CN101010115A - Electronically controlled pill and system for delivering at least one medicament - Google Patents
Electronically controlled pill and system for delivering at least one medicament Download PDFInfo
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- CN101010115A CN101010115A CNA2005800294235A CN200580029423A CN101010115A CN 101010115 A CN101010115 A CN 101010115A CN A2005800294235 A CNA2005800294235 A CN A2005800294235A CN 200580029423 A CN200580029423 A CN 200580029423A CN 101010115 A CN101010115 A CN 101010115A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
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Abstract
An electronically controlled pill (100) or medicament delivery system is provided. The pill (100) includes a housing (102); a medicament reservoir (104) for storing a medicament; an electronically controlled release valve or hatch (106) for dispensing one or more medicaments stored in the medicament reservoir (104) while traversing the gastrointestinal tract; control and timing circuitry (108) for opening and closing the valve (106); and a battery (109). The control and timing circuitry (108) opens and closes the valve (106) throughout a dispensing time period in accordance with a preset dispensing timing pattern which is programmed within the control and timing circuitry (108).
Description
The present invention relates generally to delivery system.Especially, it relates to electronically controlled pill and the system that is used to carry at least a medicine.
Medicine carries out administration with pill or liquid usually, and take at least once every day.A people may need take or give several drugs at identical or different time durations every day.This needs hold the record daily record or remember to carry out taking of which kind of medicine or administration at different time in a day of this people or his caregiver.
By the medicine that this people takes, as aspirin, usually by gastrointestinal (GI) road, it is absorbed for treatment imbalance or disease at this.Object typically passed through the GI road in 20-40 hour.Some medicines can be used as the time release capsule, are used to make the part medicine in different time is discharged into body.The time release capsule utilizes chemical substance and the chemical reaction between the capsule shell in the gastrointestinal tract to dissolve and discharge medicine.Food, particularly protein and fat, and GI chemistry affect medicine passes the travel speed of stomach.Similarly, medicine comprises the medicine as the time release capsule, can not defer to distribution or dissolution mode accurately during through the GI road.
For example, people since disease, the administration etc. of time early in gastrointestinal tract, can have the chemical substance of measuring more than " normally ", thereby cause the shell of time release capsule faster than normal reaction.Therefore, the time release capsule is to discharge medicine than desired speed faster speed.Yet another person can have the chemical substance that is less than " normally " amount and the shell of time release capsule is got slowly than normal reaction in gastrointestinal tract, thereby discharges medicine with the speed slower than desired speed.
In addition, identical with the conventional medicament that obtains with non-time releasing pattern, the time release capsule needs hold the record daily record or remember that the different time during a day carries out taking of which kind of medicine or administration of patient or caregiver.For example, some medicines must be in the usefulness that is taken at bed time, as be used for the treatment of the NSAIDS of rheumatic arthritis, to produce less gastrointestinal complication, as dyspepsia.The other medicine as antiinflammatory corticosteroid medication predisone, can cause insomnia, thereby typically take in the morning when taking higher dosage.Also have other medicines,, typically take at night so that be that the symptom that often appears at morning is prepared as hydryllin.
The invention provides a kind of being used in that simultaneously the distribution timing mode is carried or the electronically controlled pill or the delivery system of dispense medicament according to presetting by gastrointestinal tract.This presets the distribution timing mode is fixed and is not vulnerable to people's physiological activity and state, emotion, the influence of time administration etc. early.This electronically controlled pill comprises and is used for being stored in controlled delivery of pharmaceutical agents and timing circuit in the medicament reservoir of pill with distribution according to the opening and closing of presetting distribution timing mode by-pass valve control or gate.Electronically controlled pill makes the people can take whole pills basically simultaneously, as 7:00 in the morning, thereby in this day pills again.Be unsuitable for packing into an electronically controlled pill medicine can with other electronically controlled pill synergism, carry out effective dose of whole day and take.
According to the present invention, in special time period, as in 24 hour period, the whole medicines that need take can be provided in one or more electronically controlled pills, and these pills can be taken at one time.These electronically controlled pills can have different distribution timing modes, thereby can obtain the coverage (voverage) of whole day.Similarly, the present invention also provides a kind of therapy system that is used for being undertaken by one or more electronically controlled pills in the identical time two or more medicines of administration.Each pill has independently, presets the distribution timing mode, so that according to distribution mode dispense medicament in vivo.This distribution mode can change to another person from a people to some extent according to everyone health, age, sex, disease etc.In addition, the predetermined instant during the distribution timing mode is present in intravital electronically controlled pill and can be programmed to stop dispense medicament, will take one group of new pill with expectation.This by only make the pill taken recently in vivo dispense medicament prevent unexpected overtreatment.
Therapy system of the present invention makes individuality can take his whole medicines in the substantially the same time, for example in the morning or evening, rather than the different time during special time period (for example, 24 hour period).Therapy system of the present invention also make the caregiver can to each patient of hospital or the habitant of sanatorium (perhaps asylum or veterinary in animal) only carry out once all administrations (that is, per 24 hours once) of medicines every day.System of the present invention thereby avoided the caregiver need wake or bother patient or habitant for the sole purpose of administration, perhaps following the tracks of for the sole purpose of administration may be the different local patient or the habitant of hospital or sanatorium.System of the present invention has also reduced stock, the order of medicine, the burden of following the tracks of and keeping a diary.
Various embodiment of the present disclosure will reference will be made to the accompanying drawings below at this, in the accompanying drawing:
Fig. 1 is the sketch map according to electronically controlled pill of the present invention;
Fig. 2 is the chart that illustrates according to the exemplary preset distribution timing mode of electronically controlled pill of the present invention;
Fig. 3 is the sketch map that is used for the electronically controlled pill of dispense medicament according to the present invention;
Fig. 4 has the sketch map that a plurality of electronics draw the external member of pill, and this electronic pill is for customizing to the particular individual administration.
Illustrate by Fig. 1 according to electronically controlled pill of the present invention or delivery system, and after this be described further at this specially.Electronically controlled pill 100 be independently, the Electronic Control delivery system.Described in detail as follows, electronically controlled pill 100 comprises the programmed electronics according to the distribution mode sustained release mechanism of dispense medicament.Pill 100 is made by biocompatible materials, is biocompatible thereby pill 100 passes the needed time quantum of gastrointestinal tract for it at least.This biocompatible materials is preferably at room temperature stable, thereby pill has long storage life.As used herein and employed in the claims, word " medicine " refers to medicine, non-medicinal substances, contrast agent, gas, fluid, liquid, chemical substance, radiological agent, imaging label, be used to monitor the pick off of people's life indication etc.
Electronically controlled pill 100 comprises shell or housing 102; Be used to store the medicament reservoir 104 of medicine; Be used to distribute the Electronic Control relief valve or the gate 106 that are stored in the medicine in the medicament reservoir 104; Be used to open and close the control and the timing circuit 108 of valve 106; With battery 109.Control and timing circuit 108 open and close valve 106 according to the distribution timing mode that presets that further describes below in the whole distribution time period.To preset the distribution timing mode be pre-programmed and physiological activity that be not vulnerable to the people and state, emotion, the influence of time administration etc. early.
Shell 102 is preferably made by the material that is used to make implantable devices, and implantable devices comprises pacemaker wires and heart prosthesis equipment, decides auxiliary facilities as artificial heart, cardiac valve, intra-aortic oalloon and the heart.These materials comprise Pellet hane 2363 polyether urethane (polyetherurethane) series material that can obtain from Dow Chemical Company and can be from Polymer Technology Group, the Elas thane polyether urethane that Inc. obtains.Other material comprises also can be from Polymer Technology Group, PurSil and CarboSil that Inc. obtains.
Valve 106 the distribution time period each constantly the opening of (for example per second) depend in the timing circuit 110 of control and timing circuit 108, programme preset the distribution timing mode.Distribution the time period be defined as from when electronically controlled pill 100 is placed into people's oral cavity to the time period that the medicine that is stored in the medicament reservoir 104 all is distributed, perhaps spent one day (24 hour time period).This 24 hour time period slightly conversion to solve stomach and colon in differential absorption.
Shown in the exemplary preset distribution timing mode as shown in Figure 2, at distribution time period A, when D and F, the same amount of distribution medicine in the whole time period of these distribution time periods at each.Therefore, during these distribution time periods, valve 106 is stayed open so that fixed valve openings (or opening frequency) to be provided by control and timing circuit 108, thereby is distributing time period A, and each of D and F distributed the medicine of precognition amount constantly.Distribute about same amount medicine constantly in each of distribution time period A and F.During distribution time period D, than during distribution time period A and F, distributing more a large amount medicine.
Yet,, when C and E, as shown in Figure 2, distribute not commensurability medicine constantly at each at distribution time period B.Therefore, at distribution time period B, during C and the E, valve open is by control and timing circuit 108 and changing, to be distributed in the medication amount that each changes constantly.During distribution time period B, the medication amount of distribution increases than previous moment during each constantly; And at distribution time period C, during the E, the medication amount of distribution reduces than previous moment during each constantly.
According to the present invention, during the whole distribution time period, to control and timing circuit 108 programme make valve 106 close and by-pass valve control 106 openings with the size of by-pass valve control opening.By by-pass valve control opening size or valve open frequency, as startup by the microfluidic systems of ink-jet printer etc., each medication amount that discharges during (for example per second) constantly that electronically controlled pill 100 can be controlled at the distribution time period exactly.
By the reference time release mode, as by the pattern shown in Fig. 2, be informed in each medication amount that discharges constantly or approximate quantity, can determine drug accumulation amount exactly in the special time period release of distribution time period.For example, can determine in the first six hour of distribution time period, distribution preceding two hours of the time period to the last hour, the drug accumulation amount that discharges during the whole distribution time period etc.Also can determine the medication amount of distributing during the particular moment of distribution time period, as in pill 100 administrations during 15 minutes latter two hours.
Preset the distribution timing mode and programme and to change to another from an electronically controlled pill 100, to have the different distribution timing modes that preset by control and timing circuit 108 to each pill 100.Therefore, two individualities can utilize two different distribution timing modes that preset to carry out the administration of same medicine.Can adopt look-up table to determine timing mode, one or more features that this look-up table makes the people are with one or more to preset the distribution timing mode relevant.
For example, look-up table can make in age, sex, the body weight etc. one with to preset the distribution timing mode relevant.Then can carry out electronic pill 100 administrations to the people, this electronic pill 100 can be by the programming of determining of distributing in the timing mode of presetting.Therefore, pill 100 of the present invention can adopt different distribution timing modes that Different Individual is carried out administration with a kind of medicine.
In addition, for pills or remember the old young crowd of pills difficulty, preset the distribution timing mode and be a kind of minimizing at special time period, for example the method for pills quantity during 24 hour period.The whole medicines that need be during special time period individuality be carried out administration can be provided in the pill 100, and this pill 100 has and is used for presetting the distribution timing mode according to the amount of pre-determining dispense medicament during the special time period.If the effective dose in pill is not enough, then can adopt two electronically controlled pills distributions with a kind of medicine, one of them pill can not begin dispense medicament till another pill has been distributed its medicine, and promptly its distribution time period passes by or finishes.In addition, the present invention has reduced in as places such as hospital, sanatorium and veterinary institutes and gives pill the needed amount of labour.Give the number of times of pill by minimizing, can also reduce the administration margin of error.
Referring to Fig. 1, control and timing circuit 108 comprise to preset timing circuit 110, opening timing device mechanism 112, release controller 114 and the pressure mechanism 116 that the distribution timing mode is programmed.Opening timing device mechanism 112 starts timing circuit 110.Battery 109 is for control and timing circuit 108 is powered so that each electromechanical component is being distributed the time period manipulate.
In a preferred embodiment, opening timing device mechanism 112 has an induced liquid of being used for, micro electronmechanical (MEM) mechanism of the pick off 118 that exists as water, saliva etc.When pill is being taken or during administration, pick off 118 is sensed the existence of liquid, and the signal of telecommunication is sent to timing circuit 110.In an alternative embodiment, opening timing device mechanism is a button, when this button is pressed the signal of telecommunication is sent to timing circuit 110.This button was pressed before human or animal's administration at pill 100 just.
In another embodiment, this can realize the switch closure circuit by making the water-miscible coating's dissolving that separates two electrical pickofves.In another embodiment, by patient or caregiver's manual trigger switch.
In case receive the signal of telecommunication, timing circuit 110 begins distribution is carried out timing the time period and by sending signals and come it is controlled to discharging controller 114.Timing circuit 110 comprises to preset the microprocessor of distribution timing mode programming, it is used for this signal is transmitted (relay) to discharging controller 114, thereby basically according to presetting the distribution timing mode, as by the pattern shown in Fig. 2, dispense medicament during the distribution time period.
The voltage of signals level transmits the valve openings size to be controlled at each medication amount of distributing constantly of distributing the time period according to distributing timing mode by shown in Figure 2 presetting basically.In an alternative embodiment, by timing circuit 110 to discharging that signal that controller 114 sends only transmits the opening and closing of valve 106 and the size of not transmitting valve openings.
In an alternative embodiment, reservoir 104 is microsyringes, thus be applied on the injector push-rod pressure by with shell 102 in the opening needle point that carries out the microsyringe of liquid communication come dispense medicament.In this embodiment, opening replaces valve 106.Yet should consider, place test valve basis presets the drug leakage of distributing during timing mode should not carry out the time of distributing section in the distribution time period to avoid at the needle point place of microsyringe, and/or is used to be controlled at the medication amount of distributing during the distribution time period.
In an alternative embodiment, medicament reservoir 104 remains under the pressure guaranteeing the correct medication amount of degree of opening distribution according to valve 106, and need not pressure mechanism 116.Can be by pressure sensor monitoring pressure, this pressure transducer is passed to control and timing circuit 108 with the pressure that is monitored.If pressure is beyond preset range, then circuit 108 adjustable valve door openings are to increase or to reduce pressure.Certainly, the pressure of reservoir 104 can be different for every kind of medicine and be can be dependent on the viscosity of medicine.
What can consider is, can be by circuit 108 estimation look-up table or other data structures, and circuit 108 makes pressure, valve openings degree and other parameter correlation such as the time period in the distribution time period, be used for determining by known pressure, for example, the valve openings degree, perhaps vice versa.Based on the information that obtains by the estimation look-up table, the adjustable then seamless power of circuit 108, valve openings etc.Can carry out these adjust with follow the trail of basically pill 100 in, programme preset the distribution timing mode.
According to the present invention, during special time period, for example, during 24 hour time period, all medicines that need take can be provided in one or more electronically controlled pills 100, and described pill is taken simultaneously.Like this, therapy system of the present invention provides by one or more electronically controlled pills 100 and has carried out two or more medicines of administration simultaneously.Each pill 100 has independently, presets the distribution timing mode so that according to distribution mode dispense medicament in vivo.This distribution mode can change to another person from a people based on everyone health, age, sex, disease etc.
Therapy system of the present invention makes individuality take his whole medicines in same time basically, for example in the morning or evening, rather than the different time during special time period (for example 24 hour time period).Therapy system of the present invention also make the caregiver can to each patient of hospital or the habitant of sanatorium (perhaps asylum or veterinary in animal) only carry out once all administrations of medicines every day.Thereby system of the present invention has avoided the caregiver need wake or bother patient or habitant for the sole purpose of administration, and perhaps going to follow the tracks of for the sole purpose of administration may be the different local patient or the habitant of hospital or sanatorium.
The present invention also provides external member 200 as shown in Figure 4, and this external member 200 has the two or more electronically controlled pills 100 that are encapsulated in the container 202.Each pill 100 is placed in the recess of container 202 or the recess 201 and each pill 100 have programming within it independently, preset the distribution timing mode.The pill 100 of external member 200 is individual (or animal) customization, thereby can provide container 202 to individuality or his caregiver by doctor or pharmacist etc.
Be provided with timing table 204 in container, when each pill 100 of its indication external member 200 should be taken, for example the time and date in this week.Timing table 204 comprises zone 206, can write each specific date this zone doctor, pharmacist etc. and answer time and the afternoon or the morning of pills 100.May need to take two or more pills 100 for the special time place fix the date, as shown in Figure 4, wherein each pill has the different pharmaceutical that is stored in wherein and the different distribution timing modes that preset.Like this, individuality can be taken and be indicated as all pills 100 that should take to the special time place that fixes the date, and can not take the same time of any other pill 100 up to next day.
Because what each pill 100 of external member 200 had a programming presets the distribution timing mode, even pills 100 at one time, it also is inessential can interacting from the medicine of each pill 100.For example, a pill 100 of external member 200 can get started distribution, and another pill 100 of external member 200 can not begin distribution after three hours.
Described embodiments of the invention are exemplary and nonrestrictive, and are not to represent each embodiment of the present invention.Under the situation that does not depart from the spirit or scope of the present invention of illustrating by the character express of following claim and generally acknowledged legally equivalents, can carry out various modifications and change.
Claims (24)
1, a kind of delivery system (100) that is used for dispense medicament by gastrointestinal tract the time, described system (100) comprising:
Housing (102);
Be used to store the reservoir (104) of the described medicine in the described housing (102);
Valve (106) with described reservoir (104) liquid communication; With
Be used to control described valve (106) to open and close described valve (106) thus distribute described controlled delivery of pharmaceutical agents and timing circuit (108), wherein described control and timing circuit (108) are programmed, and wherein said medicine is basically according to described distribution timing mode distribution with the distribution timing mode.
2, system according to claim 1 (100), wherein said housing (102) is by being selected from Pellethane 2363 polyether urethane series materials, the Elasthane polyether urethane, at least a material manufacture among PurSil and the CarboSil .
3, system according to claim 1 (100) also comprises pressure mechanism (116), and it is used for exerting pressure to force described medicine in the described reservoir (104) towards described valve (106) to piston-type member (130).
4, system according to claim 3 (100), wherein said pressure mechanism (116) is a spring.
5, system according to claim 1 (100) also comprises the battery (109) that is used to described control and timing circuit (108) power supply.
6, system according to claim 1 (100), wherein said control and timing circuit (108) comprise opening timing device mechanism (112), timing circuit (110) and release controller (114), wherein said opening timing device mechanism (112) sends signal to described timing circuit (110), be used for the distribution time period is carried out timing, and wherein said timing circuit (110) sends signal to described release controller (114), is used to control described valve (106) and distributes described medicine according to described distribution timing mode basically during the described distribution time period.
7, system according to claim 1 (100), wherein said distribution timing mode is with relevant in each described medicine approximate quantity of distributing constantly during the distribution time period.
8, system according to claim 1 (100), wherein said release controller (114) is controlled the extent of opening of described valve (106).
9, system according to claim 6 (100), wherein said opening timing device mechanism (112) are micro electronmechanical (MEM) mechanisms with the pick off (118) that is used for the induced liquid existence.
10, system according to claim 1 (100), wherein said reservoir is a microsyringe.
11, a kind of Drug therapy external member (200) comprising:
The container (202) that is used at a plurality of delivery systems (100) of carrying medicine by gastrointestinal tract simultaneously is housed, and wherein each system (100) comprising:
Housing (102);
The reservoir (104) that is used for the described medicine of storage in described housing (102);
Valve (106) with described reservoir (104) liquid communication; With
Be used to control described valve (106) to open and close described valve (106) thus distribute described controlled delivery of pharmaceutical agents and timing circuit (108), wherein with the distribution timing mode described control and timing circuit (108) are programmed, wherein said medicine is basically according to described distribution timing mode distribution; With
When indication adopts the timetable (204) of each delivery system (100).
12, external member according to claim 11 (200), wherein each delivery system (100) also comprises pressure mechanism (116), and it is used for exerting pressure to force described medicine in the described reservoir (104) towards described valve (106) to piston-type member (130).
13, external member according to claim 11 (200), wherein said control and timing circuit (108) comprise opening timing device mechanism (112), timing circuit (110) and release controller (114), wherein said opening timing device mechanism (112) sends signal to described timing circuit (110), be used for the distribution time period is carried out timing, and wherein said timing circuit (110) sends signal to described release controller (114), is used to draw described valve (106) and distributes described medicine according to described distribution timing mode basically during the described distribution time period.
14, external member according to claim 11 (200), wherein said distribution timing mode is relevant with the described medicine approximate quantity that will distribute during each delivery time during the time period.
15, external member according to claim 11 (200), wherein said release controller (114) is controlled the extent of opening of described valve (106).
16, external member according to claim 11 (200), at least two of wherein a plurality of described delivery systems (100) have different distribution timing modes.
17, a kind of therapy system that is used to carry out at least two kinds of drug administrations comprises:
Be used for distributing first and second delivery systems (100) of medicine separately according to distribution timing mode separately simultaneously by gastrointestinal tract, each described first and second system (100) comprising:
Housing (102);
The reservoir (104) that is used for the described medicine of storage in described housing (102);
Valve (106) with described reservoir (104) liquid communication; With
Be used to control described valve (106) to open and close described valve (106) thus distribute described controlled delivery of pharmaceutical agents separately and timing circuit (108), wherein use described distribution timing mode separately that described control and timing circuit (108) are programmed, and wherein the described medicine separately of each described system (100) is distributed basically according to the described timing mode of distributing separately.
18, system according to claim 17, wherein said first and second delivery systems (100) also comprise pressure mechanism (116), and it is used for exerting pressure to force described medicine in the described reservoir (104) towards described valve (106) to piston-type member (130).
19, system according to claim 17, wherein said control and timing circuit (108) comprise opening timing device mechanism (112), timing circuit (110) and release controller (114), wherein said opening timing device mechanism (112) sends signal to described timing circuit (110), be used for the distribution time period is carried out timing, and wherein said timing circuit (110) sends signal to described release controller (114), is used to control described valve (106) and distributes described medicine according to described distribution timing mode separately basically during the described distribution time period.
20, system according to claim 17, wherein each described distribution timing mode separately is with relevant in each described medicine approximate quantity of distributing constantly during the distribution time period.
21, a kind of being used at the delivery system (100) by gastrointestinal tract while dispense medicament, described system (100) comprising:
Housing (102) with opening;
Be used in described housing (102) the described medicine of storage and with the reservoir (104) of described open fluid communication; With
Be used to control the control and the timing circuit (108) of described medicine distribution, wherein described control and timing circuit (108) programmed, and wherein said medicine is basically according to described distribution timing mode distribution with the distribution timing mode.
22, system according to claim 21 (100), wherein said control and timing circuit (108) comprise opening timing device mechanism (112), timing circuit (110) and release controller (114), wherein said opening timing device mechanism (112) sends signal to described timing circuit (110), be used for the distribution time period is carried out timing, and wherein said timing circuit (110) sends signal to described release controller (114), is used to control described valve (106) to distribute described medicine according to described distribution timing mode by described opening basically during the described distribution time period.
23, system according to claim 21 (100), wherein said distribution timing mode is with relevant in each described medicine approximate quantity of distributing constantly during the distribution time period.
24, system according to claim 22 (100), wherein said release controller (114) is controlled the extent of opening of described valve (106).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60627604P | 2004-09-01 | 2004-09-01 | |
| US60/606,276 | 2004-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101010115A true CN101010115A (en) | 2007-08-01 |
Family
ID=35559422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005800294235A Pending CN101010115A (en) | 2004-09-01 | 2005-08-29 | Electronically controlled pill and system for delivering at least one medicament |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1796776A1 (en) |
| JP (1) | JP2008511370A (en) |
| CN (1) | CN101010115A (en) |
| WO (1) | WO2006025013A1 (en) |
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| CN107374773A (en) * | 2017-08-31 | 2017-11-24 | 中国疾病预防控制中心寄生虫病预防控制所 | A kind of self-timing dog expelling parasite dispensing necklace |
| US10586022B2 (en) | 2011-12-05 | 2020-03-10 | Omnicell, Inc. | System and method for managing inventory at dispensing units |
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| CN102065930B (en) | 2008-06-19 | 2013-05-22 | 皇家飞利浦电子股份有限公司 | Device for delivery of powder like medication in a humid environment |
| WO2009156919A1 (en) | 2008-06-25 | 2009-12-30 | Koninklijke Philips Electronics N.V. | Electronic pill comprising a plurality of medicine reservoirs |
| JP5497176B2 (en) | 2009-08-12 | 2014-05-21 | コーニンクレッカ フィリップス エヌ ヴェ | Chemical delivery device with compressible chemical reservoir |
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| US3797492A (en) * | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
| US5167626A (en) * | 1990-10-02 | 1992-12-01 | Glaxo Inc. | Medical capsule device actuated by radio-frequency (RF) signal |
| FR2794654B1 (en) * | 1999-06-08 | 2001-10-19 | Ct De Transfert Des Microtechn | DEVICE FOR RELEASING SUBSTANCES IN A DIGESTIVE TUBE |
| FR2835730B1 (en) * | 2002-02-11 | 2004-12-10 | C T M Ct De Transfert Des Micr | DEVICE FOR DELIVERY OF SUBSTANCES AND INTRACORPOREAL SAMPLING |
| JP2005131012A (en) * | 2003-10-29 | 2005-05-26 | Olympus Corp | Capsule medication system |
-
2005
- 2005-08-29 CN CNA2005800294235A patent/CN101010115A/en active Pending
- 2005-08-29 JP JP2007529112A patent/JP2008511370A/en active Pending
- 2005-08-29 EP EP05781618A patent/EP1796776A1/en not_active Withdrawn
- 2005-08-29 WO PCT/IB2005/052820 patent/WO2006025013A1/en active Application Filing
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103827851A (en) * | 2011-05-02 | 2014-05-28 | 欧美尼公司 | Medication dispensing cabinet systems and methods |
| US9355220B2 (en) | 2011-05-02 | 2016-05-31 | Omnicell, Inc. | Medication dispensing cabinet systems and methods |
| CN103827851B (en) * | 2011-05-02 | 2017-03-08 | 欧美尼公司 | Rack system and method distributed by medicine |
| US10268804B2 (en) | 2011-05-02 | 2019-04-23 | Omnicell, Inc. | Medication dispensing cabinet systems and methods |
| US10839952B2 (en) | 2011-05-02 | 2020-11-17 | Omnicell, Inc. | Medication dispensing cabinet systems and methods |
| US11640855B2 (en) | 2011-05-02 | 2023-05-02 | Omnicell, Inc. | Medication dispensing cabinet systems and methods |
| US10586022B2 (en) | 2011-12-05 | 2020-03-10 | Omnicell, Inc. | System and method for managing inventory at dispensing units |
| US10762173B2 (en) | 2011-12-05 | 2020-09-01 | Omnicell, Inc. | System and method for managing inventory at dispensing units |
| US12062012B2 (en) | 2011-12-05 | 2024-08-13 | Omnicell, Inc. | System and method for managing inventory at dispensing units |
| CN107374773A (en) * | 2017-08-31 | 2017-11-24 | 中国疾病预防控制中心寄生虫病预防控制所 | A kind of self-timing dog expelling parasite dispensing necklace |
| CN107374773B (en) * | 2017-08-31 | 2023-07-25 | 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) | Automatic timing dog expelling parasite and dosing necklace |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006025013A1 (en) | 2006-03-09 |
| JP2008511370A (en) | 2008-04-17 |
| EP1796776A1 (en) | 2007-06-20 |
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Open date: 20070801 |