホスピタル コーポレイション 角度走査及び分散手順を用いて波長掃引レーザを利用するための方法、構成及び装置
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
US8045177B2 (en) 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
US7571707B2 (en) * 2007-04-19 2009-08-11 Ford Global Technologies, Llc Engine mode transition utilizing dynamic torque control
JP5037215B2 (ja) * 2007-05-02 2012-09-26 富士フイルム株式会社 補償テーブル生成方法、装置、プログラムおよびこれを用いた断層画像処理装置
WO2008137637A2 (en) 2007-05-04 2008-11-13 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using brillouin microscopy
US20100160791A1 (en) * 2007-05-21 2010-06-24 Board Of Regents, The University Of Texas System Porcine biliary tract imaging
JP5291304B2 (ja) * 2007-06-29 2013-09-18 テルモ株式会社 光ケーブルおよびこれを使用した光干渉画像診断装置
US9596993B2 (en) 2007-07-12 2017-03-21 Volcano Corporation Automatic calibration systems and methods of use
WO2009009802A1 (en) 2007-07-12 2009-01-15 Volcano Corporation Oct-ivus catheter for concurrent luminal imaging
WO2009009799A1 (en) 2007-07-12 2009-01-15 Volcano Corporation Catheter for in vivo imaging
WO2009018456A2 (en) 2007-07-31 2009-02-05 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
US7995828B2 (en) * 2007-12-19 2011-08-09 Carestream Health, Inc. Speckle reporting in digital radiographic imaging
JP5608556B2 (ja) 2007-08-10 2014-10-15 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 前方結像型光干渉断層（ｏｃｔ）システムおよびプローブ
EP2191254B1 (en) 2007-08-31 2017-07-19 The General Hospital Corporation System and method for self-interference fluorescence microscopy, and computer-accessible medium associated therewith
WO2009038693A1 (en) * 2007-09-17 2009-03-26 The General Hospital Corporation Optical wavelength range for high contrast imaging of cancer
US8948846B2 (en) * 2007-09-19 2015-02-03 The Research Foundation Of State University Of New York Optical coherence tomography systems and methods
US9347765B2 (en) * 2007-10-05 2016-05-24 Volcano Corporation Real time SD-OCT with distributed acquisition and processing
US8184365B2 (en) * 2007-10-19 2012-05-22 University Of Central Florida Research Foundation, Inc. Optical instruments having dynamic focus
US7933021B2 (en) 2007-10-30 2011-04-26 The General Hospital Corporation System and method for cladding mode detection
EP2070468A1 (en) * 2007-12-14 2009-06-17 Koninklijke Philips Electronics N.V. An optical image probe
WO2009079460A1 (en) 2007-12-14 2009-06-25 University Of Florida Research Foundation, Inc. Electrothermal microactuator for large vertical displacement without tilt or lateral shift
JP5864105B2 (ja) * 2008-01-04 2016-02-17 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 光プローブ
JP2011508889A (ja) * 2008-01-04 2011-03-17 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 光学プローブ
US9332942B2 (en) 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
US20090227875A1 (en) * 2008-03-04 2009-09-10 Cao Group, Inc. Three-dimensional Imaging System
US8718743B2 (en) * 2008-04-24 2014-05-06 Duke University Methods for single-pass volumetric bidirectional blood flow imaging spectral domain optical coherence tomography using a modified hilbert transform
WO2009137701A2 (en) 2008-05-07 2009-11-12 The General Hospital Corporation System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
JP2009276327A (ja) * 2008-05-19 2009-11-26 Topcon Corp 光画像計測装置
EP3501384B1 (en) 2008-05-20 2024-07-17 University Health Network Method for fluorescence-based imaging and monitoring
US20090306520A1 (en) * 2008-06-02 2009-12-10 Lightlab Imaging, Inc. Quantitative methods for obtaining tissue characteristics from optical coherence tomography images
WO2009155536A2 (en) 2008-06-20 2009-12-23 The General Hospital Corporation Fused fiber optic coupler arrangement and method for use thereof
EP2309923B1 (en) 2008-07-14 2020-11-25 The General Hospital Corporation Apparatus and methods for color endoscopy
US8133127B1 (en) * 2008-07-21 2012-03-13 Synder Terrance W Sports training device and methods of use
KR20110050629A (ko) * 2008-07-24 2011-05-16 더 리전츠 오브 더 유니버시티 오브 캘리포니아 분산 푸리에-변환 이미징을 위한 장치 및 방법
WO2010045400A2 (en) * 2008-10-14 2010-04-22 Tissuevision, Inc. Devices and methods for direct sampling analog time-resolved detection
JPWO2010044322A1 (ja) * 2008-10-17 2012-03-15 コニカミノルタオプト株式会社 光断層測定装置
US8386015B2 (en) * 2008-10-27 2013-02-26 Siemens Aktiengesellschaft Integration of micro and macro information for biomedical imaging
US8440952B2 (en) 2008-11-18 2013-05-14 The Regents Of The University Of California Methods for optical amplified imaging using a two-dimensional spectral brush
FR2938917B1 (fr) * 2008-11-26 2018-05-18 Formulaction Dispositif d'analyse d'un melange polyphasique via un faisceau de lumiere retrodiffusee par celui-ci
JP2010127902A (ja) * 2008-12-01 2010-06-10 Fujifilm Corp 光立体構造像装置及びその光信号処理方法
US8275226B2 (en) * 2008-12-09 2012-09-25 Spectral Applied Research Ltd. Multi-mode fiber optically coupling a radiation source module to a multi-focal confocal microscope
JP5731394B2 (ja) 2008-12-10 2015-06-10 ザ ジェネラル ホスピタル コーポレイション 光サブサンプリングを通じて、光コヒーレンストモグラヒィーのイメージング深度範囲を伸ばすためのシステム、装置及び方法
TWI414818B (zh) * 2008-12-22 2013-11-11 Academia Sinica 使用空間光調變器的超解析率廣視野光切片顯微鏡
US20100188739A1 (en) * 2009-01-19 2010-07-29 Visiongate, Inc. Tomographic Light Field Microscope
WO2010090837A2 (en) * 2009-01-20 2010-08-12 The General Hospital Corporation Endoscopic biopsy apparatus, system and method
JP2012515930A (ja) 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション 広視野の超解像顕微鏡を提供するためのシステム、方法及びコンピューターがアクセス可能な媒体
JP2010175448A (ja) * 2009-01-30 2010-08-12 Kowa Co 光学撮像装置
JP5404078B2 (ja) * 2009-02-03 2014-01-29 株式会社トプコン 光画像計測装置
CN104134928A (zh) 2009-02-04 2014-11-05 通用医疗公司 利用高速光学波长调谐源的设备和方法
US10485422B2 (en) * 2009-02-19 2019-11-26 Manish Dinkarrao Kulkarni System and method for imaging subsurface of specimen
JP5321145B2 (ja) 2009-03-04 2013-10-23 日本電気株式会社 画像診断支援装置、画像診断支援方法、画像診断支援プログラム、及びその記憶媒体
WO2010105197A2 (en) 2009-03-12 2010-09-16 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measuring at least one mechanical property of tissue using coherent speckle techniques(s)
EP2427723B1 (en) * 2009-05-04 2018-12-19 Duke University Methods and computer program products for quantitative three-dimensional image correction and clinical parameter computation in optical coherence tomography
AU2010256775B2 (en) * 2009-06-01 2015-09-03 Channel Medsystems, Inc. Methods and apparatus for treatment of a body cavity or lumen
JP5498728B2 (ja) * 2009-06-09 2014-05-21 Ｈｏｙａ株式会社 医療用観察システム
US8812087B2 (en) * 2009-06-16 2014-08-19 Technion Research & Development Foundation Limited Method and system of spectrally encoded imaging
DE102009029831A1 (de) * 2009-06-17 2011-01-13 W.O.M. World Of Medicine Ag Vorrichtung und Verfahren für die Mehr-Photonen-Fluoreszenzmikroskopie zur Gewinnung von Informationen aus biologischem Gewebe
BR112012001042A2 (pt) * 2009-07-14 2016-11-22 Gen Hospital Corp equipamento e método de medição do fluxo de fluído dentro de estrutura anatômica.
JP2011045525A (ja) * 2009-08-27 2011-03-10 Fujifilm Corp 内視鏡
JP5298352B2 (ja) * 2009-09-16 2013-09-25 株式会社トプコン 光構造像観察装置及び内視鏡装置
WO2011037980A2 (en) * 2009-09-22 2011-03-31 Bioptigen, Inc. Systems for extended depth frequency domain optical coherence tomography (fdoct) and related methods
US20180344174A9 (en) 2009-09-23 2018-12-06 Lightlab Imaging, Inc. Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods
WO2011038044A2 (en) * 2009-09-23 2011-03-31 Lightlab Imaging, Inc. Lumen morphology and vascular resistance measurements data collection systems, apparatus and methods
EP2485641A4 (en) * 2009-10-06 2015-10-14 Gen Hospital Corp APPARATUS AND METHODS FOR IMAGING PARTICULAR CELLS INCLUDING EOSINOPHILES
WO2011050249A1 (en) 2009-10-23 2011-04-28 Bioptigen, Inc. Systems for comprehensive fourier domain optical coherence tomography (fdoct) and related methods
US9210288B2 (en) 2009-11-20 2015-12-08 Faro Technologies, Inc. Three-dimensional scanner with dichroic beam splitters to capture a variety of signals
US9529083B2 (en) 2009-11-20 2016-12-27 Faro Technologies, Inc. Three-dimensional scanner with enhanced spectroscopic energy detector
US9113023B2 (en) 2009-11-20 2015-08-18 Faro Technologies, Inc. Three-dimensional scanner with spectroscopic energy detector
DE102009057101A1 (de) 2009-11-20 2011-05-26 Faro Technologies, Inc., Lake Mary Vorrichtung zum optischen Abtasten und Vermessen einer Umgebung
US9879976B2 (en) 2010-01-20 2018-01-30 Faro Technologies, Inc. Articulated arm coordinate measurement machine that uses a 2D camera to determine 3D coordinates of smoothly continuous edge features
US9628775B2 (en) 2010-01-20 2017-04-18 Faro Technologies, Inc. Articulated arm coordinate measurement machine having a 2D camera and method of obtaining 3D representations
US9607239B2 (en) 2010-01-20 2017-03-28 Faro Technologies, Inc. Articulated arm coordinate measurement machine having a 2D camera and method of obtaining 3D representations
TW201140226A (en) * 2010-02-08 2011-11-16 Oregon Health & Amp Science University Method and apparatus for ultrahigh sensitive optical microangiography
JP5934121B2 (ja) 2010-03-05 2016-06-15 ザ ジェネラル ホスピタル コーポレイション 特定の分解能にて少なくとも１つの解剖構造の微細画像を提供するシステム、方法およびコンピュータがアクセス可能な媒体
US9044142B2 (en) * 2010-03-12 2015-06-02 Carl Zeiss Meditec Ag Surgical optical systems for detecting brain tumors
CN101852982B (zh) * 2010-04-15 2012-05-23 万事利集团有限公司 四维动感照片的制作方法
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
WO2011143121A2 (en) 2010-05-10 2011-11-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Spatial-domain low-coherence quantitative phase microscopy
DE102010020925B4 (de) 2010-05-10 2014-02-27 Faro Technologies, Inc. Verfahren zum optischen Abtasten und Vermessen einer Umgebung
EP2575597B1 (en) * 2010-05-25 2022-05-04 The General Hospital Corporation Apparatus for providing optical imaging of structures and compositions
EP2575598A2 (en) 2010-05-25 2013-04-10 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
WO2011153434A2 (en) 2010-06-03 2011-12-08 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
CN102934005B (zh) * 2010-06-03 2016-06-15 株式会社尼康 显微镜装置
US20110301414A1 (en) * 2010-06-04 2011-12-08 Robert Hotto Intelligent endoscopy systems and methods
JP5541972B2 (ja) * 2010-06-09 2014-07-09 オリンパス株式会社 走査型共焦点顕微鏡
FR2962531B1 (fr) * 2010-07-08 2014-01-17 Lltech Inc Methode et dispositif d'imagerie tridimensionnelle par microscopie interferentielle plein champ
DE102010032724A1 (de) * 2010-07-26 2012-01-26 Faro Technologies, Inc. Vorrichtung zum optischen Abtasten und Vermessen einer Umgebung
US9046419B2 (en) * 2010-07-28 2015-06-02 Technion Research & Development Foundation Limited Systems and methods for spectrally encoded imaging
US20140147836A1 (en) * 2010-09-14 2014-05-29 Albert Einstein College Of Medicine Of Yeshiva University Methods and apparatus for imaging molecules in living systems
EP2615966A1 (en) * 2010-09-17 2013-07-24 Lltech Management Full-field optical coherence tomography system for imaging an object
EP2615967B1 (en) * 2010-09-17 2017-08-16 LLtech Management Optical tissue sectioning using full field optical coherence tomography
CN101975769A (zh) * 2010-09-17 2011-02-16 福建师范大学 一种基于不同波长光源激发的人体组织自体荧光检测系统
US9482659B2 (en) * 2010-09-27 2016-11-01 Progyny, Inc. Apparatus, method, and system for the automated imaging and evaluation of embryos, oocytes and stem cells
US9329308B2 (en) * 2010-10-26 2016-05-03 The Board Of Trustees Of The Leland Stanford Junior University Longitudinally graded index lens
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
US8792102B2 (en) * 2010-10-28 2014-07-29 General Electric Company Interferometric spectral imaging of a two-dimensional array of samples using surface plasmon resonance
US20130248695A1 (en) * 2010-10-29 2013-09-26 Duncan MacIntyre Method and apparatus for analyte detection
EP2641079A2 (en) 2010-11-15 2013-09-25 Tissuevision, Inc. Systems and methods for imaging and processing tissue
US9168654B2 (en) 2010-11-16 2015-10-27 Faro Technologies, Inc. Coordinate measuring machines with dual layer arm
US11141063B2 (en) * 2010-12-23 2021-10-12 Philips Image Guided Therapy Corporation Integrated system architectures and methods of use
US11040140B2 (en) 2010-12-31 2021-06-22 Philips Image Guided Therapy Corporation Deep vein thrombosis therapeutic methods
WO2012100213A2 (en) 2011-01-21 2012-07-26 Duke University Systems and methods for complex conjugate artifact resolved optical coherence tomography
US8851675B2 (en) * 2011-01-26 2014-10-07 Josh N. Hogan Hybrid OCT scanning device
CA3012538C (en) 2011-02-01 2021-03-30 Channel Medsystems, Inc. Method and apparatus for cyrogenic treatment of a body cavity or lumen
US9446189B2 (en) * 2011-02-11 2016-09-20 Lifecell Corporation Tissue transfer systems
US9864190B2 (en) * 2011-02-24 2018-01-09 The Board Of Trustees Of The Leland Stanford Junior University Confocal microscope, system and method therefor
US9835591B2 (en) 2011-02-25 2017-12-05 Panorama Synergy Ltd Optical cantilever based analysis
US20130205455A1 (en) * 2012-02-07 2013-08-08 University Of Western Australia System and method of performing atomic force measurements
US9057706B2 (en) 2011-02-25 2015-06-16 University Of Western Australia Optical cantilever based analyte detection
EP2683422B1 (en) 2011-03-07 2019-05-08 Potrero Medical, Inc. Sensing foley catheter
WO2014099527A1 (en) 2012-12-17 2014-06-26 Theranova, Llc Wearable apparatus for the treatment or prevention of osteopenia and osteoporosis, stimulating bone growth, preserving or improving bone mineral density, and inhibiting adipogenesis
EP2690425B1 (en) * 2011-03-24 2018-08-08 Nikon Corporation Optical coherence tomography observation device, method for determining relative position between images, and program for determining relative position between images
ES2527004T3 (es) * 2011-04-06 2015-01-19 Agfa Healthcare N.V. Sistema y procedimiento para tomografía de coherencia óptica
WO2012135961A1 (en) * 2011-04-08 2012-10-11 British Columbia Cancer Agency Branch Apparatus and methods for multiphoton microscopy
WO2012149175A1 (en) 2011-04-29 2012-11-01 The General Hospital Corporation Means for determining depth-resolved physical and/or optical properties of scattering media
JP2014523536A (ja) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体
WO2013066447A1 (en) * 2011-08-01 2013-05-10 The Trustees Of Columbia University In The City Of New York Lens-free planar imager and wireless transmitter
US10241028B2 (en) 2011-08-25 2019-03-26 The General Hospital Corporation Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
WO2013033489A1 (en) 2011-08-31 2013-03-07 Volcano Corporation Optical rotary joint and methods of use
KR101849974B1 (ko) 2011-09-16 2018-04-19 삼성전자주식회사 개구수 제어 유닛, 이를 채용한 가변형 광 프로브 및 깊이 스캐닝 방법
US9678007B2 (en) * 2011-10-14 2017-06-13 Northwestern University Biological tissue analysis by inverse spectroscopic optical coherence tomography
JP2015502562A (ja) 2011-10-18 2015-01-22 ザ ジェネラル ホスピタル コーポレイション 再循環光学遅延を生成および／または提供するための装置および方法
WO2013059665A1 (en) 2011-10-19 2013-04-25 The Trustees Of Columbia University In The City Of New York Ultracompact fabry-perot array for ultracompact hyperspectral imaging
US8953911B1 (en) 2011-10-28 2015-02-10 Lightlab Imaging, Inc. Spectroscopic imaging probes, devices, and methods
GB201118773D0 (en) 2011-10-31 2011-12-14 Univ Bristol Probe
US8831321B1 (en) 2011-11-07 2014-09-09 Lightlab Imaging, Inc. Side branch detection methods, systems and devices
US8864309B2 (en) 2011-12-05 2014-10-21 Bioptigen, Inc. Optical imaging systems having input beam shape control and path length control
WO2013093788A1 (en) * 2011-12-20 2013-06-27 Ecole Polytechnique Federale De Lausanne (Epfl) Fiber sensing system based on a bragg grating and optical time domain reflectometry
DE102012100609A1 (de) 2012-01-25 2013-07-25 Faro Technologies, Inc. Vorrichtung zum optischen Abtasten und Vermessen einer Umgebung
EP2817609B1 (en) 2012-02-26 2021-04-07 Caliber Imaging & Diagnostics Inc. Tissue specimen stage for an optical sectioning microscope
US20130250088A1 (en) * 2012-03-22 2013-09-26 Molecular Devices, Llc Multi-color confocal microscope and imaging methods
WO2013148349A1 (en) 2012-03-30 2013-10-03 The Trustees Of Columbia University In The City Of New York Graphene photonics for resonator-enhanced electro-optic devices and all-optical interactions
US9629528B2 (en) 2012-03-30 2017-04-25 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
US9613401B2 (en) * 2012-04-13 2017-04-04 Tessonics Corporation Method to obtain 3D images of a flowing region beneath an object using speckle reflections
US8896840B2 (en) * 2012-04-25 2014-11-25 Canon Kabushiki Kaisha Interferometric method and digital holographic microscope
JP2015517387A (ja) * 2012-05-21 2015-06-22 ザ ジェネラル ホスピタル コーポレイション カプセル顕微鏡検査のための装置、デバイスおよび方法
DE102012104874B4 (de) * 2012-06-05 2016-05-19 Technische Universität München Optisches Messsystem mit Polarisationskompensation, sowie entsprechendes Verfahren
WO2013188520A2 (en) * 2012-06-12 2013-12-19 Yale University Multimode optical fiber spectrometer
US9541375B2 (en) 2012-07-20 2017-01-10 Samsung Electronics Co., Ltd. Method and apparatus for generating tomography images
EP2690396A1 (de) * 2012-07-24 2014-01-29 Hexagon Technology Center GmbH Interferometrische Entfernungsmessanordnung und ebensolches Verfahren
CN102818768A (zh) * 2012-07-31 2012-12-12 苏州微清医疗器械有限公司 一种多功能生物医学显微镜
JP6227652B2 (ja) 2012-08-22 2017-11-08 ザ ジェネラル ホスピタル コーポレイション ソフトリソグラフィを用いてミニチュア内視鏡を製作するためのシステム、方法、およびコンピュータ・アクセス可能媒体
US9858668B2 (en) 2012-10-05 2018-01-02 Volcano Corporation Guidewire artifact removal in images
US11272845B2 (en) 2012-10-05 2022-03-15 Philips Image Guided Therapy Corporation System and method for instant and automatic border detection
US9286673B2 (en) 2012-10-05 2016-03-15 Volcano Corporation Systems for correcting distortions in a medical image and methods of use thereof
US9324141B2 (en) 2012-10-05 2016-04-26 Volcano Corporation Removal of A-scan streaking artifact
US10568586B2 (en) 2012-10-05 2020-02-25 Volcano Corporation Systems for indicating parameters in an imaging data set and methods of use
DE102012109481A1 (de) 2012-10-05 2014-04-10 Faro Technologies, Inc. Vorrichtung zum optischen Abtasten und Vermessen einer Umgebung
US10067231B2 (en) 2012-10-05 2018-09-04 Faro Technologies, Inc. Registration calculation of three-dimensional scanner data performed between scans based on measurements by two-dimensional scanner
US10070827B2 (en) 2012-10-05 2018-09-11 Volcano Corporation Automatic image playback
US9513107B2 (en) 2012-10-05 2016-12-06 Faro Technologies, Inc. Registration calculation between three-dimensional (3D) scans based on two-dimensional (2D) scan data from a 3D scanner
US9292918B2 (en) 2012-10-05 2016-03-22 Volcano Corporation Methods and systems for transforming luminal images
US9367965B2 (en) 2012-10-05 2016-06-14 Volcano Corporation Systems and methods for generating images of tissue
JP2015532536A (ja) 2012-10-05 2015-11-09 デイビッド ウェルフォード， 光を増幅するためのシステムおよび方法
US9307926B2 (en) 2012-10-05 2016-04-12 Volcano Corporation Automatic stent detection
US9840734B2 (en) 2012-10-22 2017-12-12 Raindance Technologies, Inc. Methods for analyzing DNA
US9417127B2 (en) * 2012-10-23 2016-08-16 Eric Udd Fiber grating sensor system for measuring key parameters during high speed
US9212948B2 (en) 2012-11-07 2015-12-15 The Trustees Of Columbia University In The City Of New York Lossless hyperspectral imaging
DE102012111008B4 (de) * 2012-11-15 2014-05-22 Precitec Optronik Gmbh Optisches Messverfahren und optische Messvorrichtung zum Erfassen einer Oberflächentopographie
WO2014078855A1 (en) 2012-11-19 2014-05-22 Apton Biosystems, Inc. Digital analysis of molecular analytes using single molecule detection
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
WO2014077871A2 (en) 2012-11-19 2014-05-22 Lightlab Imaging, Inc. Interface devices, systems and methods for multimodal probes
WO2014085911A1 (en) 2012-12-05 2014-06-12 Tornado Medical Systems, Inc. System and method for wide field oct imaging
ES2641487T3 (es) 2012-12-12 2017-11-10 Lightlab Imaging, Inc. Aparato para la determinación automatizada de un contorno luminal de un vaso sanguíneo
CA2894403A1 (en) 2012-12-13 2014-06-19 Volcano Corporation Devices, systems, and methods for targeted cannulation
US10942022B2 (en) 2012-12-20 2021-03-09 Philips Image Guided Therapy Corporation Manual calibration of imaging system
US10939826B2 (en) 2012-12-20 2021-03-09 Philips Image Guided Therapy Corporation Aspirating and removing biological material
US11406498B2 (en) 2012-12-20 2022-08-09 Philips Image Guided Therapy Corporation Implant delivery system and implants
US9730613B2 (en) 2012-12-20 2017-08-15 Volcano Corporation Locating intravascular images
JP2016504589A (ja) 2012-12-20 2016-02-12 ナサニエル ジェイ． ケンプ， 異なる撮像モード間で再構成可能な光コヒーレンストモグラフィシステム
US10595820B2 (en) 2012-12-20 2020-03-24 Philips Image Guided Therapy Corporation Smooth transition catheters
EP2934323A4 (en) 2012-12-21 2016-08-17 Andrew Hancock SYSTEM AND METHOD FOR MULTI-PASS PROCESSING OF IMAGE SIGNALS
CA2896006A1 (en) 2012-12-21 2014-06-26 David Welford Systems and methods for narrowing a wavelength emission of light
US10413317B2 (en) 2012-12-21 2019-09-17 Volcano Corporation System and method for catheter steering and operation
US9612105B2 (en) 2012-12-21 2017-04-04 Volcano Corporation Polarization sensitive optical coherence tomography system
WO2014099763A1 (en) 2012-12-21 2014-06-26 Jason Spencer System and method for graphical processing of medical data
US10058284B2 (en) 2012-12-21 2018-08-28 Volcano Corporation Simultaneous imaging, monitoring, and therapy
EP2934653B1 (en) 2012-12-21 2018-09-19 Douglas Meyer Rotational ultrasound imaging catheter with extended catheter body telescope
EP2936241B1 (en) 2012-12-21 2020-10-21 Nathaniel J. Kemp Power-efficient optical buffering using a polarisation-maintaining active optical switch
JP2016501625A (ja) 2012-12-21 2016-01-21 ジェローム マイ， 可変線密度での超音波撮像
US9486143B2 (en) 2012-12-21 2016-11-08 Volcano Corporation Intravascular forward imaging device
JP6338597B2 (ja) * 2013-01-09 2018-06-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 無線周波数多重励起を用いた蛍光イメージングのための装置及び方法
US10580128B2 (en) * 2013-01-10 2020-03-03 Akoya Biosciences, Inc. Whole slide multispectral imaging systems and methods
US9968261B2 (en) 2013-01-28 2018-05-15 The General Hospital Corporation Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging
US10893806B2 (en) * 2013-01-29 2021-01-19 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
US9655521B2 (en) * 2013-01-31 2017-05-23 Physical Sciences, Inc. Combined reflectance confocal microscopy-optical coherence tomography system for imaging of biological tissue
CN105073186B (zh) 2013-01-31 2018-07-10 迪格玛医疗有限公司 用于减少受试者的器官中的神经活性的方法和系统
TW201447282A (zh) * 2013-01-31 2014-12-16 Univ California 檢查方法及檢查裝置
US11179028B2 (en) 2013-02-01 2021-11-23 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
CN103134784B (zh) * 2013-02-05 2015-04-29 华中科技大学 光纤化活体荧光激发光谱成像装置
US9770172B2 (en) 2013-03-07 2017-09-26 Volcano Corporation Multimodal segmentation in intravascular images
SG11201505637XA (en) * 2013-03-07 2015-08-28 Univ Nanyang Tech Optical imaging device and method for imaging a sample
US10226597B2 (en) 2013-03-07 2019-03-12 Volcano Corporation Guidewire with centering mechanism
US11154313B2 (en) 2013-03-12 2021-10-26 The Volcano Corporation Vibrating guidewire torquer and methods of use
EP2967391A4 (en) 2013-03-12 2016-11-02 Donna Collins SYSTEMS AND METHODS FOR DIAGNOSING CORONARY MICROVASCULAR DISEASE
US9351698B2 (en) 2013-03-12 2016-05-31 Lightlab Imaging, Inc. Vascular data processing and image registration systems, methods, and apparatuses
US11026591B2 (en) 2013-03-13 2021-06-08 Philips Image Guided Therapy Corporation Intravascular pressure sensor calibration
US10758207B2 (en) 2013-03-13 2020-09-01 Philips Image Guided Therapy Corporation Systems and methods for producing an image from a rotational intravascular ultrasound device
US9301687B2 (en) 2013-03-13 2016-04-05 Volcano Corporation System and method for OCT depth calibration
US10219887B2 (en) 2013-03-14 2019-03-05 Volcano Corporation Filters with echogenic characteristics
US20160030151A1 (en) 2013-03-14 2016-02-04 Volcano Corporation Filters with echogenic characteristics
US10292677B2 (en) 2013-03-14 2019-05-21 Volcano Corporation Endoluminal filter having enhanced echogenic properties
EP2967491B1 (en) 2013-03-15 2022-05-11 The General Hospital Corporation A transesophageal endoscopic system for determining a mixed venous oxygen saturation of a pulmonary artery
US9684076B1 (en) 2013-03-15 2017-06-20 Daniel Feldkhun Frequency multiplexed ranging
US9833221B2 (en) 2013-03-15 2017-12-05 Lightlab Imaging, Inc. Apparatus and method of image registration
JP6120624B2 (ja) * 2013-03-18 2017-04-26 オリンパス株式会社 光ファイバスキャナ、照明装置および観察装置
CN105050475B (zh) * 2013-03-29 2017-10-13 索尼公司 激光扫描观察装置和激光扫描方法
GB201307116D0 (en) * 2013-04-18 2013-05-29 Mbda Uk Ltd Imaging apparatus and method
WO2014186353A1 (en) 2013-05-13 2014-11-20 The General Hospital Corporation Detecting self-interefering fluorescence phase and amplitude
WO2014186660A1 (en) * 2013-05-17 2014-11-20 Ninepoint Medical, Inc. Determining angular orientation for imaging
US9464883B2 (en) 2013-06-23 2016-10-11 Eric Swanson Integrated optical coherence tomography systems and methods
US9683928B2 (en) 2013-06-23 2017-06-20 Eric Swanson Integrated optical system and components utilizing tunable optical sources and coherent detection and phased array for imaging, ranging, sensing, communications and other applications
JP6217185B2 (ja) * 2013-07-02 2017-10-25 株式会社ニデック 眼科撮影装置及び眼科画像処理プログラム
WO2015009932A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
EP3021735A4 (en) 2013-07-19 2017-04-19 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
US9668652B2 (en) 2013-07-26 2017-06-06 The General Hospital Corporation System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography
JP6585046B2 (ja) 2013-08-22 2019-10-02 アプトン バイオシステムズ インコーポレイテッド 電気的方法を用いた分子分析物のデジタル分析の方法
WO2015089308A1 (en) * 2013-12-11 2015-06-18 The General Hospital Corporation Apparatus and method for high-speed full field optical coherence microscopy
US9709440B2 (en) 2013-12-18 2017-07-18 Massachusetts Institute Of Technology Methods and apparatus for spectrometry using multimode interference in a tapered spiral-shaped waveguide
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
CN103776474A (zh) * 2014-01-10 2014-05-07 江苏昂德光电科技有限公司 一种3d矩阵式多通道光纤传感解调系统
EP3099215B1 (en) * 2014-01-31 2024-03-06 Canon U.S.A., Inc. Apparatus for color endoscopy
JP6725421B2 (ja) 2014-01-31 2020-07-15 ザ ジェネラル ホスピタル コーポレイション ナノインプリントリソグラフィを用いた小型内視鏡
US10736494B2 (en) 2014-01-31 2020-08-11 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
EP3099214B1 (en) 2014-01-31 2023-08-09 Canon U.S.A., Inc. Forward viewing endoscopic probe and system
US9482796B2 (en) * 2014-02-04 2016-11-01 California Institute Of Technology Controllable planar optical focusing system
EP3120130B1 (en) 2014-03-18 2023-07-26 The Regents of the University of California Parallel flow cytometer using radiofrequency mulitplexing, and method
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
EP3131490B1 (en) * 2014-04-17 2019-08-07 Digma Medical Ltd. Systems for blocking neural activity in the duodenum
KR101609365B1 (ko) * 2014-05-27 2016-04-21 주식회사 고영테크놀러지 착탈식 oct 장치
JP6512756B2 (ja) * 2014-06-06 2019-05-15 キヤノン株式会社 光源装置およびこれを用いた情報取得装置
US9636011B2 (en) 2014-07-03 2017-05-02 Carl Zeiss Meditec, Inc. Systems and methods for spectrally dispersed illumination optical coherence tomography
US9907507B2 (en) * 2014-07-11 2018-03-06 Lancaster University Business Enterprises Limited Diagnostic methods and device
PL3171765T3 (pl) 2014-07-24 2022-01-03 University Health Network Zbieranie i analiza danych do celów diagnostycznych
KR102513779B1 (ko) 2014-07-25 2023-03-24 더 제너럴 하스피탈 코포레이션 생체 내 이미징 및 진단을 위한 장치, 디바이스 및 방법
US10499813B2 (en) 2014-09-12 2019-12-10 Lightlab Imaging, Inc. Methods, systems and apparatus for temporal calibration of an intravascular imaging system
US10664705B2 (en) 2014-09-26 2020-05-26 Nec Corporation Object tracking apparatus, object tracking system, object tracking method, display control device, object detection device, and computer-readable medium
JP6378602B2 (ja) * 2014-10-03 2018-08-22 日本電信電話株式会社 光計測装置
US10184892B2 (en) * 2014-10-29 2019-01-22 Horiba Instruments Incorporated Determination of water treatment parameters based on absorbance and fluorescence
TWI553294B (zh) * 2014-11-05 2016-10-11 Univ Nat Taiwan 干涉式光學成像裝置、其應用之系統及方法
US20160143589A1 (en) * 2014-11-26 2016-05-26 Panasonic Intellectual Property Management Co., Ltd. Biological measurement device and biological measurement method
CA2970658A1 (en) 2014-12-12 2016-06-16 Lightlab Imaging, Inc. Systems and methods to detect and display endovascular features
AU2015367283B2 (en) * 2014-12-14 2021-05-20 Cylite Pty Ltd Multichannel optical receivers
US10105107B2 (en) 2015-01-08 2018-10-23 St. Jude Medical International Holding S.À R.L. Medical system having combined and synergized data output from multiple independent inputs
CN104568777A (zh) * 2015-01-12 2015-04-29 南京理工大学 基于频谱编码的共焦显微成像装置及方法
EP3268715B1 (en) 2015-03-11 2024-09-25 TissueVision, Inc. System and methods for serial staining and imaging
US10070055B2 (en) 2015-03-25 2018-09-04 Massachusetts Institute Of Technology Devices and methods for optically multiplexed imaging
FR3034858B1 (fr) * 2015-04-10 2017-05-26 Lltech Man Procede et systeme d'imagerie par microscopie interferentielle plein champ
WO2016167204A1 (ja) * 2015-04-16 2016-10-20 住友電気工業株式会社 光プローブ
JP2016202866A (ja) * 2015-04-16 2016-12-08 住友電気工業株式会社 光プローブ
EP4035586A1 (en) 2015-04-16 2022-08-03 Gentuity LLC Micro-optic probes for neurology
DE102015207328A1 (de) * 2015-04-22 2016-10-27 Siemens Aktiengesellschaft Verfahren zur Tiefenbestimmung
US20160357007A1 (en) 2015-05-05 2016-12-08 Eric Swanson Fixed distal optics endoscope employing multicore fiber
US10646198B2 (en) 2015-05-17 2020-05-12 Lightlab Imaging, Inc. Intravascular imaging and guide catheter detection methods and systems
US10109058B2 (en) 2015-05-17 2018-10-23 Lightlab Imaging, Inc. Intravascular imaging system interfaces and stent detection methods
US10222956B2 (en) 2015-05-17 2019-03-05 Lightlab Imaging, Inc. Intravascular imaging user interface systems and methods
US9996921B2 (en) 2015-05-17 2018-06-12 LIGHTLAB IMAGING, lNC. Detection of metal stent struts
EP4335373A3 (en) 2015-05-20 2024-05-29 Gravitas Medical, Inc. Methods and apparatus for guiding medical care based on sensor data from the gastrointestinal tract
WO2016191367A1 (en) * 2015-05-22 2016-12-01 Massachusetts Institute Of Technology Rapid and precise optically multiplexed imaging
IL239113A (en) * 2015-06-01 2016-12-29 Elbit Systems Land & C4I Ltd A system and method for determining audio characteristics from a body
JP6678189B2 (ja) * 2015-06-02 2020-04-08 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック 音響光学撮像方法およびシステム
DE102015108759A1 (de) * 2015-06-03 2016-12-08 Valeo Schalter Und Sensoren Gmbh Verfahren zum Klassifizieren eines länglich ausgedehnten stationären Objektes in einem seitlichen Umgebungsbereich eines Kraftfahrzeugs, Fahrerassistenzsystem sowie Kraftfahrzeug
US10542961B2 (en) 2015-06-15 2020-01-28 The Research Foundation For The State University Of New York System and method for infrasonic cardiac monitoring
DE102015111426B3 (de) 2015-07-14 2016-10-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Phasenkontrastmikroskopie sowie Phasenkontrastmikroskop
JP6867385B2 (ja) 2015-07-25 2021-04-28 ライトラボ・イメージング・インコーポレーテッド 血管内データ視覚化方法
KR101898220B1 (ko) * 2015-08-04 2018-09-12 한국과학기술원 공초점 현미경 및 이를 이용한 영상 처리 방법
WO2017024145A1 (en) 2015-08-05 2017-02-09 Canon U.S.A., Inc. Forward and angle view endoscope
US10194065B2 (en) 2015-08-05 2019-01-29 Canon U.S.A., Inc. Endoscope probes and systems, and methods for use therewith
US10631718B2 (en) 2015-08-31 2020-04-28 Gentuity, Llc Imaging system includes imaging probe and delivery devices
EP3362778B1 (en) 2015-10-13 2022-08-03 Omega Biosystems Incorporated Multi-modal fluorescence imaging flow cytometry system
WO2020206362A1 (en) * 2019-04-04 2020-10-08 Inscopix, Inc. Multi-modal microscopic imaging
US9772282B2 (en) * 2015-11-12 2017-09-26 Massachusetts Institute Of Technology System for wide field-of-view, highly oblique illumination microscopy for scatter-based discrimination of cells
CN108633312B (zh) 2015-11-18 2022-11-08 光学实验室成像公司 一种在x射线图像中的造影云检测方法
JP6898927B2 (ja) 2015-11-23 2021-07-07 ライトラボ・イメージング・インコーポレーテッド 血管内画像における影の検出および検証
US9869820B2 (en) 2015-12-09 2018-01-16 Canon U.S.A, Inc. Optical probe, light intensity detection, imaging method and system
US9869854B2 (en) 2015-12-16 2018-01-16 Canon U.S.A, Inc. Endoscopic system
ES2943382T3 (es) * 2015-12-23 2023-06-12 Siemens Healthcare Gmbh Celda de flujo para el análisis de partículas en un líquido que va a ser examinado, procedimiento y uso
JP2019502519A (ja) 2015-12-28 2019-01-31 キヤノン ユーエスエイ, インコーポレイテッドCanon U.S.A., Inc 光プローブ、光強度検出、撮像方法およびシステム
CN105534606B (zh) * 2016-02-04 2018-11-09 清华大学 用于外科手术的智能成像系统
US10551245B2 (en) 2016-02-12 2020-02-04 Canon U.S.A., Inc. Simple monolithic optical element for forward-viewing spectrally encoded endoscopy
CN105675615B (zh) * 2016-02-26 2018-04-06 苏州塞罗尔医学影像科技有限公司 一种高速大范围高分辨率成像系统
KR20180129832A (ko) 2016-03-17 2018-12-05 비디 바이오사이언시스 고효율 형광 유세포분석기를 사용하는 세포 선별
CN105699401A (zh) * 2016-03-22 2016-06-22 杭州惠威无损探伤设备有限公司 一种具有双向电路开关的x射线探伤机
WO2017165511A1 (en) 2016-03-24 2017-09-28 Canon U.S.A., Inc. Multi-channel optical fiber rotary junction
EP3222964B1 (en) * 2016-03-25 2020-01-15 Fogale Nanotech Chromatic confocal device and method for 2d/3d inspection of an object such as a wafer
JP7027331B2 (ja) 2016-04-14 2022-03-01 ライトラボ・イメージング・インコーポレーテッド 血管の分枝の識別
CN109477784B (zh) 2016-05-12 2022-04-01 Bd生物科学公司 具有增强图像分辨率的荧光成像流式细胞术
ES2854729T3 (es) 2016-05-16 2021-09-22 Lightlab Imaging Inc Método y sistema para la detección de endoprótesis autoexpansible, o stent, intravascular absorbible
US11058388B2 (en) 2016-05-20 2021-07-13 Perimeter Medical Imaging, Inc. Method and system for combining microscopic imaging with X-Ray imaging
EP3478182A4 (en) * 2016-05-25 2020-02-26 Carson, Benjamin METHOD, SYSTEM, SOFTWARE AND DEVICE FOR IMAGING AND MINIATURIZED THREE-DIMENSIONAL ANALYSIS REMOTELY OF HUMAN LESION CLINICAL APPLICATIONS AND RESEARCH THEREOF
EP3252446B1 (en) 2016-05-30 2019-07-24 Hitachi High-Tech Analytical Science Limited A detector assembly for analysis of elemental composition of a sample using optical emission spectroscopy
US10969571B2 (en) * 2016-05-30 2021-04-06 Eric Swanson Few-mode fiber endoscope
US10578422B2 (en) 2016-06-08 2020-03-03 Canon U.S.A., Inc. Devices, systems, methods and storage mediums using full range optical coherence tomography
US10321810B2 (en) 2016-06-13 2019-06-18 Canon U.S.A., Inc. Spectrally encoded endoscopic probe having a fixed fiber
EP3472591B1 (en) * 2016-06-20 2023-08-30 Plair SA Device and method for detecting and/or characterizing fluid-borne particles
US10952702B2 (en) 2016-06-21 2021-03-23 Canon U.S.A., Inc. Non-uniform rotational distortion detection catheter system
US10234694B2 (en) 2016-07-15 2019-03-19 Canon U.S.A., Inc. Spectrally encoded probes
US10401610B2 (en) * 2016-07-15 2019-09-03 Canon Usa, Inc. Spectrally encoded probe with multiple diffraction orders
WO2018031462A1 (en) 2016-08-12 2018-02-15 Canon U.S.A. Inc. Coherence range imaging using common path interference
US11109913B2 (en) 2016-08-14 2021-09-07 Digma Medical Ltd. Apparatus and method for nerve ablation in the wall of the gastointestinal tract
US10575904B1 (en) 2016-08-14 2020-03-03 Digma Medical Ltd. Apparatus and method for selective submucosal ablation
KR101903074B1 (ko) * 2016-08-24 2018-10-01 울산과학기술원 회전형 동축 광-전자기 도파관 집합체를 포함하는 광음향-초음파 내시경 시스템과 그 구현 방법
US10602989B2 (en) 2016-09-02 2020-03-31 Canon U.S.A., Inc. Capacitive sensing and encoding for imaging probes
US10006852B2 (en) 2016-09-13 2018-06-26 Becton, Dickinson And Company Flow cytometer with optical equalization
JP2019534069A (ja) 2016-09-23 2019-11-28 キヤノン ユーエスエイ, インコーポレイテッドCanon U.S.A., Inc スペクトル符号化内視鏡検査装置および方法
US10898068B2 (en) 2016-11-01 2021-01-26 Canon U.S.A., Inc. Multi-bandwidth spectrally encoded endoscope
JP2018094395A (ja) 2016-11-03 2018-06-21 キヤノン ユーエスエイ, インコーポレイテッドCanon U.S.A., Inc 診断用スペクトル符号化内視鏡検査装置およびシステム、ならびにこれらと共に使用するための方法
EP3538941A4 (en) 2016-11-10 2020-06-17 The Trustees of Columbia University in the City of New York METHODS FOR FAST IMAGING OF HIGH RESOLUTION LARGE SAMPLES
WO2018094290A1 (en) 2016-11-18 2018-05-24 Tissuevision, Inc. Automated tissue section capture, indexing and storage system and methods
CN106419853B (zh) * 2016-11-30 2018-03-30 苏州阿格斯医疗技术有限公司 闭环oct导管自动回撤方法及其装置
US10234265B2 (en) 2016-12-12 2019-03-19 Precitec Optronik Gmbh Distance measuring device and method for measuring distances
US10222607B2 (en) 2016-12-14 2019-03-05 Canon U.S.A., Inc. Three-dimensional endoscope
WO2018119077A1 (en) 2016-12-21 2018-06-28 Acucela Inc. Miniaturized mobile, low cost optical coherence tomography system for home based ophthalmic applications
WO2018132490A1 (en) 2017-01-12 2018-07-19 Canon U.S.A., Inc. Spectrally encoded forward view endoscope and spectrally encoded multi-view endoscope, probe, and imaging apparatus
US11010877B2 (en) 2017-01-27 2021-05-18 Canon U.S.A., Inc. Apparatus, system and method for dynamic in-line spectrum compensation of an image
DE102017104617A1 (de) 2017-03-06 2018-09-06 Grintech Gmbh Optische Sonde und Verfahren zum Betrieb der optischen Sonde
CN110650794B (zh) 2017-03-17 2022-04-29 雅普顿生物系统公司 测序和高分辨率成像
WO2018175094A1 (en) 2017-03-21 2018-09-27 Canon U.S.A., Inc. Methods, apparatuses and storage mediums for ablation planning and performance
WO2018204674A1 (en) 2017-05-04 2018-11-08 Massachusetts Institute Of Technology Scanning optical imaging device
US10274312B2 (en) * 2017-05-11 2019-04-30 Nanovea, Inc. 3d surface scanning white light axial chromatism device
US10895692B2 (en) 2017-06-01 2021-01-19 Canon U.S.A., Inc. Fiber optic rotary joints and methods of using and manufacturing same
US10337987B2 (en) * 2017-06-16 2019-07-02 Canon U.S.A. , Inc. Radial-line scanning spectrometer with two-dimensional sensor
US10323926B2 (en) 2017-06-21 2019-06-18 Canon U.S.A., Inc. Crosstalk elimination or mitigation in optical coherence tomography
CN110785110B (zh) * 2017-06-29 2022-07-12 索尼公司 医学成像系统、方法以及计算机程序产品
DE102017115922C5 (de) * 2017-07-14 2023-03-23 Precitec Gmbh & Co. Kg Verfahren und Vorrichtung zur Messung und Einstellung eines Abstands zwischen einem Bearbeitungskopf und einem Werkstück sowie dazugehöriges Verfahren zur Regelung
WO2019014767A1 (en) 2017-07-18 2019-01-24 Perimeter Medical Imaging, Inc. SAMPLE CONTAINER FOR STABILIZING AND ALIGNING EXCISED ORGANIC TISSUE SAMPLES FOR EX VIVO ANALYSIS
US10678044B2 (en) 2017-08-23 2020-06-09 Canon U.S.A., Inc. Beam-steering devices employing electrowetting prisms
US10825152B2 (en) 2017-09-14 2020-11-03 Canon U.S.A., Inc. Distortion measurement and correction for spectrally encoded endoscopy
JP2019054223A (ja) * 2017-09-14 2019-04-04 日本電信電話株式会社 波長掃引光源
CN107561059A (zh) * 2017-09-28 2018-01-09 中国科学院苏州生物医学工程技术研究所 多波长线扫描拉曼光谱仪
CN107462336B (zh) * 2017-09-30 2019-01-22 飞秒激光研究中心（广州）有限公司 一种飞秒激光多模态分子影像系统
US11147453B2 (en) 2017-10-03 2021-10-19 Canon U.S.A., Inc. Calibration for OCT-NIRAF multimodality probe
US10621748B2 (en) 2017-10-03 2020-04-14 Canon U.S.A., Inc. Detecting and displaying stent expansion
US11571129B2 (en) 2017-10-03 2023-02-07 Canon U.S.A., Inc. Detecting and displaying stent expansion
US10357160B2 (en) 2017-10-05 2019-07-23 Canon U.S.A., Inc. Image acquiring apparatus, systems, and methods
US11408770B2 (en) 2017-10-30 2022-08-09 University Of Maryland, College Park Brillouin imaging devices, and systems and methods employing such devices
US10502546B2 (en) 2017-11-07 2019-12-10 Santec Corporation Systems and methods for variable-range fourier domain imaging
DE102017126310A1 (de) 2017-11-09 2019-05-09 Precitec Optronik Gmbh Abstandsmessvorrichtung
US11224336B2 (en) * 2017-11-17 2022-01-18 Canon U.S.A., Inc. Rotational extender and/or repeater for rotating fiber based optical imaging systems, and methods and storage mediums for use therewith
US10809538B2 (en) 2017-11-27 2020-10-20 Canon U.S.A., Inc. Image acquisition apparatus, spectral apparatus, methods, and storage medium for use with same
US11684242B2 (en) 2017-11-28 2023-06-27 Gentuity, Llc Imaging system
US10401883B2 (en) 2018-01-11 2019-09-03 Eric Swanson Optical probe using multimode optical waveguide and proximal processing
US10606064B2 (en) 2018-01-24 2020-03-31 Canon U.S.A., Inc. Optical probes with astigmatism correction
US10816789B2 (en) 2018-01-24 2020-10-27 Canon U.S.A., Inc. Optical probes that include optical-correction components for astigmatism correction
US10806329B2 (en) 2018-01-24 2020-10-20 Canon U.S.A., Inc. Optical probes with optical-correction components
US10234676B1 (en) 2018-01-24 2019-03-19 Canon U.S.A., Inc. Optical probes with reflecting components for astigmatism correction
US10561303B2 (en) 2018-01-24 2020-02-18 Canon U.S.A., Inc. Optical probes with correction components for astigmatism correction
EP3743698A1 (en) * 2018-01-26 2020-12-02 Khoury, Jed Micro wideband spectroscopic analysis device
US11650296B2 (en) * 2018-02-16 2023-05-16 Xiaotian Steve Yao Optical sensing based on wavelength division multiplexed (WDM) light at different wavelengths in light detection and ranging LiDAR systems
JP6969459B2 (ja) * 2018-03-15 2021-11-24 オムロン株式会社 センサヘッド
EP3542710A1 (de) * 2018-03-23 2019-09-25 JenLab GmbH Multimodales bildgebungssystem und verfahren zur nicht-invasiven untersuchung eines untersuchungsobjekts
CN108519329B (zh) * 2018-03-26 2021-01-15 华中科技大学 一种多路扫描与探测的线共聚焦成像装置
US10952616B2 (en) 2018-03-30 2021-03-23 Canon U.S.A., Inc. Fluorescence imaging apparatus
US10506922B2 (en) 2018-04-06 2019-12-17 Canon U.S.A., Inc. Spectrometer for color spectrally-encoded endoscopy
CN108732133B (zh) * 2018-04-12 2020-10-16 杭州电子科技大学 一种基于光学成像技术的植物病害在体无损检测系统
US10838047B2 (en) * 2018-04-17 2020-11-17 Santec Corporation Systems and methods for LIDAR scanning of an environment over a sweep of wavelengths
US11406327B2 (en) 2018-04-17 2022-08-09 Canon U.S.A., Inc. Imaging catheter assembly
US11067671B2 (en) 2018-04-17 2021-07-20 Santec Corporation LIDAR sensing arrangements
US10314469B1 (en) 2018-05-02 2019-06-11 Canon U.S.A., Inc. Spectrally encoded probes
JP7075371B2 (ja) 2018-05-03 2022-05-25 キヤノン ユーエスエイ，インコーポレイテッド マルチプルイメージングモダリティにわたって関心領域を強調するためのデバイス、システム、および方法
CN112384748B (zh) 2018-05-15 2022-06-17 轻物质公司 光子处理系统和方法
TW202032187A (zh) 2018-06-04 2020-09-01 美商萊特美特股份有限公司 實數光子編碼
US11382516B2 (en) 2018-06-08 2022-07-12 Canon U.S.A., Inc. Apparatuses, methods, and storage mediums for lumen and artifacts detection in one or more images, such as in optical coherence tomography images
WO2019246412A1 (en) 2018-06-20 2019-12-26 Acucela Inc. Miniaturized mobile, low cost optical coherence tomography system for home based ophthalmic applications
JP7239285B2 (ja) * 2018-08-27 2023-03-14 セメス株式会社 Ｘ線検査装置
CN109171650A (zh) * 2018-08-31 2019-01-11 秦少平 一种生物组织三维成像装置
CN109061863B (zh) * 2018-09-11 2021-02-26 深圳立仪科技有限公司 一种侧向照射光谱共焦镜头
US10743749B2 (en) 2018-09-14 2020-08-18 Canon U.S.A., Inc. System and method for detecting optical probe connection
EP3853382A4 (en) 2018-09-19 2022-06-22 Apton Biosystems, Inc. DENSELY PACKED ANALYTE LAYERS AND DETECTION METHODS
US10791923B2 (en) 2018-09-24 2020-10-06 Canon U.S.A., Inc. Ball lens for optical probe and methods therefor
EP3871020A4 (en) * 2018-10-22 2022-06-29 California Institute of Technology Color and multi-spectral image sensor based on 3d engineered material
US10794732B2 (en) 2018-11-08 2020-10-06 Canon U.S.A., Inc. Apparatus, system and method for correcting nonuniform rotational distortion in an image comprising at least two stationary light transmitted fibers with predetermined position relative to an axis of rotation of at least one rotating fiber
WO2020106036A1 (en) * 2018-11-19 2020-05-28 Samsung Electronics Co., Ltd. Multimodal dust sensor
KR102135593B1 (ko) * 2018-11-29 2020-07-20 재단법인대구경북과학기술원 다중모드 현미경
DE102018130901A1 (de) 2018-12-04 2020-06-04 Precitec Optronik Gmbh Optische Messeinrichtung
CN109758114A (zh) * 2019-01-21 2019-05-17 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 用于角膜神经成像的光片显微镜
WO2020159984A1 (en) 2019-01-30 2020-08-06 Canon U.S.A., Inc. Apparatuses, systems, methods and storage mediums for performance of co-registration
WO2020163587A1 (en) * 2019-02-06 2020-08-13 The Johns Hopkins University External and internal intraoperative optical coherence tomography imaging for subretinal material delivery
TW202111467A (zh) 2019-02-25 2021-03-16 美商萊特美特股份有限公司 路徑數平衡式通用光子網路
JP7555944B2 (ja) 2019-02-26 2024-09-25 ライトマター インコーポレイテッド ハイブリッドアナログ・デジタル行列プロセッサ
US11284786B2 (en) * 2019-03-07 2022-03-29 ZSquare Ltd. Spatial encoding system decoding system imaging system and methods thereof
US11175126B2 (en) 2019-04-08 2021-11-16 Canon U.S.A., Inc. Automated polarization control
US11644424B2 (en) 2019-04-29 2023-05-09 Waverly Industries, Llc Interferometric method and apparatus for non-invasive assessment of oocyte maturity and competency
US11661845B2 (en) * 2019-05-10 2023-05-30 Baker Hughes Oilfield Operations Llc Attenuated total internal reflection optical sensor for obtaining downhole fluid properties
US11707186B2 (en) 2019-06-14 2023-07-25 Canon U.S.A., Inc. Fluorescence or auto-fluorescence trigger or triggers
EP3997439A4 (en) 2019-07-10 2023-07-19 Becton, Dickinson and Company RECONFIGURABLE INTEGRATED CIRCUITS TO ADJUST CELL SORTING CLASSIFICATION
US11950881B2 (en) 2019-07-28 2024-04-09 Holovsions LLC Smart bra for optical scanning of breast tissue to detect abnormal tissue with selectively-expandable components to reduce air gaps
US11304456B2 (en) 2019-07-28 2022-04-19 Holovisions LLC Smart bra with optical sensors to detect abnormal breast tissue
CN114514490A (zh) 2019-07-29 2022-05-17 轻物质公司 使用线性光子处理器进行模拟计算的系统和方法
EP4021274A4 (en) * 2019-08-27 2023-09-13 The General Hospital Corporation SYSTEM AND METHOD FOR HIGH-RESOLUTION RAPID CAPSULE ENDOMICROSCOPY
CN110530609A (zh) * 2019-08-28 2019-12-03 中国科学院合肥物质科学研究院 利用回音壁模式激光光源测fp透过率曲线的装置和方法
US12109056B2 (en) 2019-09-17 2024-10-08 Canon U.S.A., Inc. Constructing or reconstructing 3D structure(s)
JP7514300B2 (ja) 2019-09-20 2024-07-10 キヤノン ユーエスエイ，インコーポレイテッド 機械学習及びその結果の使用を含む人工知能コレジストレーション並びにマーカ検出
US11239276B2 (en) 2019-10-18 2022-02-01 California Institute Of Technology CMOS color image sensors with metamaterial color splitting
CN115023909A (zh) 2019-11-22 2022-09-06 光物质公司 线性光子处理器和相关方法
US12121211B2 (en) * 2019-11-22 2024-10-22 Lake Region Manufacturing, Inc. Guidewire and catheter system for in-vivo forward viewing of the vasculature
US11963740B2 (en) 2019-12-05 2024-04-23 Canon U.S.A., Inc. Lumen, stent, and/or artifact detection in one or more images, such as in optical coherence tomography images
US11730363B2 (en) 2019-12-26 2023-08-22 Acucela Inc. Optical coherence tomography patient alignment system for home based ophthalmic applications
US11513228B2 (en) 2020-03-05 2022-11-29 Santec Corporation Lidar sensing arrangements
US20210319900A1 (en) * 2020-04-14 2021-10-14 Siemens Healthcare Gmbh Cardiovascular assessment of patients suspected of having covid-19
US11681093B2 (en) 2020-05-04 2023-06-20 Eric Swanson Multicore fiber with distal motor
US11802759B2 (en) 2020-05-13 2023-10-31 Eric Swanson Integrated photonic chip with coherent receiver and variable optical delay for imaging, sensing, and ranging applications
EP4154365A4 (en) 2020-05-19 2023-11-08 Becton, Dickinson and Company METHOD FOR MODULATING AN INTENSITY PROFILE OF A LASER BEAM AND SYSTEMS THEREFOR
JP2023532895A (ja) 2020-06-26 2023-08-01 ベクトン・ディキンソン・アンド・カンパニー フローストリーム中の試料を照射するためのデュアル励起ビーム、及びそれを使用するための方法
CN116171438A (zh) 2020-06-29 2023-05-26 光物质公司 快速预测处理器
US11922633B2 (en) 2020-06-30 2024-03-05 Canon U.S.A., Inc. Real-time lumen distance calculation based on three-dimensional (3D) A-line signal data
WO2022020667A1 (en) 2020-07-24 2022-01-27 Lightmatter, Inc. Systems and methods for utilizing photonic degrees of freedom in a photonic processor
US10959613B1 (en) 2020-08-04 2021-03-30 Acucela Inc. Scan pattern and signal processing for optical coherence tomography
US11972561B2 (en) 2020-08-06 2024-04-30 Canon U.S.A., Inc. Auto-pullback triggering method for intracoronary imaging apparatuses or systems using blood clearing
US12112488B2 (en) 2020-08-06 2024-10-08 Canon U.S.A., Inc. Methods and systems for image synchronization
US11944778B2 (en) 2020-08-06 2024-04-02 Canon U.S.A., Inc. Methods and systems for automatic pullback trigger
US11920929B2 (en) 2020-08-06 2024-03-05 Canon U.S.A., Inc. Detecting and guiding optical connection(s) for one or more imaging modalities, such as in optical coherence tomography
EP4195998A4 (en) 2020-08-14 2024-08-21 Acucela Inc SYSTEM AND METHOD FOR A-SCAN DECURRENCE IN OPTICAL COHERENCE TOMOGRAPHY
KR102488298B1 (ko) * 2020-08-21 2023-01-12 동아대학교 산학협력단 파장 선택 필터
US11393094B2 (en) 2020-09-11 2022-07-19 Acucela Inc. Artificial intelligence for evaluation of optical coherence tomography images
CA3192083A1 (en) 2020-09-30 2022-04-07 Acucela Inc. Myopia prediction, diagnosis, planning, and monitoring device
WO2022079721A1 (en) * 2020-10-18 2022-04-21 Technion Research And Development Foundation Ltd. System for in vivo measurements of tympanic membrane vibration
EP4260045A1 (en) * 2020-12-14 2023-10-18 Life Technologies Corporation Systems and methods for improved imaging and fluorescence in flow cytometry and other applications
WO2022204622A1 (en) 2021-03-24 2022-09-29 Acucela Inc. Axial length measurement monitor
US12076118B2 (en) 2021-10-01 2024-09-03 Canon U.S.A., Inc. Devices, systems, and methods for detecting external elastic lamina (EEL) from intravascular OCT images
US20230213377A1 (en) * 2021-12-30 2023-07-06 Technion Research & Development Foundation Limited Homodyne time-domain acousto-optic imaging for low-gain photodetectors
US12085387B1 (en) 2023-09-23 2024-09-10 Hamamatsu Photonics K.K. Optical coherence tomography system for subsurface inspection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6396941B1 (en) * 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides

Family Cites Families (663)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US126048A (en) * 1872-04-23 Improvement in printing-telegraphs
US86347A (en) * 1869-02-02 Improvement in the manufacture of tin-lined lead pipes
US53613A (en) * 1866-04-03 Improvement in steam-engines
US53673A (en) * 1866-04-03 Improved railway-frog
US2002503A (en) * 1930-11-19 1935-05-28 John Speranza Direction signal for automobiles
US2002309A (en) * 1932-03-28 1935-05-21 Mccabe Maier Corp Refrigerating apparatus and method
US2339754A (en) 1941-03-04 1944-01-25 Westinghouse Electric & Mfg Co Supervisory apparatus
US3090753A (en) 1960-08-02 1963-05-21 Exxon Research Engineering Co Ester oil compositions containing acid anhydride
GB1257778A (zh) 1967-12-07 1971-12-22
US3601480A (en) 1968-07-10 1971-08-24 Physics Int Co Optical tunnel high-speed camera system
JPS4932484U (zh) 1972-06-19 1974-03-20
US3872407A (en) * 1972-09-01 1975-03-18 Us Navy Rapidly tunable laser
JPS584481Y2 (ja) 1973-06-23 1983-01-26 オリンパス光学工業株式会社 ナイシキヨウシヤヘンカンコウガクケイ
FR2253410A5 (zh) * 1973-12-03 1975-06-27 Inst Nat Sante Rech Med
US4077949A (en) * 1973-12-28 1978-03-07 Sloan-Kettering Institute For Cancer Research Polypeptide hormones of the thymus
US3941121A (en) 1974-12-20 1976-03-02 The University Of Cincinnati Focusing fiber-optic needle endoscope
US3983507A (en) 1975-01-06 1976-09-28 Research Corporation Tunable laser systems and method
US3973219A (en) 1975-04-24 1976-08-03 Cornell Research Foundation, Inc. Very rapidly tuned cw dye laser
DE2601226C3 (de) * 1976-01-14 1982-01-14 Zahnradfabrik Friedrichshafen Ag, 7990 Friedrichshafen Steuereinrichtung für die automotive Ansteuerung der Hydroverstellpumpe eines Hydrostaten
US4030831A (en) * 1976-03-22 1977-06-21 The United States Of America As Represented By The Secretary Of The Navy Phase detector for optical figure sensing
US4141362A (en) 1977-05-23 1979-02-27 Richard Wolf Gmbh Laser endoscope
US4224929A (en) 1977-11-08 1980-09-30 Olympus Optical Co., Ltd. Endoscope with expansible cuff member and operation section
US4339954A (en) 1978-03-09 1982-07-20 National Research Development Corporation Measurement of small movements
GB2030313A (en) 1978-06-29 1980-04-02 Wolf Gmbh Richard Endoscopes
FR2448728A1 (fr) 1979-02-07 1980-09-05 Thomson Csf Dispositif joint tournant pour liaison par conducteurs optiques et systeme comportant un tel dispositif
US4295738A (en) 1979-08-30 1981-10-20 United Technologies Corporation Fiber optic strain sensor
US4300816A (en) 1979-08-30 1981-11-17 United Technologies Corporation Wide band multicore optical fiber
US4428643A (en) 1981-04-08 1984-01-31 Xerox Corporation Optical scanning system with wavelength shift correction
US5065331A (en) 1981-05-18 1991-11-12 Vachon Reginald I Apparatus and method for determining the stress and strain in pipes, pressure vessels, structural members and other deformable bodies
GB2106736B (en) 1981-09-03 1985-06-12 Standard Telephones Cables Ltd Optical transmission system
US4479499A (en) 1982-01-29 1984-10-30 Alfano Robert R Method and apparatus for detecting the presence of caries in teeth using visible light
US5302025A (en) 1982-08-06 1994-04-12 Kleinerman Marcos Y Optical systems for sensing temperature and other physical parameters
US4601036A (en) 1982-09-30 1986-07-15 Honeywell Inc. Rapidly tunable laser
HU187188B (en) 1982-11-25 1985-11-28 Koezponti Elelmiszeripari Device for generating radiation of controllable spectral structure
US4451706A (en) * 1982-12-20 1984-05-29 Gte Automatic Electric Inc. Telephone substation transmitter muting circuit
CH663466A5 (fr) 1983-09-12 1987-12-15 Battelle Memorial Institute Procede et dispositif pour determiner la position d'un objet par rapport a une reference.
US4639999A (en) * 1984-11-02 1987-02-03 Xerox Corporation High resolution, high efficiency I.R. LED printing array fabrication method
US4763977A (en) 1985-01-09 1988-08-16 Canadian Patents And Development Limited-Societe Optical fiber coupler with tunable coupling ratio and method of making
EP0590268B1 (en) 1985-03-22 1998-07-01 Massachusetts Institute Of Technology Fiber Optic Probe System for Spectrally Diagnosing Tissue
US5318024A (en) 1985-03-22 1994-06-07 Massachusetts Institute Of Technology Laser endoscope for spectroscopic imaging
US4734578A (en) * 1985-03-27 1988-03-29 Olympus Optical Co., Ltd. Two-dimensional scanning photo-electric microscope
US4607622A (en) 1985-04-11 1986-08-26 Charles D. Fritch Fiber optic ocular endoscope
US4631498A (en) 1985-04-26 1986-12-23 Hewlett-Packard Company CW Laser wavemeter/frequency locking technique
US4650327A (en) 1985-10-28 1987-03-17 Oximetrix, Inc. Optical catheter calibrating assembly
JPS62188001U (zh) 1986-05-20 1987-11-30
US5040889A (en) 1986-05-30 1991-08-20 Pacific Scientific Company Spectrometer with combined visible and ultraviolet sample illumination
CA1290019C (en) 1986-06-20 1991-10-01 Hideo Kuwahara Dual balanced optical signal receiver
US4770492A (en) 1986-10-28 1988-09-13 Spectran Corporation Pressure or strain sensitive optical fiber
JPH0824665B2 (ja) * 1986-11-28 1996-03-13 オリンパス光学工業株式会社 内視鏡装置
US4744656A (en) 1986-12-08 1988-05-17 Spectramed, Inc. Disposable calibration boot for optical-type cardiovascular catheter
JPS63158363A (ja) 1986-12-22 1988-07-01 Daikin Mfg Co Ltd エア回転継手のシ−ル装置
US4751706A (en) 1986-12-31 1988-06-14 The United States Of America As Represented By The Secretary Of The Army Laser for providing rapid sequence of different wavelengths
US4834111A (en) 1987-01-12 1989-05-30 The Trustees Of Columbia University In The City Of New York Heterodyne interferometer
GB2209221B (en) 1987-09-01 1991-10-23 Litton Systems Inc Hydrophone demodulator circuit and method
US5202931A (en) * 1987-10-06 1993-04-13 Cell Analysis Systems, Inc. Methods and apparatus for the quantitation of nuclear protein
US4909631A (en) * 1987-12-18 1990-03-20 Tan Raul Y Method for film thickness and refractive index determination
US4890901A (en) * 1987-12-22 1990-01-02 Hughes Aircraft Company Color corrector for embedded prisms
US4892406A (en) 1988-01-11 1990-01-09 United Technologies Corporation Method of and arrangement for measuring vibrations
FR2626367B1 (fr) 1988-01-25 1990-05-11 Thomson Csf Capteur de temperature multipoints a fibre optique
FR2626383B1 (fr) 1988-01-27 1991-10-25 Commissariat Energie Atomique Procede de microscopie optique confocale a balayage et en profondeur de champ etendue et dispositifs pour la mise en oeuvre du procede
US5372138A (en) * 1988-03-21 1994-12-13 Boston Scientific Corporation Acousting imaging catheters and the like
US4925302A (en) 1988-04-13 1990-05-15 Hewlett-Packard Company Frequency locking device
US5730731A (en) 1988-04-28 1998-03-24 Thomas J. Fogarty Pressure-based irrigation accumulator
US4998972A (en) 1988-04-28 1991-03-12 Thomas J. Fogarty Real time angioscopy imaging system
US4905169A (en) * 1988-06-02 1990-02-27 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for simultaneously measuring a plurality of spectral wavelengths present in electromagnetic radiation
US5242437A (en) 1988-06-10 1993-09-07 Trimedyne Laser Systems, Inc. Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium
EP1245987B1 (en) * 1988-07-13 2008-01-23 Optiscan Pty Ltd Scanning confocal microscope
US5214538A (en) 1988-07-25 1993-05-25 Keymed (Medical And Industrial Equipment) Limited Optical apparatus
GB8817672D0 (en) 1988-07-25 1988-09-01 Sira Ltd Optical apparatus
US4868834A (en) 1988-09-14 1989-09-19 The United States Of America As Represented By The Secretary Of The Army System for rapidly tuning a low pressure pulsed laser
DE3833602A1 (de) * 1988-10-03 1990-02-15 Krupp Gmbh Spektrometer zur gleichzeitigen intensitaetsmessung in verschiedenen spektralbereichen
US4940328A (en) * 1988-11-04 1990-07-10 Georgia Tech Research Corporation Optical sensing apparatus and method
US4966589A (en) 1988-11-14 1990-10-30 Hemedix International, Inc. Intravenous catheter placement device
WO1990006718A1 (en) 1988-12-21 1990-06-28 Massachusetts Institute Of Technology A method for laser induced fluorescence of tissue
US5046501A (en) 1989-01-18 1991-09-10 Wayne State University Atherosclerotic identification
US5085496A (en) 1989-03-31 1992-02-04 Sharp Kabushiki Kaisha Optical element and optical pickup device comprising it
US5205186A (en) * 1989-05-23 1993-04-27 Eldra-Kunststofftechnik Gmbh Steering wheel
US5317389A (en) * 1989-06-12 1994-05-31 California Institute Of Technology Method and apparatus for white-light dispersed-fringe interferometric measurement of corneal topography
US4965599A (en) 1989-11-13 1990-10-23 Eastman Kodak Company Scanning apparatus for halftone image screen writing
US5133035A (en) 1989-11-14 1992-07-21 Hicks John W Multifiber endoscope with multiple scanning modes to produce an image free of fixed pattern noise
US4984888A (en) * 1989-12-13 1991-01-15 Imo Industries, Inc. Two-dimensional spectrometer
KR930003307B1 (ko) 1989-12-14 1993-04-24 주식회사 금성사 입체용 프로젝터
US5251009A (en) 1990-01-22 1993-10-05 Ciba-Geigy Corporation Interferometric measuring arrangement for refractive index measurements in capillary tubes
DD293205B5 (de) 1990-03-05 1995-06-29 Zeiss Carl Jena Gmbh Lichtleiterfuehrung fuer ein medizinisches Beobachtungsgeraet
US5039193A (en) 1990-04-03 1991-08-13 Focal Technologies Incorporated Fibre optic single mode rotary joint
US5262644A (en) 1990-06-29 1993-11-16 Southwest Research Institute Remote spectroscopy for raman and brillouin scattering
US5197470A (en) * 1990-07-16 1993-03-30 Eastman Kodak Company Near infrared diagnostic method and instrument
GB9015793D0 (en) 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5127730A (en) 1990-08-10 1992-07-07 Regents Of The University Of Minnesota Multi-color laser scanning confocal imaging system
US5845639A (en) 1990-08-10 1998-12-08 Board Of Regents Of The University Of Washington Optical imaging methods
JP2543516Y2 (ja) 1990-09-25 1997-08-06 因幡電機産業株式会社 連結具
US5305759A (en) 1990-09-26 1994-04-26 Olympus Optical Co., Ltd. Examined body interior information observing apparatus by using photo-pulses controlling gains for depths
US5241364A (en) 1990-10-19 1993-08-31 Fuji Photo Film Co., Ltd. Confocal scanning type of phase contrast microscope and scanning microscope
US5250186A (en) 1990-10-23 1993-10-05 Cetus Corporation HPLC light scattering detector for biopolymers
US5202745A (en) * 1990-11-07 1993-04-13 Hewlett-Packard Company Polarization independent optical coherence-domain reflectometry
US5275594A (en) * 1990-11-09 1994-01-04 C. R. Bard, Inc. Angioplasty system having means for identification of atherosclerotic plaque
JP3035336B2 (ja) * 1990-11-27 2000-04-24 興和株式会社 血流測定装置
US5228001A (en) 1991-01-23 1993-07-13 Syracuse University Optical random access memory
US5784162A (en) 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
US6198532B1 (en) * 1991-02-22 2001-03-06 Applied Spectral Imaging Ltd. Spectral bio-imaging of the eye
US5293872A (en) * 1991-04-03 1994-03-15 Alfano Robert R Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy
US6501551B1 (en) 1991-04-29 2002-12-31 Massachusetts Institute Of Technology Fiber optic imaging endoscope interferometer with at least one faraday rotator
US5748598A (en) * 1995-12-22 1998-05-05 Massachusetts Institute Of Technology Apparatus and methods for reading multilayer storage media using short coherence length sources
US6564087B1 (en) 1991-04-29 2003-05-13 Massachusetts Institute Of Technology Fiber optic needle probes for optical coherence tomography imaging
US5465147A (en) 1991-04-29 1995-11-07 Massachusetts Institute Of Technology Method and apparatus for acquiring images using a ccd detector array and no transverse scanner
EP0581871B2 (en) 1991-04-29 2009-08-12 Massachusetts Institute Of Technology Apparatus for optical imaging and measurement
US6485413B1 (en) * 1991-04-29 2002-11-26 The General Hospital Corporation Methods and apparatus for forward-directed optical scanning instruments
US5956355A (en) 1991-04-29 1999-09-21 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser
US6134003A (en) 1991-04-29 2000-10-17 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
US6111645A (en) 1991-04-29 2000-08-29 Massachusetts Institute Of Technology Grating based phase control optical delay line
US5441053A (en) 1991-05-03 1995-08-15 University Of Kentucky Research Foundation Apparatus and method for multiple wavelength of tissue
US5281811A (en) * 1991-06-17 1994-01-25 Litton Systems, Inc. Digital wavelength division multiplex optical transducer having an improved decoder
US5208651A (en) * 1991-07-16 1993-05-04 The Regents Of The University Of California Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes
AU2519892A (en) 1991-08-20 1993-03-16 Douglas C.B. Redd Optical histochemical analysis, in vivo detection and real-time guidance for ablation of abnormal tissues using a raman spectroscopic detection system
DE4128744C1 (zh) 1991-08-29 1993-04-22 Siemens Ag, 8000 Muenchen, De
US5177488A (en) * 1991-10-08 1993-01-05 Hughes Aircraft Company Programmable fiber optic delay line, and radar target simulation system incorporating the same
EP0550929B1 (en) 1991-12-30 1997-03-19 Koninklijke Philips Electronics N.V. Optical device and apparatus for scanning an information plane, comprising such an optical device
US5353790A (en) 1992-01-17 1994-10-11 Board Of Regents, The University Of Texas System Method and apparatus for optical measurement of bilirubin in tissue
US5212667A (en) 1992-02-03 1993-05-18 General Electric Company Light imaging in a scattering medium, using ultrasonic probing and speckle image differencing
US5217456A (en) 1992-02-24 1993-06-08 Pdt Cardiovascular, Inc. Device and method for intra-vascular optical radial imaging
US5248876A (en) 1992-04-21 1993-09-28 International Business Machines Corporation Tandem linear scanning confocal imaging system with focal volumes at different heights
US5283795A (en) * 1992-04-21 1994-02-01 Hughes Aircraft Company Diffraction grating driven linear frequency chirped laser
US5486701A (en) 1992-06-16 1996-01-23 Prometrix Corporation Method and apparatus for measuring reflectance in two wavelength bands to enable determination of thin film thickness
US5716324A (en) 1992-08-25 1998-02-10 Fuji Photo Film Co., Ltd. Endoscope with surface and deep portion imaging systems
US5348003A (en) 1992-09-03 1994-09-20 Sirraya, Inc. Method and apparatus for chemical analysis
EP0587514A1 (en) 1992-09-11 1994-03-16 Welch Allyn, Inc. Processor module for video inspection probe
US5772597A (en) 1992-09-14 1998-06-30 Sextant Medical Corporation Surgical tool end effector
US5698397A (en) 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
EP0669820B1 (en) 1992-11-18 1997-04-16 Spectrascience, Inc. Apparatus for diagnostic imaging
US5383467A (en) * 1992-11-18 1995-01-24 Spectrascience, Inc. Guidewire catheter and apparatus for diagnostic imaging
US5785663A (en) 1992-12-21 1998-07-28 Artann Corporation Method and device for mechanical imaging of prostate
JPH06209953A (ja) * 1993-01-21 1994-08-02 Olympus Optical Co Ltd 手術用顕微鏡装置
US5400771A (en) 1993-01-21 1995-03-28 Pirak; Leon Endotracheal intubation assembly and related method
JPH06222242A (ja) * 1993-01-27 1994-08-12 Shin Etsu Chem Co Ltd 光ファイバカプラおよびその製造方法
US5987346A (en) 1993-02-26 1999-11-16 Benaron; David A. Device and method for classification of tissue
US5414509A (en) 1993-03-08 1995-05-09 Associated Universities, Inc. Optical pressure/density measuring means
JP3112595B2 (ja) * 1993-03-17 2000-11-27 安藤電気株式会社 光周波数シフタを用いる光ファイバ歪位置測定装置
FI93781C (fi) 1993-03-18 1995-05-26 Wallac Oy Biospesifinen multiparametrinen määritysmenetelmä
DE4309056B4 (de) 1993-03-20 2006-05-24 Häusler, Gerd, Prof. Dr. Verfahren und Vorrichtung zur Ermittlung der Entfernung und Streuintensität von streuenden Punkten
US5485079A (en) 1993-03-29 1996-01-16 Matsushita Electric Industrial Co., Ltd. Magneto-optical element and optical magnetic field sensor
DE4310209C2 (de) * 1993-03-29 1996-05-30 Bruker Medizintech Optische stationäre Bildgebung in stark streuenden Medien
US5424827A (en) 1993-04-30 1995-06-13 Litton Systems, Inc. Optical system and method for eliminating overlap of diffraction spectra
DE4314189C1 (de) 1993-04-30 1994-11-03 Bodenseewerk Geraetetech Vorrichtung zur Untersuchung von Lichtleitfasern aus Glas mittels Heterodyn-Brillouin-Spektroskopie
SE501932C2 (sv) * 1993-04-30 1995-06-26 Ericsson Telefon Ab L M Anordning och förfarande för dispersionskompensering i ett fiberoptiskt transmissionssystem
US5454807A (en) 1993-05-14 1995-10-03 Boston Scientific Corporation Medical treatment of deeply seated tissue using optical radiation
DE69418248T2 (de) 1993-06-03 1999-10-14 Hamamatsu Photonics Kk Optisches Laser-Abtastsystem mit Axikon
JP3234353B2 (ja) 1993-06-15 2001-12-04 富士写真フイルム株式会社 断層情報読取装置
US5840031A (en) 1993-07-01 1998-11-24 Boston Scientific Corporation Catheters for imaging, sensing electrical potentials and ablating tissue
US5995645A (en) 1993-08-18 1999-11-30 Applied Spectral Imaging Ltd. Method of cancer cell detection
US5803082A (en) 1993-11-09 1998-09-08 Staplevision Inc. Omnispectramammography
US5983125A (en) 1993-12-13 1999-11-09 The Research Foundation Of City College Of New York Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy
US5450203A (en) 1993-12-22 1995-09-12 Electroglas, Inc. Method and apparatus for determining an objects position, topography and for imaging
US5411016A (en) * 1994-02-22 1995-05-02 Scimed Life Systems, Inc. Intravascular balloon catheter for use in combination with an angioscope
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
DE4411017C2 (de) 1994-03-30 1995-06-08 Alexander Dr Knuettel Optische stationäre spektroskopische Bildgebung in stark streuenden Objekten durch spezielle Lichtfokussierung und Signal-Detektion von Licht unterschiedlicher Wellenlängen
TW275570B (zh) * 1994-05-05 1996-05-11 Boehringer Mannheim Gmbh
DE69531118D1 (de) 1994-07-14 2003-07-24 Washington Res Foundation Seat Vorrichtung zum nachweis der barrett metaplasie in der speiseröhre
US5459325A (en) 1994-07-19 1995-10-17 Molecular Dynamics, Inc. High-speed fluorescence scanner
US6159445A (en) 1994-07-20 2000-12-12 Nycomed Imaging As Light imaging contrast agents
US5623940A (en) 1994-08-02 1997-04-29 S.L.T. Japan Co., Ltd. Catheter apparatus with a sensor
WO1996004839A1 (en) 1994-08-08 1996-02-22 Computed Anatomy, Incorporated Processing of keratoscopic images using local spatial phase
ES2180597T4 (es) 1994-08-18 2003-07-01 Zeiss Carl Aparato quirurgico asistido por tomografia de coherencia optica.
US5491524A (en) 1994-10-05 1996-02-13 Carl Zeiss, Inc. Optical coherence tomography corneal mapping apparatus
US5740808A (en) * 1996-10-28 1998-04-21 Ep Technologies, Inc Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions
US5817144A (en) 1994-10-25 1998-10-06 Latis, Inc. Method for contemporaneous application OF laser energy and localized pharmacologic therapy
US6033721A (en) * 1994-10-26 2000-03-07 Revise, Inc. Image-based three-axis positioner for laser direct write microchemical reaction
JPH08136345A (ja) 1994-11-10 1996-05-31 Anritsu Corp 複単色計
JPH08160129A (ja) 1994-12-05 1996-06-21 Uniden Corp 速度検出装置
US5566267A (en) 1994-12-15 1996-10-15 Ceram Optec Industries Inc. Flat surfaced optical fibers and diode laser medical delivery devices
US5600486A (en) * 1995-01-30 1997-02-04 Lockheed Missiles And Space Company, Inc. Color separation microlens
US5648848A (en) 1995-02-01 1997-07-15 Nikon Precision, Inc. Beam delivery apparatus and method for interferometry using rotatable polarization chucks
DE19506484C2 (de) * 1995-02-24 1999-09-16 Stiftung Fuer Lasertechnologie Verfahren und Vorrichtung zur selektiven nichtinvasiven Lasermyographie (LMG)
RU2100787C1 (ru) 1995-03-01 1997-12-27 Геликонов Валентин Михайлович Оптоволоконный интерферометр и оптоволоконный пьезоэлектрический преобразователь
WO1996028212A1 (en) 1995-03-09 1996-09-19 Innotech Usa, Inc. Laser surgical device and method of its use
US5868731A (en) 1996-03-04 1999-02-09 Innotech Usa, Inc. Laser surgical device and method of its use
US5526338A (en) * 1995-03-10 1996-06-11 Yeda Research & Development Co. Ltd. Method and apparatus for storage and retrieval with multilayer optical disks
US5697373A (en) 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US5735276A (en) * 1995-03-21 1998-04-07 Lemelson; Jerome Method and apparatus for scanning and evaluating matter
US5926592A (en) 1995-03-24 1999-07-20 Optiscan Pty Ltd Optical fibre confocal imager with variable near-confocal control
US5565983A (en) 1995-05-26 1996-10-15 The Perkin-Elmer Corporation Optical spectrometer for detecting spectra in separate ranges
JP2738343B2 (ja) 1995-05-29 1998-04-08 株式会社日立製作所 圧延機の形状制御方法および装置
US5745496A (en) * 1995-06-02 1998-04-28 Dsc Communications Corporation Apparatus and method of establishing a downlink communication path in a wireless telecommunications system
US5621830A (en) 1995-06-07 1997-04-15 Smith & Nephew Dyonics Inc. Rotatable fiber optic joint
US5785651A (en) 1995-06-07 1998-07-28 Keravision, Inc. Distance measuring confocal microscope
WO1997001167A1 (en) 1995-06-21 1997-01-09 Massachusetts Institute Of Technology Apparatus and method for accessing data on multilayered optical media
ATA107495A (de) 1995-06-23 1996-06-15 Fercher Adolf Friedrich Dr Kohärenz-biometrie und -tomographie mit dynamischem kohärentem fokus
US6104945A (en) 1995-08-01 2000-08-15 Medispectra, Inc. Spectral volume microprobe arrays
EP0846262A4 (en) 1995-08-24 1999-11-03 Purdue Research Foundation IMAGING SPECTROSCOPY OF TISSUE AND OTHER STRONG DISTRIBUTING MEDIA BASED ON FLUORESCENT LIFETIME
US6016197A (en) * 1995-08-25 2000-01-18 Ceramoptec Industries Inc. Compact, all-optical spectrum analyzer for chemical and biological fiber optic sensors
FR2738343B1 (fr) 1995-08-30 1997-10-24 Cohen Sabban Joseph Dispositif de microstratigraphie optique
US5638178A (en) * 1995-09-01 1997-06-10 Phase Metrics Imaging polarimeter detector for measurement of small spacings
US6615071B1 (en) 1995-09-20 2003-09-02 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US6763261B2 (en) * 1995-09-20 2004-07-13 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
AU709432B2 (en) 1995-09-20 1999-08-26 California Institute Of Technology Detecting thermal discrepancies in vessel walls
US5742419A (en) 1995-11-07 1998-04-21 The Board Of Trustees Of The Leland Stanford Junior Universtiy Miniature scanning confocal microscope
DE19542955C2 (de) 1995-11-17 1999-02-18 Schwind Gmbh & Co Kg Herbert Endoskop
US5719399A (en) * 1995-12-18 1998-02-17 The Research Foundation Of City College Of New York Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough
JP3699761B2 (ja) * 1995-12-26 2005-09-28 オリンパス株式会社 落射蛍光顕微鏡
US5748318A (en) * 1996-01-23 1998-05-05 Brown University Research Foundation Optical stress generator and detector
US5840023A (en) 1996-01-31 1998-11-24 Oraevsky; Alexander A. Optoacoustic imaging for medical diagnosis
US5642194A (en) 1996-02-05 1997-06-24 The Regents Of The University Of California White light velocity interferometer
US5862273A (en) 1996-02-23 1999-01-19 Kaiser Optical Systems, Inc. Fiber optic probe with integral optical filtering
US5843000A (en) 1996-05-07 1998-12-01 The General Hospital Corporation Optical biopsy forceps and method of diagnosing tissue
ATA84696A (de) * 1996-05-14 1998-03-15 Adolf Friedrich Dr Fercher Verfahren und anordnungen zur kontrastanhebung in der optischen kohärenztomographie
US6020963A (en) 1996-06-04 2000-02-01 Northeastern University Optical quadrature Interferometer
US5795295A (en) 1996-06-25 1998-08-18 Carl Zeiss, Inc. OCT-assisted surgical microscope with multi-coordinate manipulator
US5842995A (en) 1996-06-28 1998-12-01 Board Of Regents, The Univerisity Of Texas System Spectroscopic probe for in vivo measurement of raman signals
US6296608B1 (en) 1996-07-08 2001-10-02 Boston Scientific Corporation Diagnosing and performing interventional procedures on tissue in vivo
JP3517535B2 (ja) * 1996-07-10 2004-04-12 日本碍子株式会社 表示装置
US6245026B1 (en) 1996-07-29 2001-06-12 Farallon Medsystems, Inc. Thermography catheter
US5840075A (en) 1996-08-23 1998-11-24 Eclipse Surgical Technologies, Inc. Dual laser device for transmyocardial revascularization procedures
US6544193B2 (en) * 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
JPH1090603A (ja) * 1996-09-18 1998-04-10 Olympus Optical Co Ltd 内視鏡光学系
US5801831A (en) 1996-09-20 1998-09-01 Institute For Space And Terrestrial Science Fabry-Perot spectrometer for detecting a spatially varying spectral signature of an extended source
EP0928433A1 (fr) 1996-09-27 1999-07-14 Vincent Lauer Microscope generant une representation tridimensionnelle d'un objet
DE19640495C2 (de) 1996-10-01 1999-12-16 Leica Microsystems Vorrichtung zur konfokalen Oberflächenvermessung
US5843052A (en) 1996-10-04 1998-12-01 Benja-Athon; Anuthep Irrigation kit for application of fluids and chemicals for cleansing and sterilizing wounds
US5752518A (en) 1996-10-28 1998-05-19 Ep Technologies, Inc. Systems and methods for visualizing interior regions of the body
US5904651A (en) 1996-10-28 1999-05-18 Ep Technologies, Inc. Systems and methods for visualizing tissue during diagnostic or therapeutic procedures
US6044288A (en) * 1996-11-08 2000-03-28 Imaging Diagnostics Systems, Inc. Apparatus and method for determining the perimeter of the surface of an object being scanned
US5872879A (en) 1996-11-25 1999-02-16 Boston Scientific Corporation Rotatable connecting optical fibers
US6517532B1 (en) * 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
US6437867B2 (en) 1996-12-04 2002-08-20 The Research Foundation Of The City University Of New York Performing selected optical measurements with optical coherence domain reflectometry
US6249630B1 (en) 1996-12-13 2001-06-19 Imra America, Inc. Apparatus and method for delivery of dispersion-compensated ultrashort optical pulses with high peak power
US5871449A (en) 1996-12-27 1999-02-16 Brown; David Lloyd Device and method for locating inflamed plaque in an artery
US6272268B1 (en) 1996-12-31 2001-08-07 Corning Incorporated Optical couplers with multilayer fibers
US5991697A (en) 1996-12-31 1999-11-23 The Regents Of The University Of California Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media
US5760901A (en) 1997-01-28 1998-06-02 Zetetic Institute Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation
JP3213250B2 (ja) 1997-01-29 2001-10-02 株式会社生体光情報研究所 光計測装置
US5801826A (en) 1997-02-18 1998-09-01 Williams Family Trust B Spectrometric device and method for recognizing atomic and molecular signatures
US5836877A (en) 1997-02-24 1998-11-17 Lucid Inc System for facilitating pathological examination of a lesion in tissue
US6010449A (en) * 1997-02-28 2000-01-04 Lumend, Inc. Intravascular catheter system for treating a vascular occlusion
US5968064A (en) 1997-02-28 1999-10-19 Lumend, Inc. Catheter system for treating a vascular occlusion
US6120516A (en) 1997-02-28 2000-09-19 Lumend, Inc. Method for treating vascular occlusion
JP2001515382A (ja) 1997-03-06 2001-09-18 マサチューセッツ インスティチュート オブ テクノロジー 生体組織の光学走査用機器
WO1998040007A1 (en) 1997-03-13 1998-09-17 Biomax Technologies, Inc. Methods and apparatus for detecting the rejection of transplanted tissue
US6078047A (en) 1997-03-14 2000-06-20 Lucent Technologies Inc. Method and apparatus for terahertz tomographic imaging
US5994690A (en) 1997-03-17 1999-11-30 Kulkarni; Manish D. Image enhancement in optical coherence tomography using deconvolution
JPH10267631A (ja) 1997-03-26 1998-10-09 Kowa Co 光学測定装置
JPH10267830A (ja) 1997-03-26 1998-10-09 Kowa Co 光学測定装置
GB9707414D0 (en) 1997-04-11 1997-05-28 Imperial College Anatomical probe
ES2213899T3 (es) 1997-04-29 2004-09-01 Amersham Health As Agentes de contraste utilizados en tecnicas de formacion de imagen en base a la luz.
WO1998048846A1 (en) 1997-04-29 1998-11-05 Nycomed Imaging As Light imaging contrast agents
US6117128A (en) 1997-04-30 2000-09-12 Kenton W. Gregory Energy delivery catheter and method for the use thereof
US5887009A (en) 1997-05-22 1999-03-23 Optical Biopsy Technologies, Inc. Confocal optical scanning system employing a fiber laser
US6002480A (en) 1997-06-02 1999-12-14 Izatt; Joseph A. Depth-resolved spectroscopic optical coherence tomography
WO1998055830A1 (en) 1997-06-02 1998-12-10 Izatt Joseph A Doppler flow imaging using optical coherence tomography
US6208415B1 (en) 1997-06-12 2001-03-27 The Regents Of The University Of California Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography
EP0989822A4 (en) 1997-06-23 2004-07-28 Focus Surgery Inc ACOUSTIC HEMOSTASIS METHODS AND DEVICES
US5920390A (en) 1997-06-26 1999-07-06 University Of North Carolina Fiberoptic interferometer and associated method for analyzing tissue
US6048349A (en) 1997-07-09 2000-04-11 Intraluminal Therapeutics, Inc. Systems and methods for guiding a medical instrument through a body
US6058352A (en) 1997-07-25 2000-05-02 Physical Optics Corporation Accurate tissue injury assessment using hybrid neural network analysis
US5921926A (en) 1997-07-28 1999-07-13 University Of Central Florida Three dimensional optical imaging colposcopy
US6014214A (en) 1997-08-21 2000-01-11 Li; Ming-Chiang High speed inspection of a sample using coherence processing of scattered superbroad radiation
US5892583A (en) 1997-08-21 1999-04-06 Li; Ming-Chiang High speed inspection of a sample using superbroad radiation coherent interferometer
US6069698A (en) 1997-08-28 2000-05-30 Olympus Optical Co., Ltd. Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US5920373A (en) 1997-09-24 1999-07-06 Heidelberg Engineering Optische Messysteme Gmbh Method and apparatus for determining optical characteristics of a cornea
US5951482A (en) 1997-10-03 1999-09-14 Intraluminal Therapeutics, Inc. Assemblies and methods for advancing a guide wire through body tissue
US6193676B1 (en) * 1997-10-03 2001-02-27 Intraluminal Therapeutics, Inc. Guide wire assembly
US6091984A (en) 1997-10-10 2000-07-18 Massachusetts Institute Of Technology Measuring tissue morphology
JPH11119106A (ja) 1997-10-16 1999-04-30 Olympus Optical Co Ltd レーザ走査型顕微鏡
US5955737A (en) 1997-10-27 1999-09-21 Systems & Processes Engineering Corporation Chemometric analysis for extraction of individual fluorescence spectrum and lifetimes from a target mixture
US6052186A (en) * 1997-11-05 2000-04-18 Excel Precision, Inc. Dual laser system for extended heterodyne interferometry
US6134010A (en) 1997-11-07 2000-10-17 Lucid, Inc. Imaging system using polarization effects to enhance image quality
US6037579A (en) * 1997-11-13 2000-03-14 Biophotonics Information Laboratories, Ltd. Optical interferometer employing multiple detectors to detect spatially distorted wavefront in imaging of scattering media
US6107048A (en) 1997-11-20 2000-08-22 Medical College Of Georgia Research Institute, Inc. Method of detecting and grading dysplasia in epithelial tissue
EP1103041B1 (en) * 1998-01-28 2016-03-23 Immersion Medical, Inc. Interface device and method for interfacing instruments to medical procedure simulation system
US6165170A (en) 1998-01-29 2000-12-26 International Business Machines Corporation Laser dermablator and dermablation
US6134033A (en) 1998-02-26 2000-10-17 Tyco Submarine Systems Ltd. Method and apparatus for improving spectral efficiency in wavelength division multiplexed transmission systems
US6831781B2 (en) 1998-02-26 2004-12-14 The General Hospital Corporation Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy
EP1057063A4 (en) * 1998-02-26 2004-10-06 Gen Hospital Corp CONFOCAL MICROSCOPY WITH MULTISPECTRAL CODING
US6048742A (en) * 1998-02-26 2000-04-11 The United States Of America As Represented By The Secretary Of The Air Force Process for measuring the thickness and composition of thin semiconductor films deposited on semiconductor wafers
RU2148378C1 (ru) 1998-03-06 2000-05-10 Геликонов Валентин Михайлович Устройство для оптической когерентной томографии, оптоволоконное сканирующее устройство и способ диагностики биоткани in vivo
US6174291B1 (en) * 1998-03-09 2001-01-16 Spectrascience, Inc. Optical biopsy system and methods for tissue diagnosis
US6066102A (en) 1998-03-09 2000-05-23 Spectrascience, Inc. Optical biopsy forceps system and method of diagnosing tissue
US6201608B1 (en) * 1998-03-13 2001-03-13 Optical Biopsy Technologies, Inc. Method and apparatus for measuring optical reflectivity and imaging through a scattering medium
US6151522A (en) 1998-03-16 2000-11-21 The Research Foundation Of Cuny Method and system for examining biological materials using low power CW excitation raman spectroscopy
US6384915B1 (en) 1998-03-30 2002-05-07 The Regents Of The University Of California Catheter guided by optical coherence domain reflectometry
US6175669B1 (en) * 1998-03-30 2001-01-16 The Regents Of The Universtiy Of California Optical coherence domain reflectometry guidewire
DE19814057B4 (de) * 1998-03-30 2009-01-02 Carl Zeiss Meditec Ag Anordnung zur optischen Kohärenztomographie und Kohärenztopographie
US5975699A (en) 1998-04-29 1999-11-02 Carl Zeiss, Inc. Method and apparatus for simultaneously measuring the length and refractive error of an eye
AU3781799A (en) 1998-05-01 1999-11-23 Board Of Regents, The University Of Texas System Method and apparatus for subsurface imaging
US6996549B2 (en) * 1998-05-01 2006-02-07 Health Discovery Corporation Computer-aided image analysis
JPH11326826A (ja) 1998-05-13 1999-11-26 Sony Corp 照明方法及び照明装置
US6053613A (en) 1998-05-15 2000-04-25 Carl Zeiss, Inc. Optical coherence tomography with new interferometer
FR2778838A1 (fr) 1998-05-19 1999-11-26 Koninkl Philips Electronics Nv Procede de detection de variations d'elasticite et appareil echographique pour mettre en oeuvre ce procede
US5995223A (en) 1998-06-01 1999-11-30 Power; Joan Fleurette Apparatus for rapid phase imaging interferometry and method therefor
JPH11352409A (ja) 1998-06-05 1999-12-24 Olympus Optical Co Ltd 蛍光検出装置
US6549801B1 (en) 1998-06-11 2003-04-15 The Regents Of The University Of California Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity
CA2337113C (en) 1998-07-15 2009-06-23 Corazon Technologies, Inc. Methods and devices for reducing the mineral content of vascular calcified lesions
US6166373A (en) 1998-07-21 2000-12-26 The Institute For Technology Development Focal plane scanner with reciprocating spatial window
JP2000046729A (ja) 1998-07-31 2000-02-18 Takahisa Mitsui 波長分散を用いた高速光断層像計測装置および計測方法
US8024027B2 (en) 1998-09-03 2011-09-20 Hyperspectral Imaging, Inc. Infrared endoscopic balloon probes
US6741884B1 (en) 1998-09-03 2004-05-25 Hypermed, Inc. Infrared endoscopic balloon probes
JP4474050B2 (ja) 1998-09-11 2010-06-02 スペクトルックス・インコーポレイテッド マルチモード光学組織診断システム
JP4163301B2 (ja) * 1998-09-21 2008-10-08 オリンパス株式会社 走査型サイトメータ
AU6417599A (en) 1998-10-08 2000-04-26 University Of Kentucky Research Foundation, The Methods and apparatus for (in vivo) identification and characterization of vulnerable atherosclerotic plaques
JP2000121961A (ja) 1998-10-13 2000-04-28 Olympus Optical Co Ltd 共焦点光走査プローブシステム
US6274871B1 (en) 1998-10-22 2001-08-14 Vysis, Inc. Method and system for performing infrared study on a biological sample
US6324419B1 (en) 1998-10-27 2001-11-27 Nejat Guzelsu Apparatus and method for non-invasive measurement of stretch
JP2000126116A (ja) 1998-10-28 2000-05-09 Olympus Optical Co Ltd 光診断システム
US6524249B2 (en) 1998-11-11 2003-02-25 Spentech, Inc. Doppler ultrasound method and apparatus for monitoring blood flow and detecting emboli
AU1524700A (en) * 1998-11-13 2000-06-05 Research And Development Institute, Inc. Programmable frequency reference for laser frequency stabilization, and arbitrary optical clock generator, using persistent spectral hole burning
EP1002497B1 (en) * 1998-11-20 2006-07-26 Fuji Photo Film Co., Ltd. Blood vessel imaging system
US5975697A (en) 1998-11-25 1999-11-02 Oti Ophthalmic Technologies, Inc. Optical mapping apparatus with adjustable depth resolution
US6352502B1 (en) 1998-12-03 2002-03-05 Lightouch Medical, Inc. Methods for obtaining enhanced spectroscopic information from living tissue, noninvasive assessment of skin condition and detection of skin abnormalities
RU2149464C1 (ru) 1999-01-19 2000-05-20 Таганрогский государственный радиотехнический университет Динамическое запоминающее устройство радиосигналов
US6191862B1 (en) 1999-01-20 2001-02-20 Lightlab Imaging, Llc Methods and apparatus for high speed longitudinal scanning in imaging systems
US6272376B1 (en) 1999-01-22 2001-08-07 Cedars-Sinai Medical Center Time-resolved, laser-induced fluorescence for the characterization of organic material
US6445944B1 (en) 1999-02-01 2002-09-03 Scimed Life Systems Medical scanning system and related method of scanning
US6615072B1 (en) 1999-02-04 2003-09-02 Olympus Optical Co., Ltd. Optical imaging device
US6185271B1 (en) * 1999-02-16 2001-02-06 Richard Estyn Kinsinger Helical computed tomography with feedback scan control
DE19908883A1 (de) 1999-03-02 2000-09-07 Rainer Heintzmann Verfahren zur Erhöhung der Auflösung optischer Abbildung
US20070048818A1 (en) * 1999-03-12 2007-03-01 Human Genome Sciences, Inc. Human secreted proteins
US6263133B1 (en) 1999-03-29 2001-07-17 Scimed Life Systems, Inc. Optical focusing, collimating and coupling systems for use with single mode optical fiber
US6859275B2 (en) 1999-04-09 2005-02-22 Plain Sight Systems, Inc. System and method for encoded spatio-spectral information processing
US6264610B1 (en) 1999-05-05 2001-07-24 The University Of Connecticut Combined ultrasound and near infrared diffused light imaging system
US6353693B1 (en) * 1999-05-31 2002-03-05 Sanyo Electric Co., Ltd. Optical communication device and slip ring unit for an electronic component-mounting apparatus
JP3973904B2 (ja) * 1999-06-01 2007-09-12 花王株式会社 多糖誘導体
US6611833B1 (en) 1999-06-23 2003-08-26 Tissueinformatics, Inc. Methods for profiling and classifying tissue using a database that includes indices representative of a tissue population
JP2001004447A (ja) 1999-06-23 2001-01-12 Yokogawa Electric Corp 分光器
US6993170B2 (en) 1999-06-23 2006-01-31 Icoria, Inc. Method for quantitative analysis of blood vessel structure
US6208887B1 (en) 1999-06-24 2001-03-27 Richard H. Clarke Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions
US7426409B2 (en) 1999-06-25 2008-09-16 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
GB9915082D0 (en) 1999-06-28 1999-08-25 Univ London Optical fibre probe
US6359692B1 (en) 1999-07-09 2002-03-19 Zygo Corporation Method and system for profiling objects having multiple reflective surfaces using wavelength-tuning phase-shifting interferometry
WO2001004828A1 (en) 1999-07-13 2001-01-18 Chromavision Medical Systems, Inc. Automated detection of objects in a biological sample
ATE296578T1 (de) 1999-07-30 2005-06-15 Boston Scient Ltd Katheter mit antrieb und kupplung zur dreh- und längsverschiebung
EP1284672B1 (en) 1999-07-30 2006-12-27 CeramOptec GmbH Dual wavelength medical diode laser system
US6445939B1 (en) 1999-08-09 2002-09-03 Lightlab Imaging, Llc Ultra-small optical probes, imaging optics, and methods for using same
JP2001046321A (ja) 1999-08-09 2001-02-20 Asahi Optical Co Ltd 内視鏡装置
US6725073B1 (en) * 1999-08-17 2004-04-20 Board Of Regents, The University Of Texas System Methods for noninvasive analyte sensing
JP3869589B2 (ja) 1999-09-02 2007-01-17 ペンタックス株式会社 ファイババンドル及び内視鏡装置
US6687010B1 (en) 1999-09-09 2004-02-03 Olympus Corporation Rapid depth scanning optical imaging device
JP4464519B2 (ja) * 2000-03-21 2010-05-19 オリンパス株式会社 光イメージング装置
US6198956B1 (en) * 1999-09-30 2001-03-06 Oti Ophthalmic Technologies Inc. High speed sector scanning apparatus having digital electronic control
JP2001174744A (ja) 1999-10-06 2001-06-29 Olympus Optical Co Ltd 光走査プローブ装置
US6308092B1 (en) 1999-10-13 2001-10-23 C. R. Bard Inc. Optical fiber tissue localization device
US6393312B1 (en) 1999-10-13 2002-05-21 C. R. Bard, Inc. Connector for coupling an optical fiber tissue localization device to a light source
AU1182401A (en) * 1999-10-15 2001-04-23 Cellavision Ab Microscope and method for manufacturing a composite image with a high resolution
US6538817B1 (en) 1999-10-25 2003-03-25 Aculight Corporation Method and apparatus for optical coherence tomography with a multispectral laser source
JP2001125009A (ja) 1999-10-28 2001-05-11 Asahi Optical Co Ltd 内視鏡装置
IL132687A0 (en) 1999-11-01 2001-03-19 Keren Mechkarim Ichilov Pnimit System and method for evaluating body fluid samples
EP1232387A4 (en) 1999-11-19 2008-10-22 Jobin Yvon Inc COMPACT SPECTROFLUOROMETER
ATE263356T1 (de) 1999-11-24 2004-04-15 Haag Ag Streit Verfahren und vorrichtung zur messung optischer eigenschaften wenigstens zweier voneinander distanzierter bereiche in einem transparenten und/oder diffusiven gegenstand
US7236637B2 (en) 1999-11-24 2007-06-26 Ge Medical Systems Information Technologies, Inc. Method and apparatus for transmission and display of a compressed digitized image
EP1240476A1 (en) * 1999-12-09 2002-09-18 Oti Ophthalmic Technologies Inc. Optical mapping apparatus with adjustable depth resolution
JP2001174404A (ja) 1999-12-15 2001-06-29 Takahisa Mitsui 光断層像計測装置および計測方法
US6738144B1 (en) 1999-12-17 2004-05-18 University Of Central Florida Non-invasive method and low-coherence apparatus system analysis and process control
US6680780B1 (en) * 1999-12-23 2004-01-20 Agere Systems, Inc. Interferometric probe stabilization relative to subject movement
US6445485B1 (en) 2000-01-21 2002-09-03 At&T Corp. Micro-machine polarization-state controller
CA2398278C (en) 2000-01-27 2012-05-15 National Research Council Of Canada Visible-near infrared spectroscopy in burn injury assessment
JP3660185B2 (ja) * 2000-02-07 2005-06-15 独立行政法人科学技術振興機構 断層像形成方法及びそのための装置
US6475210B1 (en) 2000-02-11 2002-11-05 Medventure Technology Corp Light treatment of vulnerable atherosclerosis plaque
US6556305B1 (en) 2000-02-17 2003-04-29 Veeco Instruments, Inc. Pulsed source scanning interferometer
US6618143B2 (en) 2000-02-18 2003-09-09 Idexx Laboratories, Inc. High numerical aperture flow cytometer and method of using same
US6751490B2 (en) 2000-03-01 2004-06-15 The Board Of Regents Of The University Of Texas System Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit
US6687013B2 (en) * 2000-03-28 2004-02-03 Hitachi, Ltd. Laser interferometer displacement measuring system, exposure apparatus, and electron beam lithography apparatus
US6593101B2 (en) 2000-03-28 2003-07-15 Board Of Regents, The University Of Texas System Enhancing contrast in biological imaging
US6567585B2 (en) 2000-04-04 2003-05-20 Optiscan Pty Ltd Z sharpening for fibre confocal microscopes
US6692430B2 (en) 2000-04-10 2004-02-17 C2Cure Inc. Intra vascular imaging apparatus
AU2001259188A1 (en) 2000-04-27 2001-11-07 Iridex Corporation Method and apparatus for real-time detection, control and recording of sub-clinical therapeutic laser lesions during ocular laser photocoagulation
WO2001082786A2 (en) 2000-05-03 2001-11-08 Flock Stephen T Optical imaging of subsurface anatomical structures and biomolecules
US6711283B1 (en) * 2000-05-03 2004-03-23 Aperio Technologies, Inc. Fully automatic rapid microscope slide scanner
US6441959B1 (en) 2000-05-19 2002-08-27 Avanex Corporation Method and system for testing a tunable chromatic dispersion, dispersion slope, and polarization mode dispersion compensator utilizing a virtually imaged phased array
US6301048B1 (en) 2000-05-19 2001-10-09 Avanex Corporation Tunable chromatic dispersion and dispersion slope compensator utilizing a virtually imaged phased array
JP4172898B2 (ja) 2000-05-31 2008-10-29 Ｈｏｙａ株式会社 電子内視鏡装置
US6560259B1 (en) 2000-05-31 2003-05-06 Applied Optoelectronics, Inc. Spatially coherent surface-emitting, grating coupled quantum cascade laser with unstable resonance cavity
US6720094B2 (en) * 2000-06-13 2004-04-13 Toda Kogyo Corporation Secondary agglomerates of magnetic metal particles for magnetic recording and process for producing the same
US6975898B2 (en) 2000-06-19 2005-12-13 University Of Washington Medical imaging, diagnosis, and therapy using a scanning single optical fiber system
JP4460117B2 (ja) 2000-06-29 2010-05-12 独立行政法人理化学研究所 グリズム
US6450949B1 (en) 2000-06-30 2002-09-17 Inner Vision Imaging, Inc. Endoscope
AU2001272261A1 (en) * 2000-07-10 2002-01-21 University Health Network Method and apparatus for high resolution coherent optical imaging
JP2002035005A (ja) 2000-07-21 2002-02-05 Olympus Optical Co Ltd 治療装置
US6757467B1 (en) 2000-07-25 2004-06-29 Optical Air Data Systems, Lp Optical fiber system
US6441356B1 (en) * 2000-07-28 2002-08-27 Optical Biopsy Technologies Fiber-coupled, high-speed, angled-dual-axis optical coherence scanning microscopes
US6882432B2 (en) * 2000-08-08 2005-04-19 Zygo Corporation Frequency transform phase shifting interferometry
WO2002014944A1 (en) 2000-08-11 2002-02-21 Crystal Fibre A/S Optical wavelength converter
US7625335B2 (en) 2000-08-25 2009-12-01 3Shape Aps Method and apparatus for three-dimensional optical scanning of interior surfaces
DE10042840A1 (de) * 2000-08-30 2002-03-14 Leica Microsystems Vorrichtung und Verfahren zur Anregung von Fluoreszenzmikroskopmarkern bei der Mehrphotonen-Rastermikroskopie
AU2001288320A1 (en) 2000-09-05 2002-03-22 Arroyo Optics, Inc. System and method for fabricating components of precise optical path length
JP2002095663A (ja) 2000-09-26 2002-04-02 Fuji Photo Film Co Ltd センチネルリンパ節光断層画像取得方法および装置
JP2002113017A (ja) 2000-10-05 2002-04-16 Fuji Photo Film Co Ltd レーザ治療装置
EP1434522B1 (en) 2000-10-30 2010-01-13 The General Hospital Corporation Optical systems for tissue analysis
JP3842101B2 (ja) 2000-10-31 2006-11-08 富士写真フイルム株式会社 内視鏡装置
US6900943B2 (en) 2000-10-31 2005-05-31 Forskningscenter Riso Optical amplification in coherent optical frequency modulated continuous wave reflectometry
US6687036B2 (en) 2000-11-03 2004-02-03 Nuonics, Inc. Multiplexed optical scanner technology
JP2002148185A (ja) 2000-11-08 2002-05-22 Fuji Photo Film Co Ltd Ｏｃｔ装置
US9295391B1 (en) * 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
EP1409721A2 (de) * 2000-11-13 2004-04-21 Gnothis Holding SA Nachweis von nukleinsäure-polymorphismen
US6665075B2 (en) 2000-11-14 2003-12-16 Wm. Marshurice University Interferometric imaging system and method
DE10057539B4 (de) 2000-11-20 2008-06-12 Robert Bosch Gmbh Interferometrische Messvorrichtung
US6558324B1 (en) 2000-11-22 2003-05-06 Siemens Medical Solutions, Inc., Usa System and method for strain image display
US6856712B2 (en) 2000-11-27 2005-02-15 University Of Washington Micro-fabricated optical waveguide for use in scanning fiber displays and scanned fiber image acquisition
US7027633B2 (en) * 2000-11-30 2006-04-11 Foran David J Collaborative diagnostic systems
JP4786027B2 (ja) * 2000-12-08 2011-10-05 オリンパス株式会社 光学系及び光学装置
US6687007B1 (en) * 2000-12-14 2004-02-03 Kestrel Corporation Common path interferometer for spectral image generation
US6501878B2 (en) 2000-12-14 2002-12-31 Nortel Networks Limited Optical fiber termination
DE60124585T2 (de) 2000-12-28 2007-10-04 Palomar Medical Technologies, Inc., Burlington Apparat zur therapeutischen elektromagnetischen Strahlentherapie von der Haut
WO2002054046A1 (fr) 2000-12-28 2002-07-11 Dmitri Olegovich Lapotko Procede et dispositif d'examen phototermique d'irregularites microscopique
US6515752B2 (en) 2000-12-28 2003-02-04 Coretek, Inc. Wavelength monitoring system
EP1221581A1 (en) 2001-01-04 2002-07-10 Universität Stuttgart Interferometer
JP2002205434A (ja) 2001-01-10 2002-07-23 Seiko Epson Corp 画像出力装置及びプリンティングシステム
WO2002054948A1 (en) 2001-01-11 2002-07-18 The Johns Hopkins University Assessment of tooth structure using laser based ultrasonics
US7177491B2 (en) 2001-01-12 2007-02-13 Board Of Regents The University Of Texas System Fiber-based optical low coherence tomography
JP3628615B2 (ja) 2001-01-16 2005-03-16 独立行政法人科学技術振興機構 ヘテロダインビート画像同期測定装置
US6697652B2 (en) * 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
EP1358443A2 (en) 2001-01-22 2003-11-05 Jonathan E. Roth Method and apparatus for polarization-sensitive optical coherence tomography
US7973936B2 (en) 2001-01-30 2011-07-05 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
US6989441B2 (en) 2001-02-15 2006-01-24 Millennium Pharmaceuticals, Inc. 25466, a human transporter family member and uses therefor
US20020140942A1 (en) 2001-02-17 2002-10-03 Fee Michale Sean Acousto-optic monitoring and imaging in a depth sensitive manner
GB0104378D0 (en) 2001-02-22 2001-04-11 Expro North Sea Ltd Improved tubing coupling
US6654127B2 (en) 2001-03-01 2003-11-25 Carl Zeiss Ophthalmic Systems, Inc. Optical delay line
US6721094B1 (en) 2001-03-05 2004-04-13 Sandia Corporation Long working distance interference microscope
US7244232B2 (en) 2001-03-07 2007-07-17 Biomed Solutions, Llc Process for identifying cancerous and/or metastatic cells of a living organism
IL142773A (en) 2001-03-08 2007-10-31 Xtellus Inc Fiber optic damper
JP2002263055A (ja) 2001-03-12 2002-09-17 Olympus Optical Co Ltd 内視鏡先端フード
US6563995B2 (en) 2001-04-02 2003-05-13 Lightwave Electronics Optical wavelength filtering apparatus with depressed-index claddings
US6552796B2 (en) * 2001-04-06 2003-04-22 Lightlab Imaging, Llc Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography
US7139598B2 (en) 2002-04-04 2006-11-21 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence
WO2002083003A1 (en) 2001-04-11 2002-10-24 Clarke Dana S Tissue structure identification in advance of instrument
US20020158211A1 (en) 2001-04-16 2002-10-31 Dakota Technologies, Inc. Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures
DE10118760A1 (de) 2001-04-17 2002-10-31 Med Laserzentrum Luebeck Gmbh Verfahren zur Ermittlung der Laufzeitverteilung und Anordnung
EP1402244B1 (en) 2001-04-30 2020-03-11 The General Hospital Corporation Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating
US7616986B2 (en) 2001-05-07 2009-11-10 University Of Washington Optical fiber scanner for performing multimodal optical imaging
US6615062B2 (en) * 2001-05-31 2003-09-02 Infraredx, Inc. Referencing optical catheters
US6701181B2 (en) * 2001-05-31 2004-03-02 Infraredx, Inc. Multi-path optical catheter
AU2002327180A1 (en) 2001-06-04 2003-01-21 The General Hospital Corporation Detection and therapy of vulnerable plaque with photodynamic compounds
EP1191321B1 (en) 2001-06-07 2002-12-11 Agilent Technologies, Inc. (a Delaware corporation) Determination of properties of an optical device
US6879851B2 (en) 2001-06-07 2005-04-12 Lightlab Imaging, Llc Fiber optic endoscopic gastrointestinal probe
DE10129651B4 (de) 2001-06-15 2010-07-08 Carl Zeiss Jena Gmbh Verfahren zur Kompensation der Dispersion in Signalen von Kurzkohärenz- und/oder OCT-Interferometern
US6702744B2 (en) * 2001-06-20 2004-03-09 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
US20040166593A1 (en) 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US6685885B2 (en) * 2001-06-22 2004-02-03 Purdue Research Foundation Bio-optical compact dist system
WO2003003903A2 (en) 2001-07-02 2003-01-16 Palomar Medical Technologies, Inc. Laser device for medical/cosmetic procedures
US6847454B2 (en) * 2001-07-16 2005-01-25 Scimed Life Systems, Inc. Systems and methods for processing signals from an interferometer by an ultrasound console
US6795199B2 (en) * 2001-07-18 2004-09-21 Avraham Suhami Method and apparatus for dispersion compensated reflected time-of-flight tomography
DE10137530A1 (de) 2001-08-01 2003-02-13 Presens Prec Sensing Gmbh Anordnung und Verfahren zur Mehrfach-Fluoreszenzmessung
JP2003344268A (ja) * 2002-05-29 2003-12-03 Olympus Optical Co Ltd 光イメージング装置
AU2002337666A1 (en) 2001-08-03 2003-02-17 Joseph A. Izatt Aspects of basic oct engine technologies for high speed optical coherence tomography and light source and other improvements in oct
US20030030816A1 (en) * 2001-08-11 2003-02-13 Eom Tae Bong Nonlinearity error correcting method and phase angle measuring method for displacement measurement in two-freqency laser interferometer and displacement measurement system using the same
US6900899B2 (en) * 2001-08-20 2005-05-31 Agilent Technologies, Inc. Interferometers with coated polarizing beam splitters that are rotated to optimize extinction ratios
US20030045798A1 (en) 2001-09-04 2003-03-06 Richard Hular Multisensor probe for tissue identification
EP1293925A1 (en) 2001-09-18 2003-03-19 Agfa-Gevaert Radiographic scoring method
US6961123B1 (en) 2001-09-28 2005-11-01 The Texas A&M University System Method and apparatus for obtaining information from polarization-sensitive optical coherence tomography
JP2003102672A (ja) 2001-10-01 2003-04-08 Japan Science & Technology Corp 病変等の対象部位を自動的に検知かつ治療または採取する方法およびその装置
DE10150934A1 (de) 2001-10-09 2003-04-10 Zeiss Carl Jena Gmbh Verfahren und Anordnung zur tiefenaufgelösten Erfassung von Proben
US7822470B2 (en) 2001-10-11 2010-10-26 Osypka Medical Gmbh Method for determining the left-ventricular ejection time TLVE of a heart of a subject
US6980299B1 (en) 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
US6658278B2 (en) 2001-10-17 2003-12-02 Terumo Cardiovascular Systems Corporation Steerable infrared imaging catheter having steering fins
US7006231B2 (en) * 2001-10-18 2006-02-28 Scimed Life Systems, Inc. Diffraction grating based interferometric systems and methods
US6749344B2 (en) 2001-10-24 2004-06-15 Scimed Life Systems, Inc. Connection apparatus for optical coherence tomography catheters
US6661513B1 (en) 2001-11-21 2003-12-09 Roygbiv, Llc Refractive-diffractive spectrometer
US7588535B2 (en) 2001-12-11 2009-09-15 C2Cure Inc. Apparatus, method and system for intravascular photographic imaging
US20030216719A1 (en) 2001-12-12 2003-11-20 Len Debenedictis Method and apparatus for treating skin using patterns of optical energy
US6856384B1 (en) * 2001-12-13 2005-02-15 Nanometrics Incorporated Optical metrology system with combined interferometer and ellipsometer
AU2002250917A1 (en) 2001-12-14 2003-06-30 Agilent Technologies, Inc. Retro-reflecting device in particular for tunable lasers
US7365858B2 (en) * 2001-12-18 2008-04-29 Massachusetts Institute Of Technology Systems and methods for phase measurements
US7736301B1 (en) 2001-12-18 2010-06-15 Advanced Cardiovascular Systems, Inc. Rotatable ferrules and interfaces for use with an optical guidewire
US6975891B2 (en) 2001-12-21 2005-12-13 Nir Diagnostics Inc. Raman spectroscopic system with integrating cavity
US6947787B2 (en) 2001-12-21 2005-09-20 Advanced Cardiovascular Systems, Inc. System and methods for imaging within a body lumen
JP3943927B2 (ja) * 2001-12-25 2007-07-11 オリンパス株式会社 光走査型観測装置
EP1324051A1 (en) 2001-12-26 2003-07-02 Kevin R. Forrester Motion measuring device
US20080154090A1 (en) 2005-01-04 2008-06-26 Dune Medical Devices Ltd. Endoscopic System for In-Vivo Procedures
DE60336534D1 (de) * 2002-01-11 2011-05-12 Gen Hospital Corp Vorrichtung zur OCT Bildaufnahme mit axialem Linienfokus für verbesserte Auflösung und Tiefenschärfe
US7072045B2 (en) 2002-01-16 2006-07-04 The Regents Of The University Of California High resolution optical coherence tomography with an improved depth range using an axicon lens
US7355716B2 (en) * 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
EP1470410B1 (en) 2002-01-24 2012-01-11 The General Hospital Corporation Apparatus and method for rangings and noise reduction of low coherence interferometry (lci) and optical coherence tomography (oct) signals by parallel detection of spectral bands
WO2003069272A1 (fr) 2002-02-14 2003-08-21 Imalux Corporation Procede d'examen d'objet et interferometre optique permettant la mise en oeuvre dudit procede
US20030165263A1 (en) 2002-02-19 2003-09-04 Hamer Michael J. Histological assessment
US7116887B2 (en) 2002-03-19 2006-10-03 Nufern Optical fiber
US7006232B2 (en) * 2002-04-05 2006-02-28 Case Western Reserve University Phase-referenced doppler optical coherence tomography
US7113818B2 (en) 2002-04-08 2006-09-26 Oti Ophthalmic Technologies Inc. Apparatus for high resolution imaging of moving organs
US7016048B2 (en) 2002-04-09 2006-03-21 The Regents Of The University Of California Phase-resolved functional optical coherence tomography: simultaneous imaging of the stokes vectors, structure, blood flow velocity, standard deviation and birefringence in biological samples
US20030236443A1 (en) 2002-04-19 2003-12-25 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US7503904B2 (en) 2002-04-25 2009-03-17 Cardiac Pacemakers, Inc. Dual balloon telescoping guiding catheter
JP4135551B2 (ja) 2002-05-07 2008-08-20 松下電工株式会社 ポジションセンサ
JP3834789B2 (ja) * 2002-05-17 2006-10-18 独立行政法人科学技術振興機構 自律型超短光パルス圧縮・位相補償・波形整形装置
US7272252B2 (en) 2002-06-12 2007-09-18 Clarient, Inc. Automated system for combining bright field and fluorescent microscopy
WO2003105678A2 (en) 2002-06-12 2003-12-24 Advanced Research And Technology Institute, Inc. Method and apparatus for improving both lateral and axial resolution in ophthalmoscopy
RU2213421C1 (ru) 2002-06-21 2003-09-27 Южно-Российский государственный университет экономики и сервиса Динамическое запоминающее устройство радиосигналов
JP4045140B2 (ja) 2002-06-21 2008-02-13 国立大学法人 筑波大学 偏光感受型光スペクトル干渉コヒーレンストモグラフィー装置及び該装置による試料内部の偏光情報の測定方法
US20040039252A1 (en) 2002-06-27 2004-02-26 Koch Kenneth Elmon Self-navigating endotracheal tube
US20040002625A1 (en) 2002-06-27 2004-01-01 Timothy Dietz Apparatus and methods for cardiac surgery
CA2390072C (en) * 2002-06-28 2018-02-27 Adrian Gh Podoleanu Optical mapping apparatus with adjustable depth resolution and multiple functionality
JP3621693B2 (ja) 2002-07-01 2005-02-16 フジノン株式会社 干渉計装置
US7072047B2 (en) 2002-07-12 2006-07-04 Case Western Reserve University Method and system for quantitative image correction for optical coherence tomography
JP3950378B2 (ja) 2002-07-19 2007-08-01 新日本製鐵株式会社 同期機
JP4258015B2 (ja) 2002-07-31 2009-04-30 毅 椎名 超音波診断システム、歪み分布表示方法及び弾性係数分布表示方法
US7283247B2 (en) 2002-09-25 2007-10-16 Olympus Corporation Optical probe system
JP2004145302A (ja) * 2002-10-02 2004-05-20 Olympus Corp 光走査型観察装置
WO2004029566A1 (en) 2002-09-26 2004-04-08 Bio Techplex Corporation Method and apparatus for screening using a waveform modulated led
US6842254B2 (en) * 2002-10-16 2005-01-11 Fiso Technologies Inc. System and method for measuring an optical path difference in a sensing interferometer
WO2004034869A2 (en) 2002-10-18 2004-04-29 Arieh Sher Atherectomy system with imaging guidewire
US20040092829A1 (en) 2002-11-07 2004-05-13 Simon Furnish Spectroscope with modified field-of-view
JP2004159924A (ja) * 2002-11-13 2004-06-10 Olympus Corp 内視鏡
JP4246986B2 (ja) 2002-11-18 2009-04-02 株式会社町田製作所 振動物体観察システム及び声帯観察用処理装置
US6847449B2 (en) 2002-11-27 2005-01-25 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for reducing speckle in optical coherence tomography images
EP1426799A3 (en) 2002-11-29 2005-05-18 Matsushita Electric Industrial Co., Ltd. Optical demultiplexer, optical multi-/demultiplexer, and optical device
DE10260256B9 (de) 2002-12-20 2007-03-01 Carl Zeiss Interferometersystem und Meß-/Bearbeitungswerkzeug
GB0229734D0 (en) * 2002-12-23 2003-01-29 Qinetiq Ltd Grading oestrogen and progesterone receptors expression
JP4148771B2 (ja) 2002-12-27 2008-09-10 株式会社トプコン 医療機械のレーザ装置
US7123363B2 (en) 2003-01-03 2006-10-17 Rose-Hulman Institute Of Technology Speckle pattern analysis method and system
US8054468B2 (en) 2003-01-24 2011-11-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7075658B2 (en) * 2003-01-24 2006-07-11 Duke University Method for optical coherence tomography imaging with molecular contrast
WO2004088361A2 (en) 2003-03-31 2004-10-14 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
EP2319404B1 (en) * 2003-01-24 2015-03-11 The General Hospital Corporation System and method for identifying tissue low-coherence interferometry
US6943892B2 (en) 2003-01-29 2005-09-13 Sarnoff Corporation Instrument having a multi-mode optical element and method
US7474407B2 (en) 2003-02-20 2009-01-06 Applied Science Innovations Optical coherence tomography with 3d coherence scanning
JP4338412B2 (ja) 2003-02-24 2009-10-07 Ｈｏｙａ株式会社 共焦点プローブおよび共焦点顕微鏡
US7271918B2 (en) 2003-03-06 2007-09-18 Zygo Corporation Profiling complex surface structures using scanning interferometry
JP4135550B2 (ja) 2003-04-18 2008-08-20 日立電線株式会社 半導体発光デバイス
JP2004317437A (ja) 2003-04-18 2004-11-11 Olympus Corp 光イメージング装置
US7110109B2 (en) 2003-04-18 2006-09-19 Ahura Corporation Raman spectroscopy system and method and specimen holder therefor
JP2004321696A (ja) 2003-04-28 2004-11-18 Olympus Corp 光イメージング装置
WO2004098396A2 (en) * 2003-05-01 2004-11-18 The Cleveland Clinic Foundation Method and apparatus for measuring a retinal sublayer characteristic
CA2536969C (en) * 2003-05-05 2009-09-29 D4D Technologies, L.P. Optical coherence tomography imaging
CN100522043C (zh) 2003-05-12 2009-08-05 富士能株式会社 气囊式内窥镜
SE527164C2 (sv) 2003-05-14 2006-01-10 Spectracure Ab Anordning och metod för terapi och diagnostik innefattande optiska komponenter för distribution av strålning
DK1631788T3 (da) * 2003-05-16 2007-07-23 Univ Bruxelles Digitalt holografisk mikroskop til 3D billedfrembringelse og en proces til anvendelse deraf
US7376455B2 (en) 2003-05-22 2008-05-20 Scimed Life Systems, Inc. Systems and methods for dynamic optical imaging
US7697145B2 (en) * 2003-05-28 2010-04-13 Duke University System for fourier domain optical coherence tomography
CN1795405A (zh) * 2003-05-29 2006-06-28 密歇根大学董事会 双包层光纤扫描显微镜
EP1644697A4 (en) * 2003-05-30 2006-11-29 Univ Duke SYSTEM AND METHOD FOR BROADBAND QUADRATURE INTERFEROMETRY WITH LOW COHERENCE
US6943881B2 (en) 2003-06-04 2005-09-13 Tomophase Corporation Measurements of optical inhomogeneity and other properties in substances using propagation modes of light
US7263394B2 (en) 2003-06-04 2007-08-28 Tomophase Corporation Coherence-gated optical glucose monitor
EP1639330B1 (en) * 2003-06-06 2008-10-08 The General Hospital Corporation Wavelength tunable light source
US7458683B2 (en) 2003-06-16 2008-12-02 Amo Manufacturing Usa, Llc Methods and devices for registering optical measurement datasets of an optical system
US7170913B2 (en) 2003-06-19 2007-01-30 Multiwave Photonics, Sa Laser source with configurable output beam characteristics
US20040260182A1 (en) 2003-06-23 2004-12-23 Zuluaga Andres F. Intraluminal spectroscope with wall contacting probe
JP4677208B2 (ja) 2003-07-29 2011-04-27 オリンパス株式会社 共焦点顕微鏡
WO2005017495A2 (en) 2003-08-14 2005-02-24 University Of Central Florida Interferometric sensor for characterizing materials
US7539530B2 (en) 2003-08-22 2009-05-26 Infraredx, Inc. Method and system for spectral examination of vascular walls through blood during cardiac motion
US20050083534A1 (en) 2003-08-28 2005-04-21 Riza Nabeel A. Agile high sensitivity optical sensor
JP2005077964A (ja) 2003-09-03 2005-03-24 Fujitsu Ltd 分光装置
US20050057680A1 (en) * 2003-09-16 2005-03-17 Agan Martin J. Method and apparatus for controlling integration time in imagers
US20050059894A1 (en) * 2003-09-16 2005-03-17 Haishan Zeng Automated endoscopy device, diagnostic method, and uses
US7935055B2 (en) * 2003-09-19 2011-05-03 Siemens Medical Solutions Usa, Inc. System and method of measuring disease severity of a patient before, during and after treatment
US6949072B2 (en) 2003-09-22 2005-09-27 Infraredx, Inc. Devices for vulnerable plaque detection
US8172747B2 (en) 2003-09-25 2012-05-08 Hansen Medical, Inc. Balloon visualization for traversing a tissue wall
JP3796550B2 (ja) * 2003-09-26 2006-07-12 日本電信電話株式会社 光干渉トモグラフィ装置
US7142835B2 (en) 2003-09-29 2006-11-28 Silicon Laboratories, Inc. Apparatus and method for digital image correction in a receiver
US7292792B2 (en) 2003-09-30 2007-11-06 Lucent Technologies Inc. High speed modulation of optical subcarriers
DE10349230A1 (de) 2003-10-23 2005-07-07 Carl Zeiss Meditec Ag Gerät zur interferometrischen Augenlängenmessung mit erhöhter Empfindlichkeit
US7733497B2 (en) 2003-10-27 2010-06-08 The General Hospital Corporation Method and apparatus for performing optical imaging using frequency-domain interferometry
DE10351319B4 (de) 2003-10-31 2005-10-20 Med Laserzentrum Luebeck Gmbh Interferometer für die optische Kohärenztomographie
US7130320B2 (en) 2003-11-13 2006-10-31 Mitutoyo Corporation External cavity laser with rotary tuning element
US7551293B2 (en) 2003-11-28 2009-06-23 The General Hospital Corporation Method and apparatus for three-dimensional spectrally encoded imaging
US7359062B2 (en) 2003-12-09 2008-04-15 The Regents Of The University Of California High speed spectral domain functional optical coherence tomography and optical doppler tomography for in vivo blood flow dynamics and tissue structure
DE10358735B4 (de) 2003-12-15 2011-04-21 Siemens Ag Kathetereinrichtung umfassend einen Katheter, insbesondere einen intravaskulären Katheter
US7145661B2 (en) * 2003-12-31 2006-12-05 Carl Zeiss Meditec, Inc. Efficient optical coherence tomography (OCT) system and method for rapid imaging in three dimensions
JP4414771B2 (ja) 2004-01-08 2010-02-10 オリンパス株式会社 共焦点顕微分光装置
JP2005230202A (ja) * 2004-02-19 2005-09-02 Fujinon Corp 断層映像装置
RU2255426C1 (ru) 2004-02-19 2005-06-27 Южно-Российский государственный университет экономики и сервиса Динамическое запоминающее устройство радиосигналов с последовательной бинарной волоконно-оптической структурой
JP4462959B2 (ja) * 2004-02-25 2010-05-12 富士通株式会社 顕微鏡画像撮影システム及び方法
EP1722669A4 (en) 2004-02-27 2009-05-27 Optiscan Pty Ltd OPTICAL ELEMENT
US20050254059A1 (en) 2004-05-14 2005-11-17 Alphonse Gerard A Low coherence interferometric system for optical metrology
US7242480B2 (en) 2004-05-14 2007-07-10 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
US7190464B2 (en) * 2004-05-14 2007-03-13 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
AU2004320269B2 (en) 2004-05-29 2011-07-21 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (OCT) imaging
JP4995720B2 (ja) 2004-07-02 2012-08-08 ザ ジェネラル ホスピタル コーポレイション ダブルクラッドファイバを有する内視鏡撮像プローブ
DE102004035269A1 (de) * 2004-07-21 2006-02-16 Rowiak Gmbh Laryngoskop mit OCT
WO2006017837A2 (en) * 2004-08-06 2006-02-16 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
WO2006020605A2 (en) 2004-08-10 2006-02-23 The Regents Of The University Of California Device and method for the delivery and/or elimination of compounds in tissue
KR101269455B1 (ko) 2004-09-10 2013-05-30 더 제너럴 하스피탈 코포레이션 광 간섭 영상화를 위한 시스템 및 방법
EP1804638B1 (en) * 2004-09-29 2012-12-19 The General Hospital Corporation System and method for optical coherence imaging
US7113625B2 (en) 2004-10-01 2006-09-26 U.S. Pathology Labs, Inc. System and method for image analysis of slides
SE0402435L (sv) 2004-10-08 2006-04-09 Trajan Badju Förfarande och system för alstring av tredimensionella bilder
JP2008517281A (ja) 2004-10-22 2008-05-22 ファーミスカン・オーストラリア・ピーティーワイ・リミテッド 分析の方法および装置
JP2006122195A (ja) * 2004-10-27 2006-05-18 Olympus Corp 内視鏡光学系
JP5175101B2 (ja) 2004-10-29 2013-04-03 ザ ジェネラル ホスピタル コーポレイション 偏光感応性光コヒーレンストモグラフィを用いて偏光非解消の偏光パラメータを測定するジョーンズ行列に基づく解析を行うシステム及び方法
JP5623692B2 (ja) 2004-11-02 2014-11-12 ザ ジェネラル ホスピタル コーポレイション 試料の画像形成のための光ファイバ回転装置、光学システム及び方法
US7417740B2 (en) * 2004-11-12 2008-08-26 Medeikon Corporation Single trace multi-channel low coherence interferometric sensor
US8617152B2 (en) 2004-11-15 2013-12-31 Medtronic Ablation Frontiers Llc Ablation system with feedback
GB0425419D0 (en) 2004-11-18 2004-12-22 Sira Ltd Interference apparatus and method and probe
WO2006058187A2 (en) 2004-11-23 2006-06-01 Robert Eric Betzig Optical lattice microscopy
GB2420881B (en) 2004-12-01 2008-01-16 Westerngeco Ltd Processing seismic data
US7301644B2 (en) * 2004-12-02 2007-11-27 University Of Miami Enhanced optical coherence tomography for anatomical mapping
GB0426609D0 (en) 2004-12-03 2005-01-05 Ic Innovations Ltd Analysis
JP2006162366A (ja) 2004-12-06 2006-06-22 Fujinon Corp 光断層映像装置
US7450242B2 (en) 2004-12-10 2008-11-11 Fujifilm Corporation Optical tomography apparatus
US7336366B2 (en) * 2005-01-20 2008-02-26 Duke University Methods and systems for reducing complex conjugate ambiguity in interferometric data
US7342659B2 (en) 2005-01-21 2008-03-11 Carl Zeiss Meditec, Inc. Cross-dispersed spectrometer in a spectral domain optical coherence tomography system
US7330270B2 (en) * 2005-01-21 2008-02-12 Carl Zeiss Meditec, Inc. Method to suppress artifacts in frequency-domain optical coherence tomography
HU227859B1 (en) 2005-01-27 2012-05-02 E Szilveszter Vizi Real-time 3d nonlinear microscope measuring system and its application
US7267494B2 (en) 2005-02-01 2007-09-11 Finisar Corporation Fiber stub for cladding mode coupling reduction
US7860555B2 (en) 2005-02-02 2010-12-28 Voyage Medical, Inc. Tissue visualization and manipulation system
US7664300B2 (en) * 2005-02-03 2010-02-16 Sti Medical Systems, Llc Uterine cervical cancer computer-aided-diagnosis (CAD)
DE102005007574B3 (de) 2005-02-18 2006-08-31 Siemens Ag Kathetereinrichtung
EP1910996A1 (en) * 2005-02-23 2008-04-16 Lyncee Tec S.A. Wave front sensing method and apparatus
JP4628820B2 (ja) 2005-02-25 2011-02-09 サンテック株式会社 波長走査型ファイバレーザ光源
US7530948B2 (en) 2005-02-28 2009-05-12 University Of Washington Tethered capsule endoscope for Barrett's Esophagus screening
DE102005010790A1 (de) 2005-03-09 2006-09-14 Basf Ag Photovoltaische Zelle mit einem darin enthaltenen photovoltaisch aktiven Halbleitermaterial
US20060224053A1 (en) 2005-03-30 2006-10-05 Skyline Biomedical, Inc. Apparatus and method for non-invasive and minimally-invasive sensing of venous oxygen saturation and pH levels
US20070038040A1 (en) * 2005-04-22 2007-02-15 The General Hospital Corporation Arrangements, systems and methods capable of providing spectral-domain polarization-sensitive optical coherence tomography
US9599611B2 (en) * 2005-04-25 2017-03-21 Trustees Of Boston University Structured substrates for optical surface profiling
US20070009935A1 (en) 2005-05-13 2007-01-11 The General Hospital Corporation Arrangements, systems and methods capable of providing spectral-domain optical coherence reflectometry for a sensitive detection of chemical and biological sample
EP2453241B1 (en) * 2005-05-23 2017-01-11 Harald F. Hess Optical microscopy with phototransformable optical labels
US7859679B2 (en) 2005-05-31 2010-12-28 The General Hospital Corporation System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging
EP1889037A2 (en) 2005-06-01 2008-02-20 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
WO2006131859A2 (en) 2005-06-07 2006-12-14 Philips Intellectual Property & Standards Gmbh Laser optical feedback tomography sensor and method
US7391520B2 (en) 2005-07-01 2008-06-24 Carl Zeiss Meditec, Inc. Fourier domain optical coherence tomography employing a swept multi-wavelength laser and a multi-channel receiver
US20080218696A1 (en) 2005-07-01 2008-09-11 Jose Mir Non-Invasive Monitoring System
DE102005034443A1 (de) 2005-07-22 2007-02-22 Carl Zeiss Jena Gmbh Auflösungsgesteigerte Lumineszenz-Mikroskopie
US7292347B2 (en) * 2005-08-01 2007-11-06 Mitutoyo Corporation Dual laser high precision interferometer
JP4376837B2 (ja) 2005-08-05 2009-12-02 サンテック株式会社 波長走査型レーザ光源
US9441948B2 (en) * 2005-08-09 2016-09-13 The General Hospital Corporation Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography
US7668342B2 (en) 2005-09-09 2010-02-23 Carl Zeiss Meditec, Inc. Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues
WO2007030835A2 (en) 2005-09-10 2007-03-15 Baer Stephen C High resolution microscopy using an optically switchable fluorophore
WO2007035553A2 (en) 2005-09-15 2007-03-29 The Regents Of The University Of California Methods and compositions for detecting neoplastic cells
JP4708937B2 (ja) 2005-09-15 2011-06-22 Ｈｏｙａ株式会社 Ｏｃｔ観察器具、固定器具、及び、ｏｃｔシステム
KR100743591B1 (ko) * 2005-09-23 2007-07-27 한국과학기술원 사이드 로브가 제거된 공초점 자가 간섭 현미경
EP1940286A1 (en) * 2005-09-29 2008-07-09 General Hospital Corporation Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
US7450241B2 (en) * 2005-09-30 2008-11-11 Infraredx, Inc. Detecting vulnerable plaque
US7400410B2 (en) 2005-10-05 2008-07-15 Carl Zeiss Meditec, Inc. Optical coherence tomography for eye-length measurement
WO2007044612A2 (en) * 2005-10-07 2007-04-19 Bioptigen, Inc. Imaging systems using unpolarized light and related methods and controllers
CA2967964A1 (en) 2005-10-11 2007-04-19 Duke University Systems and method for endoscopic angle-resolved low coherence interferometry
WO2007044786A2 (en) * 2005-10-11 2007-04-19 Zygo Corporation Interferometry method and system including spectral decomposition
US7408649B2 (en) 2005-10-26 2008-08-05 Kla-Tencor Technologies Corporation Method and apparatus for optically analyzing a surface
WO2007084945A1 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Systems and methods for performing rapid fluorescense lifetime, excitation and emission spectral measurements
DK1973466T3 (da) * 2006-01-19 2021-02-01 Massachusetts Gen Hospital Ballonbilleddannelseskateter
US8145018B2 (en) * 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
GB0601183D0 (en) 2006-01-20 2006-03-01 Perkinelmer Ltd Improvements in and relating to imaging
WO2007090147A2 (en) 2006-01-31 2007-08-09 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
JP5519152B2 (ja) 2006-02-08 2014-06-11 ザ ジェネラル ホスピタル コーポレイション 光学顕微鏡法を用いて解剖学的サンプルに関わる情報を取得するための装置
US8184367B2 (en) 2006-02-15 2012-05-22 University Of Central Florida Research Foundation Dynamically focused optical instrument
DE102006008990B4 (de) 2006-02-23 2008-05-21 Atmos Medizintechnik Gmbh & Co. Kg Verfahren und Anordnung zur Erzeugung eines dem Öffnungszustand der Stimmlippen des Kehlkopfes entsprechenden Signals
JP2007271761A (ja) 2006-03-30 2007-10-18 Fujitsu Ltd 分光装置および波長分散制御装置
CN101466298B (zh) 2006-04-05 2011-08-31 通用医疗公司 用于样本的偏振敏感光频域成像的方法、装置和系统
US20070253901A1 (en) 2006-04-27 2007-11-01 David Deng Atherosclerosis genes and related reagents and methods of use thereof
US7719692B2 (en) 2006-04-28 2010-05-18 Bioptigen, Inc. Methods, systems and computer program products for optical coherence tomography (OCT) using automatic dispersion compensation
US7782464B2 (en) 2006-05-12 2010-08-24 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
EP1859727A1 (en) 2006-05-26 2007-11-28 Stichting voor de Technische Wetenschappen optical triggering system for stroboscopy and a stroboscopic system
US7599074B2 (en) * 2006-06-19 2009-10-06 The Board Of Trustees Of The Leland Stanford Junior University Grating angle magnification enhanced angular sensor and scanner
US20070291277A1 (en) 2006-06-20 2007-12-20 Everett Matthew J Spectral domain optical coherence tomography system
US7496220B2 (en) * 2006-08-28 2009-02-24 Thermo Electron Scientific Instruments Llc Spectroscopic microscopy with image-driven analysis
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
US8554035B2 (en) * 2006-10-26 2013-10-08 Cornell Research Foundation, Inc. Production of optical pulses at a desired wavelength using soliton self-frequency shift in higher-order-mode fiber
EP2079363B1 (en) 2006-10-30 2020-06-10 Elfi-Tech Ltd Method for in vivo measurement of biological parameters
DE102006054556A1 (de) 2006-11-20 2008-05-21 Zimmer Medizinsysteme Gmbh Vorrichtung und Verfahren zum nicht-invasiven, optischen Erfassen von chemischen und physikalischen Blutwerten und Körperinhaltsstoffen
US20080204762A1 (en) 2007-01-17 2008-08-28 Duke University Methods, systems, and computer program products for removing undesired artifacts in fourier domain optical coherence tomography (FDOCT) systems using integrating buckets
US7911621B2 (en) * 2007-01-19 2011-03-22 The General Hospital Corporation Apparatus and method for controlling ranging depth in optical frequency domain imaging
JP5227525B2 (ja) 2007-03-23 2013-07-03 株式会社日立製作所 生体光計測装置
MX2009010331A (es) 2007-03-26 2009-10-16 Univ Tokyo Nat Univ Corp Marcador de celula germinal utilizando el gen vasa de pescado.
JP5683946B2 (ja) * 2007-04-10 2015-03-11 ユニヴァーシティー オブ サザン カリフォルニア ドップラー光コヒーレンス・トモグラフィを用いた血流測定のための方法とシステム
WO2008137637A2 (en) 2007-05-04 2008-11-13 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using brillouin microscopy
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US8166967B2 (en) 2007-08-15 2012-05-01 Chunyuan Qiu Systems and methods for intubation
WO2009033064A2 (en) 2007-09-05 2009-03-12 The General Hospital Corporation Systems, methods and computer-accessible medium for providing spectral-domain optical coherence phase microscopy for cell and deep tissue imaging
JP2011500173A (ja) 2007-10-12 2011-01-06 ザ ジェネラル ホスピタル コーポレイション 管腔解剖構造の光学イメージングのためのシステムおよびプロセス
US9332942B2 (en) 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
JP5192247B2 (ja) 2008-01-29 2013-05-08 並木精密宝石株式会社 Ｏｃｔプローブ
US7898656B2 (en) 2008-04-30 2011-03-01 The General Hospital Corporation Apparatus and method for cross axis parallel spectroscopy
US8184298B2 (en) 2008-05-21 2012-05-22 The Board Of Trustees Of The University Of Illinois Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization
JP5324839B2 (ja) 2008-06-19 2013-10-23 株式会社トプコン 光画像計測装置
JP5546112B2 (ja) * 2008-07-07 2014-07-09 キヤノン株式会社 眼科撮像装置および眼科撮像方法
US8133127B1 (en) * 2008-07-21 2012-03-13 Synder Terrance W Sports training device and methods of use
US20110160681A1 (en) 2008-12-04 2011-06-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods including catheters having light removable coatings based on a sensed condition
US8457715B2 (en) 2009-04-08 2013-06-04 Covidien Lp System and method for determining placement of a tracheal tube
US9089331B2 (en) * 2009-07-31 2015-07-28 Case Western Reserve University Characterizing ablation lesions using optical coherence tomography (OCT)
US20120228523A1 (en) 2009-11-09 2012-09-13 Tata Institute Of Fundamental Research Biological laser plasma x-ray point source
JP5934121B2 (ja) 2010-03-05 2016-06-15 ザ ジェネラル ホスピタル コーポレイション 特定の分解能にて少なくとも１つの解剖構造の微細画像を提供するシステム、方法およびコンピュータがアクセス可能な媒体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6396941B1 (en) * 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104224117A (zh) * 2014-09-10 2014-12-24 南京航空航天大学 一种光谱编码共焦与光学相干层析协同成像方法与系统
CN104224117B (zh) * 2014-09-10 2017-06-30 南京航空航天大学 一种光谱编码共焦与光学相干层析协同成像方法与系统

Also Published As

Publication number Publication date
US8760663B2 (en) 2014-06-24
US9304121B2 (en) 2016-04-05
EP2279691B1 (en) 2023-07-19
US20130148106A1 (en) 2013-06-13
AU2006299659A1 (en) 2007-04-12
US9513276B2 (en) 2016-12-06
US8928889B2 (en) 2015-01-06
US20070081236A1 (en) 2007-04-12
EP2279691A1 (en) 2011-02-02
US8149418B2 (en) 2012-04-03
US20110058178A1 (en) 2011-03-10
US8384907B2 (en) 2013-02-26
US7872759B2 (en) 2011-01-18
JP2013101342A (ja) 2013-05-23
CN103479331A (zh) 2014-01-01
ES2925725T3 (es) 2022-10-19
JP6046325B2 (ja) 2016-12-14
JP5275804B2 (ja) 2013-08-28
US20130176571A1 (en) 2013-07-11
JP5678024B2 (ja) 2015-02-25
PL1937137T3 (pl) 2022-11-21
EP1928306A1 (en) 2008-06-11
CN101304683A (zh) 2008-11-12
CN101365375A (zh) 2009-02-11
EP1928306B1 (en) 2021-01-13
JP2009509689A (ja) 2009-03-12
JP2013137319A (ja) 2013-07-11
CN101365375B (zh) 2013-09-11
CN101360447B (zh) 2012-12-05
US20070229801A1 (en) 2007-10-04
WO2007041412A1 (en) 2007-04-12
US7847949B2 (en) 2010-12-07
EP1940286A1 (en) 2008-07-09
JP2015099158A (ja) 2015-05-28
US20110149296A1 (en) 2011-06-23
JP2013064743A (ja) 2013-04-11
EP1937137B1 (en) 2022-06-15
DK1937137T3 (da) 2022-08-29
US20110144504A1 (en) 2011-06-16
US7843572B2 (en) 2010-11-30
JP5988383B2 (ja) 2016-09-07
JP5371433B2 (ja) 2013-12-18
US20070121196A1 (en) 2007-05-31
US20150049339A1 (en) 2015-02-19
EP1928305A1 (en) 2008-06-11
US20070233396A1 (en) 2007-10-04
CN101360447A (zh) 2009-02-04
KR20080066705A (ko) 2008-07-16
WO2007041376A1 (en) 2007-04-12
US20130100455A1 (en) 2013-04-25
WO2007038787A1 (en) 2007-04-05
CA2624109A1 (en) 2007-04-12
JP6174609B2 (ja) 2017-08-02
US8289522B2 (en) 2012-10-16
WO2007041382A1 (en) 2007-04-12
EP2275026A1 (en) 2011-01-19
CN101304682A (zh) 2008-11-12
JP2009510451A (ja) 2009-03-12
CN101304682B (zh) 2012-05-30
JP2009510531A (ja) 2009-03-12
JP2009509684A (ja) 2009-03-12
EP1937137A1 (en) 2008-07-02

Similar Documents

Publication Publication Date Title
CN101304683B (zh) 以渐进增加的分辨率观察和分析一个或多个生物样品的方法和用于该方法的设备
Wang et al. A confocal endoscope for cellular imaging
CN113812929B (zh) 一种多模态成像装置
CN113812928B (zh) 基于拉曼光谱和光学相干断层成像的多模态成像装置
AU2013204570B2 (en) Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
Gmitro et al. Optical biopsy with confocal microendoscopy
Li et al. Endomicroscopy technologies and biomedical applications
HULAND et al. CLINICAL ENDOSCOPY/MULTIPHOTON IMAGING/FIBER OPTICS: Multiphoton endoscopy for clinical applications Sept. 26, 2013 Multiphoton microscopy is a label-free technique valuable for its ability to image unprocessed biological tissues at high resolution and in real time. Multiphoton endoscopy (MPE) promises to make the approach viable for clinical application, improving outcomes for both doctors and patients by enabling real-time margin assessment during tumor resection, among other uses.

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20121212

Termination date: 20180929

CF01 Termination of patent right due to non-payment of annual fee