CN109549893A - A kind of preparation method with anti-blue light contamination and the composition repaired and essence cream and its essence cream - Google Patents
A kind of preparation method with anti-blue light contamination and the composition repaired and essence cream and its essence cream Download PDFInfo
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- CN109549893A CN109549893A CN201910058665.0A CN201910058665A CN109549893A CN 109549893 A CN109549893 A CN 109549893A CN 201910058665 A CN201910058665 A CN 201910058665A CN 109549893 A CN109549893 A CN 109549893A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
Have effects that anti-blue light contamination and the composition repaired and essence cream the present invention relates to a kind of, further relates to the preparation method of the essence cream, belong to cosmetic technical field.Essence cream provided by the invention, is not only resistant to blue light contamination, but also has effects that repair；Effect ingredient of the essence cream includes chlorella extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract, wherein, chlorella extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract weight ratio be 1~10:2~15:1~15:1~10, its functional component can resist the pollution and damage of blue light in all its bearings, and it can damage and repair caused by scytitis and blue light, to provide the survival ability and defence capability of Skin Cell, the aging of delaying skin cell.
Description
Technical field
Have effects that anti-blue light contamination and the composition repaired and essence cream the present invention relates to a kind of, further relates to the essence
The preparation method of cream, belongs to cosmetic technical field.
Background technique
" blue light " is commonly called as " high energy shortwave blue light ", is that a kind of wavelength is between 400~480nm, has relatively high energy
The light of amount.Blue light contamination refers to that the artificial blue light for being exposed to " hyperlink life style ", artificial blue light mostly come from computer, throw
In shadow instrument, motion picture screen, light-emitting diode display, mobile phone, laser pen, fluorescent lamp, outdoor lamp house, LED light and super bath.Blue light not only shadow
The secretion of melatonin is rung, also has obvious inhibiting effect to melatonin, and melatonin is the hormone of assisting sleep.People
The operating of human normal biological clock can not only be upset by contacting blue light for a long time or before sleeping, and also result in the reduction of internal melatonin
Cause a series of health problems such as insomnia.In daily life, the frequency that people contact blue light increasingly increases, so that skin is excessive
It is exposed in blue light, so as to cause consequences such as the reduction of self barrier maintenance ability of skin, aging quickenings.For example, skin is exposed to
In visible light or high energy visible light KEV, so that Skin Cell can generate a series of following bad influences: the increase of active oxygen, line
Mitochondrial DNA damages, epidermal barrier reparation delay, cascade of response of inflammation increase, carotenoid loss, Langerhans in skin corium
Cellular immunity suppression.Therefore, as resisting UV or air pollution, it is also very necessary that protection skin resists blue light contamination, this
Help to slow down the early ageing and damage of skin.
Chlorella extract is taken from rich in a variety of nutrition such as protein, lipid, carbohydrate, vitamin, minerals
The chlorella of substance.Chlorella is under the jurisdiction of Chlorella cell Chlorophyceae, contained by biological active agents have acceleration thin
The effect that bacterium, animal and plant are grown.The main component of chlorella extract is chlorella growth factor, chlorella growth factor
Nucleic acid and nucleoprotein rich in can repair human body cell and have the function of anti-aging, and there are also the works of immune cell activated
With having very strong binding force with toxin and toxin can be excluded external.Therefore, chlorella growth factor has good work to skin
With.
Crambe abyssinica extract, from strong halophytes Crambe abyssinica of the existence in special ecological environment.Contain
Multivitamin, phytosterol, thioester and carotenoid, can stimulate the update of basal confluent monolayer cells, and protection stem cell is exempted from
By the damage of UVB, the synthesis of ceramide II can be stimulated, the degradation of collagen and GAC caused by UVA is reduced, to have
Anti-aging removes free radical, slows down the effect of light aging.
Ginger root extract is a kind of unique extract from open country butterfly race portion, Madagascar, rich in sugar
Class has the function of anti-blue light and uva-resistant, passes through mitochondria network and the energy generation of protection UVA change by adjusting autophagy
It thanks, there is anti-oxidant, antipollution and cell detoxification effect.
Japanese elm extract is extracted from the root skin portion of elm, is rich in natural galactolipin, rhamnose, glucose, amino
The polysaccharide such as glucose and trehalose.Japanese elm extract can inhibit the activity of hyaluronidase, reduce trans epidermal water loss (TEWL),
Suitable for potent moisturizing and antisenescence formulation.It can inhibit the release of IL-8, IL-6 and PEG2 (prostaglandin) simultaneously, have good
Anti-inflammatory efficacy, moreover it is possible to repair UVA irradiate caused by light injury, improve cell viability measurement.
Pursuit with people to beauty cures U.S. industry and has obtained vigorous growth, and more and more people seeking beauties receive doctor
Treat beauty.However doctor beauty after skin be it is very fragile, which can not hide the infringement of blue light again.Therefore be badly in need of it is a both
It is resistant to blue light and has both the skin care item for repairing effect again, and cosmetics are many kinds of currently on the market, most essence product is more
Based on whitening, crease-resistant, anti-oxidant etc., not only functional effect is single, but also ineffective.The present invention provides a kind of primary efficacy
Ingredient includes the essence cream of chlorella extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract, is both resistant to indigo plant
Light pollution, and have the function of repairing effect, helping, which improves blue light, gives people's skin adverse effect.
Summary of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide one kind to be not only resistant to blue light contamination, but also has and repair
The composition of effect.
It is a further object of the present invention to provide one kind to be not only resistant to blue light contamination, but also has effects that the essence repaired cream.
Another object of the present invention is to provide the preparation method of the essence cream.
To achieve the above object, the technical scheme adopted by the invention is as follows: it is a kind of have effects that anti-blue light contamination and repair
Composition, including chlorella extract, Crambe abyssinica extract, ginger root extract, Japanese elm extract.It is usually in the prior art
Anti- blue light contamination or reparation are carried out using single extract, however effect is single, it is ineffective, and anti-indigo plant cannot be provided simultaneously with
Light pollution and the double action for repairing effect, present inventor has found by numerous studies, by chlorella extract, Crambe abyssinica
Extract, ginger root extract, Japanese elm extract extract are compounded, synergistic obvious, anti-blue light contamination and reparation
Effect be significantly better than independent extract.
Preferably, the weight ratio of the chlorella extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract
For 1~10:2~15:1~15:1~10.
Preferably, the weight ratio of the chlorella extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract
For 1~6:3~9:1.5~7:1~6.
Preferably, the weight ratio of the chlorella extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract
For 5:8:6:5.By chlorella extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract according to said ratio into
Row compounding, anti-blue light contamination and repairing effect are best.
The present invention provides a kind of essence cream with anti-blue light contamination and reparation, including A phase substance, B phase substance, C
Phase substance and water；Wherein, with weight, dosage of each component includes: glycerol 1-8%, butanediol in the A phase substance
1-5%, 1,3- propylene glycol 1-5%, micromolecule hyaluronic acid sodium 0.01-1.5%, xanthan gum 0.1%-1%, stearine
0.2-0.5%, hydrolecithin 0.01-0.5%, D-sorbite 0.1-3%, Phenoxyethanol 0.1-1%；In the B phase substance
Dosage of each component includes: purslane extract 0.1-1%, chlorella extract 1-10%, Crambe abyssinica extract 2-15%, Jiang Hua
Root extract 1-15%, Japanese elm extract 1-10%；Dosage of each component includes: panthenol 0.01-0.5%, institute in the C phase substance
It states water and complements to 100%.
Preferably, in essence cream provided by the invention, dosage of each component includes: glycerol 1-8%, fourth in the A phase substance
Glycol 1-5%, 1,3- propylene glycol 1-5%, micromolecule hyaluronic acid sodium 0.01-1.5%, xanthan gum 0.1%-1%, glyceryl stearate
Acid esters 0.2-0.5%, hydrolecithin 0.01-0.5%, D-sorbite 0.1-3%, Phenoxyethanol 0.1-1%；The B phase object
Dosage of each component includes: purslane extract 0.1-1%, chlorella extract 1-6%, Crambe abyssinica extract 3-9%, ginger in matter
Flower root extract 1.5-7%, Japanese elm extract 1-6%；Dosage of each component includes: panthenol 0.01-0.5% in the C phase substance.
Most preferably, in essence cream provided by the invention, dosage of each component includes: glycerol 5%, fourth in the A phase substance
Glycol 2%, 1,3- propylene glycol 3%, micromolecule hyaluronic acid sodium 1%, xanthan gum 0.5%, stearine 0.3%, hydrogenation
Lecithin 0.3%, D-sorbite 1%, Phenoxyethanol 0.5%；Dosage of each component includes: purslane extraction in the B phase substance
Object 0.5%, chlorella extract 5%, Crambe abyssinica extract 8%, ginger root extract 6%, Japanese elm extract 5%；The C phase
Dosage of each component includes: panthenol 0.3% in substance.
" % " of the present invention is weight percentage.
The present invention provides the preparation method with anti-blue light contamination and the essence cream repaired, including following step
It is rapid:
(1) water, A phase substance are separately added into emulsion pot and are mixed, when being heated to 75-85 DEG C, with 1200-1500r/
The mixing speed of min is stirred for being uniformly mixed, and then sterilize 15-20min, obtains mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Compared with prior art, the invention has the benefit that
(1) essence cream provided by the invention, is not only resistant to blue light contamination, but also has effects that repair；Effect of the essence cream
Ingredient includes chlorella extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract, and functional component can be from each
A aspect resists the pollution and damage of blue light, and can damage and repair caused by scytitis and blue light, to mention
For the survival ability and defence capability of Skin Cell, the aging of delaying skin cell；
(2) composition provided by the invention passes through chlorella extract, Crambe abyssinica extract, ginger root extract and spring
Elm extract rationally compounds in a certain range, synergistic obvious, and anti-blue light contamination and the effect for repairing effect are obvious
It is better than the effect of wherein three ingredients compounding；
(3) essence cream provided by the invention, functional component is composition of plant extracts, natural safety, non-stimulated；
(4), essence cream preparation method provided by the invention is simple, and process stabilizing is worth of widely use, and is suitble to industrial batch
Amount production.
Specific embodiment
Purposes, technical schemes and advantages in order to better illustrate the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
It is provided by the invention to have effects that raw materials used or auxiliary material is by market in anti-blue light contamination and the essence repaired cream
It buys.
Embodiment 1
It is a kind of to have effects that anti-blue light contamination and the essence repaired cream, with weight, including following components:
A phase: glycerol 1%, butanediol 5%, 1,3- propylene glycol 1%, micromolecule hyaluronic acid sodium 1.5%, xanthan gum 1%,
Stearine 0.2%, hydrolecithin 0.01%, D-sorbite 0.1%, Phenoxyethanol 1%；
B phase: purslane extract 0.1%, chlorella extract 1%, Crambe abyssinica extract 3%, ginger root extract
1.5%, Japanese elm extract 1%；
C phase: panthenol 0.5%；
Water: 82.09%；
The preparation method of the essence cream: (1) being separately added into water 82.09%, A phase substance in emulsion pot and mix, heating
When being warming up to 75-85 DEG C, with the mixing speed of 1200-1500r/min, it is stirred for being uniformly mixed, then sterilize 15-20min,
Obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Embodiment 2
It is a kind of to have effects that anti-blue light contamination and the essence repaired cream, with weight, including following components:
A phase: glycerol 5%, butanediol 2%, 1,3- propylene glycol 3%, micromolecule hyaluronic acid sodium 1%, xanthan gum 0.5%,
Stearine 0.3%, hydrolecithin 0.3%, D-sorbite 1%, Phenoxyethanol 0.5%；
B phase: purslane extract 0.5%, chlorella extract 2%, Crambe abyssinica extract 6%, ginger root extract
3%, Japanese elm extract 2%；
C phase: panthenol 0.3%；
Water: 72.6%；
The preparation method of the essence cream: (1) being separately added into water 72.6%, A phase substance in emulsion pot and mix, and heating rises
When temperature is to 75-85 DEG C, with the mixing speed of 1200-1500r/min, it is stirred for being uniformly mixed, then sterilize 15-20min, obtains
Obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Embodiment 3
It is a kind of to have effects that anti-blue light contamination and the essence repaired cream, with weight, including following components:
A phase: glycerol 5%, butanediol 2%, 1,3- propylene glycol 3%, micromolecule hyaluronic acid sodium 1%, xanthan gum 0.5%,
Stearine 0.3%, hydrolecithin 0.3%, D-sorbite 1%, Phenoxyethanol 0.5%；
B phase: purslane extract 0.5%, chlorella extract 5%, Crambe abyssinica extract 8%, ginger root extract
6%, Japanese elm extract 5%；
C phase: panthenol 0.3%；
Water: 61.6%；
The preparation method of the essence cream: (1) being separately added into water 61.6%, A phase substance in emulsion pot and mix, and heating rises
When temperature is to 75-85 DEG C, with the mixing speed of 1200-1500r/min, it is stirred for being uniformly mixed, then sterilize 15-20min, obtains
Obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Embodiment 4
It is a kind of to have effects that anti-blue light contamination and the essence repaired cream, with weight, including following components:
A phase: glycerol 5%, butanediol 2%, 1,3- propylene glycol 3%, micromolecule hyaluronic acid sodium 1%, xanthan gum 0.5%,
Stearine 0.3%, hydrolecithin 0.3%, D-sorbite 1%, Phenoxyethanol 0.5%；
B phase: purslane extract 0.5%, chlorella extract 6%, Crambe abyssinica extract 9%, ginger root extract
7%, Japanese elm extract 6%；
C phase: panthenol 0.3%；
Water: 57.6%；
The preparation method of the essence cream: (1) being separately added into water 57.6%, A phase substance in emulsion pot and mix, and heating rises
When temperature is to 75-85 DEG C, with the mixing speed of 1200-1500r/min, it is stirred for being uniformly mixed, then sterilize 15-20min, obtains
Obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Embodiment 5
It is a kind of to have effects that anti-blue light contamination and the essence repaired cream, with weight, including following components:
A phase: glycerol 8%, butanediol 1%, 1,3- propylene glycol 5%, micromolecule hyaluronic acid sodium 0.01%, xanthan gum
0.1%, stearine 0.5%, hydrolecithin 0.5%, D-sorbite 3%, Phenoxyethanol 0.1%；
B phase: purslane extract 1%, chlorella extract 10%, Crambe abyssinica extract 15%, ginger root extract
15%, Japanese elm extract 10%；
C phase: panthenol 0.01%；
Water: 30.78%；
The preparation method of the essence cream: (1) being separately added into water 30.78%, A phase substance in emulsion pot and mix, heating
When being warming up to 75-85 DEG C, with the mixing speed of 1200-1500r/min, it is stirred for being uniformly mixed, then sterilize 15-20min,
Obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Comparative example 1
It is a kind of to have effects that anti-blue light contamination and the essence repaired cream, with weight, including following components:
A phase: glycerol 5%, butanediol 2%, 1,3- propylene glycol 3%, micromolecule hyaluronic acid sodium 1%, xanthan gum 0.5%,
Stearine 0.3%, hydrolecithin 0.3%, D-sorbite 1%, Phenoxyethanol 0.5%；
B phase: purslane extract 0.5%, chlorella extract 5%, Crambe abyssinica extract 8%, ginger root extract
6%；
C phase: panthenol 0.3%；
Water: 66.6%；
The preparation method of the essence cream: (1) being separately added into water 66.6%, A phase substance in emulsion pot and mix, and heating rises
When temperature is to 75-85 DEG C, with the mixing speed of 1200-1500r/min, it is stirred for being uniformly mixed, then sterilize 15-20min, obtains
Obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Comparative example 2
It is a kind of to have effects that anti-blue light contamination and the essence repaired cream, with weight, including following components:
A phase: glycerol 5%, butanediol 2%, 1,3- propylene glycol 3%, micromolecule hyaluronic acid sodium 1%, xanthan gum 0.5%,
Stearine 0.3%, hydrolecithin 0.3%, D-sorbite 1%, Phenoxyethanol 0.5%；
B phase: purslane extract 0.5%, chlorella extract 5%, Crambe abyssinica extract 8%, Japanese elm extract 5%；
C phase: panthenol 0.3%；
Water: 67.6%；
The preparation method of the essence cream: (1) being separately added into water 67.6%, A phase substance in emulsion pot and mix, and heating rises
When temperature is to 75-85 DEG C, with the mixing speed of 1200-1500r/min, it is stirred for being uniformly mixed, then sterilize 15-20min, obtains
Obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Comparative example 3
It is a kind of to have effects that anti-blue light contamination and the essence repaired cream, with weight, including following components:
A phase: glycerol 5%, butanediol 2%, 1,3- propylene glycol 3%, micromolecule hyaluronic acid sodium 1%, xanthan gum 0.5%,
Stearine 0.3%, hydrolecithin 0.3%, D-sorbite 1%, Phenoxyethanol 0.5%；
B phase: purslane extract 0.5%, chlorella extract 5%, ginger root extract 6%, Japanese elm extract 5%；
C phase: panthenol 0.3%；
Water: 69.6%；
The preparation method of the essence cream: (1) being separately added into water 69.6%, A phase substance in emulsion pot and mix, and heating rises
When temperature is to 75-85 DEG C, with the mixing speed of 1200-1500r/min, it is stirred for being uniformly mixed, then sterilize 15-20min, obtains
Obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Comparative example 4
It is a kind of to have effects that anti-blue light contamination and the essence repaired cream, with weight, including following components:
A phase: glycerol 5%, butanediol 2%, 1,3- propylene glycol 3%, micromolecule hyaluronic acid sodium 1%, xanthan gum 0.5%,
Stearine 0.3%, hydrolecithin 0.3%, D-sorbite 1%, Phenoxyethanol 0.5%；
B phase: purslane extract 0.5%, Crambe abyssinica extract 8%, ginger root extract 6%, Japanese elm extract 5%；
C phase: panthenol 0.3%；
Water: 66.6%；
The preparation method of the essence cream: (1) being separately added into water 66.6%, A phase substance in emulsion pot and mix, and heating rises
When temperature is to 75-85 DEG C, with the mixing speed of 1200-1500r/min, it is stirred for being uniformly mixed, then sterilize 15-20min, obtains
Obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Comparative example 5
It is a kind of to have effects that anti-blue light contamination and the essence repaired cream, with weight, including following components:
A phase: glycerol 5%, butanediol 2%, 1,3- propylene glycol 3%, micromolecule hyaluronic acid sodium 1%, xanthan gum 0.5%,
Stearine 0.3%, hydrolecithin 0.3%, D-sorbite 1%, Phenoxyethanol 0.5%；
B phase: purslane extract 0.5%；
C phase: panthenol 0.3%；
Water: 85.6%；
The preparation method of the essence cream: (1) being separately added into water 85.6%, A phase substance in emulsion pot and mix, and heating rises
When temperature is to 75-85 DEG C, with the mixing speed of 1200-1500r/min, it is stirred for being uniformly mixed, then sterilize 15-20min, obtains
Obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, with the stirring speed of 1200-1500r/min
Degree stirring 30min, obtains mixed liquor b；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
Product evaluation
One, Product Safety is evaluated
Essence cream is repaired to the anti-blue light of embodiment 1-5, comparative example 1-5 and carries out cosmetics stimulation evaluation.
Tested crowd is women, 90 people, between 16~65 years old age.Subjects skin's health, no skin disease allergies, symbol
It closes subject's aspiration and is selected into standard.Random grouping, is divided into 5 groups, every group of 18 people.
Test method, which is behaved, shows consideration for patch test.Qualified spot tester is selected, tested material about 0.020-0.025g is placed in
In spot tester, the back of subject will be covered on non-stimulated adhesive tape added with the spot tester of tested material or forearm bends side, use palm
Light pressure is allowed to equably paste on the skin, continues for 24 hours.30min after tested spot tester is removed, observes skin after impression disappearance
Reaction.If result is feminine gender, observed again respectively with 48h for 24 hours after patch test primary.According to " cosmetics health rule in 2007
Model " and be reference standard in 2015 " cosmetics safety technical specification ", record its result.
Evaluation criterion: 0 grade: negative reaction；1 grade: suspicious reaction, only faint erythema；2 grades: weakly positive reaction, erythema,
Infiltration, can have papule at oedema；3 grades: strong positive reaction, erythema, oedema, can have papule, reaction that can exceed tested area at infiltration；4
Grade: extremely strong positive reaction, hence it is evident that erythema, severe infiltration, oedema, amalgamation bleb, reaction exceed tested area.
Human skin patch spot experimental result is shown: each group subject passes through the essence cream of embodiment 1-5, comparative example 1-5
Patch experiment, the dermoreaction with 48h observation subject for 24 hours after experiment, the dermoreaction of all subjects is feminine gender, is said
Bright anti-blue light reparation essence cream prepared by the present invention uses safe.
Two, product functionality is evaluated
1, anti-blue light performance detection
Essence cream is repaired to the anti-blue light of embodiment 1-5, comparative example 1-5 and carries out anti-blue light performance detection
The essence cream of embodiment 1-5 and comparative example 1-5 are dissolved in dimethyl sulfoxide respectively, it is molten to form corresponding sample
Liquid.A certain amount of people's epidermal keratinocyte (HEK) and human dermis' fibrocyte (HDF) are cultivated in 96- microwell plate, Mei Gewei
Cell quantity in orifice plate is identical.Culture is covered on the flat bottom sterile plate equipped with embodiment 1-5 and comparative example 1-5 sample solution
On the 96- microwell plate of cell, LED (476nm, 1900lux) blue light illumination 9h is carried out in the top apart from sterilizing board 30cm, then
Cell survival rate measurement is carried out with CellTiter96 (MTS), each processing is in triplicate.
Detection method: there is survival rate, the increment of the cell of metabolic activity by using CellTiter96 (MTS) detection
Rate, to study under embodiment 1-5, comparative example 1-5 essence cream protection condition, blue light is to people's epidermal keratinocyte (HEK) and people
The degree of injury of corium fabric cell (HDF), testing result are shown in Table 1.
Blank control: (37 DEG C) cell is not exposed under blue light at room temperature.
The anti-blue light performance detection of 1 each group essence cream of table
| Sample | People's epidermal keratinocyte is active (%) | Human dermis' fibrocyte is active (%) |
| Embodiment 1 | 86 | 88 |
| Embodiment 2 | 92 | 93 |
| Embodiment 3 | 98 | 99 |
| Embodiment 4 | 98 | 99 |
| Embodiment 5 | 98 | 98 |
| Comparative example 1 | 62 | 59 |
| Comparative example 2 | 58 | 57 |
| Comparative example 3 | 59 | 58 |
| Comparative example 4 | 51 | 54 |
| Comparative example 5 | 23 | 21 |
| Blank control | 100 | 100 |
As can be known from the results of Table 1, after LED (476nm, 1900lux) blue light illumination 9h, people's epidermis angle of embodiment 1-5
Cell plastid activity and human dermis' fibrocyte activity are above comparative example 1-5, illustrate the energy of the anti-blue light of essence cream of embodiment 1-5
Power is higher than comparative example 1-5, further relates to, and added efficacy has stronger indigo plant in the essence cream of the 1-5 of embodiment
Light filter capacity, and synergistic function is obvious, can injury of the block blue light to skin, therefore, the essence of the 1-5 of embodiment
Cream formula is better than comparative example 1-5；Wherein, the people's epidermal keratinocyte activity and human dermis' fibrocyte of embodiment 4 and embodiment 3
Chlorella in the effect of activity is above embodiment 1, embodiment 2 and embodiment 5, illustrates, embodiment 3 and embodiment 4 composition
Extract, Crambe abyssinica extract, the weight ratio of ginger root extract and Japanese elm extract are optimal.
2, cell activity oxygen is inhibited to generate
Essence cream is repaired to the anti-blue light of embodiment 1-5, comparative example 1-5 to carry out that cell activity oxygen is inhibited to generate test
The essence cream of embodiment 1-5 and comparative example 1-5 are dissolved in dimethyl sulfoxide respectively, it is molten to form corresponding sample
Liquid.Mouse 100, weight 20-30g for choosing health are randomly divided into 10 groups, every group 10,5 groups of test group, control group 5 are arranged
Group.The hair of back of mice is sloughed, area is about 2 × 2cm, will under the conditions of LED blue light 425nm (3mW/cm2 continues 18min)
Embodiment 1-5's and comparative example 1-5 is applied to correspondingly respectively in the exposed skin of above-mentioned 10 groups of mouse by sample,
In, embodiment 1-5 corresponds to 5 groups of test group of mouse, and comparative example 1-5 corresponds to 5 groups of control group of mouse, and each group applying amount is
1ml/cm is got over the dyeing of CellROX fluorescence intensity and the quantitative analysis of Volocity* image software, cell activity oxygen numerical value afterwards for 24 hours
The big anti-blue light performance for indicating given the test agent is poorer, persistently using in 1 month, observes within the 7th, 14,21,30 day after treatment respectively
The situation of change of mouse skin cell activity oxygen, the results are shown in Table 2.
Influence of the 2 each group essence cream of table to mouse skin cell activity oxygen
Table 2 the results show that mouse skin cell activity oxygen it is horizontal in the essence for smearing embodiment 1-5 and comparative example 1-5
Before magnificent cream, that is, at the 0th day, quite, but after smearing each group essence cream, the water of corresponding mouse skin cell activity oxygen
Flat, embodiment 1-5 is significantly lower than comparative example 1-5, illustrates that the anti-blue light contamination of embodiment 1-5 is repaired essence cream and can effectively be inhibited
The increase of mouse skin cell activity oxygen level under blue light pressure, and effect is better than more ratio 1-5 groups, wherein with embodiment 3
Inhibitory effect is best, thus further illustrates, the anti-blue light contamination of 1-5 of the embodiment of the present invention is repaired essence cream each group distribution ratio and closed
Reason, collaboration is obvious, has preferable anti-blue light performance.
3, repairing effect is evaluated
Essence cream is repaired to the anti-blue light of embodiment 1-5, comparative example 1-5 and carries out repairing effect evaluation
Choose male 30 people, 30 people of female, totally 60 25-45 year old, facial skin has different degrees of damage, and (such as skin is done
It is dry, decortication, itch the problems such as) volunteer, carry out repairing effect evaluation test.10 groups are randomly divided into, every group is divided into test again
Group and control group, test 3 people of group, compare 3 people of group, and the testing time is 28 days.During test, 10 are tested group
The morning and evening after cleaning face, respectively corresponds and smears essence made from an embodiment 1-5 and comparative example 1-5 every volunteer daily
Every volunteer of cream, control group does not smear any other cosmetics.Test group and control group normally contact LED blue light ring daily
Border is 5 hours, and test is evaluated after 28 days.
Evaluation criterion: skin injury repairs 80% the above are effective, and evaluation result is shown in Table 3.
The evaluation of 3 each group essence cream repairing effect of table
It being shown from the test result of table 3, the effective percentage of the skin repair of every volunteer of test group is above control group,
And the skin injury of embodiment 2-5 repairs 80% or more, wherein the skin repair effective percentage of embodiment 3-5 reaches 90%, and right
Ratio 1-5 skin injury reparation is below 80%, illustrates that anti-blue light of the invention repairs essence cream and has preferable repairing effect,
It is best with the formula repairing effect of embodiment 3, embodiment 4 and embodiment 5.
In conclusion essence cream provided by the invention, is not only resistant to blue light contamination, but also have effects that repair, comprehensive product function
Energy property evaluation, with the formula of embodiment 3 for best essence cream formula of the invention.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (8)
1. a kind of composition for having effects that anti-blue light contamination and repairing, which is characterized in that the composition includes that chlorella mentions
Take object, Crambe abyssinica extract, ginger root extract and Japanese elm extract.
2. the composition for having effects that anti-blue light contamination as described in claim 1 and repairing, which is characterized in that the chlorella
Extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract weight ratio be chlorella extract: Crambe abyssinica extracts
Object: ginger root extract: Japanese elm extract=1~10:2~15:1~15:1~10.
3. the composition for having effects that anti-blue light contamination as described in claim 1 and repairing, which is characterized in that the chlorella
Extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract weight ratio be chlorella extract: Crambe abyssinica extracts
Object: ginger root extract: Japanese elm extract=1~6:3~9:1.5~7:1~6.
4. the composition for having effects that anti-blue light contamination as described in claim 1 and repairing, which is characterized in that the chlorella
Extract, Crambe abyssinica extract, ginger root extract and Japanese elm extract weight ratio be chlorella extract: Crambe abyssinica extracts
Object: ginger root extract: Japanese elm extract=5:8:6:5.
5. a kind of have effects that anti-blue light contamination and the essence repaired cream, which is characterized in that including A phase substance, B phase substance, C phase
Substance and water；
Wherein, with the weight of essence cream:
The A phase substance includes: glycerol 1-8%, butanediol 1-5%, 1,3- propylene glycol 1-5%, micromolecule hyaluronic acid sodium
0.01-1.5%, xanthan gum 0.1-1%, stearine 0.2-0.5%, hydrolecithin 0.01-0.5%, D-sorbite
0.1-3%, Phenoxyethanol 0.1-1%；
The B phase substance includes: purslane extract 0.1-1%, chlorella extract 1-10%, Crambe abyssinica extract 2-
15%, ginger root extract 1-15%, Japanese elm extract 1-10%；
The C phase substance includes: panthenol 0.01-0.5%；
The water complements to 100%.
6. having effects that anti-blue light contamination and the essence repaired cream as claimed in claim 5, which is characterized in that the B phase object
Matter includes: purslane extract 0.1-1%, chlorella extract 1-6%, Crambe abyssinica extract 3-9%, ginger root extract
1.5-7%, Japanese elm extract 1-6%.
7. having effects that anti-blue light contamination and the essence repaired cream as claimed in claim 5, which is characterized in that the B phase object
Matter includes: purslane extract 0.5%, chlorella extract 5%, Crambe abyssinica extract 8%, ginger root extract 6%, Japanese elm
Extract 5%.
8. the preparation method with anti-blue light contamination and the essence cream repaired as described in claim 5-7 is any, special
Sign is, comprising the following steps:
(1) water, A phase substance are separately added into emulsion pot and are mixed, when being heated to 75-85 DEG C, with 1200-1500r/min
Mixing speed, be stirred for being uniformly mixed, then sterilize 15-20min, obtain mixed liquor a；
(2) when the temperature of liquid a to be mixed is down to 45 DEG C or less, B phase substance is added, is stirred with the mixing speed of 1200-1500r/min
30min is mixed, mixed liquor b is obtained；
(3) when liquid b to be mixed is down to room temperature, C phase substance is added, 30- is stirred with the mixing speed of 1200-1500r/min
60min obtains the essence cream.
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